Citations for
HSPD1 repressed E-cadherin expression to promote cell invasion and migration for poor prognosis in oral squamous cell carcinoma.
Kang BH, Shu CW, Chao JK, Lee CH, Fu TY, Liou HH, Ger LP, Liu PF.
Sci Rep 9(1):8932. doi: 10.1038/s41598-019-45489-1. Erratum in: Sci Rep. 2020 Jan 30;10(1):1829. 2019
HSP60 silencing promotes Warburg-like phenotypes and switches the mitochondrial function from ATP production to biosynthesis in ccRCC cells.
Teng R, Liu Z, Tang H, Zhang W, Chen Y, Xu R, Chen L, Song J, Liu X, Deng H.
Redox Biol 24:101218. doi: 10.1016/j.redox.2019.101218. Epub 2019 May 14. 2019
Heat shock protein 60 negatively regulates the biological functions of ubiquitin-like protein MNSFβ in macrophages.
Nakamura M, Notsu K, Nakagawa M.
Mol Cell Biochem 456(1-2):29-39. doi: 10.1007/s11010-018-3487-5. Epub 2019 Feb 1. 2019
Upregulation of HSP60 expression in the postnatal rat cochlea and rats with drug-induced hearing loss.
Tian K, Song Y, Zhou K, Yue B, Qiu Y, Sun F, Wang R, Zha D, Qiu J.
Cell Stress Chaperones 23(6):1311-1317. doi: 10.1007/s12192-018-0938-6. Epub 2018 Sep 8. 2018
HSP60 critically regulates endogenous IL-1β production in activated microglia by stimulating NLRP3 inflammasome pathway.
Swaroop S, Mahadevan A, Shankar SK, Adlakha YK, Basu A.
J Neuroinflammation 15(1):177. doi: 10.1186/s12974-018-1214-5. Erratum in: J Neuroinflammation. 2018 Nov 15;15(1):317. 2018
Heat shock protein 60 involvement in vascular smooth muscle cell proliferation.
Deniset JF, Hedley TE, Hlaváčková M, Chahine MN, Dibrov E, O'Hara K, Maddaford GG, Nelson D, Maddaford TG, Fandrich R, Kardami E, Pierce GN.
Cell Signal 47:44-51. doi: 10.1016/j.cellsig.2018.03.011. Epub 2018 Mar 26. 2018
HSP60 possesses a GTPase activity and mediates protein folding with HSP10.
Okamoto T, Yamamoto H, Kudo I, Matsumoto K, Odaka M, Grave E, Itoh H.
Sci Rep 7(1):16931. doi: 10.1038/s41598-017-17167-7. 2017
HSP60 activity on human bronchial epithelial cells.
Sangiorgi C, Vallese D, Gnemmi I, Bucchieri F, Balbi B, Brun P, Leone A, Giordano A, Conway de Macario E, Macario AJ, Cappello F, Di Stefano A.
Int J Immunopathol Pharmacol 30(4):333-340. doi: 10.1177/0394632017734479. Epub 2017 Oct 4. 2017
High expression of heat shock protein 10 correlates negatively with estrogen/progesterone receptor status and predicts poor prognosis in invasive ductal breast carcinoma.
Chu S, Wen Q, Qing Z, Luo J, Wang W, Chen L, Feng J, Xu L, Zang H, Fan S.
Hum Pathol 61:173-180. doi: 10.1016/j.humpath.2016.09.039. Epub 2016 Dec 16. 2017
Hsp60 exerts a tumor suppressor function by inducing cell differentiation and inhibiting invasion in hepatocellular carcinoma.
Zhang J, Zhou X, Chang H, Huang X, Guo X, Du X, Tian S, Wang L, Lyv Y, Yuan P, Xing J.
Oncotarget 7(42):68976-68989. doi: 10.18632/oncotarget.12185. 2016
Down-regulation of HSP60 Suppresses the Proliferation of Glioblastoma Cells via the ROS/AMPK/mTOR Pathway.
