| 1 | IKBKE
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| The decreased expression of IKBKE in systemic lupus erythematosus.
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| Zhu T, Hong J, Shuai Z, Xu S, Qian D, Hong X, Liu Y, Chen M, Meng Z, Zheng L, Zheng D, Zhang X, Liu L.
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| Clin Rheumatol. Sep;39(9):2611-2617. doi: 10.1007/s10067-020-05006-6. Epub 2020 Mar 7. 2020
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| 2 | IKBKE, STING1, TBK1
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| TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells
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| Balka KR, Louis C, Saunders TL, Smith AM, Calleja DJ, D'Silva DB, Moghaddas F, Tailler M, Lawlor KE, Zhan Y, Burns CJ, Wicks IP, Miner JJ, Kile BT, Masters SL, De Nardo D.
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| Cell Rep. Apr 7;31(1):107492. doi: 10.1016/j.celrep.2020.03.056. 2020
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| 3 | IKBKE
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| Identification of an IKBKE inhibitor with antitumor activity in cancer cells overexpressing IKBKE
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| Liu T, Gao X, Xin Y.
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| Cytokine. Apr;116:78-87. doi: 10.1016/j.cyto.2019.01.005. Epub 2019 Jan 24. 2019
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| 4 | IKBKE
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| IKKε regulates the breast cancer stem cell phenotype.
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| Orlova Z, Pruefer F, Castro-Oropeza R, Ordaz-Ramos A, Zampedri C, Maldonado V, Vazquez-Santillan K, Melendez-Zajgla J.
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| Biochim Biophys Acta Mol Cell Res. Apr;1866(4):598-611. doi: 10.1016/j.bbamcr.2019.01.002. Epub 2019 Jan 5. 2019
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| 5 | IKBKE
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| Activated kinase screening identifies the IKBKE oncogene as a positive regulator of autophagy. 2019 PMID:
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| Leonardi M, Perna E, Tronnolone S, Colecchia D, Chiariello M.
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| Autophagy. Feb;15(2):312-326. doi: 10.1080/15548627.2018.1517855. Epub 2018 Oct 5. 2018
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| 6 | IKBKE, PELP1
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| Cytoplasmic Localization of Proline, Glutamic Acid, Leucine-rich Protein 1 (PELP1) Induces Breast Epithelial Cell Migration through Up-regulation of Inhibitor of κB Kinase ϵ and Inflammatory Cross-talk with Macrophages.
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| Girard BJ, Knutson TP, Kuker B, McDowell L, Schwertfeger KL, Ostrander JH.
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| J Biol Chem 292(1):339-350. doi: 10.1074/jbc.M116.739847. Epub 2016 Nov 23.
2017
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| 7 | CRADD, IKBKE, IRF7
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| RAIDD Mediates TLR3 and IRF7 Driven Type I Interferon Production.
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| Maney SK, Xu HC, Huang J, Pandyra AA, Ehlting C, Aguilar-Valenzuela R, Pozdeev VI, McIlwain DR, Zimmermann A, Bode JG, Hengel H, Kirschning CJ, Kim IR, Hiscott J, Brenner D, Häussinger D, Ohashi PS, Mak TW, Lang KS, Lang PA.
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| Cell Physiol Biochem 39(4):1271-80. doi: 10.1159/000447832.
2016
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| 8 | IKBKE, NFATC1
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| IκB Kinase ε Is an NFATc1 Kinase that Inhibits T Cell Immune Response.
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| Zhang J, Feng H, Zhao J, Feldman ER, Chen SY, Yuan W, Huang C, Akbari O, Tibbetts SA, Feng P.
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| Cell Rep. Jul 12;16(2):405-418. doi: 10.1016/j.celrep.2016.05.083. Epub 2016 Jun 23. 2016
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| 9 | IKBKE
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| IKKε-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex.
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| Zhou AY, Shen RR, Kim E, Lock YJ, Xu M, Chen ZJ, Hahn WC.
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| Cell Rep. 3(3):724-33. 2013
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| 10 | IKBKE
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| RING finger protein 11 targets TBK1/IKKi kinases to inhibit antiviral signaling.
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| Charoenthongtrakul S, Gao L, Parvatiyar K, Lee D, Harhaj EW.
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| PLoS One. 8(1):e53717. 2013
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| 11 | DDX3X, IKBKE, IRF3
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| Human DEAD box helicase 3 couples IκB kinase ε to interferon regulatory factor 3 activation.
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| Gu L, Fullam A, Brennan R, Schröder M.
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| Mol Cell Biol 33(10):2004-15. doi: 10.1128/MCB.01603-12. Epub 2013 Mar 11.
2013
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| 12 | IKBKE
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| IKK epsilon kinase is crucial for viral G protein-coupled receptor tumorigenesis
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| Wang Y, Lu X, Zhu L, Shen Y, Chengedza S, Feng H, Wang L, Jung JU, Gutkind JS, Feng P.
