Citations for
1ID3, MDC1
ID3 regulates the MDC1-mediated DNA damage response in order to maintain genome stability.
Lee JH, Park SJ, Hariharasudhan G, Kim MJ, Jung SM, Jeong SY, Chang IY, Kim C, Kim E, Yu J, Bae S, You HJ.
Nat Commun 8(1):903. doi: 10.1038/s41467-017-01051-z. Erratum in: Nat Commun. 2018 Jun 6;9(1):2284. 2017
Aberrant expressions of endometrial Id3 and CTLA-4 are associated with unexplained repeated implantation failure and recurrent miscarriage.
Ding JL, Diao LH, Yin TL, Huang CY, Yin B, Chen C, Zhang Y, Li J, Cheng YX, Zeng Y, Yang J.
Am J Reprod Immunol 78(2). doi: 10.1111/aji.12632. Epub 2017 Feb 21. 2017
Id3 Orchestrates Germinal Center B Cell Development.
Chen S, Miyazaki M, Chandra V, Fisch KM, Chang AN, Murre C.
Mol Cell Biol 36(20):2543-52. doi: 10.1128/MCB.00150-16. Print 2016 Oct 15. 2016
4ID1, ID3
Combined Id1 and Id3 Deletion Leads to Severe Erythropoietic Disturbances.
Zhao Q, Chang C, Gonzalez JP, Alzahrani K, Button JL, Fraidenraich D.
PLoS One 11(4):e0154480. doi: 10.1371/journal.pone.0154480. eCollection 2016. 2016
5BMP2, ID3
The balance of Id3 and E47 determines neural stem/precursor cell differentiation into astrocytes.
Bohrer C, Pfurr S, Mammadzada K, Schildge S, Plappert L, Hils M, Pous L, Rauch KS, Dumit VI, Pfeifer D, Dengjel J, Kirsch M, Schachtrup K, Schachtrup C.
EMBO J 34(22):2804-19. doi: 10.15252/embj.201591118. Epub 2015 Oct 5. 2015
ID3 contributes to the acquisition of molecular stem cell-like signature in microvascular endothelial cells: its implication for understanding microvascular diseases.
Das JK, Voelkel NF, Felty Q.
Microvasc Res 98:126-38. doi: 10.1016/j.mvr.2015.01.006. Epub 2015 Feb 7. 2015
The potential role of inhibitor of differentiation-3 in human adipose tissue remodeling and metabolic health.
Svendstrup M, Vestergaard H.
Mol Genet Metab 113(3):149-54. doi: 10.1016/j.ymgme.2014.08.008. Epub 2014 Aug 27. Review. 2014
8ID2, ID3
Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease.
Miyazaki M, Miyazaki K, Chen S, Itoi M, Miller M, Lu LF, Varki N, Chang AN, Broide DH, Murre C.
Nat Immunol 15(8):767-76. doi: 10.1038/ni.2928. Epub 2014 Jun 29. 2014
A functionally significant polymorphism in ID3 is associated with human coronary pathology.
Manichaikul A, Rich SS, Perry H, Yeboah J, Law M, Davis M, Parker M, Ragosta M, Connelly JJ, McNamara CA, Taylor AM.
PLoS One 9(3):e90222. doi: 10.1371/journal.pone.0090222. eCollection 2014. Erratum in: PLoS One. 2014;9(9):e109222. 2014
10ID2, ID3
ID2 and ID3 protein expression mirrors granulopoietic maturation and discriminates between acute leukemia subtypes.
May AM, Frey AV, Bogatyreva L, Benkisser-Petersen M, Hauschke D, Lübbert M, Wäsch R, Werner M, Hasskarl J, Lassmann S.
Histochem Cell Biol 141(4):431-40. doi: 10.1007/s00418-013-1169-7. Epub 2013 Nov 30. 2014
ID3 mutations are recurrent events in double-hit B-cell lymphomas.
Gebauer N, Bernard V, Feller AC, Merz H.
Anticancer Res 33(11):4771-8. 2013
Ankyrin repeat domain protein 2 and inhibitor of DNA binding 3 cooperatively inhibit myoblast differentiation by physical interaction.
Mohamed JS, Lopez MA, Cox GA, Boriek AM.
J Biol Chem 288(34):24560-8. doi: 10.1074/jbc.M112.434423. Epub 2013 Jul 3. 2013
ID3 contributes to cerebrospinal fluid seeding and poor prognosis in medulloblastoma.
Phi JH, Choi SA, Lim SH, Lee J, Wang KC, Park SH, Kim SK.
BMC Cancer 13:291. doi: 10.1186/1471-2407-13-291. 2013
14ID1, ID2, ID3, ID4, ZBTB18
RP58 controls neuron and astrocyte differentiation by downregulating the expression of Id1-4 genes in the developing cortex.
Hirai S, Miwa A, Ohtaka-Maruyama C, Kasai M, Okabe S, Hata Y, Okado H.
EMBO J 31(5):1190-202. doi: 10.1038/emboj.2011.486. Epub 2012 Jan 10. 2012
Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing.