Tang H, Li J, Liu X, Wang G, Luo M, Deng H.
Sci Rep 6:28388. doi: 10.1038/srep28388. 2016
Folding of newly translated membrane protein CCR5 is assisted by the chaperonin GroEL-GroES.
Chi H, Wang X, Li J, Ren H, Huang F.
Sci Rep 5:17037. doi: 10.1038/srep17037. 2015
Heat shock protein 60 stimulates the migration of vascular smooth muscle cells via Toll-like receptor 4 and ERK MAPK activation.
Zhao Y, Zhang C, Wei X, Li P, Cui Y, Qin Y, Wei X, Jin M, Kohama K, Gao Y.
Sci Rep 5:15352. doi: 10.1038/srep15352. 2015
Functional structure and physiological functions of mammalian wild-type HSP60.
Okamoto T, Ishida R, Yamamoto H, Tanabe-Ishida M, Haga A, Takahashi H, Takahashi K, Goto D, Grave E, Itoh H.
Arch Biochem Biophys 586:10-9. doi: 10.1016/ Epub 2015 Sep 30. 2015
FUS Interacts with HSP60 to Promote Mitochondrial Damage.
Deng J, Yang M, Chen Y, Chen X, Liu J, Sun S, Cheng H, Li Y, Bigio EH, Mesulam M, Xu Q, Du S, Fushimi K, Zhu L, Wu JY.
PLoS Genet 11(9):e1005357. doi: 10.1371/journal.pgen.1005357. eCollection 2015 Sep. 2015
Hypomyelinating leukodystrophy-associated missense mutation in HSPD1 blunts mitochondrial dynamics.
Miyamoto Y, Eguchi T, Kawahara K, Hasegawa N, Nakamura K, Funakoshi-Tago M, Tanoue A, Tamura H, Yamauchi J.
Biochem Biophys Res Commun 462(3):275-81. doi: 10.1016/j.bbrc.2015.04.132. Epub 2015 May 6. 2015
HSPD1 interacts with IRF3 to facilitate interferon-beta induction.
Lin L, Pan S, Zhao J, Liu C, Wang P, Fu L, Xu X, Jin M, Zhang A.
PLoS One 9(12):e114874. doi: 10.1371/journal.pone.0114874. eCollection 2014. 2014
Human Hsp60 with its mitochondrial import signal occurs in solution as heptamers and tetradecamers remarkably stable over a wide range of concentrations.
Vilasi S, Carrotta R, Mangione MR, Campanella C, Librizzi F, Randazzo L, Martorana V, Marino Gammazza A, Ortore MG, Vilasi A, Pocsfalvi G, Burgio G, Corona D, Palumbo Piccionello A, Zummo G, Bulone D, Conway de Macario E, Macario AJ, San Biagio PL, Cappello F.
PLoS One 9(5):e97657. doi: 10.1371/journal.pone.0097657. eCollection 2014. 2014
The Hsp60 folding machinery is crucial for manganese superoxide dismutase folding and function.
Magnoni R, Palmfeldt J, Hansen J, Christensen JH, Corydon TJ, Bross P.
Free Radic Res 48(2):168-79. doi: 10.3109/10715762.2013.858147. Epub 2013 Nov 11. 2014
Leptin regulation of Hsp60 impacts hypothalamic insulin signaling.
Kleinridders A, Lauritzen HP, Ussar S, Christensen JH, Mori MA, Bross P, Kahn CR.
J Clin Invest 123(11):4667-80. 2013
Functional single-nucleotide variant of HSPD1 in sudden infant death syndrome.
Courts C, Grabmüller M, Madea B.
Pediatr Res 74(4):380-3. doi: 10.1038/pr.2013.112. Epub 2013 Jul 3. 2013
HSP60 predicts survival in advanced serous ovarian cancer.
Hjerpe E, Egyhazi S, Carlson J, Stolt MF, Schedvins K, Johansson H, Shoshan M, Avall-Lundqvist E.
