| 1 | EXOC3, HSPB1, HSPB2, MAPK14
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| Sec6 enhances cell migration and suppresses apoptosis by elevating the phosphorylation of p38 MAPK, MK2, and HSP27.
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| Tanaka T, Iino M, Goto K.
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| Cell Signal 49:1-16. doi: 10.1016/j.cellsig.2018.04.009. Epub 2018 May 2.
2018
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| 2 | HSPB1, HSPB2, NOX4, TGFB1I1
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| Hic-5 Mediates TGFβ-Induced Adhesion in Vascular Smooth Muscle Cells by a Nox4-Dependent Mechanism.
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| Fernandez I, Martin-Garrido A, Zhou DW, Clempus RE, Seidel-Rogol B, Valdivia A, Lassègue B, García AJ, Griendling KK, San Martin A.
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| Arterioscler Thromb Vasc Biol 35(5):1198-206. doi: 10.1161/ATVBAHA.114.305185. Epub 2015 Mar 26.
2015
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| 3 | HNRNPD, HSPB2
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| Chaperone Hsp27 modulates AUF1 proteolysis and AU-rich element-mediated mRNA degradation.
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| Knapinska AM, Gratacós FM, Krause CD, Hernandez K, Jensen AG, Bradley JJ, Wu X, Pestka S, Brewer G.
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| Mol Cell Biol 31(7):1419-31. Epub 2011 Jan 18.
2011
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| 4 | HSPB2
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| Downregulation of both gene expression and activity of Hsp27 improved maturation of mouse oocyte in vitro.
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| Liu JJ, Ma X, Cai LB, Cui YG, Liu JY.
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| Reprod Biol Endocrinol 8:47.PMID: 20465849 2010
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| 5 | HSPB2
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| The small heat shock protein HspB2 is a novel anti-apoptotic protein that inhibits apical caspase activation in the extrinsic apoptotic pathway.
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| Oshita SE, Chen F, Kwan T, Yehiely F, Cryns VL.
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| Breast Cancer Res Treat 124(2):307-15. Epub 2010 Jan 20.PMID: 20087649 2010
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| 6 | HSPB2
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| Participation of HSP27 in the antiapoptotic action of 17beta-estradiol in skeletal muscle cells.
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| Vasconsuelo A, Milanesi L, Boland R.
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| Cell Stress Chaperones 15(2):183-92. Epub 2009 Jul 21.PMID: 19621276 2010
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| 7 | HSPB1, HSPB2
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| Heat shock protein 27 is required for sex steroid receptor trafficking to and functioning at the plasma membrane.
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| Razandi M, Pedram A, Levin ER.
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| Mol Cell Biol 30(13):3249-61. Epub 2010 May 3.PMID: 20439495 2010
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| 8 | HSPB2, HSPB3
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| The small heat-shock proteins HSPB2 and HSPB3 form well-defined heterooligomers in a unique 3 to 1 subunit ratio.
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| den Engelsman J, Boros S, Dankers PY, Kamps B, Vree Egberts WT, Böde CS, Lane LA, Aquilina JA, Benesch JL, Robinson CV, de Jong WW, Boelens WC.
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| J Mol Biol 393(5):1022-32. Epub 2009 Aug 26.PMID: 19715703 2009
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| 9 | HSPB2
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| Hsp27 protects against ischemic brain injury via attenuation of a novel stress-response cascade upstream of mitochondrial cell death signaling.
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| Stetler RA, Cao G, Gao Y, Zhang F, Wang S, Weng Z, Vosler P, Zhang L, Signore A, Graham SH, Chen J.
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| J Neurosci 28(49):13038-55.PMID: 19052195 2008
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| 10 | HSPB2
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| HSPB2/MKBP, a novel and unique member of the small heat-shock protein family.
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| Hu Z, Yang B, Lu W, Zhou W, Zeng L, Li T, Wang X.
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| J Neurosci Res 86(10):2125-33. Review.PMID: 18615620 2008
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| 11 | HSPB2
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| HSP27 phosphorylation is correlated with ADP-induced platelet granule secretion.
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| Kato H, Takai S, Matsushima-Nishiwaki R, Adachi S, Minamitani C, Otsuka T, Tokuda H, Akamatsu S, Doi T, Ogura S, Kozawa O.
