Citations for
1IFNA1
Mechanisms of IFNalpha-1a-Induced Apoptosis in a Laryngeal Cancer Cell Line.
Xin XL, Zhang R, Yuan XM, Liu L.
Med Sci Monit 25:7100-7114. doi: 10.12659/MSM.917097. 2019
2IFNA1, IL6, SOCS3
Induction of interleukin 6 impairs the anti-HBV efficiency of IFN-α in human hepatocytes through upregulation of SOCS3.
Yang K, Guan S, Zhang H, Chen Z.
J Med Virol 91(5):803-812. doi: 10.1002/jmv.25382. Epub 2019 Jan 2. 2019
3IFNA1, STING1
IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion.
Gkirtzimanaki K, Kabrani E, Nikoleri D, Polyzos A, Blanas A, Sidiropoulos P, Makrigiannakis A, Bertsias G, Boumpas DT, Verginis P.
Cell Rep 25(4):921-933.e5. doi: 10.1016/j.celrep.2018.09.001. 2018
4IFNA1
Interferon alpha: The key trigger of type 1 diabetes.
Lombardi A, Tsomos E, Hammerstad SS, Tomer Y.
J Autoimmun 94:7-15. doi: 10.1016/j.jaut.2018.08.003. Epub 2018 Aug 14. Review. 2018
5TLR7, XBP1, iFNA1
TLR7-mediated activation of XBP1 correlates with the IFNα production in humans.
Beisel C, Ziegler S, Martrus Zapater G, Chapel A, Griesbeck M, Hildebrandt H, Lohse AW, Altfeld M.
Cytokine 94:55-58. doi: 10.1016/j.cyto.2017.04.006. Epub 2017 Apr 10. 2017
6IFNA1, STAT3
A novel anti-viral role for STAT3 in IFN-α signalling responses.
Mahony R, Gargan S, Roberts KL, Bourke N, Keating SE, Bowie AG, O'Farrelly C, Stevenson NJ.
Cell Mol Life Sci 74(9):1755-1764. doi: 10.1007/s00018-016-2435-3. Epub 2016 Dec 17. 2017
7CD180, IFNA1
Ligation of CD180 inhibits IFN-α signaling in a Lyn-PI3K-BTK-dependent manner in B cells.
You M, Dong G, Li F, Ma F, Ren J, Xu Y, Yue H, Tang R, Ren D, Hou Y.
Cell Mol Immunol 14(2):192-202. doi: 10.1038/cmi.2015.61. Epub 2015 Aug 17. 2017
8CASP4, IFNA1
Interferon α Induces the Apoptosis of Cervical Cancer HeLa Cells by Activating both the Intrinsic Mitochondrial Pathway and Endoplasmic Reticulum Stress-Induced Pathway.
Shi WY, Cao C, Liu L.
Int J Mol Sci 17(11). pii: E1832. 2016
9ARID3A, IFNA1
Human effector B lymphocytes express ARID3a and secrete interferon alpha.
Ward JM, Ratliff ML, Dozmorov MG, Wiley G, Guthridge JM, Gaffney PM, James JA, Webb CF.
J Autoimmun 75:130-140. doi: 10.1016/j.jaut.2016.08.003. Epub 2016 Aug 10. 2016
10IFNA1
Interferon-α acutely impairs whole-brain functional connectivity network architecture - A preliminary study.
Dipasquale O, Cooper EA, Tibble J, Voon V, Baglio F, Baselli G, Cercignani M, Harrison NA.
Brain Behav Immun 58:31-39. doi: 10.1016/j.bbi.2015.12.011. Epub 2015 Dec 14. 2016
11IFNA1, IFNB1
Blockade of interferon Beta, but not interferon alpha, signaling controls persistent viral infection.
Ng CT, Sullivan BM, Teijaro JR, Lee AM, Welch M, Rice S, Sheehan KC, Schreiber RD, Oldstone MB.
Cell Host Microbe 17(5):653-61. doi: 10.1016/j.chom.2015.04.005. 2015
12AKT1, IFNA1, IL2, IL7
Interferon-α inhibits CD4 T cell responses to interleukin-7 and interleukin-2 and selectively interferes with Akt signaling.
Nguyen TP, Bazdar DA, Mudd JC, Lederman MM, Harding CV, Hardy GA, Sieg SF.
J Leukoc Biol 97(6):1139-46. doi: 10.1189/jlb.4A0714-345RR. Epub 2015 Mar 17. 2015
13IFNA1
Increased IFN-α-producing plasmacytoid dendritic cells (pDCs) in human Th1-mediated type 1 diabetes: pDCs augment Th1 responses through IFN-α production.
Xia CQ, Peng R, Chernatynskaya AV, Yuan L, Carter C, Valentine J, Sobel E, Atkinson MA, Clare-Salzler MJ.
