| 1 | FZR1, IDH2
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| APC/C CDH1 ubiquitinates IDH2 contributing to ROS increase in mitosis.
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| Lambhate S, Bhattacharjee D, Jain N.
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| Cell Signal. Oct;86:110087. doi: 10.1016/j.cellsig.2021.110087. Epub 2021 Jul 13. 2021
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| 2 | IDH2, INTS3, SRSF2
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| Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis.
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| Yoshimi A, Lin KT, Wiseman DH, Rahman MA, Pastore A, Wang B, Lee SC, Micol JB, Zhang XJ, de Botton S, Penard-Lacronique V, Stein EM, Cho H, Miles RE, Inoue D, Albrecht TR, Somervaille TCP, Batta K, Amaral F, Simeoni F, Wilks DP, Cargo C, Intlekofer AM, Levine RL, Dvinge H, Bradley RK, Wagner EJ, Krainer AR, Abdel-Wahab O.
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| Nature Oct;574(7777):273-277. doi: 10.1038/s41586-019-1618-0. Epub 2019 Oct 2 2019
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| 3 | G6PD, IDH2, SIRT5
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| SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense.
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| Zhou L, Wang F, Sun R, Chen X, Zhang M, Xu Q, Wang Y, Wang S, Xiong Y, Guan KL, Yang P, Yu H, Ye D.
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| EMBO Rep 17(6):811-22. doi: 10.15252/embr.201541643. Epub 2016 Apr 9.
2016
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| 4 | IDH1, IDH2
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| Isocitrate dehydrogenase mutation is frequently observed in giant cell tumor of bone.
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| Kato Kaneko M, Liu X, Oki H, Ogasawara S, Nakamura T, Saidoh N, Tsujimoto Y, Matsuyama Y, Uruno A, Sugawara M, Tsuchiya T, Yamakawa M, Yamamoto M, Takagi M, Kato Y.
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| Cancer Sci 105(6):744-8. doi: 10.1111/cas.12413.
2014
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| 5 | COL2A1, IDH1, IDH2
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| Frequent mutation of the major cartilage collagen gene COL2A1 in chondrosarcoma.
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| Tarpey PS, Behjati S, Cooke SL, Van Loo P, Wedge DC, Pillay N, Marshall J, O'Meara S, Davies H, Nik-Zainal S, Beare D, Butler A, Gamble J, Hardy C, Hinton J, Jia MM, Jayakumar A, Jones D, Latimer C, Maddison M, Martin S, McLaren S, Menzies A, Mudie L, Raine K, Teague JW, Tubio JM, Halai D, Tirabosco R, Amary F, Campbell PJ, Stratton MR, Flanagan AM, Futreal PA.
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| Nat Genet 45(8):923-6. doi: 10.1038/ng.2668. Epub 2013 Jun 16.
2013
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| 6 | IDH1, IDH2
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| IDH mutations in tumorigenesis and their potential role as novel therapeutic targets.
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| Krell D, Mulholland P, Frampton AE, Krell J, Stebbing J, Bardella C.
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| Future Oncol 9(12):1923-35. doi: 10.2217/fon.13.143. Review.
2013
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| 7 | IDH1, IDH2
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| IDH mutation impairs histone demethylation and results in a block to cell differentiation.
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| Lu C, Ward PS, Kapoor GS, Rohle D, Turcan S, Abdel-Wahab O, Edwards CR, Khanin R, Figueroa ME, Melnick A, Wellen KE, O'Rourke DM, Berger SL, Chan TA, Levine RL, Mellinghoff IK, Thompson CB.
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| Nature 483(7390):474-8. doi: 10.1038/nature10860.
2012
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| 8 | IDH2, SIRT3
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| SIRT3 protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status.
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| Yu W, Dittenhafer-Reed KE, Denu JM.
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| J Biol Chem 287(17):14078-86. doi: 10.1074/jbc.M112.355206. Epub 2012 Mar 13.
2012
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| 9 | D2HA, D2HGDH, IDH1, IDH2
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| IDH1 and IDH2 have critical roles in 2-hydroxyglutarate production in D-2-hydroxyglutarate dehydrogenase depleted cells.