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| Proc Natl Acad Sci U S A. Jul 2;110(27):11139-44. doi: 10.1073/pnas.1219829110. Epub 2013 Jun 14. Erratum in: Proc Natl Acad Sci U S A. 2013 Jul 23;110(30 2013
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| 13 | FOXO3, IFNB1, IKBKE
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| FOXO3 as a new IKK-ε-controlled check-point of regulation of IFN-β expression.
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| Luron L, Saliba D, Blazek K, Lanfrancotti A, Udalova IA.
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| Eur J Immunol 42(4):1030-7. doi: 10.1002/eji.201141969.
2012
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| 14 | CDK2, CDK2AP1, CDK2AP2, IKBKE
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| Human cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) is dimeric in its disulfide-reduced state, with natively disordered N-terminal region.
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| Ertekin A, Aramini JM, Rossi P, Leonard PG, Janjua H, Xiao R, Maglaqui M, Lee HW, Prestegard JH, Montelione GT.
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| J Biol Chem 287(20):16541-9. doi: 10.1074/jbc.M112.343863. Epub 2012 Mar 14.
2012
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| 15 | AKT1, IKBKE, TBK1
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| IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation.
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| Guo JP, Coppola D, Cheng JQ.
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| J Biol Chem 286(43):37389-98. doi: 10.1074/jbc.M111.287433. Epub 2011 Sep 9.
2011
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| 16 | IKBKE
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| The protein kinase IKKε is a potential target for the treatment of inflammatory hyperalgesia.
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| Möser CV, Kynast K, Baatz K, Russe OQ, Ferreirós N, Costiuk H, Lu R, Schmidtko A, Tegeder I, Geisslinger G, Niederberger E.
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| J Immunol 187(5):2617-25. Epub 2011 Aug 3.
2011
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| 17 | AKT1, IKBKE, TBK1
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| IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.
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| Xie X, Zhang D, Zhao B, Lu MK, You M, Condorelli G, Wang CY, Guan KL.
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| Proc Natl Acad Sci U S A 108(16):6474-9. Epub 2011 Apr 4.
2011
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| 18 | IKBKE, PELI1, TBK1
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| The role of TBK1 and IKKε in the expression and activation of Pellino 1.
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| Smith H, Liu XY, Dai L, Goh ET, Chan AT, Xi J, Seh CC, Qureshi IA, Lescar J, Ruedl C, Gourlay R, Morton S, Hough J, McIver EG, Cohen P, Cheung PC.
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| Biochem J 434(3):537-48.
2011
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| 19 | IKBKE
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| Novel splice variants of human IKKε negatively regulate IKKε-induced IRF3 and NF-kB activation.
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| Koop A, Lepenies I, Braum O, Davarnia P, Scherer G, Fickenscher H, Kabelitz D, Adam-Klages S.
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| Eur J Immunol 41(1):224-34. doi: 10.1002/eji.201040814. Epub 2010 Dec 3.
2011
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| 20 | IKBKE
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| IKBKE is over-expressed in glioma and contributes to resistance of glioma cells to apoptosis via activating NF-κB.
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| Guan H, Zhang H, Cai J, Wu J, Yuan J, Li J, Huang Z, Li M.
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| J Pathol 223(3):436-45. doi: 10.1002/path.2815. Epub 2010 Nov 23.
2011
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| 21 | IKBKE
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| IκB kinase epsilon (IKK(epsilon)) regulates the balance between type I and type II interferon responses.
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| Ng SL, Friedman BA, Schmid S, Gertz J, Myers RM, Tenoever BR, Maniatis T.
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| Proc Natl Acad Sci U S A. 108(52):21170-5. 2011
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| 22 | IKBKE
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| ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit antiviral signaling.
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| Gao L, Coope H, Grant S, Ma A, Ley SC, Harhaj EW.
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| J Biol Chem. 286(42):36592-602. 2011
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| 23 | IKBKE
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| SUMOylation-dependent localization of IKKepsilon in PML nuclear bodies is essential for protection against DNA-damage-triggered cell death.
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| Renner F, Moreno R, Schmitz ML.
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| Mol Cell 37(4):503-15.
2010
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| 24 | CYLD, IKBKE
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| Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation.
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| Hutti JE, Shen RR, Abbott DW, Zhou AY, Sprott KM, Asara JM, Hahn WC, Cantley LC.
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| Mol Cell 34(4):461-72.
2009
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| 25 | IKBKE
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| Ubiquitin-regulated recruitment of IkappaB kinase epsilon to the MAVS interferon signaling adapter.
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| Paz S, Vilasco M, Arguello M, Sun Q, Lacoste J, Nguyen TL, Zhao T, Shestakova EA, Zaari S, Bibeau-Poirier A, Servant MJ, Lin R, Meurs EF, Hiscott J.
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| Mol Cell Biol. 29(12):3401-12. 2009
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| 26 | IKBKE
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| The protein kinase IKKepsilon regulates energy balance in obese mice.
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| Chiang SH, Bazuine M, Lumeng CN, Geletka LM, Mowers J, White NM, Ma JT, Zhou J, Qi N, Westcott D, Delproposto JB, Blackwell TS, Yull FE, Saltiel AR.
