Citations for
1CANX, HSPA5
KDELR2 Competes with Measles Virus Envelope Proteins for Cellular Chaperones Reducing Their Chaperone-Mediated Cell Surface Transport.
Tiwarekar V, Fehrholz M, Schneider-Schaulies J.
Viruses 11(1). pii: E27. doi: 10.3390/v11010027. 2019
2HSPA5, OTUD3
The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis
Du T, Li H, Fan Y, Yuan L, Guo X, Zhu Q, Yao Y, Li X, Liu C, Yu X, Liu Z, Cui CP, Han C, Zhang L.
Nat Commun. Jul 2;10(1):2914. doi: 10.1038/s41467-019-10824-7. 2019
3HSP90AA1, HSPA5, PRDM14
PRDM14 directly interacts with heat shock proteins HSP90α and glucose-regulated protein 78.
Moriya C, Taniguchi H, Nagatoishi S, Igarashi H, Tsumoto K, Imai K.
Cancer Sci 109(2):373-383. doi: 10.1111/cas.13458. Epub 2017 Dec 28. 2018
4HSPA5, MUL1
HSPA5 negatively regulates lysosomal activity through ubiquitination of MUL1 in head and neck cancer.
Kim SY, Kim HJ, Kim HJ, Kim DH, Han JH, Byeon HK, Lee K, Kim CH.
Autophagy 14(3):385-403. doi: 10.1080/15548627.2017.1414126. Epub 2018 Feb 21. 2018
5ATE1, HSPA5
The endoplasmic reticulum-residing chaperone BiP is short-lived and metabolized through N-terminal arginylation.
Shim SM, Choi HR, Sung KW, Lee YJ, Kim ST, Kim D, Mun SR, Hwang J, Cha-Molstad H, Ciechanover A, Kim BY, Kwon YT.
Sci Signal. Jan 2;11(511):eaan0630. doi: 10.1126/scisignal.aan0630 2018
6ADAM17, HSPA5, PDIA6
GRP78 protects a disintegrin and metalloprotease 17 against protein-disulfide isomerase A6 catalyzed inactivation.
Schäfer M, Granato DC, Krossa S, Bartels AK, Yokoo S, Düsterhöft S, Koudelka T, Scheidig AJ, Tholey A, Paes Leme AF, Grötzinger J, Lorenzen I.
FEBS Lett 591(21):3567-3587. doi: 10.1002/1873-3468.12858. Epub 2017 Oct 11. 2017
7HSPA5, METTL21A
Lysine trimethylation regulates 78-kDa glucose-regulated protein proteostasis during endoplasmic reticulum stress
Sieber J, Wieder N, Ostrosky-Frid M, Dvela-Levitt M, Aygün O, Udeshi ND, Carr SA, Greka A.
J Biol Chem. Nov 17;292(46):18878-18885. doi: 10.1074/jbc.M117.797084. Epub 2017 Sep 14 2017
8ATAD3A, HSPA5, WASF3
Mitochondrial ATAD3A combines with GRP78 to regulate the WASF3 metastasis-promoting protein.
Teng Y, Ren X, Li H, Shull A, Kim J, Cowell JK.
Oncogene 35(3):333-43. doi: 10.1038/onc.2015.86. 2016
9HSPA5, INPP5K, PAK1
Glucose-regulated protein 78 (GRP78) binds directly to PIP3 phosphatase SKIP and determines its localization.
Ijuin T, Hatano N, Takenawa T.
Genes Cells 21(5):457-65. doi: 10.1111/gtc.12353. Epub 2016 Mar 4. 2016
10CRELD2, HSPA5, MANF
Characterization of the Role of MANF in Regulating the Secretion of CRELD2.
Oh-Hashi K, Norisada J, Hirata Y, Kiuchi K.
Biol Pharm Bull 38(5):722-31. doi: 10.1248/bpb.b14-00825. 2015
11HSPA5, SEC61
Protein transport into the human endoplasmic reticulum.
Dudek J, Pfeffer S, Lee PH, Jung M, Cavalié A, Helms V, Förster F, Zimmermann R.
