| 1 | IAPP, IDE
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| Inhibition of Insulin-Degrading Enzyme Does Not Increase Islet Amyloid Deposition in Vitro.
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| Hogan MF, Meier DT, Zraika S, Templin AT, Mellati M, Hull RL, Leissring MA, Kahn SE.
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| Endocrinology 157(9):3462-8. doi: 10.1210/en.2016-1410. Epub 2016 Jul 12.
2016
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| 2 | IDE
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| Insulin-degrading enzyme binds to the nonglycosylated precursor of varicella-zoster virus gE protein found in the endoplasmic reticulum.
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| Carpenter JE, Jackson W, de Souza GA, Haarr L, Grose C.
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| J Virol 84(2):847-55. Epub 2009 Oct 28.PMID: 19864391 2010
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| 3 | IDE, PPARG
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| PPARgamma transcriptionally regulates the expression of insulin-degrading enzyme in primary neurons.
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| Du J, Zhang L, Liu S, Zhang C, Huang X, Li J, Zhao N, Wang Z.
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| Biochem Biophys Res Commun 383(4):485-90. Epub 2009 Apr 19.PMID: 19383491 2009
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| 4 | IDE
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| Polymorphisms within insulin-degrading enzyme (IDE) gene determine insulin metabolism and risk of type 2 diabetes.
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| Rudovich N, Pivovarova O, Fisher E, Fischer-Rosinsky A, Spranger J, Möhlig M, Schulze MB, Boeing H, Pfeiffer AF.
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| J Mol Med 87(11):1145-51. Epub 2009 Oct 7.PMID: 19809796 2009
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| 5 | IDE
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| Molecular basis of catalytic chamber-assisted unfolding and cleavage of human insulin by human insulin-degrading enzyme.
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| Manolopoulou M, Guo Q, Malito E, Schilling AB, Tang WJ.
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| J Biol Chem 284(21):14177-88. Epub 2009 Mar 25.PMID: 19321446 2009
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| 6 | IDE, MME
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| Neprilysin and insulin-degrading enzyme levels are increased in Alzheimer disease in relation to disease severity.
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| Miners JS, Baig S, Tayler H, Kehoe PG, Love S.
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| J Neuropathol Exp Neurol 68(8):902-14. doi: 10.1097/NEN.0b013e3181afe475.
2009
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| 7 | IDE
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| Molecular bases for the recognition of short peptide substrates and cysteine-directed modifications of human insulin-degrading enzyme.
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| Malito E, Ralat LA, Manolopoulou M, Tsay JL, Wadlington NL, Tang WJ.
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| Biochemistry 47(48):12822-34.PMID: 18986166 2008
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| 8 | IDE
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| Molecular basis for the thiol sensitivity of insulin-degrading enzyme.
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| Neant-Fery M, Garcia-Ordoñez RD, Logan TP, Selkoe DJ, Li L, Reinstatler L, Leissring MA.
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| Proc Natl Acad Sci U S A 105(28):9582-7. Epub 2008 Jul 8.PMID: 18621727 2008
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| 9 | HHEX, SLC30A8, KIF11, IDE
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| A genome-wide association study identifies novel risk loci for type 2 diabetes.
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| Sladek R, Rocheleau G, Rung J, Dina C, Shen L, Serre D, Boutin P, Vincent D, Belisle A, Hadjadj S, Balkau B, Heude B, Charpentier G, Hudson TJ, Montpetit A, Pshezhetsky AV, Prentki M, Posner BI, Balding DJ, Meyre D, Polychronakos C, Froguel P.
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| Nature 445(7130):881-5. Epub 2007 Feb 11. 2007
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| 10 | IDE
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| Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families.
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| Kim M, Hersh LB, Leissring MA, Ingelsson M, Matsui T, Farris W, Lu A, Hyman BT, Selkoe DJ, Bertram L, Tanzi RE.
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| J Biol Chem 282(11):7825-32. Epub 2007 Jan 22. 2007
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| 11 | ACE, APOE, CHRNB2, CST3, ESR1, GAPDHS, IDE, MTHFR, NCSTN, PRNP, PSEN1, TF, TFAM, TNF
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| Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database.
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| Bertram L, McQueen MB, Mullin K, Blacker D, Tanzi RE.
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| Nat Genet 39(1):17-23. 2007
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| 12 | IDE
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| The C-terminal domain of human insulin degrading enzyme is required for dimerization and substrate recognition.
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| Li P, Kuo WL, Yousef M, Rosner MR, Tang WJ.
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| Biochem Biophys Res Commun 343(4):1032-7. Epub 2006 Mar 22. 2006
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| 13 | IDE
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| Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
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| Shen Y, Joachimiak A, Rosner MR, Tang WJ.
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| Nature 443(7113):870-4. Epub 2006 Oct 11. 2006
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| 14 | IDE
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| Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein.
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| Farris W, Leissring MA, Hemming ML, Chang AY, Selkoe DJ.
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| Biochemistry 44(17):6513-25. 2005
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| 15 | IDE
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| Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility.
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| Groves CJ, Wiltshire S, Smedley D, Owen KR, Frayling TM, Walker M, Hitman GA, Levy JC, O'Rahilly S, Menzel S, Hattersley AT, McCarthy MI.
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| Diabetes 52(5):1300-5. 2003
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| 16 | ENTPD1, CYP2C@, DNTT, GOT1, IDE, IFIT1, PAX2, PDE6C, RBP4, WNT8B
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| An integrated physical and genetic map spanning chromosome band 10q24.
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| Gray IC, Fallowfield J, Ford S, Nobile C, Volpi EV, Spurr NK.
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| Genomics 43(1):85-8. 1997
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| 17 | IDE
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| Localization of the gene encoding insulin-degrading enzyme to human chromosome 10, bands q23-q25.
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| Espinosa R, et al.
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| Cytogenet Cell Genet 57 : 184-186. 1991
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| 18 | IDE
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| Insulin-degrading enzyme : stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes.
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| Affholter JA, et al.
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| Mol Endocrinol 4 : 1125-1135. 1990
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