| 1 | IDH1, IDH2
|
| Isocitrate dehydrogenase mutation is frequently observed in giant cell tumor of bone.
|
| Kato Kaneko M, Liu X, Oki H, Ogasawara S, Nakamura T, Saidoh N, Tsujimoto Y, Matsuyama Y, Uruno A, Sugawara M, Tsuchiya T, Yamakawa M, Yamamoto M, Takagi M, Kato Y.
|
| Cancer Sci 105(6):744-8. doi: 10.1111/cas.12413.
2014
|
| 2 | COL2A1, IDH1, IDH2
|
| Frequent mutation of the major cartilage collagen gene COL2A1 in chondrosarcoma.
|
| Tarpey PS, Behjati S, Cooke SL, Van Loo P, Wedge DC, Pillay N, Marshall J, O'Meara S, Davies H, Nik-Zainal S, Beare D, Butler A, Gamble J, Hardy C, Hinton J, Jia MM, Jayakumar A, Jones D, Latimer C, Maddison M, Martin S, McLaren S, Menzies A, Mudie L, Raine K, Teague JW, Tubio JM, Halai D, Tirabosco R, Amary F, Campbell PJ, Stratton MR, Flanagan AM, Futreal PA.
|
| Nat Genet 45(8):923-6. doi: 10.1038/ng.2668. Epub 2013 Jun 16.
2013
|
| 3 | IDH1, IDH2
|
| IDH mutations in tumorigenesis and their potential role as novel therapeutic targets.
|
| Krell D, Mulholland P, Frampton AE, Krell J, Stebbing J, Bardella C.
|
| Future Oncol 9(12):1923-35. doi: 10.2217/fon.13.143. Review.
2013
|
| 4 | IDH1, IDH2
|
| IDH mutation impairs histone demethylation and results in a block to cell differentiation.
|
| Lu C, Ward PS, Kapoor GS, Rohle D, Turcan S, Abdel-Wahab O, Edwards CR, Khanin R, Figueroa ME, Melnick A, Wellen KE, O'Rourke DM, Berger SL, Chan TA, Levine RL, Mellinghoff IK, Thompson CB.
|
| Nature 483(7390):474-8. doi: 10.1038/nature10860.
2012
|
| 5 | IDH1
|
| IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype.
|
| Turcan S, Rohle D, Goenka A, Walsh LA, Fang F, Yilmaz E, Campos C, Fabius AW, Lu C, Ward PS, Thompson CB, Kaufman A, Guryanova O, Levine R, Heguy A, Viale A, Morris LG, Huse JT, Mellinghoff IK, Chan TA.
|
| Nature 483(7390):479-83. doi: 10.1038/nature10866.
2012
|
| 6 | D2HA, D2HGDH, IDH1, IDH2
|
| IDH1 and IDH2 have critical roles in 2-hydroxyglutarate production in D-2-hydroxyglutarate dehydrogenase depleted cells.
|
| Matsunaga H, Futakuchi-Tsuchida A, Takahashi M, Ishikawa T, Tsuji M, Ando O.
|
| Biochem Biophys Res Commun 423(3):553-6. doi: 10.1016/j.bbrc.2012.06.002. Epub 2012 Jun 7.
2012
|
| 7 | ECDMM3, ECDMM4, IDH1, IDH2
|
| Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome.
|
| Pansuriya TC, van Eijk R, d'Adamo P, van Ruler MA, Kuijjer ML, Oosting J, Cleton-Jansen AM, van Oosterwijk JG, Verbeke SL, Meijer D, van Wezel T, Nord KH, Sangiorgi L, Toker B, Liegl-Atzwanger B, San-Julian M, Sciot R, Limaye N, Kindblom LG, Daugaard S, Godfraind C, Boon LM, Vikkula M, Kurek KC, Szuhai K, French PJ, Bovée JV.
|
| Nat Genet 43(12):1256-61. doi: 10.1038/ng.1004. 2011
|
| 8 | IDH1, IDH2
|
| Ollier disease and Maffucci syndrome are caused by somatic mosaic mutations of IDH1 and IDH2.
|
| Amary MF, Damato S, Halai D, Eskandarpour M, Berisha F, Bonar F, McCarthy S, Fantin VR, Straley KS, Lobo S, Aston W, Green CL, Gale RE, Tirabosco R, Futreal A, Campbell P, Presneau N, Flanagan AM.
|
| Nat Genet 43(12):1262-5. doi: 10.1038/ng.994.
2011
|
| 9 | IDH1, IDH2
|
| Ollier disease and Maffucci syndrome are caused by somatic mosaic mutations of IDH1 and IDH2.
|
| Amary MF, Damato S, Halai D, Eskandarpour M, Berisha F, Bonar F, McCarthy S, Fantin VR, Straley KS, Lobo S, Aston W, Green CL, Gale RE, Tirabosco R, Futreal A, Campbell P, Presneau N, Flanagan AM.
|
| Nat Genet 43(12):1262-5. doi: 10.1038/ng.994.
