| 1 | HSPA9, SLC25A6
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| Mortalin (HSPA9) facilitates BRAF-mutant tumor cell survival by suppressing ANT3-mediated mitochondrial membrane permeability.
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| Wu PK, Hong SK, Chen W, Becker AE, Gundry RL, Lin CW, Shao H, Gestwicki JE, Park JI.
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| Sci Signal 13(622). pii: eaay1478. doi: 10.1126/scisignal.aay1478.
2020
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| 2 | HSPA9, PARK7
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| Mortalin and DJ-1 coordinately regulate hematopoietic stem cell function through the control of oxidative stress.
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| Tai-Nagara I, Matsuoka S, Ariga H, Suda T.
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| Blood 123(1):41-50. doi: 10.1182/blood-2013-06-508333. Epub 2013 Nov 15.
2014
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| 3 | HSPA8, HSPA9
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| Analysis of HSPA8 and HSPA9 mRNA expression and promoter methylation in the brain and blood of Alzheimer's disease patients.
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| Silva PN, Furuya TK, Braga IL, Rasmussen LT, Labio RW, Bertolucci PH, Chen ES, Turecki G, Mechawar N, Payão SL, Mill J, Smith MC.
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| J Alzheimers Dis 38(1):165-70. doi: 10.3233/JAD-130428.
2014
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| 4 | ACSL5, HSPA9
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| TP53 status regulates ACSL5-induced expression of mitochondrial mortalin in enterocytes and colorectal adenocarcinomas.
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| Klaus C, Kaemmerer E, Reinartz A, Schneider U, Plum P, Jeon MK, Hose J, Hartmann F, Schnölzer M, Wagner N, Kopitz J, Gassler N.
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| Cell Tissue Res 357(1):267-78. doi: 10.1007/s00441-014-1826-8. Epub 2014 Apr 29.
2014
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| 5 | HSCB, HSPA9, ISCU, LYRM4, NFS1
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| Human mitochondrial chaperone (mtHSP70) and cysteine desulfurase (NFS1) bind preferentially to the disordered conformation, whereas co-chaperone (HSC20) binds to the structured conformation of the iron-sulfur cluster scaffold protein (ISCU).
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| Cai K, Frederick RO, Kim JH, Reinen NM, Tonelli M, Markley JL.
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| J Biol Chem 288(40):28755-70. doi: 10.1074/jbc.M113.482042. Epub 2013 Aug 12. 2013
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| 6 | CDKN1A, HSPA9
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| A mortalin/HSPA9-mediated switch in tumor-suppressive signaling of Raf/MEK/extracellular signal-regulated kinase.
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| Wu PK, Hong SK, Veeranki S, Karkhanis M, Starenki D, Plaza JA, Park JI.
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| Mol Cell Biol 33(20):4051-67. doi: 10.1128/MCB.00021-13. Epub 2013 Aug 19.
2013
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| 7 | BCL2, BCL2L1, HSPA9
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| Molecular interactions of Bcl-2 and Bcl-xL with mortalin: identification and functional characterization.
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| Saxena N, Katiyar SP, Liu Y, Grover A, Gao R, Sundar D, Kaul SC, Wadhwa R.
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| Biosci Rep 33(5). pii: e00073. doi: 10.1042/BSR20130034.
2013
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| 8 | FXN, HSCB, HSPA9, ISCU
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| HSC20 interacts with frataxin and is involved in iron-sulfur cluster biogenesis and iron homeostasis.
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| Shan Y, Cortopassi G.
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| Hum Mol Genet 21(7):1457-69. doi: 10.1093/hmg/ddr582. Epub 2011 Dec 13.
2012
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| 9 | DNLZ, HSPA9
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| A conserved histidine in human DNLZ/HEP is required for stimulation of HSPA9 ATPase activity.
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| Zhai P, Vu MT, Hoff KG, Silberg JJ.