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| Matsunaga H, Futakuchi-Tsuchida A, Takahashi M, Ishikawa T, Tsuji M, Ando O.
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| Biochem Biophys Res Commun 423(3):553-6. doi: 10.1016/j.bbrc.2012.06.002. Epub 2012 Jun 7.
2012
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| 10 | ECDMM3, ECDMM4, IDH1, IDH2
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| Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome.
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| Pansuriya TC, van Eijk R, d'Adamo P, van Ruler MA, Kuijjer ML, Oosting J, Cleton-Jansen AM, van Oosterwijk JG, Verbeke SL, Meijer D, van Wezel T, Nord KH, Sangiorgi L, Toker B, Liegl-Atzwanger B, San-Julian M, Sciot R, Limaye N, Kindblom LG, Daugaard S, Godfraind C, Boon LM, Vikkula M, Kurek KC, Szuhai K, French PJ, Bovée JV.
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| Nat Genet 43(12):1256-61. doi: 10.1038/ng.1004. 2011
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| 11 | IDH1, IDH2
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| Ollier disease and Maffucci syndrome are caused by somatic mosaic mutations of IDH1 and IDH2.
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| Amary MF, Damato S, Halai D, Eskandarpour M, Berisha F, Bonar F, McCarthy S, Fantin VR, Straley KS, Lobo S, Aston W, Green CL, Gale RE, Tirabosco R, Futreal A, Campbell P, Presneau N, Flanagan AM.
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| Nat Genet 43(12):1262-5. doi: 10.1038/ng.994.
2011
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| 12 | IDH2
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| Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability.
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| Wise DR, Ward PS, Shay JE, Cross JR, Gruber JJ, Sachdeva UM, Platt JM, DeMatteo RG, Simon MC, Thompson CB.
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| Proc Natl Acad Sci U S A 108(49):19611-6. doi: 10.1073/pnas.1117773108. Epub 2011 Nov 21.
2011
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| 13 | IDH1, IDH2
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| Ollier disease and Maffucci syndrome are caused by somatic mosaic mutations of IDH1 and IDH2.
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| Amary MF, Damato S, Halai D, Eskandarpour M, Berisha F, Bonar F, McCarthy S, Fantin VR, Straley KS, Lobo S, Aston W, Green CL, Gale RE, Tirabosco R, Futreal A, Campbell P, Presneau N, Flanagan AM.
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| Nat Genet 43(12):1262-5. doi: 10.1038/ng.994.
2011
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| 14 | D2HA2, IDH2
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| IDH2 mutations in patients with D-2-hydroxyglutaric aciduria.
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| Kranendijk M, Struys EA, van Schaftingen E, Gibson KM, Kanhai WA, van der Knaap MS, Amiel J, Buist NR, Das AM, de Klerk JB, Feigenbaum AS, Grange DK, Hofstede FC, Holme E, Kirk EP, Korman SH, Morava E, Morris A, Smeitink J, Sukhai RN, Vallance H, Jakobs C, Salomons GS.
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| Science 330(6002):336. Epub 2010 Sep 16. 2010
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| 15 | IDH1, IDH2
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| IDH1 or IDH2 mutations predict longer survival and response to temozolomide in low-grade gliomas.
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| Houillier C, Wang X, Kaloshi G, Mokhtari K, Guillevin R, Laffaire J, Paris S, Boisselier B, Idbaih A, Laigle-Donadey F, Hoang-Xuan K, Sanson M, Delattre JY.
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| Neurology 75(17):1560-6.
2010
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| 16 | IDH1, IDH2
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| Glioma-derived mutations in IDH: from mechanism to potential therapy.
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| Fu Y, Huang R, Du J, Yang R, An N, Liang A.
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| Biochem Biophys Res Commun 397(2):127-30. Epub 2010 May 27. Review.
2010
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| 17 | IDH1, IDH2
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| Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value.
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| Abbas S, Lugthart S, Kavelaars FG, Schelen A, Koenders JE, Zeilemaker A, van Putten WJ, Rijneveld AW, Löwenberg B, Valk PJ.