J Mol Biol 427(6 Pt A):1159-75. doi: 10.1016/j.jmb.2014.06.011. Epub 2014 Jun 23. Review. 2015
12ATE1, HSPA5
Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding.
Cha-Molstad H, Sung KS, Hwang J, Kim KA, Yu JE, Yoo YD, Jang JM, Han DH, Molstad M, Kim JG, Lee YJ, Zakrzewska A, Kim SH, Kim ST, Kim SY, Lee HG, Soung NK, Ahn JS, Ciechanover A, Kim BY, Kwon YT.
Nat Cell Biol. Jul;17(7):917-29. doi: 10.1038/ncb3177. Epub 2015 Jun 15 2015
13DNAJC3, HSPA5, JDND
Absence of BiP Co-chaperone DNAJC3 Causes Diabetes Mellitus and Multisystemic Neurodegeneration.
Synofzik M, Haack TB, Kopajtich R, Gorza M, Rapaport D, Greiner M, Schönfeld C, Freiberg C, Schorr S, Holl RW, Gonzalez MA, Fritsche A, Fallier-Becker P, Zimmermann R, Strom TM, Meitinger T, Züchner S, Schüle R, Schöls L, Prokisch H.
Am J Hum Genet 95(6):689-97. doi: 10.1016/j.ajhg.2014.10.013. Epub 2014 Nov 20. 2014
14HSPA5, SNCA
GRP78 clustering at the cell surface of neurons transduces the action of exogenous alpha-synuclein.
Bellani S, Mescola A, Ronzitti G, Tsushima H, Tilve S, Canale C, Valtorta F, Chieregatti E.
Cell Death Differ 21(12):1971-83. doi: 10.1038/cdd.2014.111. Epub 2014 Aug 15. 2014
15HSPA5, TDGF1
CRIPTO/GRP78 signaling maintains fetal and adult mammary stem cells ex vivo.
Spike BT, Kelber JA, Booker E, Kalathur M, Rodewald R, Lipianskaya J, La J, He M, Wright T, Klemke R, Wahl GM, Gray PC.
Stem Cell Reports 2(4):427-39. doi: 10.1016/j.stemcr.2014.02.010. 2014
16ATF6, HSPA5, RRBP1
Endoplasmic reticulum ribosome-binding protein 1 (RRBP1) overexpression is frequently found in lung cancer patients and alleviates intracellular stress-induced apoptosis through the enhancement of GRP78.
Tsai HY, Yang YF, Wu AT, Yang CJ, Liu YP, Jan YH, Lee CH, Hsiao YW, Yeh CT, Shen CN, Lu PJ, Huang MS, Hsiao M.
Oncogene 32(41):4921-31. doi: 10.1038/onc.2012.514. Epub 2013 Jan 14. 2013
17AGR2, HSPA5
Dimerization of pro-oncogenic protein Anterior Gradient 2 is required for the interaction with BiP/GRP78.
Ryu J, Park SG, Lee PY, Cho S, Lee do H, Kim GH, Kim JH, Park BC.
Biochem Biophys Res Commun 430(2):610-5. doi: 10.1016/j.bbrc.2012.11.105. Epub 2012 Dec 4. 2013
18DNAJB11, HSPA5, SLC61A1
ERdj3 regulates BiP occupancy in living cells.
Guo F, Snapp EL.
J Cell Sci 126(Pt 6):1429-39. doi: 10.1242/jcs.118182. Epub 2013 Feb 1. 2013
19HSPA5, PAWR
Role of prostate apoptosis response 4 in translocation of GRP78 from the endoplasmic reticulum to the cell surface of trophoblastic cells.
Cohen M, Ribaux P, Epiney M, Irion O.
PLoS One 8(11):e80231. doi: 10.1371/journal.pone.0080231. eCollection 2013. 2013
20EIF2AK3, ERN1, HSPA5
Binding of human BiP to the ER stress transducers IRE1 and PERK requires ATP.
Sou SN, Ilieva KM, Polizzi KM.
