| 1 | IAPP
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| Islet amyloid polypeptide response to maximal hyperglycemia and arginine is altered in impaired glucose tolerance and type 2 diabetes mellitus.
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| Guardado-Mendoza R, Chávez AO, Jiménez-Ceja LM, Hansis-Diarte A, DeFronzo RA, Folli F, Tripathy D.
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| Acta Diabetol cta Diabetol. 2016 Sep 13. [Epub ahead of print]
2016
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| 2 | IAPP
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| Diabetic Risk Factors Promote Islet Amyloid Polypeptide Misfolding by a Common, Membrane-mediated Mechanism.
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| Okada AK, Teranishi K, Isas JM, Bedrood S, Chow RH, Langen R.
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| Sci Rep 6:31094. doi: 10.1038/srep31094.
2016
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| 3 | IAPP, IDE
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| Inhibition of Insulin-Degrading Enzyme Does Not Increase Islet Amyloid Deposition in Vitro.
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| Hogan MF, Meier DT, Zraika S, Templin AT, Mellati M, Hull RL, Leissring MA, Kahn SE.
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| Endocrinology 157(9):3462-8. doi: 10.1210/en.2016-1410. Epub 2016 Jul 12.
2016
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| 4 | HSP1A1, IAPP
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| Hsp72 (HSPA1A) Prevents Human Islet Amyloid Polypeptide Aggregation and Toxicity: A New Approach for Type 2 Diabetes Treatment.
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| Rosas PC, Nagaraja GM, Kaur P, Panossian A, Wickman G, Garcia LR, Al-Khamis FA, Asea AA.
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| PLoS One 11(3):e0149409. doi: 10.1371/journal.pone.0149409. eCollection 2016.
2016
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| 5 | IAPP
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| Protein disulfide isomerase ameliorates β-cell dysfunction in pancreatic islets overexpressing human islet amyloid polypeptide.
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| Montane J, de Pablo S, Obach M, Cadavez L, Castaño C, Alcarraz-Vizán G, Visa M, Rodríguez-Comas J, Parrizas M, Servitja JM, Novials A.
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| Mol Cell Endocrinol 420:57-65. doi: 10.1016/j.mce.2015.11.018. Epub 2015 Dec 1.
2016
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| 6 | IAPP, MMP9
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| Matrix Metalloproteinase-9 Protects Islets from Amyloid-induced Toxicity.
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| Meier DT, Tu LH, Zraika S, Hogan MF, Templin AT, Hull RL, Raleigh DP, Kahn SE.
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| J Biol Chem 290(51):30475-85. doi: 10.1074/jbc.M115.676692. Epub 2015 Oct 19.
2015
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| 7 | IAPP
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| Heparan Sulfate Proteoglycans Are Important for Islet Amyloid Formation and Islet Amyloid Polypeptide-induced Apoptosis.
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| Oskarsson ME, Singh K, Wang J, Vlodavsky I, Li JP, Westermark GT.
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| J Biol Chem 290(24):15121-32. doi: 10.1074/jbc.M114.631697. Epub 2015 Apr 28.
2015
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| 8 | IAPP
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| Islet amyloid polypeptide exerts a novel autocrine action in β-cell signaling and proliferation.
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| Visa M, Alcarraz-Vizán G, Montane J, Cadavez L, Castaño C, Villanueva-Peñacarrillo ML, Servitja JM, Novials A.
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| FASEB J 29(7):2970-9. doi: 10.1096/fj.15-270553. Epub 2015 Mar 25.
2015
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| 9 | IAPP
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| Cholesterol modulates the interaction of the islet amyloid polypeptide with membranes.
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| Caillon L, Duma L, Lequin O, Khemtemourian L.
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| Mol Membr Biol 31(7-8):239-49. doi: 10.3109/09687688.2014.987182. Epub 2014 Dec 15.
2014
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| 10 | IAPP
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| Human IAPP amyloidogenic properties and pancreatic β-cell death.
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| Fernández MS.
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| Cell Calcium 56(5):416-27. doi: 10.1016/j.ceca.2014.08.011. Epub 2014 Aug 27. Review.
2014
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| 11 | IAPP
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| Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity.
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| Rivera JF, Costes S, Gurlo T, Glabe CG, Butler PC.
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| J Clin Invest 124(8):3489-500. doi: 10.1172/JCI71981. Epub 2014 Jul 18.
2014
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| 12 | IAPP
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| Chaperones ameliorate beta cell dysfunction associated with human islet amyloid polypeptide overexpression.
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| Cadavez L, Montane J, Alcarraz-Vizán G, Visa M, Vidal-Fàbrega L, Servitja JM, Novials A.
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| PLoS One 9(7):e101797. doi: 10.1371/journal.pone.0101797. eCollection 2014.
2014
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| 13 | IAPP, UCHL1
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| UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in β-cells: evidence of interplay between the ubiquitin/proteasome system and autophagy.