Int J Gynecol Cancer 23(3):448-55. doi: 10.1097/IGC.0b013e318284308b. 2013
Microglial LOX-1 reacts with extracellular HSP60 to bridge neuroinflammation and neurotoxicity.
Zhang D, Sun L, Zhu H, Wang L, Wu W, Xie J, Gu J.
Neurochem Int 61(7):1021-35. doi: 10.1016/j.neuint.2012.07.019. Epub 2012 Jul 27. 2012
Heat shock protein 60 as a mediator of adipose tissue inflammation and insulin resistance.
Märker T, Sell H, Zillessen P, Glöde A, Kriebel J, Ouwens DM, Pattyn P, Ruige J, Famulla S, Roden M, Eckel J, Habich C.
Diabetes 61(3):615-25. doi: 10.2337/db10-1574. Epub 2012 Feb 7. 2012
Heat shock protein 60 protects skeletal tissue against glucocorticoid-induced bone mass loss by regulating osteoblast survival.
Wang FS, Wu RW, Ko JY, Tai MH, Ke HC, Yeh DW, Wu SL, Chen MW.
Bone 49(5):1080-9. doi: 10.1016/j.bone.2011.08.006. Epub 2011 Aug 11. 2011
Heat shock protein 60 regulation of the mitochondrial permeability transition pore in tumor cells.
Ghosh JC, Siegelin MD, Dohi T, Altieri DC.
Cancer Res 70(22):8988-93. doi: 10.1158/0008-5472.CAN-10-2225. Epub 2010 Oct 26. 2010
Inactivation of the hereditary spastic paraplegia-associated Hspd1 gene encoding the Hsp60 chaperone results in early embryonic lethality in mice.
Christensen JH, Nielsen MN, Hansen J, Füchtbauer A, Füchtbauer EM, West M, Corydon TJ, Gregersen N, Bross P.
Cell Stress Chaperones 15(6):851-63. doi: 10.1007/s12192-010-0194-x. 2010
HSP60 interacts with YB-1 and affects its polysome association and subcellular localization.
Ohashi S, Atsumi M, Kobayashi S.
Biochem Biophys Res Commun 385(4):545-50. Epub 2009 May 24. 2009
The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor.
Stefano L, Racchetti G, Bianco F, Passini N, Gupta RS, Panina Bordignon P, Meldolesi J.
J Neurochem 110(1):284-94. Epub 2009 Apr 29. 2009
Mitochondrial hsp60 chaperonopathy causes an autosomal-recessive neurodegenerative disorder linked to brain hypomyelination and leukodystrophy.
Magen D, Georgopoulos C, Bross P, Ang D, Segev Y, Goldsher D, Nemirovski A, Shahar E, Ravid S, Luder A, Heno B, Gershoni-Baruch R, Skorecki K, Mandel H.
Am J Hum Genet 83(1):30-42. Epub 2008 Jun 19. 2008
A new susceptibility locus for hypospadias on chromosome 7q32.2-q36.1.
Thai HT, Söderhäll C, Lagerstedt K, Omrani MD, Frisén L, Lundin J, Kockum I, Nordenskjöld A.
Hum Genet 124(2):155-60. Epub 2008 Jul 27. 2008
32HSPD1, SPG13
The Hsp60-(p.V98I) mutation associated with hereditary spastic paraplegia SPG13 compromises chaperonin function both in vitro and in vivo.
Bross P, Naundrup S, Hansen J, Nielsen MN, Christensen JH, Kruh¿ffer M, Palmfeldt J, Corydon TJ, Gregersen N, Ang D, Georgopoulos C, Nielsen KL.
J Biol Chem 283(23):15694-700. Epub 2008 Apr 8. 2008
Direct regulation of HSP60 expression by c-MYC induces transformation.
Tsai YP, Teng SC, Wu KJ.
FEBS Lett 582(29):4083-8. Epub 2008 Nov 20. 2008
34HSPD1, SPG13
Decreased expression of the mitochondrial matrix proteases Lon and ClpP in cells from a patient with hereditary spastic paraplegia (SPG13).