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| Cell. 138(5):961-75. 2009
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| 27 | AZI2, IKBKE, TANK, TBKBP1
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| Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated?
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| Chau TL, Gioia R, Gatot JS, Patrascu F, Carpentier I, Chapelle JP, O'Neill L, Beyaert R, Piette J, Chariot A.
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| Trends Biochem Sci 33(4):171-80. Epub 2008 Mar 18. Review. 2008
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| 28 | IKBKE
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| Integrative genomic approaches identify IKBKE as a breast cancer oncogene.
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| Boehm JS, Zhao JJ, Yao J, Kim SY, Firestein R, Dunn IF, Sjostrom SK, Garraway LA, Weremowicz S, Richardson AL, Greulich H, Stewart CJ, Mulvey LA, Shen RR, Ambrogio L, Hirozane-Kishikawa T, Hill DE, Vidal M, Meyerson M, Grenier JK, Hinkle G, Root DE, Roberts TM, Lander ES, Polyak K, Hahn WC.
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| Cell 129(6):1065-79. 2007
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| 29 | IKBKE, TBK1
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| Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF.
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| Gatot JS, Gioia R, Chau TL, Patrascu F, Warnier M, Close P, Chapelle JP, Muraille E, Brown K, Siebenlist U, Piette J, Dejardin E, Chariot A.
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| J Biol Chem 282(43):31131-46. Epub 2007 Sep 6. 2007
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| 30 | IKBKE
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| Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity.
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| Tenoever BR, Ng SL, Chua MA, McWhirter SM, García-Sastre A, Maniatis T.
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| Science. 315(5816):1274-8. 2007
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| 31 | IKBKE
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| IKK-i/IKKepsilon controls constitutive, cancer cell-associated NF-kappaB activity via regulation of Ser-536 p65/RelA phosphorylation.
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| Adli M, Baldwin AS.
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| J Biol Chem 281(37):26976-84. Epub 2006 Jul 13. 2006
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| 32 | IKBKE
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| The Ret finger protein inhibits signaling mediated by the noncanonical and canonical IkappaB kinase family members.
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| Zha J, Han KJ, Xu LG, He W, Zhou Q, Chen D, Zhai Z, Shu HB.
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| J Immunol. 176(2):1072-80. 2006
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| 33 | IKBKE
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| Genomic structure and functional characterization of the promoter region of human IkappaB kinase-related kinase IKKi/IKKvarepsilon gene.
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| Wang N, Ahmed S, Haqqi TM.
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| Gene 353(1):118-33. 2005
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| 34 | IKBKE, SIKE, TBK1
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| SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.
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| Huang J, Liu T, Xu LG, Chen D, Zhai Z, Shu HB.
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| EMBO J 24(23):4018-28. Epub 2005 Nov 10. 2005
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| 35 | IKBKE
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| A20 is a negative regulator of IFN regulatory factor 3 signaling.
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| Saitoh T, Yamamoto M, Miyagishi M, Taira K, Nakanishi M, Fujita T, Akira S, Yamamoto N, Yamaoka S.
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| J Immunol. 174(3):1507-12. 2005
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| 36 | IKBKE
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| IKKi/IKKepsilon plays a key role in integrating signals induced by pro-inflammatory stimuli.
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| Kravchenko VV, Mathison JC, Schwamborn K, Mercurio F, Ulevitch RJ.
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| J Biol Chem 278(29):26612-9. Epub 2003 May 6. 2003
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| 37 | AZI2, IKBKE
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| Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling.
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| Fujita F, Taniguchi Y, Kato T, Narita Y, Furuya A, Ogawa T, Sakurai H, Joh T, Itoh M, Delhase M, Karin M, Nakanishi M.
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| Mol Cell Biol 23(21):7780-93. 2003
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| 38 | IKBKE, IKBKG, TANK, TBK1
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| Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases.
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| Chariot A, Leonardi A, Muller J, Bonif M, Brown K, Siebenlist U.
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| J Biol Chem 277(40):37029-36. 2002
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| 39 | IKBKE, TBK1
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| IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2.
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| Kishore N, Huynh QK, Mathialagan S, Hall T, Rouw S, Creely D, Lange G, Caroll J, Reitz B, Donnelly A, Boddupalli H, Combs RG, Kretzmer K, Tripp CS.
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| J Biol Chem 277(16):13840-7. 2002
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| 40 | IKBKE, TANK, TRAF2
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| NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation.
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| Nomura F, Kawai T, Nakanishi K, Akira S.
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| Genes Cells 5(3):191-202. 2000
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| 41 | IKBKE
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| IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex.
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| Peters RT, Liao SM, Maniatis T.
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| Mol Cell 5(3):513-22. 2000
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| 42 | IKBKE
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| IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases.
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| Shimada T, Kawai T, Takeda K, Matsumoto M, Inoue J, Tatsumi Y, Kanamaru A, Akira S.
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| Int Immunol 11(8):1357-62. 1999
|