Citations for
1IGF2, MYOD1, PRDM16
Double Myod and Igf2 inactivation promotes brown adipose tissue development by increasing Prdm16 expression.
Borensztein M, Viengchareun S, Montarras D, Journot L, Binart N, Lombès M, Dandolo L.
FASEB J 26(11):4584-91. doi: 10.1096/fj.12-208496. Epub 2012 Aug 2. 2012
2AKT1, IGF2
Akt1 and insulin-like growth factor 2 (Igf2) regulate placentation and fetal/postnatal development.
Kent LN, Ohboshi S, Soares MJ.
Int J Dev Biol 56(4):255-61. doi: 10.1387/ijdb.113407lk. 2012
3IGF2, MYOD1, PRDM16, UCP1
Double Myod and Igf2 inactivation promotes brown adipose tissue development by increasing Prdm16 expression.
Borensztein M, Viengchareun S, Montarras D, Journot L, Binart N, Lombès M, Dandolo L.
FASEB J 26(11):4584-91. doi: 10.1096/fj.12-208496. Epub 2012 Aug 2. 2012
4BWS, H19, IGF2, SRS11
Disruption of genomic neighbourhood at the imprinted IGF2-H19 locus in Beckwith-Wiedemann syndrome and Silver-Russell syndrome.
Nativio R, Sparago A, Ito Y, Weksberg R, Riccio A, Murrell A.
Hum Mol Genet 20(7):1363-74. Epub 2011 Jan 31. 2011
5BWS, H19, IGF2, SRS11
Analysis of the IGF2/H19 imprinting control region uncovers new genetic defects, including mutations of OCT-binding sequences, in patients with 11p15 fetal growth disorders.
Demars J, Shmela ME, Rossignol S, Okabe J, Netchine I, Azzi S, Cabrol S, Le Caignec C, David A, Le Bouc Y, El-Osta A, Gicquel C.
Hum Mol Genet 19(5):803-14. Epub 2009 Dec 9.PMID: 20007505 2010
6H19, IGF2, SRS11
Epigenetic mutations of the imprinted IGF2-H19 domain in Silver-Russell syndrome (SRS): results from a large cohort of patients with SRS and SRS-like phenotypes.
Bartholdi D, Krajewska-Walasek M, Ounap K, Gaspar H, Chrzanowska KH, Ilyana H, Kayserili H, Lurie IW, Schinzel A, Baumer A.
J Med Genet 46(3):192-7. Epub 2008 Dec 9. 2009
7CXCL12, IGF2, PPBP
IGF2 modulates the microenvironment for osteoclastogenesis.
Nakao K, Aoyama M, Fukuoka H, Fujita M, Miyazawa K, Asai K, Goto S.
Biochem Biophys Res Commun 378(3):462-6. Epub 2008 Dec 3. 2009
8BWS, CDKN1C, IGF2, SRS11
Phenotypic discordance upon paternal or maternal transmission of duplications of the 11p15 imprinted regions.
Bliek J, Snijder S, Maas SM, Polstra A, van der Lip K, Alders M, Knegt AC, Mannens MM.
Eur J Med Genet 52(6):404-8. Epub 2009 Sep 6. 2009
9H19, IGF2
Hypomethylated and hypermethylated profiles of H19DMR are associated with the aberrant imprinting of IGF2 and H19 in human hepatocellular carcinoma.
Wu J, Qin Y, Li B, He WZ, Sun ZL.
Genomics 91(5):443-50. Epub 2008 Mar 20. 2008
10IGF2, H19, RB, BWS
Different mechanisms cause imprinting defects at the IGF2/H19 locus in Beckwith-Wiedemann syndrome and Wilms' tumour.
Cerrato F, Sparago A, Verde G, De Crescenzo A, Citro V, Cubellis MV, Rinaldi MM, Boccuto L, Neri G, Magnani C, D'Angelo P, Collini P, Perotti D, Sebastio G, Maher ER, Riccio A.
Hum Mol Genet 17(10):1427-35. Epub 2008 Feb 1. 2008
11IGF2
Somatically acquired hypomethylation of IGF2 in breast and colorectal cancer.
Ito Y, Koessler T, Ibrahim AE, Rai S, Vowler SL, Abu-Amero S, Silva AL, Maia AT, Huddleston JE, Uribe-Lewis S, Woodfine K, Jagodic M, Nativio R, Dunning A, Moore G, Klenova E, Bingham S, Pharoah PD, Brenton JD, Beck S, Sandhu MS, Murrell A.