Hansen J, Corydon TJ, Palmfeldt J, Dürr A, Fontaine B, Nielsen MN, Christensen JH, Gregersen N, Bross P.
Neuroscience 153(2):474-82. Epub 2008 Feb 19.PMID: 18378094 2008
Chaperonin chamber accelerates protein folding through passive action of preventing aggregation.
Apetri AC, Horwich AL.
Proc Natl Acad Sci U S A 105(45):17351-5. doi: 10.1073/pnas.0809794105. Epub 2008 Nov 5. 2008
Protective effect of human heat shock protein 60 suggested by its association with decreased seropositivity to pathogens.
Steptoe A, Shamaei-Tousi A, Gylfe A, Bailey L, Bergstrom S, Coates AR, Henderson B.
Clin Vaccine Immunol 14(2):204-7. Epub 2007 Jan 3. 2007
Single-nucleotide variations in the genes encoding the mitochondrial Hsp60/Hsp10 chaperone system and their disease-causing potential.
Bross P, Li Z, Hansen J, Hansen JJ, Nielsen MN, Corydon TJ, Georgopoulos C, Ang D, Lundemose JB, Niezen-Koning K, Eiberg H, Yang H, Kolvraa S, Bolund L, Gregersen N.
J Hum Genet 52(1):56-65. Epub 2006 Oct 27. 2007
38HSPD1, SPG13
A novel mutation in the HSPD1 gene in a patient with hereditary spastic paraplegia.
Hansen J, Svenstrup K, Ang D, Nielsen MN, Christensen JH, Gregersen N, Nielsen JE, Georgopoulos C, Bross P.
J Neurol 254(7):897-900. Epub 2007 Apr 10. 2007
CXorf6 is a causative gene for hypospadias.
Fukami M, Wada Y, Miyabayashi K, Nishino I, Hasegawa T, Camerino G, Kretz C, Buj-Bello A, Laporte J, Yamada G, Morohashi K, Ogata T.
Nat Genet 38(12):1369-71. Epub 2006 Nov 5. 2006
40SPG7, SPG13, MRPL32, HSPD1
Hereditary spastic paraplegia: respiratory choke or unactivated substrate?
Claypool SM, Koehler CM.
Cell 123(2):183-5. 2005
Identification and characterization of molecular interactions between mortalin/mtHsp70 and HSP60.
Wadhwa R, Takano S, Kaur K, Aida S, Yaguchi T, Kaul Z, Hirano T, Taira K, Kaul SC.
Biochem J 391(Pt 2):185-90. 2005
Genomic structure of the human mitochondrial chaperonin genes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoter.
Hansen JJ, Bross P, Westergaard M, Nielsen MN, Eiberg H, Borglum AD, Mogensen J, Kristiansen K, Bolund L, Gregersen N.
Hum Genet 2003
Hereditary spastic paraplegia SPG13 is associated with a mutation in the gene encoding the mitochondrial chaperonin Hsp60.
Hansen JJ, Durr A, Cournu-Rebeix I, Georgopoulos C, Ang D, Nielsen MN, Davoine CS, Brice A, Fontaine B, Gregersen N, Bross P.
Am J Hum Genet 70(5):1328-32. 2002
Identification of two calcineurin B-binding proteins: tubulin and heat shock protein 60.
Li W, Handschumacher RE.
Biochim Biophys Acta 1599(1-2):72-81. 2002
Mammalian HSP60 is quickly sorted into the mitochondria under conditions of dehydration.
Itoh H, Komatsuda A, Ohtani H, Wakui H, Imai H, Sawada K, Otaka M, Ogura M, Suzuki A, Hamada F.
Eur J Biochem 269(23):5931-8. 2002
Genetic and environmental factors in hypospadias.
Stoll C, Alembik Y, Roth MP, Dott B.
J Med Genet 27(9):559-63. 1990