J Immunol 193(3):1024-34. doi: 10.4049/jimmunol.1303230. Epub 2014 Jun 27. 2014
14IFNA1
Critical role of interferon-α constitutively produced in human hepatocytes in response to RNA virus infection.
Tsugawa Y, Kato H, Fujita T, Shimotohno K, Hijikata M.
PLoS One 9(2):e89869. doi: 10.1371/journal.pone.0089869. eCollection 2014. 2014
15IFNA1
Interferon alpha association with neuromyelitis optica.
Asgari N, Voss A, Steenstrup T, Kyvik KO, Stenager E, Lillevang ST.
Clin Dev Immunol 2013:713519. doi: 10.1155/2013/713519. Epub 2013 Nov 18. 2013
16IFNA1, ISG15
ISG15 inhibits IFN-α-resistant liver cancer cell growth.
Wan XX, Chen HC, Khan MA, Xu AH, Yang FL, Zhang YY, Zhang DZ.
Biomed Res Int 2013:570909. doi: 10.1155/2013/570909. Epub 2013 Aug 20. 2013
17ADRB2, IFNA1, TLR9
Beta2-adrenoceptor stimulation suppresses TLR9-dependent IFNA1 secretion in human peripheral blood mononuclear cells.
Hilbert T, Bongartz J, Weisheit C, Knüfermann P, Baumgarten G, Hoeft A, Poth JM.
PLoS One 8(5):e65024. doi: 10.1371/journal.pone.0065024. Print 2013. 2013
18IFNA1
Association of interferon-alpha gene polymorphisms with chronic hepatitis B virus infection.
Kimkong I, Tangkijvanich P, Hirankarn N.
Int J Immunogenet 40(6):476-81. doi: 10.1111/iji.12055. Epub 2013 Apr 8. 2013
19IFNA1, IFNG
Autocrine IFN-γ promotes naive CD8 T cell differentiation and synergizes with IFN-α to stimulate strong function.
Curtsinger JM, Agarwal P, Lins DC, Mescher MF.
J Immunol 189(2):659-68. doi: 10.4049/jimmunol.1102727. Epub 2012 Jun 15. 2012
20IFNA1
Interferon alpha as a primary pathogenic factor in human lupus.
Niewold TB.
J Interferon Cytokine Res 31(12):887-92. doi: 10.1089/jir.2011.0071. Epub 2011 Sep 16. Review. 2011
21IFNA1, TLR9
IFN-α production by human mononuclear cells infected with varicella-zoster virus through TLR9-dependent and -independent pathways.
Yu HR, Huang HC, Kuo HC, Sheen JM, Ou CY, Hsu TY, Yang KD.
Cell Mol Immunol 8(2):181-8. doi: 10.1038/cmi.2010.84. Epub 2011 Feb 14. 2011
22IFNA1, PDCD1
IFN-α directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity.
Terawaki S, Chikuma S, Shibayama S, Hayashi T, Yoshida T, Okazaki T, Honjo T.
J Immunol 186(5):2772-9. doi: 10.4049/jimmunol.1003208. Epub 2011 Jan 24. 2011
23IFNA1
Interferon-alpha regulates the dynamic balance between human activated regulatory and effector T cells: implications for antiviral and autoimmune responses.
Golding A, Rosen A, Petri M, Akhter E, Andrade F.
Immunology 131(1):107-17. doi: 10.1111/j.1365-2567.2010.03280.x. Epub 2010 May 6. Erratum in: Immunology. 2011 May;133(1):141. 2010
24IFNA1, TLR9
IFN-alpha amplifies human naive B cell TLR-9-mediated activation and Ig production.
Giordani L, Sanchez M, Libri I, Quaranta MG, Mattioli B, Viora M.
J Leukoc Biol 86(2):261-71. doi: 10.1189/jlb.0908560. Epub 2009 Apr 28. 2009
25IFIT3, IFNA1, MAPK8, PRKCD
Sequential activation of protein kinase C delta and JNK is required for interferon-alpha-induced expression of IFIT4.
Huang X, Yang N, Ou X, Li D, Wang Z, Xie Q, Chen Y, Lin H, Yin G, Wen F.
Cell Signal 20(1):112-9. 2008
26IFNA1
Interferon-alpha: a key factor in autoimmune disease?
Plskova J, Greiner K, Muckersie E, Duncan L, Forrester JV.
Invest Ophthalmol Vis Sci 47(9):3946-50. 2006
27IFNA1
Reduced IFN-alpha secretion by blood dendritic cells in human diabetes.
Summers KL, Marleau AM, Mahon JL, McManus R, Hramiak I, Singh B.
Clin Immunol 121(1):81-9. Epub 2006 Jul 21. 2006
28IFNA1, APOBEC3G
Anti-viral protein APOBEC3G is induced by interferon-alpha stimulation in human hepatocytes.
Tanaka Y, Marusawa H, Seno H, Matsumoto Y, Ueda Y, Kodama Y, Endo Y, Yamauchi J, Matsumoto T, Takaori-Kondo A, Ikai I, Chiba T.