Hum Mol Genet 17(17):2633-43. Epub 2008 Jun 9. 2008
12IGF2
IGF-2 and FLT-1/VEGF-R1 mRNA levels reveal distinctions and similarities between congenital and common infantile hemangioma.
Picard A, Boscolo E, Khan ZA, Bartch TC, Mulliken JB, Vazquez MP, Bischoff J.
Pediatr Res 63(3):263-7. 2008
13IGF2, SRS11
Molecular and clinical findings and their correlations in Silver-Russell syndrome: implications for a positive role of IGF2 in growth determination and differential imprinting regulation of the IGF2-H19 domain in bodies and placentas.
Yamazawa K, Kagami M, Nagai T, Kondoh T, Onigata K, Maeyama K, Hasegawa T, Hasegawa Y, Yamazaki T, Mizuno S, Miyoshi Y, Miyagawa S, Horikawa R, Matsuoka K, Ogata T.
J Mol Med 86(10):1171-81. Epub 2008 Jul 8. 2008
14IGF2, BWS, WT1
Paternally inherited submicroscopic duplication at 11p15.5 implicates insulin-like growth factor II in overgrowth and Wilms' tumorigenesis.
Algar EM, St Heaps L, Darmanian A, Dagar V, Prawitt D, Peters GB, Collins F.
Cancer Res 67(5):2360-5. Epub 2007 Feb 26. 2007
15IGF2, MEST, IPW, SNRPN, PEG3, MEG3, KCNQ1OT1
Status of genomic imprinting in human embryonic stem cells as revealed by a large cohort of independently derived and maintained lines.
Rugg-Gunn PJ, Ferguson-Smith AC, Pedersen RA.
Hum Mol Genet 16 Spec No 2:R243-51. 2007
16IGF2
Duplication of the paternal IGF2 allele in trisomy 11 and elevated expression levels of IGF2 mRNA in congenital mesoblastic nephroma of the cellular or mixed type.
Watanabe N, Haruta M, Soejima H, Fukushi D, Yokomori K, Nakadate H, Okita H, Hata JI, Fukuzawa M, Kaneko Y.
Genes Chromosomes Cancer 46(10):929-35. 2007
17IGF2
Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk.
Kaneda A, Wang CJ, Cheong R, Timp W, Onyango P, Wen B, Iacobuzio-Donahue CA, Ohlsson R, Andraos R, Pearson MA, Sharov AA, Longo DL, Ko MS, Levchenko A, Feinberg AP.
Proc Natl Acad Sci U S A 104(52):20926-31. Epub 2007 Dec 17. 2007
18IGF2R, IGF2
Insulin-like growth factor 2 (IGF2) and IGF2 receptor gene variants are associated with fetal growth.
Kaku K, Osada H, Seki K, Sekiya S.
Acta Paediatr 96(3):363-7. 2007
19IGF2
Loss of imprinting of insulin-like growth factor II is associated with increased risk of proximal colon cancer.
Liou JM, Wu MS, Lin JT, Wang HP, Huang SP, Chiu HM, Lee YC, Lin YB, Shun CT, Liang JT.
Eur J Cancer 43(8):1276-82. Epub 2007 Mar 26. 2007
20IGF2
Insulin-like growth factor-II regulates the 12-lipoxygenase gene expression and promotes cell proliferation in human keratinocytes via the extracellular regulatory kinase and phosphatidylinositol 3-kinase pathways.
Yoo H, Kim SJ, Kim Y, Lee H, Kim TY.
Int J Biochem Cell Biol 39(6):1248-59. Epub 2007 Apr 20. 2007
21IGF2
Imprinting of IGF2 P0 transcript and novel alternatively spliced INS-IGF2 isoforms show differences between mouse and human.
Monk D, Sanches R, Arnaud P, Apostolidou S, Hills FA, Abu-Amero S, Murrell A, Friess H, Reik W, Stanier P, Constancia M, Moore GE.
Hum Mol Genet 15(8):1259-69. Epub 2006 Mar 10. 2006
22H19, IGF2, IH
Constitutional UPD for chromosome 11p15 in individuals with isolated hemihyperplasia is associated with high tumor risk and occurs following assisted reproductive technologies.
Shuman C, Smith AC, Steele L, Ray PN, Clericuzio C, Zackai E, Parisi MA, Meadows AT, Kelly T, Tichauer D, Squire JA, Sadowski P, Weksberg R.
Am J Med Genet A 140(14):1497-503. 2006
23IGF2
Loss of imprinting and promoter usage of the IGF2 in laryngeal squamous cell carcinoma.
Grbesa I, Ivkic M, Pegan B, Gall-Troselj K.