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| Biochem Biophys Res Commun 408(4):589-94. Epub 2011 Apr 21.
2011
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| 10 | HSPA9
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| Mortalin-p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy.
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| Lu WJ, Lee NP, Kaul SC, Lan F, Poon RT, Wadhwa R, Luk JM.
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| Cell Death Differ 18(6):1046-56. Epub 2011 Jan 14.
2011
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| 11 | HSPA9, PRKN
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| Mitochondrial dysfunction induced by knockdown of mortalin is rescued by Parkin.
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| Yang H, Zhou X, Liu X, Yang L, Chen Q, Zhao D, Zuo J, Liu W.
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| Biochem Biophys Res Commun 410(1):114-20. Epub 2011 May 26. 2011
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| 12 | HSPA9, RXRA
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| Nuclear GRP75 binds retinoic acid receptors to promote neuronal differentiation of neuroblastoma.
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| Shih YY, Lee H, Nakagawara A, Juan HF, Jeng YM, Tsay YG, Lin DT, Hsieh FJ, Pan CY, Hsu WM, Liao YF.
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| PLoS One 6(10):e26236. doi: 10.1371/journal.pone.0026236. Epub 2011 Oct 14.
2011
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| 13 | HSPA9, PINK1, PRKN
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| Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients.
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| Rakovic A, Grünewald A, Seibler P, Ramirez A, Kock N, Orolicki S, Lohmann K, Klein C.
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| Hum Mol Genet 19(16):3124-37. Epub 2010 May 27.PMID: 20508036 2010
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| 14 | HSPA9
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| Magnetic nanoparticle-based isolation of endocytic vesicles reveals a role of the heat shock protein GRP75 in macromolecular delivery.
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| Wittrup A, Zhang SH, Svensson KJ, Kucharzewska P, Johansson MC, Mörgelin M, Belting M.
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| Proc Natl Acad Sci U S A 107(30):13342-7. Epub 2010 Jul 12. 2010
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| 15 | HSPA9
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| Knockdown of mortalin within the medial prefrontal cortex impairs normal sensorimotor gating.
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| Gabriele N, Pontoriero GF, Thomas N, Shethwala SK, Pristupa ZB, Gabriele JP.
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| Synapse 64(11):808-13. 2010
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| 16 | HSPA9
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| Dissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease: functional impact of disease-related variants on mitochondrial homeostasis.
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| Burbulla LF, Schelling C, Kato H, Rapaport D, Woitalla D, Schiesling C, Schulte C, Sharma M, Illig T, Bauer P, Jung S, Nordheim A, Schöls L, Riess O, Krüger R.
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| Hum Mol Genet 19(22):4437-52. Epub 2010 Sep 2.
2010
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| 17 | HSPA9
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| Reconstitution of the mitochondrial Hsp70 (mortalin)-p53 interaction using purified proteins--identification of additional interacting regions.
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| Iosefson O, Azem A.
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| FEBS Lett 584(6):1080-4. Epub 2010 Feb 12. 2010
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| 18 | HSPA9
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| Mortalin inhibitors sensitize K562 leukemia cells to complement-dependent cytotoxicity.
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| Pilzer D, Saar M, Koya K, Fishelson Z.
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| Int J Cancer 126(6):1428-35. 2010
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| 19 | HSPA9
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| Mutational screening of the mortalin gene (HSPA9) in Parkinson's disease.
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| De Mena L, Coto E, Sánchez-Ferrero E, Ribacoba R, Guisasola LM, Salvador C, Blázquez M, Alvarez V.
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| J Neural Transm 116(10):1289-93. Epub 2009 Aug 6. 2009
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| 20 | HSPA9
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| Cloning, characterization, and functional studies of a human 40-kDa catecholamine-regulated protein: implications in central nervous system disorders.
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| Gabriele J, Pontoriero GF, Thomas N, Thomson CA, Skoblenick K, Pristupa ZB, Mishra RK.