Biochem Biophys Res Commun 341(2):314-9. Epub 2006 Jan 10. 2006
29IFNA1, CR2
Characterization of human complement receptor type 2 (CR2/CD21) as a receptor for IFN-alpha: a potential role in systemic lupus erythematosus.
Asokan R, Hua J, Young KA, Gould HJ, Hannan JP, Kraus DM, Szakonyi G, Grundy GJ, Chen XS, Crow MK, Holers VM.
J Immunol 177(1):383-94. 2006
30IFNA1
Constitutive expression of alpha interferon by skin dendritic cells confers resistance to infection by foot-and-mouth disease virus.
Bautista EM, Ferman GS, Gregg D, Brum MC, Grubman MJ, Golde WT.
J Virol 79(8):4838-47. 2005
31IFNA1
Association between IFNA genotype and the risk of systemic lupus erythematosus.
Nakashima H, Matsuno S, Akahoshi M, Miyake K, Inoue Y, Tanaka Y, Ninomiya I, Shimizu S, Igawa T, Sadanaga A, Otsuka T, Harada M.
Clin Rheumatol 24(1):38-40. Epub 2004 Jul 20. 2005
32IFNA1
Hepatitis C virus inhibits intracellular interferon alpha expression in human hepatic cell lines.
Zhang T, Lin RT, Li Y, Douglas SD, Maxcey C, Ho C, Lai JP, Wang YJ, Wan Q, Ho WZ.
Hepatology 42(4):819-27. 2005
33IFNA1, PDCD1
The genetic basis of systemic lupus erythematosus--knowledge of today and thoughts for tomorrow.
Prokunina L, Alarcon-Riquelme M.
Hum Mol Genet 13 Spec No 1:R143-8. Epub 2004 Feb 05. 2004
34IFNA1, STAT1
STAT1 deficiency unexpectedly and markedly exacerbates the pathophysiological actions of IFN-alpha in the central nervous system.
Wang J, Schreiber RD, Campbell IL.
Proc Natl Acad Sci U S A 99(25):16209-14. 2002
35IFNA1, IFNA2, IFNA10, IFNA14, IFNA17
Polymorphism in the interferon-alpha gene family.
Golovleva I, et al.
Am J Hum Genet 59 : 570-578. 1996
36IFN1@, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAP22, IFNW1, IFNWP15, IFNWP18, IFNWP19, IFNWP2, IFNWP5, IFNWP9
Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia.
Olopade OI, et al.
Genomics 14 : 437-443. 1992
37IFN1@, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA16, IFNA17, IFNA21, IFNAP22
Dinucleotide repeat polymorphism at the IFNA locus (9p22).
Kwiatkowski DJ, et al.
Hum Mol Genet 1 : 658. 1992
38ETS1, IFN1@, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA16, IFNA17, IFNA21, IFNAP22, IFNB1
Interferon and c-ets-1 genes in the translocation (9:11)(p22:q23) in human acute monocytic leukemia.
Diaz MO, et al.
Science 231 : 265-267. 1986
39IFN1@, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA16, IFNA17, IFNA21, IFNAP22, IFNB1
Close linkage of alpha and beta interferons and infrequent duplication of beta interferon in humans.
Ohlsson M, et al.
Proc Natl Acad Sci U S A 82 : 4473-4476. 1985
40IFN1@, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA16, IFNA17, IFNA21, IFNAP22
Structural relationship of human interferon alpha genes and pseudogenes.
Henco K, et al.
J Mol Biol 185 : 227-260. 1985
41IFN1@, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA16, IFNA17, IFNA21, IFNAP22
Family of human alpha-interferon like sequences.
Feinstein SI, et al.
Mol Cell Biol 5 : 510-517. 1985
42IFN1@, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA16, IFNA17, IFNA21, IFNAP22, IFNB1
Clustering of leukocyte and fibroblast interferon genes on human chromosome 9.
Shows TB, Sakaguchi AY, Naylor SL, Goedell DV, Lawn RM.
Science 218 : 373-374. 1982
43IFN1@, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA16, IFNA17, IFNA21, IFNAP22, IFNB1
Both leucocyte (IFL) and fibroblast (IFF) interferon genes are on chromosome 9.
Owerbach D, et al.
Cytogenet Cell Genet 32 : 307. 1982
44IFN1@, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA16, IFNA17, IFNA21, IFNAP22, IFNB1, IFNG
Chromosomal localization of human leukocyte, fibroblast, and immune interferon genes by means of in situ hybridization.
Trent JM, et al.
Proc Natl Acad Sci U S A 79 : 7809-7813. 1982
45IFN1@, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA16, IFNA17, IFNA21, IFNAP22
Leukocyte and fibroblast interferon genes are located on human chromosome 9.
Owerbach D, et al.
Proc Natl Acad Sci U S A 78 : 3123-3127. 1981