| 1 | IFNA1
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| Mechanisms of IFNalpha-1a-Induced Apoptosis in a Laryngeal Cancer Cell Line.
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| Xin XL, Zhang R, Yuan XM, Liu L.
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| Med Sci Monit 25:7100-7114. doi: 10.12659/MSM.917097.
2019
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| 2 | IFNA1, IL6, SOCS3
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| Induction of interleukin 6 impairs the anti-HBV efficiency of IFN-α in human hepatocytes through upregulation of SOCS3.
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| Yang K, Guan S, Zhang H, Chen Z.
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| J Med Virol 91(5):803-812. doi: 10.1002/jmv.25382. Epub 2019 Jan 2.
2019
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| 3 | IFNA1, STING1
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| IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion.
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| Gkirtzimanaki K, Kabrani E, Nikoleri D, Polyzos A, Blanas A, Sidiropoulos P, Makrigiannakis A, Bertsias G, Boumpas DT, Verginis P.
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| Cell Rep 25(4):921-933.e5. doi: 10.1016/j.celrep.2018.09.001.
2018
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| 4 | IFNA1
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| Interferon alpha: The key trigger of type 1 diabetes.
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| Lombardi A, Tsomos E, Hammerstad SS, Tomer Y.
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| J Autoimmun 94:7-15. doi: 10.1016/j.jaut.2018.08.003. Epub 2018 Aug 14. Review.
2018
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| 5 | TLR7, XBP1, iFNA1
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| TLR7-mediated activation of XBP1 correlates with the IFNα production in humans.
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| Beisel C, Ziegler S, Martrus Zapater G, Chapel A, Griesbeck M, Hildebrandt H, Lohse AW, Altfeld M.
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| Cytokine 94:55-58. doi: 10.1016/j.cyto.2017.04.006. Epub 2017 Apr 10.
2017
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| 6 | IFNA1, STAT3
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| A novel anti-viral role for STAT3 in IFN-α signalling responses.
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| Mahony R, Gargan S, Roberts KL, Bourke N, Keating SE, Bowie AG, O'Farrelly C, Stevenson NJ.
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| Cell Mol Life Sci 74(9):1755-1764. doi: 10.1007/s00018-016-2435-3. Epub 2016 Dec 17.
2017
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| 7 | CD180, IFNA1
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| Ligation of CD180 inhibits IFN-α signaling in a Lyn-PI3K-BTK-dependent manner in B cells.
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| You M, Dong G, Li F, Ma F, Ren J, Xu Y, Yue H, Tang R, Ren D, Hou Y.
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| Cell Mol Immunol 14(2):192-202. doi: 10.1038/cmi.2015.61. Epub 2015 Aug 17.
2017
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| 8 | CASP4, IFNA1
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| Interferon α Induces the Apoptosis of Cervical Cancer HeLa Cells by Activating both the Intrinsic Mitochondrial Pathway and Endoplasmic Reticulum Stress-Induced Pathway.
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| Shi WY, Cao C, Liu L.
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| Int J Mol Sci 17(11). pii: E1832.
2016
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| 9 | ARID3A, IFNA1
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| Human effector B lymphocytes express ARID3a and secrete interferon alpha.
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| Ward JM, Ratliff ML, Dozmorov MG, Wiley G, Guthridge JM, Gaffney PM, James JA, Webb CF.
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| J Autoimmun 75:130-140. doi: 10.1016/j.jaut.2016.08.003. Epub 2016 Aug 10.
2016
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| 10 | IFNA1
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| Interferon-α acutely impairs whole-brain functional connectivity network architecture - A preliminary study.
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| Dipasquale O, Cooper EA, Tibble J, Voon V, Baglio F, Baselli G, Cercignani M, Harrison NA.
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| Brain Behav Immun 58:31-39. doi: 10.1016/j.bbi.2015.12.011. Epub 2015 Dec 14.
2016
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| 11 | IFNA1, IFNB1
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| Blockade of interferon Beta, but not interferon alpha, signaling controls persistent viral infection.