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| Costes S, Gurlo T, Rivera JF, Butler PC.
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| Autophagy 10(6):1004-14. doi: 10.4161/auto.28478.
2014
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| 14 | IAPP
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| High plasma levels of islet amyloid polypeptide in young with new-onset of type 1 diabetes mellitus.
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| Paulsson JF, Ludvigsson J, Carlsson A, Casas R, Forsander G, Ivarsson SA, Kockum I, Lernmark Å, Marcus C, Lindblad B, Westermark GT.
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| PLoS One 9(3):e93053. doi: 10.1371/journal.pone.0093053. eCollection 2014.
2014
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| 15 | IAPP
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| Effect of proline mutations on the monomer conformations of amylin.
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| Chiu CC, Singh S, de Pablo JJ.
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| Biophys J 105(5):1227-35. doi: 10.1016/j.bpj.2013.07.029.
2013
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| 16 | IAPP
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| Mechanisms of islet amyloidosis toxicity in type 2 diabetes.
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| Abedini A, Schmidt AM.
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| FEBS Lett 587(8):1119-27. doi: 10.1016/j.febslet.2013.01.017. Epub 2013 Jan 18. Review.
2013
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| 17 | IAPP, MMP9
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| Matrix metalloproteinase-9 reduces islet amyloid formation by degrading islet amyloid polypeptide.
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| Aston-Mourney K, Zraika S, Udayasankar J, Subramanian SL, Green PS, Kahn SE, Hull RL.
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| J Biol Chem 288(5):3553-9. doi: 10.1074/jbc.M112.438457. Epub 2012 Dec 10.
2013
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| 18 | IAPP, MME
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| Degradation of islet amyloid polypeptide by neprilysin.
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| Guan H, Chow KM, Shah R, Rhodes CJ, Hersh LB.
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| Diabetologia 55(11):2989-98. doi: 10.1007/s00125-012-2678-y. Epub 2012 Aug 17.
2012
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| 19 | IAPP, NUCB1
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| Nucleobindin 1 caps human islet amyloid polypeptide protofibrils to prevent amyloid fibril formation.
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| Gupta R, Kapoor N, Raleigh DP, Sakmar TP.
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| J Mol Biol 421(2-3):378-89. doi: 10.1016/j.jmb.2012.04.017. Epub 2012 Apr 24.
2012
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| 20 | IAPP
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| Fibril structure of human islet amyloid polypeptide.
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| Bedrood S, Li Y, Isas JM, Hegde BG, Baxa U, Haworth IS, Langen R.
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| J Biol Chem 287(8):5235-41. doi: 10.1074/jbc.M111.327817. Epub 2011 Dec 20.
2012
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| 21 | IAPP
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| Involvement of ATP-sensitive potassium (K(ATP)) channels in the loss of beta-cell function induced by human islet amyloid polypeptide.
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| Soty M, Visa M, Soriano S, Carmona Mdel C, Nadal Á, Novials A.
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| J Biol Chem 286(47):40857-66. doi: 10.1074/jbc.M111.232801. Epub 2011 Oct 7.
2011
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| 22 | IAPP
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| Islet amyloid polypeptide, islet amyloid, and diabetes mellitus.
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| Westermark P, Andersson A, Westermark GT.
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| Physiol Rev 91(3):795-826. doi: 10.1152/physrev.00042.2009. Review.
2011
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| 23 | IAPP
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| A two-site mechanism for the inhibition of IAPP amyloidogenesis by zinc.
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| Salamekh S, Brender JR, Hyung SJ, Nanga RP, Vivekanandan S, Ruotolo BT, Ramamoorthy A.
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| J Mol Biol 410(2):294-306. doi: 10.1016/j.jmb.2011.05.015. Epub 2011 May 17.
2011
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| 24 | IAPP
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| Role of zinc in human islet amyloid polypeptide aggregation.
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| Brender JR, Hartman K, Nanga RP, Popovych N, de la Salud Bea R, Vivekanandan S, Marsh EN, Ramamoorthy A.
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| J Am Chem Soc 132(26):8973-83. doi: 10.1021/ja1007867.
2010
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| 25 | APP, iAPP
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| Abeta and human amylin share a common toxicity pathway via mitochondrial dysfunction.
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| Lim YA, Rhein V, Baysang G, Meier F, Poljak A, Raftery MJ, Guilhaus M, Ittner LM, Eckert A, Götz J.
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| Proteomics 10(8):1621-33. doi: 10.1002/pmic.200900651.
2010
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| 26 | IAPP
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| Increased secretion of amylin in women with polycystic ovary syndrome.
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| James S, Moralez J, Nagamani M.
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| Fertil Steril 94(1):211-5. doi: 10.1016/j.fertnstert.2009.02.086. Epub 2009 Apr 1.
2010
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| 27 | IAPP, SERPINA12
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| Vaspin and amylin are expressed in human and rat placenta and regulated by nutritional status.