Biochem Biophys Res Commun 420(2):473-8. Epub 2012 Mar 13. 2012
21DMKN, HSPA5
Dermokine-β impairs ERK signaling through direct binding to GRP78.
Higashi K, Hasegawa M, Yokoyama C, Tachibana T, Mitsui S, Saito K.
FEBS Lett 586(16):2300-5. doi: 10.1016/j.febslet.2012.06.022. Epub 2012 Jun 23. 2012
22HSPA5, MSS, SIL1
C-terminal mutations destabilize SIL1/BAP and can cause Marinesco-Sjögren syndrome.
Howes J, Shimizu Y, Feige MJ, Hendershot LM.
J Biol Chem 287(11):8552-60. doi: 10.1074/jbc.M111.333286. Epub 2012 Jan 4. 2012
23HSP90B1, HSPA5, TLR4
Chaperone insufficiency links TLR4 protein signaling to endoplasmic reticulum stress.
Coope A, Milanski M, Arruda AP, Ignacio-Souza LM, Saad MJ, Anhê GF, Velloso LA.
J Biol Chem 287(19):15580-9. doi: 10.1074/jbc.M111.315218. Epub 2012 Mar 16. 2012
24HSPA5, SEC61A1
BiP-mediated closing of the Sec61 channel limits Ca2+ leakage from the ER.
Schäuble N, Lang S, Jung M, Cappel S, Schorr S, Ulucan Ö, Linxweiler J, Dudek J, Blum R, Helms V, Paton AW, Paton JC, Cavalié A, Zimmermann R.
EMBO J 31(15):3282-96. doi: 10.1038/emboj.2012.189. Epub 2012 Jul 13. Erratum in: EMBO J. 2012 Sep 12;31(18):3784. 2012
25HSPA5
Endoplasmic reticulum chaperone GRP78 suppresses the aggregation of proteins containing expanded polyglutamine tract.
Yamagishi N, Magara S, Tamura S, Saito Y, Hatayama T.
Biochem Biophys Res Commun 422(3):527-33. doi: 10.1016/j.bbrc.2012.05.078. Epub 2012 May 22. 2012
26HSPA5
Endoplasmic reticulum chaperone GRP78 suppresses the aggregation of proteins containing expanded polyglutamine tract.
Yamagishi N, Magara S, Tamura S, Saito Y, Hatayama T.
Biochem Biophys Res Commun 422(3):527-33. doi: 10.1016/j.bbrc.2012.05.078. Epub 2012 May 22. 2012
27GPX7, HSPA5
Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease.
Wei PC, Hsieh YH, Su MI, Jiang X, Hsu PH, Lo WT, Weng JY, Jeng YM, Wang JM, Chen PL, Chang YC, Lee KF, Tsai MD, Shew JY, Lee WH.
Mol Cell 48(5):747-59. doi: 10.1016/j.molcel.2012.10.007. Epub 2012 Nov 1. 2012
28HSPA5
A critical role for GRP78/BiP in the tumor microenvironment for neovascularization during tumor growth and metastasis.
Dong D, Stapleton C, Luo B, Xiong S, Ye W, Zhang Y, Jhaveri N, Zhu G, Ye R, Liu Z, Bruhn KW, Craft N, Groshen S, Hofman FM, Lee AS.
Cancer Res 71(8):2848-57. Epub 2011 Apr 5. 2011
29ADAM7, CANX, HSPA5, ITM2B
Identification of heat shock protein 5, calnexin and integral membrane protein 2B as Adam7-interacting membrane proteins in mouse sperm.
Han C, Park I, Lee B, Jin S, Choi H, Kwon JT, Kwon YI, Kim do H, Park ZY, Cho C.
J Cell Physiol 226(5):1186-95. doi: 10.1002/jcp.22444. 2011
30BIK, HSPA5, PMAIP1
Novel mechanism of anti-apoptotic function of 78-kDa glucose-regulated protein (GRP78): endocrine resistance factor in breast cancer, through release of B-cell lymphoma 2 (BCL-2) from BCL-2-interacting killer (BIK).