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| Arch Biochem Biophys 475(1):80-6. Epub 2008 Apr 29.PMID: 18471985 2008
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| 12 | HNRNPD, HSPB2
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| Chaperone Hsp27, a novel subunit of AUF1 protein complexes, functions in AU-rich element-mediated mRNA decay.
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| Sinsimer KS, Gratacós FM, Knapinska AM, Lu J, Krause CD, Wierzbowski AV, Maher LR, Scrudato S, Rivera YM, Gupta S, Turrin DK, De La Cruz MP, Pestka S, Brewer G.
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| Mol Cell Biol 28(17):5223-37. Epub 2008 Jun 23.
2008
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| 13 | HSPB2
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| Regulation of the mouse alphaB-crystallin and MKBP/HspB2 promoter activities by shared and gene specific intergenic elements: the importance of context dependency.
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| Swamynathan SK, Piatigorsky J.
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| Int J Dev Biol 51(8):689-700.PMID: 17939115 2007
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| 14 | HSPB2
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| Hsp27 regulates Akt activation and polymorphonuclear leukocyte apoptosis by scaffolding MK2 to Akt signal complex.
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| Wu R, Kausar H, Johnson P, Montoya-Durango DE, Merchant M, Rane MJ.
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| J Biol Chem 282(30):21598-608. Epub 2007 May 17.PMID: 17510053 2007
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| 15 | HSPB1, HSPB2
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| A protective role of 27-kDa heat shock protein in glucocorticoid-evoked apoptotic cell death of hippocampal progenitor cells.
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| Son GH, Geum D, Chung S, Park E, Lee KH, Choi S, Kim K.
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| Biochem Biophys Res Commun 338(4):1751-8. Epub 2005 Nov 2. 2005
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| 16 | HSPB2
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| Heat shock protein 27 association with the I kappa B kinase complex regulates tumor necrosis factor alpha-induced NF-kappa B activation.
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| Park KJ, Gaynor RB, Kwak YT.
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| J Biol Chem 278(37):35272-8. Epub 2003 Jun 25. 2003
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| 17 | HSPB2
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| Phosphatase inhibitors prevent HSP27 dephosphorylation, destruction of stress fibrils, and morphological changes in endothelial cells during ATP depletion.
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| Loktionova SA, Kabakov AE.
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| Bull Exp Biol Med 132(3):914-7. 2001
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| 18 | HSPB2, HSPB3
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| Muscle develops a specific form of small heat shock protein complex composed of MKBP/HSPB2 and HSPB3 during myogenic differentiation.
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| Sugiyama Y, Suzuki A, Kishikawa M, Akutsu R, Hirose T, Waye MM, Tsui SK, Yoshida S, Ohno S.
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| J Biol Chem 275(2):1095-104. 2000
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| 19 | DMPK, HSPB2
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| MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase.
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| Suzuki A, Sugiyama Y, Hayashi Y, Nyu-i N, Yoshida M, Nonaka I, Ishiura S, Arahata K, Ohno S.
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| J Cell Biol 140(5):1113-24 1998
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| 20 | CRYAB, HSPB2
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| Identification and characterization of the gene encoding a new member of the alpha-crystallin/Small hsp family, closely linked to the alphaB-crystallin gene in a head-to-head manner.
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| Iwaki A, Nagano T, Nakagawa M, Iwaki T, Fukumaki Y.
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| Genomics 45(2):386-94. 1997
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| 21 | CRYAA,CRYAB,HSPBL1,HSPBL2,HSPBL3,HSPB1,HSPB2,HSPB3,HSPB7
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| Structure-function studies on small heat shock protein oligomeric assembly and interaction with unfolded polypeptides.
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| Leroux MR, Melki R, Gordon B, Batelier G, Candido EP.
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| J Biol Chem 272(39):24646-56 1997
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| 22 | CRYAA,CRYAB,HSPBL1,HSPBL2,HSPBL3,HSPB1,HSPB2,HSPB3,HSPB7
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| Sequence and organization of genes encoding the human 27 kDa heat shock protein.
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| Hickey E, Brandon SE, Potter R, Stein G, Stein J, Weber LA.
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| Nucleic Acids Res 14(10):4127-45 1986
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