Cancer Lett 238(2):224-9. Epub 2005 Aug 18. 2006
24CTCF, H19, IGF2, BWS, WT1
Microdeletion of target sites for insulator protein CTCF in a chromosome 11p15 imprinting center in Beckwith-Wiedemann syndrome and Wilms' tumor.
Prawitt D, Enklaar T, Gartner-Rupprecht B, Spangenberg C, Oswald M, Lausch E, Schmidtke P, Reutzel D, Fees S, Lucito R, Korzon M, Brozek I, Limon J, Housman DE, Pelletier J, Zabel B.
Proc Natl Acad Sci U S A 102(11):4085-90. Epub 2005 Mar 2. 2005
25PLAG1, IGF2
Amplification and overexpression of the IGF2 regulator PLAG1 in hepatoblastoma.
Zatkova A, Rouillard JM, Hartmann W, Lamb BJ, Kuick R, Eckart M, von Schweinitz D, Koch A, Fonatsch C, Pietsch T, Hanash SM, Wimmer K.
Genes Chromosomes Cancer 39(2):126-37. 2004
26TRPM5, INS, DMR1, KCNQ1OT1, IGF2, BWS
The KCNQ1OT1 promoter, a key regulator of genomic imprinting in human chromosome 11p15.5.
Du M, Zhou W, Beatty LG, Weksberg R, Sadowski PD.
Genomics 84(2):288-300. 2004
27BWS, IGF2, H19
Microdeletions in the human H19 DMR result in loss of IGF2 imprinting and Beckwith-Wiedemann syndrome.
Sparago A, Cerrato F, Vernucci M, Ferrero GB, Silengo MC, Riccio A.
Nat Genet 36(9):958-60. Epub 2004 Aug 15. 2004
28IGF2, BWS
An association between variants in the IGF2 gene and Beckwith-Wiedemann syndrome: interaction between genotype and epigenotype.
Murrell A, Heeson S, Cooper WN, Douglas E, Apostolidou S, Moore GE, Maher ER, Reik W.
Hum Mol Genet 13(2):247-55. Epub 2003 Nov 25. 2004
29IGF2
Genomic imprinting of IGF2 is maintained in infantile hemangioma despite its high level of expression.
Yu Y, Wylie-Sears J, Boscolo E, Mulliken JB, Bischoff J.
Mol Med 10(7-12):117-23. 2004
30IGF2
Loss of IGF2 imprinting: a potential marker of colorectal cancer risk.
Cui H, Cruz-Correa M, Giardiello FM, Hutcheon DF, Kafonek DR, Brandenburg S, Wu Y, He X, Powe NR, Feinberg AP.
Science 299(5613):1753-5. 2003
31CDKN1C, H19, IGF2, KCNQ1OT1, SLC22A18, PHLDA2, BWS
Beckwith-Wiedemann syndrome demonstrates a role for epigenetic control of normal development.
Weksberg R, Smith AC, Squire J, Sadowski P.
Hum Mol Genet 12 Spec No 1:R61-8. 2003
32IGF2, INS
Evidence of multiple causal sites affecting weight in the IGF2-INS-TH region of human chromosome 11.
Gu D, O'Dell SD, Chen Xh XH, Miller GJ, Day IM.
Hum Genet 110(2):173-81. 2002
33H19, IGF2, KCNQ1
A differentially methylated imprinting control region within the Kcnq1 locus harbors a methylation-sensitive chromatin insulator.
Kanduri C, Fitzpatrick G, Mukhopadhyay R, Kanduri M, Lobanenkov V, Higgins M, Ohlsson R.
J Biol Chem 277(20):18106-10. 2002
34IGF2
Placental-specific IGF-II is a major modulator of placental and fetal growth.
Constancia M, Hemberger M, Hughes J, Dean W, Ferguson-Smith A, Fundele R, Stewart F, Kelsey G, Fowden A, Sibley C, Reik W.
Nature 417(6892):945-8. 2002
35IGF2
Loss of genomic imprinting of insulin-like growth factor 2 is strongly associated with cellular proliferation in normal hematopoietic cells.
Hofmann WK, Takeuchi S, Frantzen MA, Hoelzer D, Koeffler HP.
Exp Hematol 30(4):318-23. 2002
36IGF2
Loss of imprinting of the insulin-like growth factor II gene occurs by biallelic methylation in a core region of H19-associated CTCF-binding sites in colorectal cancer.
Nakagawa H, Chadwick RB, Peltomaki P, Plass C, Nakamura Y, de La Chapelle A.