Zhou H, Zhang Y, Fu Y, Chan L, Lee AS.
J Biol Chem 286(29):25687-96. Epub 2011 May 26. 2011
31BCAP31, HSPA5
BAP31 and BiP are essential for dislocation of SV40 from the endoplasmic reticulum to the cytosol.
Geiger R, Andritschke D, Friebe S, Herzog F, Luisoni S, Heger T, Helenius A.
Nat Cell Biol. 13(11):1305-14. 2011
32HSPA5, SIGMAR1, SRR
Sigma receptor 1 modulates endoplasmic reticulum stress in retinal neurons.
Ha Y, Dun Y, Thangaraju M, Duplantier J, Dong Z, Liu K, Ganapathy V, Smith SB.
Invest Ophthalmol Vis Sci 52(1):527-40. doi: 10.1167/iovs.10-5731. Print 2011 Jan. 2011
33HSPA5
Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis.
Wang M, Ye R, Barron E, Baumeister P, Mao C, Luo S, Fu Y, Luo B, Dubeau L, Hinton DR, Lee AS.
Cell Death Differ 17(3):488-98. Epub 2009 Oct 9. 2010
34CHS1, HPS, HSPA5, LYST
Identification of proteins in the ceroid-like autofluorescent aggregates from liver lysosomes of Beige, a mouse model for human Chediak-Higashi syndrome.
Zhang H, Mahuran DJ, Callahan JW.
Mol Genet Metab 99(4):389-95. Epub 2009 Dec 21. 2010
35DNAJB1, HSPA4, HSPA5
The chaperone proteins HSP70, HSP40/DnaJ and GRP78/BiP suppress misfolding and formation of β-sheet-containing aggregates by human amylin: a potential role for defective chaperone biology in Type 2 diabetes.
Chien V, Aitken JF, Zhang S, Buchanan CM, Hickey A, Brittain T, Cooper GJ, Loomes KM.
Biochem J. 432(1):113-21. 2010
36HSPA5, PDIA2
GRP78, but Not Protein-disulfide Isomerase, Partially Reverses Hyperglycemia-induced Inhibition of Insulin Synthesis and Secretion in Pancreatic {beta}-Cells.
Zhang L, Lai E, Teodoro T, Volchuk A.
J Biol Chem 284(8):5289-98. Epub 2008 Dec 22. 2009
37HSPA5, TDGF1
Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways.
Kelber JA, Panopoulos AD, Shani G, Booker EC, Belmonte JC, Vale WW, Gray PC.
Oncogene 28(24):2324-36. Epub 2009 May 4. 2009
38HSPA5, PAWR
The tumor suppressor Par-4 activates an extrinsic pathway for apoptosis.
Burikhanov R, Zhao Y, Goswami A, Qiu S, Schwarze SR, Rangnekar VM.
Cell 138(2):377-88. Erratum in: Cell. 2009 Sep 4;138(5):1032. 2009
39HSPA5, HSPH1
Expression of heat shock protein 105 and 70 in malignant melanoma and benign melanocytic nevi.
Park HS, Park CH, Choi BR, Lim MS, Heo SH, Kim CH, Kang SG, Whang KU, Cho MK.
J Cutan Pathol 36(5):511-6. Epub 2009 Mar 30.PMID: 19476517 2009
40HSPA5, UGGT1
Identification of HUGT1 as a potential BiP activator and a cellular target for improvement of recombinant protein production using a cDNA screening system.
Ku SC, Lwa TR, Giam M, Yap MG, Chao SH.
Mol Cells 27(5):577-82. doi: 10.1007/s10059-009-0078-z. Epub 2009 May 15. 2009
41GSK3B, HSPA5, HSPH1
HSP105 interacts with GRP78 and GSK3 and promotes ER stress-induced caspase-3 activation.
Meares GP, Zmijewska AA, Jope RS.
Cell Signal 20(2):347-58. Epub 2007 Nov 17. 2008
42HSPA5
T cell receptor-mediated signaling induces GRP78 expression in T cells: the implications in maintaining T cell viability.