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| Blood 116(12):2122-6. Epub 2010 Jun 10.
2010
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| 18 | IDH1, IDH2
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| The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate.
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| Ward PS, Patel J, Wise DR, Abdel-Wahab O, Bennett BD, Coller HA, Cross JR, Fantin VR, Hedvat CV, Perl AE, Rabinowitz JD, Carroll M, Su SM, Sharp KA, Levine RL, Thompson CB.
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| Cancer Cell 17(3):225-34. Epub 2010 Feb 18.PMID: 20171147 2010
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| 19 | IDH2, SIRT3
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| Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction.
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| Someya S, Yu W, Hallows WC, Xu J, Vann JM, Leeuwenburgh C, Tanokura M, Denu JM, Prolla TA.
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| Cell 143(5):802-12.
2010
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| 20 | IDH1, IDH2
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| Diagnostic use of IDH1/2 mutation analysis in routine clinical testing of formalin-fixed, paraffin-embedded glioma tissues.
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| Horbinski C, Kofler J, Kelly LM, Murdoch GH, Nikiforova MN.
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| J Neuropathol Exp Neurol 68(12):1319-25.
2009
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| 21 | IDH1, IDH2
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| IDH1 and IDH2 mutations in gliomas.
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| Yan H, Parsons DW, Jin G, McLendon R, Rasheed BA, Yuan W, Kos I, Batinic-Haberle I, Jones S, Riggins GJ, Friedman H, Friedman A, Reardon D, Herndon J, Kinzler KW, Velculescu VE, Vogelstein B, Bigner DD.
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| N Engl J Med 360(8):765-73.PMID: 19228619 2009
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| 22 | IDH1, IDH2
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| Novel allosteric properties produced by residue substitutions in the subunit interface of yeast NAD+-specific isocitrate dehydrogenase.
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| Hu G, McAlister-Henn L.
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| Arch Biochem Biophys 453(2):207-16. Epub 2006 Jul 12.PMID: 16884682 2006
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| 23 | IDH1, IDH2
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| Physiological consequences of loss of allosteric activation of yeast NAD+-specific isocitrate dehydrogenase.
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| Hu G, Lin AP, McAlister-Henn L.
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| J Biol Chem 281(25):16935-42. Epub 2006 Apr 18.PMID: 16621803 2006
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| 24 | IDH2, IDH3A
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| Assignment of the human mitochondrial NADP+-specific isocitrate dehydrogenase (IDH2) gene to 15q26.1 by in situ hybridization.
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| Oh IU, et al.
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| Genomics 38 : 104-106. 1996
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| 25 | IDH2
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| Cloning of a cDNA encoding bovine mitochondrial NADP+-specific isocitrate dehydrogenase and structural comparison with its isoenzymes from different species.
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| Huh TL, et al.
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| Biochem J 292 : 705-710. 1993
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| 26 | IDH2, MAN2C1, MPI, PKM
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| Assignment of cytoplasmic alpha-mannosidase (MANN-A) and confirmation of mitochondrial isocitrate dehydrogenase (IDH-M) to the q11-qter region of chromosome 15 in man.
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| Champion MJ, et al.
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| Cytogenet Cell Genet 22 : 498-502. 1978
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| 27 | IDH2
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| Human mitochondrial NADP-dependent isocitrate dehydrogenase in man-mouse somatic cell hybrids.
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| Bruns GAP, et al.
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| Cytogenet Cell Genet 17 : 200-211. 1976
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| 28 | IDH2
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| Assignment of a gene for human mitochondrial isocitrate dehydrogenase (ICD-M, EC 1.1.1.41) to chromosome 15.
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| Grzeschik KH.
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| Hum Genet 34 : 23-28. 1976
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| 29 | AK1, ENO2, GUSB, IDH2
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| Assignment of human genes: beta-glucuronidase to chromosome 7, adenylate kinase-1 to 9, a second enzyme with enolase activity to 12, and mitochondrial IDH to 15.
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| Grzeschik KH.
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| Cytogenet Cell Genet 16 : 142-148. 1976
|