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| Caminos JE, Bravo SB, Garcés MF, González CR, Cepeda LA, González AC, Nogueiras R, Gallego R, García-Caballero T, Cordido F, López M, Diéguez C.
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| Histol Histopathol 24(8):979-90. 2009
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| 28 | IAPP
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| Residual structure in islet amyloid polypeptide mediates its interactions with soluble insulin.
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| Wei L, Jiang P, Yau YH, Summer H, Shochat SG, Mu Y, Pervushin K.
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| Biochemistry 48(11):2368-76. doi: 10.1021/bi802097b.
2009
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| 29 | IAPP
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| Disturbed alpha-cell function in mice with beta-cell specific overexpression of human islet amyloid polypeptide.
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| Ahrén B, Sörhede Winzell M.
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| Exp Diabetes Res 2008:304513. doi: 10.1155/2008/304513.
2008
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| 30 | IAPP
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| Characterization of the heparin binding site in the N-terminus of human pro-islet amyloid polypeptide: implications for amyloid formation.
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| Abedini A, Tracz SM, Cho JH, Raleigh DP.
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| Biochemistry 45(30):9228-37. 2006
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| 31 | IAPP
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| Estrogen can prevent or reverse obesity and diabetes in mice expressing human islet amyloid polypeptide.
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| Geisler JG, Zawalich W, Zawalich K, Lakey JR, Stukenbrok H, Milici AJ, Soeller WC.
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| Diabetes 51(7):2158-69. 2002
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| 32 | IAPP
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| S20G mutation of the amylin gene is associated with Type II diabetes in Japanese. Study Group of Comprehensive Analysis of Genetic Factors in Diabetes Mellitus.
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| Seino S.
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| Diabetologia 44(7):906-9. 2001
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| 33 | IAPP, NIDDM12
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| The S20G islet-associated polypeptide gene mutation in familial NIDDM.
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| Birch CL, Fagan LJ, Armstrong MJ, Turnbull DM, Walker M.
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| Diabetologia 40(9):1113. 1997
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| 34 | NIDDM12, IAPP
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| Missense mutation of amylin gene (S20G) in Japanese NIDDM patients.
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| Sakagashira S, et al.
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| Diabetes 45 : 1279-1281. 1996
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| 35 | CALCA, CALCB, CALCP, IAPP
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| High-resolution chromosomal localization of the human calcitonin/CGRP/IAPP gene family members.
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| Hoovers JMN, et al.
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| Genomics 15 : 525-529. 1993
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| 36 | COL2A1, KITLG, IAPP
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| Subregional mapping of 13 single-copy genes on the long arm of chromosome 12 by fluorescence in situ hybridization.
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| Mathew S, et al.
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| Genomics 14 : 775-779. 1992
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| 37 | IAPP
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| The human islet amyloid polypeptide (IAPP) gene. Organization, chromosomal localization and functional identification of a promoter region.
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| Christmanson L, et al.
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| FEBS Lett 267 : 160-166. 1990
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| 38 | IAPP
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| Islet amyloid, islet-amyloid polypeptide, and diabetes mellitus.
|
| Johnson KH, et al.
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| N Engl J Med 321 : 513-518. 1989
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| 39 | IAPP
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| Localization of the human islet amyloid polypeptide (IAPP) gene to 12p11.2-p12.3.
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| Buckle VJ, et al.
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| (HGM10) Cytogenet Cell Genet 51 : 972. 1989
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| 40 | IAPP
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| Localization of the amylin locus to chromosome 12.
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| Cockburn DC, et al.
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| (HGM10) Cytogenet Cell Genet 51 : 977. 1989
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| 41 | IAPP
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| Localization of the human islet amyloid polypeptide gene (IAP) to chromosome 12p12.3.
|
| Fan YS, et al.
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| (HGM10) Cytogenet Cell Genet 51 : 997. 1989
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| 42 | IAPP
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| An RFLP associated with insulinoma amyloid polypeptide locus (IAPP).
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| Patel P, et al.
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| Nucleic Acids Res 17 : 6758. 1989
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| 43 | IAPP
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| Molecular and functional characterization of amylin, a peptide associated with type 2 diabetes mellitus.
|
| Roberts AN, et al.
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| Proc Natl Acad Sci U S A 86 : 9662-9666. 1989
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| 44 | IAPP
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| Islet amyloid polypeptide : identification and chromosomal localization of the human gene.
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| Mosselman S, Hoppener JW, Zandberg J, van Mansfeld AD, Geurts van Kessel AH, Lips CJ, Jansz HS.
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| FEBS Lett 239 : 227-232. 1988
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| 45 | IAPP, NIDDM12
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| Amylin found in amyloid deposits in human type 2 diabetes mellitus may be a hormone that regulates glycogen metabolism in skeletal muscle.
|
| Cooper GJ, et al.
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| Proc Natl Acad Sci U S A 85 : 7763-7766. 1988
|