2011
|
| 10 | IDH1
|
| Identification and functional characterization of isocitrate dehydrogenase 1 (IDH1) mutations in thyroid cancer.
|
| Murugan AK, Bojdani E, Xing M.
|
| Biochem Biophys Res Commun 393(3):555-9. Epub 2010 Feb 18.PMID: 20171178 2010
|
| 11 | IDH1, IDH2
|
| IDH1 or IDH2 mutations predict longer survival and response to temozolomide in low-grade gliomas.
|
| Houillier C, Wang X, Kaloshi G, Mokhtari K, Guillevin R, Laffaire J, Paris S, Boisselier B, Idbaih A, Laigle-Donadey F, Hoang-Xuan K, Sanson M, Delattre JY.
|
| Neurology 75(17):1560-6.
2010
|
| 12 | IDH1, IDH2
|
| Glioma-derived mutations in IDH: from mechanism to potential therapy.
|
| Fu Y, Huang R, Du J, Yang R, An N, Liang A.
|
| Biochem Biophys Res Commun 397(2):127-30. Epub 2010 May 27. Review.
2010
|
| 13 | IDH1, IDH2
|
| Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value.
|
| Abbas S, Lugthart S, Kavelaars FG, Schelen A, Koenders JE, Zeilemaker A, van Putten WJ, Rijneveld AW, Löwenberg B, Valk PJ.
|
| Blood 116(12):2122-6. Epub 2010 Jun 10.
2010
|
| 14 | IDH1, IDH2
|
| The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate.
|
| Ward PS, Patel J, Wise DR, Abdel-Wahab O, Bennett BD, Coller HA, Cross JR, Fantin VR, Hedvat CV, Perl AE, Rabinowitz JD, Carroll M, Su SM, Sharp KA, Levine RL, Thompson CB.
|
| Cancer Cell 17(3):225-34. Epub 2010 Feb 18.PMID: 20171147 2010
|
| 15 | IDH1
|
| IDH1 mutations are detected in 6.6% of 1414 AML patients and are associated with intermediate risk karyotype and unfavorable prognosis in adults younger than 60 years and unmutated NPM1 status.
|
| Schnittger S, Haferlach C, Ulke M, Alpermann T, Kern W, Haferlach T.
|
| Blood 116(25):5486-96. Epub 2010 Aug 30.
2010
|
| 16 | IDH1
|
| Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha.
|
| Zhao S, Lin Y, Xu W, Jiang W, Zha Z, Wang P, Yu W, Li Z, Gong L, Peng Y, Ding J, Lei Q, Guan KL, Xiong Y.
|
| Science 324(5924):261-5.
2009
|
| 17 | IDH1
|
| Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.
|
| Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, Fantin VR, Jang HG, Jin S, Keenan MC, Marks KM, Prins RM, Ward PS, Yen KE, Liau LM, Rabinowitz JD, Cantley LC, Thompson CB, Vander Heiden MG, Su SM.
|
| Nature 462(7274):739-44. Epub .
2009
|
| 18 | IDH1, IDH2
|
| Diagnostic use of IDH1/2 mutation analysis in routine clinical testing of formalin-fixed, paraffin-embedded glioma tissues.
|
| Horbinski C, Kofler J, Kelly LM, Murdoch GH, Nikiforova MN.
|
| J Neuropathol Exp Neurol 68(12):1319-25.
2009
|
| 19 | IDH1, IDH2
|
| IDH1 and IDH2 mutations in gliomas.
|
| Yan H, Parsons DW, Jin G, McLendon R, Rasheed BA, Yuan W, Kos I, Batinic-Haberle I, Jones S, Riggins GJ, Friedman H, Friedman A, Reardon D, Herndon J, Kinzler KW, Velculescu VE, Vogelstein B, Bigner DD.
|
| N Engl J Med 360(8):765-73.PMID: 19228619 2009
|
| 20 | GBM, IDH1
|
| An integrated genomic analysis of human glioblastoma multiforme.
|
| Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Siu IM, Gallia GL, Olivi A, McLendon R, Rasheed BA, Keir S, Nikolskaya T, Nikolsky Y, Busam DA, Tekleab H, Diaz LA Jr, Hartigan J, Smith DR, Strausberg RL, Marie SK, Shinjo SM, Yan H, Riggins GJ, Bigner DD, Karchin R, Papadopoulos N, Parmigiani G, Vogelstein B, Velculescu VE, Kinzler KW.
|
| Science 321(5897):1807-12. Epub 2008 Sep 4. 2008
|
| 21 | FEOA,IDH1,NRP2
|
| Mutation analysis of candidate genes within the 2q33.3 linkage area for familial early-onset generalised osteoarthritis.