Proc Natl Acad Sci U S A 98(2):591-6. 2001
37IGF2, MEST
Frequent loss of imprinting of IGF2 and MEST in lung adenocarcinoma.
Kohda M, Hoshiya H, Katoh M, Tanaka I, Masuda R, Takemura T, Fujiwara M, Oshimura M.
Mol Carcinog 31(4):184-91. 2001
38BWS, IGF2, KTWS1
Relaxation of insulin-like growth factor 2 imprinting and discordant methylation at KvDMR1 in two first cousins affected by Beckwith-Wiedemann and Klippel-Trenaunay-Weber syndromes.
Sperandeo MP, Ungaro P, Vernucci M, Pedone PV, Cerrato F, Perone L, Casola S, Cubellis MV, Bruni CB, Andria G, Sebastio G, Riccio A.
Am J Hum Genet 66(3):841-7. 2000
39BWS, CDKN1C, H19, IGF2, NAP1L4
Mutation analysis of H19 and NAP1L4 (hNAP2) candidate genes and IGF2 DMR2 in Beckwith-Wiedemann syndrome.
Catchpoole D, Smallwood AV, Joyce JA, Murrell A, Lam W, Tang T, Munroe D, Reik W, Schofield PN, Maher ER.
J Med Genet 37(3):212-5. No abstract available. 2000
40IGF2, INS
Transmission ratio distortion at the INS-IGF2 VNTR.
Eaves IA, et al.
Nat Genet 22(4):324-5. No abstract available 1999
41H19, IGF2
Enhancer competition between H19 and Igf2 does not mediate their imprinting.
Schmidt JV, et al.
Proc Natl Acad Sci U S A 96(17):9733-8 1999
42IGF2, INS, MODY10
Associations of IGF2 apaI RFLP and INS VNTR class I allele size with obesity.
O'Dell SD, et al.
Eur J Hum Genet 7(7):821-7 1999
43IGF2
Cloning of breakpoints in and downstream the IGF2 gene that are associated with overexpression of IGF2 transcripts in colorectal tumours.
Hodzic D, Frey B, Marechal D, Scarcez T, Grooteclaes M, Winkler R.
Oncogene 18(33):4710-7 1999
44H19, IGF2
Frequent loss of imprinting at the IGF2 and H19 genes in head and neck squamous carcinoma.
el-Naggar AK, Lai S, Tucker SA, Clayman GL, Goepfert H, Hong WK, Huff V.
Oncogene 18(50):7063-9. 1999
45CDKN1C, IGF2
Oppositely imprinted genes p57(Kip2) and igf2 interact in a mouse model for Beckwith-Wiedemann syndrome.
Caspary T, Cleary MA, Perlman EJ, Zhang P, Elledge SJ, Tilghman SM.
Genes Dev 13(23):3115-24. 1999
46H19, IGF2
Dissociation of IGF2 and H19 imprinting in human brain.
Pham NV, et al.
Brain Res 810 : 1-8. 1998
47IGF2
IGF2 is parentally imprinted in human preimplantation embryos.
Lighten AD, et al.
Nat Genet 15 : 122-123. 1997
48IGF2
Loss of imprinting of human insulin-like growth factor II gene, IGF2, in acute myeloid leukemia.
Wu HK, et al.
Biochem Biophys Res Commun 231 : 466-472. 1997
49IGF2, H19, WT2
Epigenetic changes at the insulin-like growth factor II/H19 locus in developing kidney is an early event in Wilms tumorigenesis.
Okamoto K, et al.
Proc Natl Acad Sci U S A 94 : 5367-5371. 1997
50BWS, IGF2, H19
Imprinting of IGF2 and H19: lack of reciprocity in sporadic Beckwith-Wiedemann syndrome.
Joyce JA, Lam WK, Catchpoole DJ, Jenks P, Reik W, Maher ER, Schofield PN.
Hum Mol Genet 6(9):1543-8. 1997
51IGF2
Transactivation of Igf2 in a mouse model of Beckwith-Wiedemann syndrome.
Sun FL, Dean WL, Kelsey G, Allen ND, Reik W.
Nature 389(6653):809-15. 1997
52IGF2
Novel splicing of an IGF2 polymorphic region in human adrenocortical carcinomas.
Gray SG, Kjellman M, Larsson C, Ekstrom TJ.
Biochem Biophys Res Commun 239(3):878-83. 1997
53IGF2
Biallelic expression of the IGF2 gene in human breast disease.
McCann AH, et al.
Hum Mol Genet 5 : 1123-1127. 1996
54BWS, H19, IGF2
Imprinting mutation in the Beckwith-Wiedemann syndrome leads to biallelic IGF2 expression through an H19-independent pathway.