Takano S, Ando T, Hiramatsu N, Kanayama A, Maekawa S, Ohnuma Y, Enomoto N, Ogawa H, Paton AW, Paton JC, Kitamura M, Nakao A.
Biochem Biophys Res Commun 371(4):762-6. Epub 2008 May 5. 2008
43DNAJC10, EDEM1, HSPA5
ERdj5 is required as a disulfide reductase for degradation of misfolded proteins in the ER.
Ushioda R, Hoseki J, Araki K, Jansen G, Thomas DY, Nagata K.
Science 321(5888):569-72. 2008
44DMP1, HSPA5
Endoplasmic reticulum chaperone protein GRP-78 mediates endocytosis of dentin matrix protein 1.
Ravindran S, Narayanan K, Eapen AS, Hao J, Ramachandran A, Blond S, George A.
J Biol Chem 283(44):29658-70. Epub 2008 Aug 28. 2008
45E2F1, HSPA5
Transcriptional repression of the prosurvival endoplasmic reticulum chaperone GRP78/BIP by E2F1.
Racek T, Buhlmann S, Rüst F, Knoll S, Alla V, Pützer BM.
J Biol Chem 283(49):34305-14. Epub 2008 Oct 7. 2008
46HSPA5, TDGF1
GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth.
Shani G, Fischer WH, Justice NJ, Kelber JA, Vale W, Gray PC.
Mol Cell Biol 28(2):666-77. Epub 2007 Nov 8.PMID: 17991893 2008
47HSPA5, RAF1
GRP78 and Raf-1 cooperatively confer resistance to endoplasmic reticulum stress-induced apoptosis.
Shu CW, Sun FC, Cho JH, Lin CC, Liu PF, Chen PY, Chang MD, Fu HW, Lai YK.
J Cell Physiol 215(3):627-35.PMID: 18064632 2008
48CASP12, HSPA5
Upregulation of GRP78 and caspase-12 in diastolic failing heart.
Sun Y, Liu G, Song T, Liu F, Kang W, Zhang Y, Ge Z.
Acta Biochim Pol 55(3):511-6. Epub 2008 Sep 12. 2008
49DNAJB9, DNAJC10, HSPA5, SFTPC
ERdj4 and ERdj5 are required for endoplasmic reticulum-associated protein degradation of misfolded surfactant protein C.
Dong M, Bridges JP, Apsley K, Xu Y, Weaver TE.
Mol Biol Cell 19(6):2620-30. doi: 10.1091/mbc.E07-07-0674. Epub 2008 Apr 9. 2008
50CFC1, HSPA5, TDGF1
GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth.
Shani G, Fischer WH, Justice NJ, Kelber JA, Vale W, Gray PC.
Mol Cell Biol 28(2):666-77. 2008
51HSPA5
Plasminogen structural domains exhibit different functions when associated with cell surface GRP78 or the voltage-dependent anion channel.
Gonzalez-Gronow M, Kaczowka SJ, Payne S, Wang F, Gawdi G, Pizzo SV.
J Biol Chem 282(45):32811-20. Epub 2007 Sep 11. 2007
52FKBP7, HSPA5
Binding of FKBP23 to BiP in ER shown by gel filtration chromatography.
Chen C, Ma H, Wang Y, Mi H.
Z Naturforsch [C] 62(1-2):133-7. 2007
53FKBP7, HSPA5
The binding of FKBP23 to BiP modulates BiP's ATPase activity with its PPIase activity.
Wang Y, Han R, Wu D, Li J, Chen C, Ma H, Mi H.
Biochem Biophys Res Commun 354(1):315-20. Epub 2007 Jan 8. 2007
54HSPA5
Reduction of GRP78 expression with siRNA activates unfolded protein response leading to apoptosis in HeLa cells.
Suzuki T, Lu J, Zahed M, Kita K, Suzuki N.
Arch Biochem Biophys 468(1):1-14. Epub 2007 Sep 15.PMID: 17936241 2007
55HSPA5, LMAN2
Stable interaction of the cargo receptor VIP36 with molecular chaperone BiP.