|
| Min JL, Meulenbelt I, Kloppenburg M, van Duijn CM, Slagboom PE.
|
| Eur J Hum Genet 15(7):791-9. Epub 2007 Apr 4. 2007
|
| 22 | IDH1
|
| A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion.
|
| Ronnebaum SM, Ilkayeva O, Burgess SC, Joseph JW, Lu D, Stevens RD, Becker TC, Sherry AD, Newgard CB, Jensen MV.
|
| J Biol Chem 281(41):30593-602. Epub 2006 Aug 15.PMID: 16912049 2006
|
| 23 | IDH1, IDH2
|
| Novel allosteric properties produced by residue substitutions in the subunit interface of yeast NAD+-specific isocitrate dehydrogenase.
|
| Hu G, McAlister-Henn L.
|
| Arch Biochem Biophys 453(2):207-16. Epub 2006 Jul 12.PMID: 16884682 2006
|
| 24 | IDH1, IDH2
|
| Physiological consequences of loss of allosteric activation of yeast NAD+-specific isocitrate dehydrogenase.
|
| Hu G, Lin AP, McAlister-Henn L.
|
| J Biol Chem 281(25):16935-42. Epub 2006 Apr 18.PMID: 16621803 2006
|
| 25 | IDH1
|
| Identification of differentially expressed proteins during human urinary bladder cancer progression.
|
| Memon AA, Chang JW, Oh BR, Yoo YJ.
|
| Cancer Detect Prev 29(3):249-55. Epub 2005 Apr 13.PMID: 15936593 2005
|
| 26 | SIX3, SIX6, IDH1, CDH18
|
| Expression analysis of SIX3 and SIX6 in human tissues reveals differences in expression and a novel correlation between the expression of SIX3 and the genes encoding isocitrate dehyhrogenase and cadherin 18.
|
| Aijaz S, Allen J, Tregidgo R, van Heyningen V, Hanson I, Clark BJ.
|
| Genomics 86(1):86-99. Epub 2005 Apr 18. 2005
|
| 27 | IDH1
|
| IDH1 gene transcription is sterol regulated and activated by SREBP-1a and SREBP-2 in human hepatoma HepG2 cells: evidence that IDH1 may regulate lipogenesis in hepatic cells.
|
| Shechter I, Dai P, Huo L, Guan G.
|
| J Lipid Res 44(11):2169-80. Epub 2003 Aug 16.PMID: 12923220 2003
|
| 28 | IDH1
|
| Cytosolic isocitrate dehydrogenase in humans, mice, and voles and phylogenetic analysis of the enzyme family.
|
| Nekrutenko A, Hillis DM, Patton JC, Bradley RD, Baker RJ.
|
| Mol Biol Evol 15(12):1674-84.PMID: 9866202 1998
|
| 29 | IDH1
|
| Probable assignment of soluble isocitrate dehydrogenase (IDH1) to 2q33.3.
|
| Narahara K, et al.
|
| Hum Genet 71 : 37-40. 1985
|
| 30 | GSD2, GLA, HEXB, MDH1, IDH1, PGK1
|
| Regional mapping of enzyme loci on human chromosomes 2,17,5 and X by use of somatic cell hybridization.
|
| Weil D, et al.
|
| Cytogenet Cell Genet 25 : 215-216. 1979
|
| 31 | IDH1
|
| Localisation rŽgionale des gnes humains IDHs, MDHs, PGK, alpha-GAL, G6PD par l'hybridation cellulaire interspŽcifique.
|
| Weil D, et al.
|
| Hum Genet 36 : 205-211. 1977
|
| 32 | IDH1
|
| Synteny of the human genes for Gal-1-PT, ACP1, MDH-1, and Gal+-Act and assignment to chromosome 2.
|
| Chu EHY, et al.
|
| Cytogenet Cell Genet 14 : 103-106. 1975
|
| 33 | MDH1, IDH1
|
| Regional localization of the human genes for malate dehydrogenase-1 and isocitrate dehydrogenase-1 on chromosome 2 by interspecific hybridization using human cells with the balanced reciprocal translocation t(1;2)(q32;q13).
|
| Francke U.
|
| Cytogenet Cell Genet 14 :138-142. 1975
|
| 34 | IDH1, MDH1
|
| Chromosome assignment of genes in man using mouse-human somatic cell hybrids: cytoplasmic isocitrate dehydrogenase (IDH 1) and malate dehydrogenase (MDH 1) to chromosome 2.
|
| Creagan RP, et al.
|
| Am J Hum Genet 26 : 604-613. 1974
|
| 35 | IDH1, MDH1
|
| Synteny of the IDH-1 and MDH-1 gene loci in man and probable assignment to chromosome 2.
|
| Gee PA, et al.
|
| Cytogenet Cell Genet 13 : 89-90. 1974
|