Citations for
1CFTR, DNAJA1, DNAJA2, HSPA4, HSPA8, STUB1
Hsp70 and DNAJA2 limit CFTR levels through degradation.
Kim Chiaw P, Hantouche C, Wong MJH, Matthes E, Robert R, Hanrahan JW, Shrier A, Young JC.
PLoS One 14(8):e0220984. doi: 10.1371/journal.pone.0220984. eCollection 2019. 2019
2GKN2, HSPA8
GKN2 promotes oxidative stress-induced gastric cancer cell apoptosis via the Hsc70 pathway.
Zhang Z, Xue H, Dong Y, Zhang J, Pan Y, Shi L, Xiong P, Zhu J, Li W, Zheng W, Liu J, Du J.
J Exp Clin Cancer Res. Aug 5;38(1):338. doi: 10.1186/s13046-019-1336-3 2019
3HSPA8, SGTA
SGTA-Dependent Regulation of Hsc70 Promotes Cytosol Entry of Simian Virus 40 from the Endoplasmic Reticulum.
Dupzyk A, Williams JM, Bagchi P, Inoue T, Tsai B.
J Virol 91(12). pii: e00232-17. doi: 10.1128/JVI.00232-17. Print 2017 Jun 15. 2017
4BBC3, HSPA8
Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA.
Xie W, Zhang L, Jiao H, Guan L, Zha J, Li X, Wu M, Wang Z, Han J, You H.
Autophagy 11(9):1623-35. doi: 10.1080/15548627.2015.1075688. 2015
5HSPA8, PPP5C
The molecular chaperone Hsp70 activates protein phosphatase 5 (PP5) by binding the tetratricopeptide repeat (TPR) domain.
Connarn JN, Assimon VA, Reed RA, Tse E, Southworth DR, Zuiderweg ER, Gestwicki JE, Sun D.
J Biol Chem 289(5):2908-17. doi: 10.1074/jbc.M113.519421. Epub 2013 Dec 10. 2014
6HSPA8, RAB1A
Hsc70 contributes to cancer cell survival by preventing Rab1A degradation under stress conditions.
Tanaka M, Mun S, Harada A, Ohkawa Y, Inagaki A, Sano S, Takahashi K, Izumi Y, Osada-Oka M, Wanibuchi H, Yamagata M, Yukimura T, Miura K, Shiota M, Iwao H.
PLoS One 9(5):e96785. doi: 10.1371/journal.pone.0096785. eCollection 2014. 2014
7HSPA8
Heat-shock protein A8 restores sperm membrane integrity by increasing plasma membrane fluidity.
Moein-Vaziri N, Phillips I, Smith S, Almiňana C, Maside C, Gil MA, Roca J, Martinez EA, Holt WV, Pockley AG, Fazeli A.
Reproduction 147(5):719-32. doi: 10.1530/REP-13-0631. Print 2014 May. 2014
8HSPA8, HSPA9
Analysis of HSPA8 and HSPA9 mRNA expression and promoter methylation in the brain and blood of Alzheimer's disease patients.
Silva PN, Furuya TK, Braga IL, Rasmussen LT, Labio RW, Bertolucci PH, Chen ES, Turecki G, Mechawar N, Payão SL, Mill J, Smith MC.
J Alzheimers Dis 38(1):165-70. doi: 10.3233/JAD-130428. 2014
9HSPA8, SRY
70-kDa heat shock cognate protein hsc70 mediates calmodulin-dependent nuclear import of the sex-determining factor SRY.
Kaur G, Lieu KG, Jans DA.
J Biol Chem 288(6):4148-57. doi: 10.1074/jbc.M112.436741. Epub 2012 Dec 12. 2013
10HSPA8, STUB1
The E3 ubiquitin ligase CHIP and the molecular chaperone Hsc70 form a dynamic, tethered complex.
Smith MC, Scaglione KM, Assimon VA, Patury S, Thompson AD, Dickey CA, Southworth DR, Paulson HL, Gestwicki JE, Zuiderweg ER.
Biochemistry 52(32):5354-64. doi: 10.1021/bi4009209. Epub 2013 Aug 2. 2013
11HSPA8, MAPK1
Stress-induced interaction between p38 MAPK and HSP70.
Gong X, Luo T, Deng P, Liu Z, Xiu J, Shi H, Jiang Y.
Biochem Biophys Res Commun 425(2):357-62. doi: 10.1016/j.bbrc.2012.07.096. Epub 2012 Jul 25. 2012
12HSPA8, NCL
Heat shock cognate 70 regulates the translocation and angiogenic function of nucleolin.
Ding Y, Song N, Liu C, He T, Zhuo W, He X, Chen Y, Song X, Fu Y, Luo Y.
Arterioscler Thromb Vasc Biol 32(9):e126-34. doi: 10.1161/ATVBAHA.112.247502. Epub 2012 Jun 28. 2012
13HSPA8
The cellular chaperone hsc70 is specifically recruited to reovirus viral factories independently of its chaperone function.
Kaufer S, Coffey CM, Parker JS.
J Virol 86(2):1079-89. doi: 10.1128/JVI.02662-10. Epub 2011 Nov 16. 2012
14CDKN1B, CDKN1C, HSPA8
p57(Kip2) and p27(Kip1) cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70.
