1 | ADAM17, IFNG
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| A-Disintegrin and Metalloproteinase (ADAM) 17 Enzymatically Degrades Interferon-gamma.
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| Kanzaki H, Shinohara F, Suzuki M, Wada S, Miyamoto Y, Yamaguchi Y, Katsumata Y, Makihira S, Kawai T, Taubman MA, Nakamura Y.
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| Sci Rep 6:32259. doi: 10.1038/srep32259.
2016
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2 | CD274, IFNG, JAK1, JAK2
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| Interferon-γ-induced activation of JAK1 and JAK2 suppresses tumor cell susceptibility to NK cells through upregulation of PD-L1 expression.
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| Bellucci R, Martin A, Bommarito D, Wang K, Hansen SH, Freeman GJ, Ritz J.
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| Oncoimmunology Mar 2;4(6):e1008824. doi: 10.1080/2162402X.2015.1008824. eCollection 2015 Jun. 2015
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3 | IFNG, PRDM1, TLE4
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| Tle4 regulates epigenetic silencing of gamma interferon expression during effector T helper cell tolerance.
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| Bandyopadhyay S, Valdor R, Macian F.
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| Mol Cell Biol 34(2):233-45. doi: 10.1128/MCB.00902-13. Epub 2013 Nov 4. 2014
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4 | IFNG, IL33, PSMB9, STAT1
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| IFN-γ directly controls IL-33 protein level through a STAT1- and LMP2-dependent mechanism.
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| Kopach P, Lockatell V, Pickering EM, Haskell RE, Anderson RD, Hasday JD, Todd NW, Luzina IG, Atamas SP.
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| J Biol Chem 289(17):11829-43. doi: 10.1074/jbc.M113.534396. Epub 2014 Mar 11.
2014
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5 | GBP1, IFNG
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| Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton.
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| Forster F, Paster W, Supper V, Schatzlmaier P, Sunzenauer S, Ostler N, Saliba A, Eckerstorfer P, Britzen-Laurent N, Schütz G, Schmid JA, Zlabinger GJ, Naschberger E, Stürzl M, Stockinger H.
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| J Immunol 192(2):771-81. doi: 10.4049/jimmunol.1300377. Epub 2013 Dec 13.
2014
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6 | IFNG, TBX21
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| NK cells gain higher IFN-γ competence during terminal differentiation.
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| Luetke-Eversloh M, Cicek BB, Siracusa F, Thom JT, Hamann A, Frischbutter S, Baumgrass R, Chang HD, Thiel A, Dong J, Romagnani C.
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| Eur J Immunol 44(7):2074-84. doi: 10.1002/eji.201344072. Epub 2014 May 19.
2014
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7 | IFNG
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| Genetic polymorphisms of IFNG and IFNGR1 in association with the risk of pulmonary tuberculosis.
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| Lü J, Pan H, Chen Y, Tang S, Feng Y, Qiu S, Zhang S, Wu L, Xu R, Peng X, Wang J, Lu C.
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| Gene 543(1):140-4. doi: 10.1016/j.gene.2014.03.042. Epub 2014 Mar 25.
2014
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8 | IFNG, NR1H3
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| Identification of interferon-γ as a new molecular target of liver X receptor.
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| Wang Q, Ma X, Chen Y, Zhang L, Jiang M, Li X, Xiang R, Miao R, Hajjar DP, Duan Y, Han J.
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| Biochem J 459(2):345-54. doi: 10.1042/BJ20131442.
2014
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9 | IFNG
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| IFN-γ-dependent activation of the brain's choroid plexus for CNS immune surveillance and repair.
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| Kunis G, Baruch K, Rosenzweig N, Kertser A, Miller O, Berkutzki T, Schwartz M.
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| Brain 136(Pt 11):3427-40. doi: 10.1093/brain/awt259. Epub 2013 Oct 1.
2013
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10 | IFNG
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| Interferon-γ and systemic autoimmunity.
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| Pollard KM, Cauvi DM, Toomey CB, Morris KV, Kono DH.
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| Discov Med 16(87):123-31. Review.
2013
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11 | IFNG, IRF1, OPTN
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| IRF-1-binding site in the first intron mediates interferon-γ-induced optineurin promoter activation.
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| Sudhakar C, Vaibhava V, Swarup G.
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| Biochem Biophys Res Commun 437(1):179-84. doi: 10.1016/j.bbrc.2013.06.065. Epub 2013 Jun 27.
2013
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12 | IFNG, MYD88
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| MyD88 signaling in CD4 T cells promotes IFN-γ production and hematopoietic progenitor cell expansion in response to intracellular bacterial infection.
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| Zhang Y, Jones M, McCabe A, Winslow GM, Avram D, MacNamara KC.
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| J Immunol 190(9):4725-35. doi: 10.4049/jimmunol.1203024. Epub 2013 Mar 22.
2013
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13 | IFNG, IL33
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| Evidence for a regulatory loop between IFN-γ and IL-33 in skin inflammation.
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| Seltmann J, Werfel T, Wittmann M.