Brown KW, et al.
Hum Mol Genet 5 : 2027-2032. 1996
55BWS, H19, IGF2
Imprinting mutations in the Beckwith-Wiedemann syndrome suggested by an altered imprinting pattern in the IGF2-H19 domain.
Reik W, et al.
Hum Mol Genet 4 : 2379-2385. 1995
56H19, IGF2
Expression, promoter usage and parental imprinting status of insulin-like growth factor II (IGF2) in human hepatoblastoma : uncoupling of IGF2 and H19 imprinting.
Li X, et al.
Oncogene 11 : 221-229. 1995
57IGF2
Transcribed dinucleotide repeat polymorphism in the IGF2 gene.
Rainier S, et al.
Hum Mol Genet 3 : 386. 1994
58H19, IGF2, WT2
Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms'tumour.
Steenman MJC, et al.
Nat Genet 7 : 433-439. 1994
59IGF2
Parental genomic imprinting of the human IGF2 gene.
Giannoukakis N, et al.
Nat Genet 4 : 98-101. 1993
60IGF2, BWS
IGF2 is parentally imprinted during human embryogenesis and in the Beckwith-Wiedemann syndrome.
Ohlsson R, et al.
Nat Genet 4 : 94-97. 1993
61H19, IGF2
Physical linkage of two mammalian imprinted genes, H19 and insulin-like growth factor 2.
Zemel S, et al.
Nat Genet 2 : 61-65. 1992
62IGF2
Polymerase chain reaction (PCR) for detection of ApaI polymorphism at the insulin like growth factor II gene (IGF2).
Tadokoro K, et al.
Nucleic Acids Res 19 : 6967. 1991
63IGF2
Ava II RFLP at the insulin-like growth factor II (IGF II) locus on chromosome 11.
Schneid H, Girard F, Binoux M, Le Bouc Y.
Nucleic Acids Res 17 : 466. 1989
64IGF2
Insulin-like growth factor II and the riddle of tumor-induced hypoglycemia.
Axelrod L, Ron D.
N Engl J Med 319 : 1477-1479. 1988
65IGF2
Synthesis and secretion of insulin-like growth factor II by a leiomyosarcoma with associated hypoglycemia.
Daughaday WH, Emanuele MA, Brooks MH, Barbato AL, Kapadia M, Rotwein P.
N Engl J Med 319 : 1434-1440. 1988
66IGF2
ApaI and SstI RFLPs at the insulin-like growth factor II (IGF2) locus on chromosome 11.
Xiang K, et al.
Nucleic Acids Res 16 : 3599. 1988
67IGF2
EcoRI RFLP in the human IGF II gene.
Cocozza S, et al.
Nucleic Acids Res 16 : 2737. 1988
68IGF2
BamHI RFLP at the insulin-like growth factor II (IGF2) locus on chromosome 11.
Xiang K, et al.
Nucleic Acids Res 15 : 7655. 1987
69EGF, IGF1, IGF2
Human genes for insulin-like growth factors I and II and epidermal growth factor are located on 12q22-q24.1, 11p15, and 4q25-q27, respectively.
Morton CC, et al.
Cytogenet Cell Genet 41 : 245-249. 1986
70IGF2
Regional assignment of IGF2 to distal 11p15.
Henry I, et al.
(HGM8) Cytogenet Cell Genet 40 : 648-649. 1985
71IGF2
Nucleotide sequences of cDNAs encoding precursors of human insulin-like growth factor II (IGF-II) and an IGF-II variant.
Jansen M, van Schaik FM, van Tol H, Van den Brande JL, Sussenbach JS.
FEBS Lett 179 : 243-246. 1985
72IGF1, IGF2
The insulin-like growth factor-1 (IGF1) is encoded at 12q22-q24.1, and insulin-like growth factor-2 (IGF2) is at 11p15.
Morton C, et al.
(HGM8) Cytogenet Cell Genet 40 : 703. 1985
73IGF1, IGF2
Sub-regional localization of human genes for insulin-like growth factors (IGF1) and II (IGF2) by in situ hybridization.
Yang-Feng TL, et al.
(HGM8) Cytogenet Cell Genet 40 : 782. 1985
74IGF2
Chromosomal localization and preliminary characterization of the human gene encoding insulin-like growth factor II.
Patger-Holthuizen P de, et al.
Hum Genet 69 : 170-173. 1985
75EGF, IGF2
Human chromosomal mapping of genes for insulin-like growth factors I and II and epidermal growth factor.
Brissenden JE, et al.
Nature 310 : 781-784. 1984