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| Ng CT, Sullivan BM, Teijaro JR, Lee AM, Welch M, Rice S, Sheehan KC, Schreiber RD, Oldstone MB.
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| Cell Host Microbe 17(5):653-61. doi: 10.1016/j.chom.2015.04.005.
2015
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| 12 | AKT1, IFNA1, IL2, IL7
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| Interferon-α inhibits CD4 T cell responses to interleukin-7 and interleukin-2 and selectively interferes with Akt signaling.
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| Nguyen TP, Bazdar DA, Mudd JC, Lederman MM, Harding CV, Hardy GA, Sieg SF.
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| J Leukoc Biol 97(6):1139-46. doi: 10.1189/jlb.4A0714-345RR. Epub 2015 Mar 17.
2015
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| 13 | IFNA1
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| Increased IFN-α-producing plasmacytoid dendritic cells (pDCs) in human Th1-mediated type 1 diabetes: pDCs augment Th1 responses through IFN-α production.
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| Xia CQ, Peng R, Chernatynskaya AV, Yuan L, Carter C, Valentine J, Sobel E, Atkinson MA, Clare-Salzler MJ.
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| J Immunol 193(3):1024-34. doi: 10.4049/jimmunol.1303230. Epub 2014 Jun 27.
2014
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| 14 | IFNA1
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| Critical role of interferon-α constitutively produced in human hepatocytes in response to RNA virus infection.
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| Tsugawa Y, Kato H, Fujita T, Shimotohno K, Hijikata M.
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| PLoS One 9(2):e89869. doi: 10.1371/journal.pone.0089869. eCollection 2014.
2014
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| 15 | IFNA1
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| Interferon alpha association with neuromyelitis optica.
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| Asgari N, Voss A, Steenstrup T, Kyvik KO, Stenager E, Lillevang ST.
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| Clin Dev Immunol 2013:713519. doi: 10.1155/2013/713519. Epub 2013 Nov 18.
2013
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| 16 | IFNA1, ISG15
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| ISG15 inhibits IFN-α-resistant liver cancer cell growth.
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| Wan XX, Chen HC, Khan MA, Xu AH, Yang FL, Zhang YY, Zhang DZ.
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| Biomed Res Int 2013:570909. doi: 10.1155/2013/570909. Epub 2013 Aug 20.
2013
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| 17 | ADRB2, IFNA1, TLR9
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| Beta2-adrenoceptor stimulation suppresses TLR9-dependent IFNA1 secretion in human peripheral blood mononuclear cells.
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| Hilbert T, Bongartz J, Weisheit C, Knüfermann P, Baumgarten G, Hoeft A, Poth JM.
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| PLoS One 8(5):e65024. doi: 10.1371/journal.pone.0065024. Print 2013.
2013
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| 18 | IFNA1
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| Association of interferon-alpha gene polymorphisms with chronic hepatitis B virus infection.
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| Kimkong I, Tangkijvanich P, Hirankarn N.
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| Int J Immunogenet 40(6):476-81. doi: 10.1111/iji.12055. Epub 2013 Apr 8.
2013
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| 19 | IFNA1, IFNG
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| Autocrine IFN-γ promotes naive CD8 T cell differentiation and synergizes with IFN-α to stimulate strong function.
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| Curtsinger JM, Agarwal P, Lins DC, Mescher MF.
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| J Immunol 189(2):659-68. doi: 10.4049/jimmunol.1102727. Epub 2012 Jun 15.
2012
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| 20 | IFNA1
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| Interferon alpha as a primary pathogenic factor in human lupus.
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| Niewold TB.
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| J Interferon Cytokine Res 31(12):887-92. doi: 10.1089/jir.2011.0071. Epub 2011 Sep 16. Review.
2011
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| 21 | IFNA1, TLR9
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| IFN-α production by human mononuclear cells infected with varicella-zoster virus through TLR9-dependent and -independent pathways.
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| Yu HR, Huang HC, Kuo HC, Sheen JM, Ou CY, Hsu TY, Yang KD.