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| Exp Dermatol 22(2):102-7. doi: 10.1111/exd.12076.
2013
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14 | IFNG, TNFSF13B
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| Induction of BAFF expression by IFN-γ via JAK/STAT signaling pathways in human intestinal epithelial cells.
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| Woo SJ, Im J, Jeon JH, Kang SS, Lee MH, Yun CH, Moon EY, Song MK, Kim HH, Han SH.
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| J Leukoc Biol 93(3):363-8. doi: 10.1189/jlb.0412210. Epub 2012 Dec 27.
2013
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15 | IFNG, IL26
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| Lineage-specific adjacent IFNG and IL26 genes share a common distal enhancer element.
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| Collins PL, Henderson MA, Aune TM.
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| Genes Immun 13(6):481-8. doi: 10.1038/gene.2012.22. Epub 2012 May 24.
2012
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16 | IFNG, RUNX3, TWIST1
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| Twist1 regulates Ifng expression in Th1 cells by interfering with Runx3 function.
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| Pham D, Vincentz JW, Firulli AB, Kaplan MH.
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| J Immunol 189(2):832-40. doi: 10.4049/jimmunol.1200854. Epub 2012 Jun 8.
2012
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17 | FXN, IFNG
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| Interferon gamma upregulates frataxin and corrects the functional deficits in a Friedreich ataxia model.
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| Tomassini B, Arcuri G, Fortuni S, Sandi C, Ezzatizadeh V, Casali C, Condò I, Malisan F, Al-Mahdawi S, Pook M, Testi R.
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| Hum Mol Genet 21(13):2855-61. doi: 10.1093/hmg/dds110. Epub 2012 Mar 23.
2012
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18 | IFNA1, IFNG
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| Autocrine IFN-γ promotes naive CD8 T cell differentiation and synergizes with IFN-α to stimulate strong function.
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| Curtsinger JM, Agarwal P, Lins DC, Mescher MF.
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| J Immunol 189(2):659-68. doi: 10.4049/jimmunol.1102727. Epub 2012 Jun 15.
2012
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19 | IFNG, TBX21
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| Ikaros silences T-bet expression and interferon-gamma production during T helper 2 differentiation.
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| Thomas RM, Chen C, Chunder N, Ma L, Taylor J, Pearce EJ, Wells AD.
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| J Biol Chem 285(4):2545-53. Epub 2009 Nov 18.PMID: 19923223 2010
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20 | DUOX2, IFNG
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| IFNgamma mediates DUOX2 expression via a STAT-independent signaling pathway.
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| Hill T 3rd, Xu C, Harper RW.
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| Biochem Biophys Res Commun 395(2):270-4. Epub 2010 Apr 8.
2010
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21 | IFNG, IL27, SPP1
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| Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation.
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| Murugaiyan G, Mittal A, Weiner HL.
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| Proc Natl Acad Sci U S A 107(25):11495-500. Epub 2010 Jun 7.PMID: 20534530 2010
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22 | COL1A2, IFNG, RFXANK
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| RFXB and its splice variant RFXBSV mediate the antagonism between IFNgamma and TGFbeta on COL1A2 transcription in vascular smooth muscle cells.
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| Fang M, Kong X, Li P, Fang F, Wu X, Bai H, Qi X, Chen Q, Xu Y.
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| Nucleic Acids Res 37(13):4393-406. Epub 2009 May 22. 2009
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23 | IFNG
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| Interferon-gamma axis in graft arteriosclerosis.
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| Tellides G, Pober JS.
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| Circ Res 100(5):622-32. Review. 2007
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24 | IFNG, IGF1
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| In the absence of IGF-1 signaling, IFN-gamma suppresses human malignant T-cell growth.
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| Conti L, Regis G, Longo A, Bernabei P, Chiarle R, Giovarelli M, Novelli F.
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| Blood 109(6):2496-504. Epub 2006 Dec 5. 2007
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25 | IFNG
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| Proteasome response to interferon-gamma is altered in senescent human fibroblasts.
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| Stratford FL, Chondrogianni N, Trougakos IP, Gonos ES, Rivett AJ.
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| FEBS Lett 580(16):3989-94. Epub 2006 Jun 21. 2006
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26 | TBX21, IFNG
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| Identification of a novel type 1 diabetes susceptibility gene, T-bet.
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| Sasaki Y, Ihara K, Matsuura N, Kohno H, Nagafuchi S, Kuromaru R, Kusuhara K, Takeya R, Hoey T, Sumimoto H, Hara T.
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| Hum Genet 115(3):177-84. Epub 2004 Jul 06. 2004
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27 | IFNG, EIF2AK2
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| Human interferon-gamma mRNA autoregulates its translation through a pseudoknot that activates the interferon-inducible protein kinase PKR.
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| Ben-Asouli Y, Banai Y, Pel-Or Y, Shir A, Kaempfer R.
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| Cell 108(2):221-32. 2002
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28 | SOCS1, IFNG
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| The tumor suppressor activity of SOCS-1.