Nawa D, Shimada O, Kawasaki N, Matsumoto N, Yamamoto K.
Glycobiology 17(9):913-21. Epub 2007 Jun 22. 2007
56HSPA5
Localization of GRP78 to mitochondria under the unfolded protein response.
Sun FC, Wei S, Li CW, Chang YS, Chao CC, Lai YK.
Biochem J 396(1):31-9. 2006
57ATE1, HSPA5
Arginyltransferase, its specificity, putative substrates, bidirectional promoter, and splicing-derived isoforms.
Hu RG, Brower CS, Wang H, Davydov IV, Sheng J, Zhou J, Kwon YT, Varshavsky A.
J Biol Chem. Oct 27;281(43):32559-73. doi: 10.1074/jbc.M604355200. Epub 2006 Aug 30 2006
58SIL1, HSPA5
Protein accumulation and neurodegeneration in the woozy mutant mouse is caused by disruption of SIL1, a cochaperone of BiP.
Zhao L, Longo-Guess C, Harris BS, Lee JW, Ackerman SL.
Nat Genet 37(9):974-9. Epub 2005 Aug 14. 2005
59SIL1, HSPA5, MSS
The gene disrupted in Marinesco-Sjogren syndrome encodes SIL1, an HSPA5 cochaperone.
Anttonen AK, Mahjneh I, Hamalainen RH, Lagier-Tourenne C, Kopra O, Waris L, Anttonen M, Joensuu T, Kalimo H, Paetau A, Tranebjaerg L, Chaigne D, Koenig M, Eeg-Olofsson O, Udd B, Somer M, Somer H, Lehesjoki AE.
Nat Genet 37(12):1309-11. Epub 2005 Nov 13. 2005
60SIL1, HSPA5, MSS, SAR1B
Mutations in SIL1 cause Marinesco-Sjogren syndrome, a cerebellar ataxia with cataract and myopathy.
Senderek J, Krieger M, Stendel C, Bergmann C, Moser M, Breitbach-Faller N, Rudnik-Schoneborn S, Blaschek A, Wolf NI, Harting I, North K, Smith J, Muntoni F, Brockington M, Quijano-Roy S, Renault F, Herrmann R, Hendershot LM, Schroder JM, Lochmuller H, Topaloglu H, Voit T, Weis J, Ebinger F, Zerres K.
Nat Genet 37(12):1312-4. Epub 2005 Nov 13. 2005
61HSPA5
GRP78 expression correlates with histologic differentiation and favorable prognosis in neuroblastic tumors.
Hsu WM, Hsieh FJ, Jeng YM, Kuo ML, Tsao PN, Lee H, Lin MT, Lai HS, Chen CN, Lai DM, Chen WJ.
Int J Cancer 113(6):920-7. 2005
62KLF2, HSPA5
Kruppel-like factor 2 transcriptional regulation involves heterogeneous nuclear ribonucleoproteins and acetyltransferases.
Ahmad N, Lingrel JB.
Biochemistry 44(16):6276-85. 2005
63HSPA5
Functional polymorphisms of HSPA5: possible association with bipolar disorder.
Kakiuchi C, Ishiwata M, Nanko S, Kunugi H, Minabe Y, Nakamura K, Mori N, Fujii K, Umekage T, Tochigi M, Kohda K, Sasaki T, Yamada K, Yoshikawa T, Kato T.
Biochem Biophys Res Commun 336(4):1136-43. 2005
64DNAJC10, HSPA5
ERdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress.
Cunnea PM, Miranda-Vizuete A, Bertoli G, Simmen T, Damdimopoulos AE,Hermann S, Leinonen S, Huikko MP, Gustafsson JA, Sitia R, Spyrou G.
J Biol Chem 278(2):1059-66. Epub 2002 Oct 30. 2003
65HSPA5, TMEM132A
Cloning and characterization of a novel GRP78-binding protein in the rat brain.
Oh-hashi K, Naruse Y, Amaya F, Shimosato G, Tanaka M.