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| Cell Mol Immunol 8(2):181-8. doi: 10.1038/cmi.2010.84. Epub 2011 Feb 14.
2011
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| 22 | IFNA1, PDCD1
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| IFN-α directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity.
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| Terawaki S, Chikuma S, Shibayama S, Hayashi T, Yoshida T, Okazaki T, Honjo T.
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| J Immunol 186(5):2772-9. doi: 10.4049/jimmunol.1003208. Epub 2011 Jan 24.
2011
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| 23 | IFNA1
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| Interferon-alpha regulates the dynamic balance between human activated regulatory and effector T cells: implications for antiviral and autoimmune responses.
|
| Golding A, Rosen A, Petri M, Akhter E, Andrade F.
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| Immunology 131(1):107-17. doi: 10.1111/j.1365-2567.2010.03280.x. Epub 2010 May 6. Erratum in: Immunology. 2011 May;133(1):141.
2010
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| 24 | IFNA1, TLR9
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| IFN-alpha amplifies human naive B cell TLR-9-mediated activation and Ig production.
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| Giordani L, Sanchez M, Libri I, Quaranta MG, Mattioli B, Viora M.
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| J Leukoc Biol 86(2):261-71. doi: 10.1189/jlb.0908560. Epub 2009 Apr 28.
2009
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| 25 | IFIT3, IFNA1, MAPK8, PRKCD
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| Sequential activation of protein kinase C delta and JNK is required for interferon-alpha-induced expression of IFIT4.
|
| Huang X, Yang N, Ou X, Li D, Wang Z, Xie Q, Chen Y, Lin H, Yin G, Wen F.
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| Cell Signal 20(1):112-9.
2008
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| 26 | IFNA1
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| Interferon-alpha: a key factor in autoimmune disease?
|
| Plskova J, Greiner K, Muckersie E, Duncan L, Forrester JV.
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| Invest Ophthalmol Vis Sci 47(9):3946-50. 2006
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| 27 | IFNA1
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| Reduced IFN-alpha secretion by blood dendritic cells in human diabetes.
|
| Summers KL, Marleau AM, Mahon JL, McManus R, Hramiak I, Singh B.
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| Clin Immunol 121(1):81-9. Epub 2006 Jul 21. 2006
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| 28 | IFNA1, APOBEC3G
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| Anti-viral protein APOBEC3G is induced by interferon-alpha stimulation in human hepatocytes.
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| Tanaka Y, Marusawa H, Seno H, Matsumoto Y, Ueda Y, Kodama Y, Endo Y, Yamauchi J, Matsumoto T, Takaori-Kondo A, Ikai I, Chiba T.
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| Biochem Biophys Res Commun 341(2):314-9. Epub 2006 Jan 10. 2006
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| 29 | IFNA1, CR2
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| Characterization of human complement receptor type 2 (CR2/CD21) as a receptor for IFN-alpha: a potential role in systemic lupus erythematosus.
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| Asokan R, Hua J, Young KA, Gould HJ, Hannan JP, Kraus DM, Szakonyi G, Grundy GJ, Chen XS, Crow MK, Holers VM.
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| J Immunol 177(1):383-94. 2006
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| 30 | IFNA1
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| Constitutive expression of alpha interferon by skin dendritic cells confers resistance to infection by foot-and-mouth disease virus.
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| Bautista EM, Ferman GS, Gregg D, Brum MC, Grubman MJ, Golde WT.
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| J Virol 79(8):4838-47. 2005
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| 31 | IFNA1
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| Association between IFNA genotype and the risk of systemic lupus erythematosus.
|
| Nakashima H, Matsuno S, Akahoshi M, Miyake K, Inoue Y, Tanaka Y, Ninomiya I, Shimizu S, Igawa T, Sadanaga A, Otsuka T, Harada M.
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| Clin Rheumatol 24(1):38-40. Epub 2004 Jul 20. 2005
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| 32 | IFNA1
|
| Hepatitis C virus inhibits intracellular interferon alpha expression in human hepatic cell lines.
|
| Zhang T, Lin RT, Li Y, Douglas SD, Maxcey C, Ho C, Lai JP, Wang YJ, Wan Q, Ho WZ.