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| Rottapel R, Ilangumaran S, Neale C, La Rose J, Ho JM, Nguyen MH, Barber D, Dubreuil P, de Sepulveda P.
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| Oncogene 21(28):4351-62. 2002
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29 | IFNG, STAT1
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| Biologic consequences of Stat1-independent IFN signaling.
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| Gil MP, Bohn E, O'Guin AK, Ramana CV, Levine B, Stark GR, Virgin HW, Schreiber RD.
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| Proc Natl Acad Sci U S A 98(12):6680-5. 2001
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30 | IFNG, STAT1
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| Stat1-independent regulation of gene expression in response to IFN-gamma.
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| Ramana CV, Gil MP, Han Y, Ransohoff RM, Schreiber RD, Stark GR.
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| Proc Natl Acad Sci U S A 98(12):6674-9. 2001
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31 | IFNG
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| Interferon gamma gene polymorphism and susceptibility to, and severity of, rheumatoid arthritis.
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| Constantin A, Navaux F, Lauwers-Cances V, Abbal M, van Meerwijk JP, Mazieres B, Cambon-Thomsen A, Cantagrel A.
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| Lancet 358(9298):2051-2. 2001
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32 | BRCA1, IFNG, STAT1
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| Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-gamma target genes.
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| Ouchi T, Lee SW, Ouchi M, Aaronson SA, Horvath CM.
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| Proc Natl Acad Sci U S A 97(10):5208-13. 2000
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33 | IFNG, TNFRSF11A, TNFRSF11B, TRAF6
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| T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma.
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| Takayanagi H, Ogasawara K, Hida S, Chiba T, Murata S, Sato K, Takaoka A, Yokochi T, Oda H, Tanaka K, Nakamura K, Taniguchi T.
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| Nature 408(6812):600-5. 2000
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34 | IFNG, IL2, NMI, STAT1, STAT5A
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| Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling.
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| Zhu M, et al.
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| Cell 96(1):121-30. 1999
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35 | IFN1@, IFNG, STAT1
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| Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma.
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| Bromberg JF, Horvath CM, Wen Z, Schreiber RD, Darnell JE Jr.
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| Proc Natl Acad Sci U S A 93(15):7673-8. 1996
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36 | IFNG
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| Mapping of the immune interferon gamma gene (IFNG) to chromosome band 12q14 by fluorescence in situ hybridization.
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| Zimonjic DB, et al.
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| Cytogenet Cell Genet 71 : 247-248. 1995
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37 | IFNG, MDM2
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| The gene coding for interferon-gamma is linked to the D12S335 and D12S313 microsatellites and to the MDM2 gene.
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| Bureau JF, et al.
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| Genomics 28 : 109-112. 1995
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38 | IFN1@, IFNB1, IFNG, IFNP11, IFNP12, IFNW1, IFNWP2, IFNWP5, IFNWP9, IFNWP15, IFNWP18, IFNWP19, IFNP20, IFNP23, IFNP24
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| Structure of the human type-I interferon gene cluster determined from a YAC clone contig.
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| Diaz MO, et al.
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| Genomics 22 : 540-552. 1994
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39 | IFNG
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| Dinucleotide repeat polymorphism in the inter-feron-gamma (IFNG) gene.
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| Ruiz-Linares A.
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| Hum Mol Genet 2 : 1508. 1993
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40 | IL10, IFNG, CSF2
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| Selective expression of interleukin 10, interferon gamma, and granulocyte-macrophage colony-stimulating factor in ovarian cancer biopsies.
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| Pisa P, et al.
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| Proc Natl Acad Sci U S A 89 : 7708-7712. 1992
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41 | IFNG
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| Interferon-gamma gene expression in unstimulated bone marrow monocuclear cells predicts a good response to cyclosporine therapy in aplastic anemia.
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| Nakao S, et al.
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| Blood 79 : 2532-2535. 1992
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42 | IFNG
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| Human B cell lines express the interferon gamma gene.
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| Dayton MA, et al.
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| Cytokine 4 : 454-460. 1992
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43 | IFNG
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| Gamma-interferon increases metaiodobenzylguanidine incorporation and retention in human neuroblastoma cells.
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| Montaldo PG, et al.
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| Cancer Res 52 : 4960-4964. 1992
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44 | IFNG
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| The use of polymerase chain reaction (PCR) for assessing interferon-gamma (INF-gamma) mRNA levels in human lymphocytes.
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| Pazderka F, et al.
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| Transplant Proc 23 : 241-242. 1990
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45 | IFNG
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| Human immune interferon gene is located on chromosome 12.
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| Naylor SL, et al.
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| J Exp Med 157 : 1020-1027. 1983
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46 | IFN1@, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA16, IFNA17, IFNA21, IFNAP22, IFNB1, IFNG
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| Chromosomal localization of human leukocyte, fibroblast, and immune interferon genes by means of in situ hybridization.
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| Trent JM, et al.
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| Proc Natl Acad Sci U S A 79 : 7809-7813. 1982
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