J Biol Chem 278(12):10531-7. Epub 2003 Jan 03. 2003
66ADGRG1, ALG5, APLP2, B3GNT3, BGN, C14orf1, CD151, CD99, CDH1, CDH32, CLPTM1, CNPY3, DAG1, DHX8, FXYD5, GDF15, HSP90B1, HSPA5, KRTCAP2, LAMA3, LMAN2, LYPD3, SPINT2, TEX261, TNFRSF12A
Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes.
Bonkobara M, Das A, Takao J, Cruz PD, Ariizumi K.
Br J Dermatol 148(4):654-64. 2003
67HSPA5
Molecular chaperone GRP78/BiP interacts with the large surface protein of hepatitis B virus in vitro and in vivo.
Cho DY, Yang GH, Ryu CJ, Hong HJ.
J Virol. 77(4):2784-8. 2003
68HSPA5
Nascent lipidated apolipoprotein B is transported to the Golgi as an incompletely folded intermediate as probed by its association with network of endoplasmic reticulum molecular chaperones, GRP94, ERp72, BiP, calreticulin, and cyclophilin B.
Zhang J, Herscovitz H.
J Biol Chem. 278(9):7459-68. 2003
69HSPA5
Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation.
Reddy RK, Mao C, Baumeister P, Austin RC, Kaufman RJ, Lee AS.
J Biol Chem. 278(23):20915-24 2003
70HSPA5
GRP78, a coreceptor for coxsackievirus A9, interacts with major histocompatibility complex class I molecules which mediate virus internalization.
Triantafilou K, Fradelizi D, Wilson K, Triantafilou M.
J Virol 76(2):633-43. 2002
71HSPA5, SIL1
BAP, a mammalian BiP-associated protein, is a nucleotide exchange factor that regulates the ATPase activity of BiP.
Chung KT, Shen Y, Hendershot LM.
J Biol Chem 277(49):47557-63. Epub 2002 Sep 27. 2002
72CASP12, HSPA5
Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78.
Rao RV, Peel A, Logvinova A, del Rio G, Hermel E, Yokota T, Goldsmith PC, Ellerby LM, Ellerby HM, Bredesen DE.
FEBS Lett. 514(2-3):122-8. 2002
73CALR, HSPA5
Association of the thyrotropin receptor with calnexin, calreticulin and BiP. Efects on the maturation of the receptor.
Siffroi-Fernandez S, Giraud A, Lanet J, Franc JL.
Eur J Biochem. 269(20):4930-7. 2002
74HSPA5
The role of Grp 78 in alpha 2-macroglobulin-induced signal transduction. Evidence from RNA interference that the low density lipoprotein receptor-related protein is associated with, but not necessary for, GRP 78-mediated signal transduction.
Misra UK, Gonzalez-Gronow M, Gawdi G, Hart JP, Johnson CE, Pizzo SV.
J Biol Chem. 277(44):42082-7. 2002
75HSPA5
Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress.
Ma K, Vattem KM, Wek RC.
J Biol Chem. 277(21):18728-35. 2002
76HSPA5
Induction of glucose-regulated protein 78 by chronic hypoxia in human gastric tumor cells through a protein kinase C-epsilon/ERK/AP-1 signaling cascade.
Song MS, Park YK, Lee JH, Park K.
Cancer Res 61(22):8322-30. 2001
77CALR, HSPA5
The measles virus (MV) glycoproteins interact with cellular chaperones in the endoplasmic reticulum and MV infection upregulates chaperone expression.
Bolt G.
Arch Virol. 146(11):2055-68. 2001
78ATF6, HSPA5, MBTPS1, MBTPS2, SCAP
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs.
Ye J, Rawson RB, Komuro R, Chen X, Dave UP, Prywes R, Brown MS, Goldstein JL.
Mol Cell 6(6):1355-64. 2000
79HSPA5
The chaperone protein BiP binds to a mutant prion protein and mediates its degradation by the proteasome.
Jin T, Gu Y, Zanusso G, Sy M, Kumar A, Cohen M, Gambetti P, Singh N.