Richter J, Schlesner M, Hoffmann S, Kreuz M, Leich E, Burkhardt B, Rosolowski M, Ammerpohl O, Wagener R, Bernhart SH, Lenze D, Szczepanowski M, Paulsen M, Lipinski S, Russell RB, Adam-Klages S, Apic G, Claviez A, Hasenclever D, Hovestadt V, Hornig N, Korbel JO, Kube D, Langenberger D, Lawerenz C, Lisfeld J, Meyer K, Picelli S, Pischimarov J, Radlwimmer B, Rausch T, Rohde M, Schilhabel M, Scholtysik R, Spang R, Trautmann H, Zenz T, Borkhardt A, Drexler HG, Möller P, MacLeod RA, Pott C, Schreiber S, Trümper L, Loeffler M, Stadler PF, Lichter P, Eils R, Küppers R, Hummel M, Klapper W, Rosenstiel P, Rosenwald A, Brors B, Siebert R; ICGC MMML-Seq Project.
Nat Genet 44(12):1316-20. doi: 10.1038/ng.2469. Epub 2012 Nov 11. 2012
16ID1, ID3, SMURF2
Smurf2-mediated ubiquitination and degradation of Id1 regulates p16 expression during senescence.
Kong Y, Cui H, Zhang H.
Aging Cell 10(6):1038-46. doi: 10.1111/j.1474-9726.2011.00746.x. Epub 2011 Oct 7. 2011
The Id3/E47 axis mediates cell-cycle control in human pancreatic ducts and adenocarcinoma.
Lee SH, Hao E, Kiselyuk A, Shapiro J, Shields DJ, Lowy A, Levine F, Itkin-Ansari P.
Mol Cancer Res 9(6):782-90. Epub 2011 Apr 15. 2011
18ID1, ID3
ID1 and ID3 represent conserved negative regulators of human embryonic and induced pluripotent stem cell hematopoiesis.
Hong SH, Lee JH, Lee JB, Ji J, Bhatia M.
J Cell Sci 124(Pt 9):1445-52. Epub 2011 Apr 12. 2011
19ID1, ID3
Targeting Id1 and Id3 by a specific peptide aptamer induces E-box promoter activity, cell cycle arrest, and apoptosis in breast cancer cells.
Mern DS, Hoppe-Seyler K, Hoppe-Seyler F, Hasskarl J, Burwinkel B.
Breast Cancer Res Treat 124(3):623-33. Epub 2010 Feb 27. 2010
Id3 is a novel atheroprotective factor containing a functionally significant single-nucleotide polymorphism associated with intima-media thickness in humans.
Doran AC, Lehtinen AB, Meller N, Lipinski MJ, Slayton RP, Oldham SN, Skaflen MD, Yeboah J, Rich SS, Bowden DW, McNamara CA.
Circ Res 106(7):1303-11. Epub 2010 Feb 25. 2010
Estrogen-induced redox sensitive Id3 signaling controls the growth of vascular cells.
Felty Q, Porther N.
Atherosclerosis 198(1):12-21. Epub 2008 Feb 20. 2008
22ZBTB16, TP53INP1, TERT, ID3, ID1
Identification of apoptosis-related PLZF target genes.
Bernardo MV, Yelo E, Gimeno L, Campillo JA, Parrado A.
Biochem Biophys Res Commun 359(2):317-22. Epub 2007 May 24. 2007
23MECP2, ID1, ID2, ID3, ID4
Inhibitors of differentiation (ID1, ID2, ID3 and ID4) genes are neuronal targets of MeCP2 that are elevated in Rett syndrome.
Peddada S, Yasui DH, LaSalle JM.
Hum Mol Genet 15(12):2003-14. Epub 2006 May 8. 2006
Xenopus Id3 is required downstream of Myc for the formation of multipotent neural crest progenitor cells.
Light W, Vernon AE, Lasorella A, Iavarone A, LaBonne C.
Development 132(8):1831-41. Epub 2005 Mar 16. 2005
To proliferate or to die: role of Id3 in cell cycle progression and survival of neural crest progenitors.
Kee Y, Bronner-Fraser M.
Genes Dev 19(6):744-55. 2005
26ID1, ID3
Id proteins negatively regulate basic helix-loop-helix transcription factor function by disrupting subnuclear compartmentalization.
O'Toole PJ, Inoue T, Emerson L, Morrison IE, Mackie AR, Cherry RJ, Norton JD.
J Biol Chem 278(46):45770-6. Epub 2003 Sep 1. 2003
Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function.
Darnell JC, Jensen KB, Jin P, Brown V, Warren ST, Darnell RB.
Cell 107(4):489-99. 2001
Decreased expression of the Id3 gene at 1p36.1 in ovarian adenocarcinomas.
Arnold JM, Mok SC, Purdie D, Chenevix-Trench G.
Br J Cancer 84(3):352-9. 2001
29ID1, ID3
Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts.
Lyden D, et al.
Nature 401(6754):670-7 1999
Expression of the helix-loop-helix gene Id3 during murine embryonic development.
Ellmeier W, Weith A.
Dev Dyn 203(2):163-73. 1995
Structural organisation and chromosomal mapping of the human Id-3 gene.
Deed RW, et al.
Gene 151 : 309-314. 1994
32ID1, ID2, ID3, ID4
The expression pattern of Id4, a novel dominant negative helix-loop-helix protein, is distinct from Id1, Id2 and Id3.
R•echmann V, et al.
Nucleic Acids Res 22 : 749-755. 1994
An immediate early human gene encodes an id-like helix-loop-helix protein and is regulated by protein kinase C activation in diverse cell types.
Deed RW, et al.
Oncogene 8 : 599-607. 1993
Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development.
Ellmeier W, et al.
EMBO J 11 : 2563-2571. 1992