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| Hepatology 42(4):819-27. 2005
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| 33 | IFNA1, PDCD1
|
| The genetic basis of systemic lupus erythematosus--knowledge of today and thoughts for tomorrow.
|
| Prokunina L, Alarcon-Riquelme M.
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| Hum Mol Genet 13 Spec No 1:R143-8. Epub 2004 Feb 05. 2004
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| 34 | IFNA1, STAT1
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| STAT1 deficiency unexpectedly and markedly exacerbates the pathophysiological actions of IFN-alpha in the central nervous system.
|
| Wang J, Schreiber RD, Campbell IL.
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| Proc Natl Acad Sci U S A 99(25):16209-14. 2002
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| 35 | IFNA1, IFNA2, IFNA10, IFNA14, IFNA17
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| Polymorphism in the interferon-alpha gene family.
|
| Golovleva I, et al.
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| Am J Hum Genet 59 : 570-578. 1996
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| 36 | IFN1@, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAP22, IFNW1, IFNWP15, IFNWP18, IFNWP19, IFNWP2, IFNWP5, IFNWP9
|
| Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia.
|
| Olopade OI, et al.
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| Genomics 14 : 437-443. 1992
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| 37 | IFN1@, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA16, IFNA17, IFNA21, IFNAP22
|
| Dinucleotide repeat polymorphism at the IFNA locus (9p22).
|
| Kwiatkowski DJ, et al.
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| Hum Mol Genet 1 : 658. 1992
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| 38 | ETS1, IFN1@, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA16, IFNA17, IFNA21, IFNAP22, IFNB1
|
| Interferon and c-ets-1 genes in the translocation (9:11)(p22:q23) in human acute monocytic leukemia.
|
| Diaz MO, et al.
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| Science 231 : 265-267. 1986
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| 39 | IFN1@, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA16, IFNA17, IFNA21, IFNAP22, IFNB1
|
| Close linkage of alpha and beta interferons and infrequent duplication of beta interferon in humans.
|
| Ohlsson M, et al.
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| Proc Natl Acad Sci U S A 82 : 4473-4476. 1985
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| 40 | IFN1@, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA16, IFNA17, IFNA21, IFNAP22
|
| Structural relationship of human interferon alpha genes and pseudogenes.
|
| Henco K, et al.
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| J Mol Biol 185 : 227-260. 1985
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| 41 | IFN1@, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA16, IFNA17, IFNA21, IFNAP22
|
| Family of human alpha-interferon like sequences.
|
| Feinstein SI, et al.
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| Mol Cell Biol 5 : 510-517. 1985
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| 42 | IFN1@, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA16, IFNA17, IFNA21, IFNAP22, IFNB1
|
| Clustering of leukocyte and fibroblast interferon genes on human chromosome 9.
|
| Shows TB, Sakaguchi AY, Naylor SL, Goedell DV, Lawn RM.
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| Science 218 : 373-374. 1982
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| 43 | IFN1@, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA16, IFNA17, IFNA21, IFNAP22, IFNB1
|
| Both leucocyte (IFL) and fibroblast (IFF) interferon genes are on chromosome 9.
|
| Owerbach D, et al.
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| Cytogenet Cell Genet 32 : 307. 1982
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| 44 | IFN1@, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA16, IFNA17, IFNA21, IFNAP22, IFNB1, IFNG
|
| Chromosomal localization of human leukocyte, fibroblast, and immune interferon genes by means of in situ hybridization.
|
| Trent JM, et al.
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| Proc Natl Acad Sci U S A 79 : 7809-7813. 1982
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| 45 | IFN1@, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA16, IFNA17, IFNA21, IFNAP22
|
| Leukocyte and fibroblast interferon genes are located on human chromosome 9.
|
| Owerbach D, et al.
|
| Proc Natl Acad Sci U S A 78 : 3123-3127. 1981
|