Zou P, Yoshihara H, Hosokawa K, Tai I, Shinmyozu K, Tsukahara F, Maru Y, Nakayama K, Nakayama KI, Suda T.
Cell Stem Cell 9(3):247-61. 2011
15HSPA8
Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport.
Patterson KR, Ward SM, Combs B, Voss K, Kanaan NM, Morfini G, Brady ST, Gamblin TC, Binder LI.
Biochemistry 50(47):10300-10. doi: 10.1021/bi2009147. Epub 2011 Nov 8. 2011
16HSPA8
Heat shock cognate protein 70 is essential for Akt signaling in endothelial function.
Shiota M, Kusakabe H, Izumi Y, Hikita Y, Nakao T, Funae Y, Miura K, Iwao H.
Arterioscler Thromb Vasc Biol 30(3):491-7. Epub 2009 Dec 17.PMID: 20018937 2010
17HSPA8
Heat shock cognate 70 protein secretion as a new growth arrest signal for cancer cells.
Nirdé P, Derocq D, Maynadier M, Chambon M, Basile I, Gary-Bobo M, Garcia M.
Oncogene 29(1):117-27. Epub 2009 Oct 5.PMID: 19802014 2010
18EPM2A, EPM2B, HSPA8
Sequestration of chaperones and proteasome into Lafora bodies and proteasomal dysfunction induced by Lafora disease-associated mutations of malin.
Rao SN, Maity R, Sharma J, Dey P, Shankar SK, Satishchandra P, Jana NR.
Hum Mol Genet 19(23):4726-34. Epub 2010 Sep 21. 2010
19HSPA8, SRFBP1
Interaction of Hsp70 with p49/STRAP, a serum response factor binding protein.
Lin JL, Liu FH, Wang C.
Biochem Biophys Res Commun 389(4):607-11. Epub 2009 Sep 12.PMID: 19751705 2009
20HSPA8, SLC18A2
The molecular chaperone Hsc70 interacts with the vesicular monoamine transporter-2.
Requena DF, Parra LA, Baust TB, Quiroz M, Leak RK, Garcia-Olivares J, Torres GE.
J Neurochem 110(2):581-94. Epub 2009 Apr 30.PMID: 19457116 2009
21DNAJC13, HSPA8
RME-8 regulates trafficking of the epidermal growth factor receptor.
Girard M, McPherson PS.
FEBS Lett 582(6):961-6. Epub 2008 Feb 26. 2008
22ASNA1, HSPA8
A precursor-specific role for Hsp40/Hsc70 during tail-anchored protein integration at the endoplasmic reticulum.
Rabu C, Wipf P, Brodsky JL, High S.
J Biol Chem 283(41):27504-13. Epub 2008 Jul 29. 2008
23HSPA8
Functional divergence between co-chaperones of Hsc70.
Tzankov S, Wong MJ, Shi K, Nassif C, Young JC.
J Biol Chem 283(40):27100-9. Epub 2008 Aug 6.PMID: 18684711 2008
24HSPA8
Two motifs within the tau microtubule-binding domain mediate its association with the hsc70 molecular chaperone.
Sarkar M, Kuret J, Lee G.
J Neurosci Res 86(12):2763-73.PMID: 18500754 2008
25HSPA8, TCP1
The structure of CCT-Hsc70 NBD suggests a mechanism for Hsp70 delivery of substrates to the chaperonin.
Cuéllar J, Martín-Benito J, Scheres SH, Sousa R, Moro F, López-Viñas E, Gómez-Puertas P, Muga A, Carrascosa JL, Valpuesta JM.
Nat Struct Mol Biol 15(8):858-64. Epub 2008 Jul 27. 2008
26HSPA8
Identification of a keratin-associated protein with a putative role in vesicle transport.
Planko L, Böhse K, Höhfeld J, Betz RC, Hanneken S, Eigelshoven S, Kruse R, Nöthen MM, Magin TM.
Eur J Cell Biol 86(11-12):827-39. Epub 2007 Mar 29.PMID: 17397964 2007
27ACTG1, COL1A1, COL1A2, COL2A1, COL9A1, DIO2, HSPA8, IBSP, IGF1, KAT6B, OGN, POU3F4, RBMS3, VIM, ZIC2
Cloning, characterization, and mRNA expression analysis of novel human fetal cochlear cDNAs.
Luijendijk MW, van de Pol TJ, van Duijnhoven G, den Hollander AI, ten Caat J, van Limpt V, Brunner HG, Kremer H, Cremers FP.
Genomics 82(4):480-90. 2003
28BAG1, HSPA8
The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome.
Luders J, Demand J, Hohfeld J.
J Biol Chem 275(7):4613-7. 2000
29BAG1, HSPA8
Distinct isoforms of the cofactor BAG-1 differentially affect Hsc70 chaperone function.
Luders J, Demand J, Papp O, Hohfeld J.
J Biol Chem 275(20):14817-23. 2000
30HSPA8
Role of Hsp70 in regulation of stress-kinase JNK : implications in apoptosis and aging.
Gabai VL, Meriin AB, Yaglom JA, Volloch VZ, Sherman MY.
FEBS Lett 438 : 1-4. 1998
31HSPA8
Localization of the gene encoding the human heat shock cognate protein, HSP73, to chromosome 11.
Tavaria M, et al.
Genomics 29 : 266-268. 1995