J Biol Chem. 275(49):38699-704. 2000
80HSPA5
Interaction of murine BiP/GRP78 with the DnaJ homologue MTJ1.
Chevalier M, Rhee H, Elguindi EC, Blond SY.
J Biol Chem. 275(26):19620-7. 2000
81HSPA5
Grp78 is involved in retention of mutant low density lipoprotein receptor protein in the endoplasmic reticulum.
Jørgensen MM, Jensen ON, Holst HU, Hansen JJ, Corydon TJ, Bross P, Bolund L, Gregersen N.
J Biol Chem. 275(43):33861-8. 2000
82HSPA5
Binding of BiP to the processing enzyme lymphoma proprotein convertase prevents aggregation, but slows down maturation.
Creemers JW, van de Loo JW, Plets E, Hendershot LM, Van De Ven WJ.
J Biol Chem. 275(49):38842-7. 2000
83HSPA5
Stress protein GRP78 prevents apoptosis induced by calcium ionophore, ionomycin, but not by glycosylation inhibitor, tunicamycin, in human prostate cancer cells.
Miyake H, Hara I, Arakawa S, Kamidono S.
J Cell Biochem. 77(3):396-408. 2000
84HSPA5
Role of the 78-kDa glucose-regulated protein as an activity modulator of protein phosphatase1gamma2.
Chun YS, et al.
Biochem Biophys Res Commun 259(2):300-4. 1999
85HSPA5
Calnexin and the immunoglobulin binding protein (BiP) coimmunoprecipitate with AMPA receptors.
Rubio ME, Wenthold RJ.
J Neurochem. 73(3):942-8. 1999
86HSPA5
A stress-inducible rat liver endoplasmic reticulum protein, ERp29.
Mkrtchian S, Fang C, Hellman U, Ingelman-Sundberg M.
Eur J Biochem. 251(1-2):304-13. 1998
87HSPA5
Mutagenesis of a potential immunoglobulin-binding protein-binding site enhances secretion of coagulation factor VIII.
Swaroop M, Moussalli M, Pipe SW, Kaufman RJ.
J Biol Chem. 272(39):24121-4. 1997
88HSPA5
Association of glucose-regulated protein (grp78) with human keratin 8.
Liao J, Price D, Omary MB.
FEBS Lett. 417(3):316-20. 1997
89HSPA5
Localization of the gene encoding human BiP/GRP78, the endoplasmic reticulum cognate of the HSP70 family, to chromosome 9q34.
Hendershot LM, et al.
Genomics 20 : 281-284. 1994
90HSPA5
Biogenesis of MHC class I antigens: involvement of multiple chaperone molecules.
Kahn-Perlès B, Salamero J, Jouans O.
Eur J Cell Biol. 64(1):176-85. 1994
91HSPA5
Regulating the retention of T-cell receptor alpha chain variants within the endoplasmic reticulum: Ca(2+)-dependent association with BiP.
Suzuki CK, Bonifacino JS, Lin AY, Davis MM, Klausner RD.
J Cell Biol. 114(2):189-205. 1991
92HSPA5
cDNA cloning of the immunoglobulin heavy chain binding protein.
Haas IG, Meo T.
Proc Natl Acad Sci U S A 85 : 2250-2254. 1988
93HSPA5, HSPA5P
Human gene encoding the 78,000-dalton glucose-regulated protein and its pseudogene : structure, conservation, and regulation.
Ting J, et al.
DNA 7 : 275-286. 1988
94HSPA5
The relationship of N-linked glycosylation and heavy chain-binding protein association with the secretion of glycoproteins.
Dorner AJ, et al.
J Cell Biol 105 : 2665-2674. 1987
95HSPA5
An Hsp70-like protein in the ER : identity with the 78kd glucose-regulated protein and immunoglobulin heavy chain binding protein.
Munro S, et al.
Cell 46 : 291-300. 1986
96HSPA5
Genetic mapping of the structural gene coding for a glucose-regulated protein (GRP78) of 78K-dalton to the long arm of human chromosome 9.
Law ML, et al.
(HGM7) Cytogenet Cell Genet 37 : 518-519. 1984