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| Cell Stress Chaperones 14(6):555-67. Epub 2009 Mar 12. 2009
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| 21 | HSPA9
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| From proliferative to neurological role of an hsp70 stress chaperone, mortalin.
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| Deocaris CC, Kaul SC, Wadhwa R.
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| Biogerontology 9(6):391-403. Epub 2008 Sep 4. Review.
2008
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| 22 | HSPA9
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| Identification of GRP75 as an independent favorable prognostic marker of neuroblastoma by a proteomics analysis.
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| Hsu WM, Lee H, Juan HF, Shih YY, Wang BJ, Pan CY, Jeng YM, Chang HH, Lu MY, Lin KH, Lai HS, Chen WJ, Tsay YG, Liao YF, Hsieh FJ.
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| Clin Cancer Res 14(19):6237-45.
2008
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| 23 | FXN, LYRM4, FRDA, HSPA9
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| Mitochondrial frataxin interacts with ISD11 of the NFS1/ISCU complex and multiple mitochondrial chaperones.
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| Shan Y, Napoli E, Cortopassi G.
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| Hum Mol Genet 16(8):929-41. Epub 2007 Mar 1. 2007
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| 24 | HSPA9
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| Involvement of mortalin in cellular senescence from the perspective of its mitochondrial import, chaperone, and oxidative stress management functions.
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| Yaguchi T, Aida S, Kaul SC, Wadhwa R.
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| Ann N Y Acad Sci 1100:306-11. Review. 2007
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| 25 | HSPA9
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| Mortalin controls centrosome duplication via modulating centrosomal localization of p53.
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| Ma Z, Izumi H, Kanai M, Kabuyama Y, Ahn NG, Fukasawa K.
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| Oncogene 25(39):5377-90. Epub 2006 Apr 17. 2006
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| 26 | HSPA9
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| Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis.
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| Wadhwa R, Takano S, Kaur K, Deocaris CC, Pereira-Smith OM, Reddel RR, Kaul SC.
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| Int J Cancer. 118(12):2973-80. 2006
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| 27 | HSPA9,HSPD1
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| Identification and characterization of molecular interactions between mortalin/mtHsp70 and HSP60.
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| Wadhwa R, Takano S, Kaur K, Aida S, Yaguchi T, Kaul Z, Hirano T, Taira K, Kaul SC.
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| Biochem J 391(Pt 2):185-90. 2005
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| 28 | HSPA9, HSP90B1
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| Identification and characterization of molecular interactions between glucose-regulated proteins (GRPs) mortalin/GRP75/peptide-binding protein 74 (PBP74) and GRP94.
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| Takano S, Wadhwa R, Mitsui Y, Kaul SC.
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| Biochem J 357(Pt 2):393-8. 2001
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| 29 | HSPA9
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| Extramitochondrial localization of mortalin/mthsp70/PBP74/GRP75.
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| Ran Q, Wadhwa R, Kawai R, Kaul SC, Sifers RN, Bick RJ, Smith JR, Pereira-Smith OM.
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| Biochem Biophys Res Commun 275(1):174-9. 2000
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| 30 | HSPA9
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| Mouse and human chromosomal assignments of mortalin, a novel member of the murine hsp70 family of proteins.
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| Kaul SC, et al.
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| FEBS Lett 361 : 269-272. 1995
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| 31 | HSPA9
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| Cloning and subcellular localization of human mitochondrial hsp70.
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| Bhattacharyya T, Karnezis AN, Murphy SP, Hoang T, Freeman BC, Phillips B, Morimoto RI.
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| J Biol Chem 270(4):1705-10. 1995
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| 32 | HSPA9
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| Cloning of the gene encoding peptide-binding protein 74 shows that it is a new member of the heat shock protein 70 family.
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| Domanico SZ, DeNagel DC, Dahlseid JN, Green JM, Pierce SK.
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| Mol Cell Biol 13(6):3598-610. 1993
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