| 1 | HSPA4, NEDD8
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| The HSP70 chaperone as sensor of the NEDD8 cycle upon DNA damage
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| Bailly AP, Xirodimas DP.
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| Biochem Soc Trans. Jun 30;49(3):1075-1083. doi: 10.1042/BST20200381. 2021
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| 2 | CFTR, DNAJA1, DNAJA2, HSPA4, HSPA8, STUB1
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| Hsp70 and DNAJA2 limit CFTR levels through degradation.
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| Kim Chiaw P, Hantouche C, Wong MJH, Matthes E, Robert R, Hanrahan JW, Shrier A, Young JC.
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| PLoS One 14(8):e0220984. doi: 10.1371/journal.pone.0220984. eCollection 2019.
2019
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| 3 | EMD, HSP90AA1, HSPA4, STIP1
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| Hop/STIP1 depletion alters nuclear structure via depletion of nuclear structural protein emerin.
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| Kituyi SN, Edkins AL.
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| Biochem Biophys Res Commun 507(1-4):503-509. doi: 10.1016/j.bbrc.2018.11.073. Epub 2018 Nov 16.
2018
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| 4 | DNAJB6, HSPA4, SNCA
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| The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation.
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| Aprile FA, Källstig E, Limorenko G, Vendruscolo M, Ron D, Hansen C.
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| Sci Rep 7(1):9039. doi: 10.1038/s41598-017-08324-z.
2017
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| 5 | HSPA4, NEDD1, TUBG1
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| HSP70 regulates the function of mitotic centrosomes.
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| Fang CT, Kuo HH, Pan TS, Yu FC, Yih LH.
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| Cell Mol Life Sci 73(20):3949-60. doi: 10.1007/s00018-016-2236-8. Epub 2016 Apr 30.
2016
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| 6 | DNAJC7, HSPA4, NR1I3
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| Coordinated regulation of nuclear receptor CAR by CCRP/DNAJC7, HSP70 and the ubiquitin-proteasome system.
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| Timsit YE, Negishi M.
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| PLoS One 9(5):e96092. doi: 10.1371/journal.pone.0096092. eCollection 2014.
2014
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| 7 | HSPA4, HSPH1, NMI
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| Nmi interacts with Hsp105β and enhances the Hsp105β-mediated Hsp70 expression.
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| Saito Y, Yukawa A, Matozaki M, Mikami H, Yamagami T, Yamagishi N, Kuga T, Hatayama T, Nakayama Y.
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| Exp Cell Res 327(1):163-70. doi: 10.1016/j.yexcr.2014.07.023. Epub 2014 Aug 1. 2014
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| 8 | HSP90AB1, HSPA4, HSPE1
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| The potential role of heat shock proteins in acute spinal cord injury.
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| Zhou Y, Xu L, Song X, Ding L, Chen J, Wang C, Gan Y, Zhu X, Yu Y, Liang Q.
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| Eur Spine J 23(7):1480-90. doi: 10.1007/s00586-014-3214-1. Epub 2014 Feb 6. Erratum in: Eur Spine J. 2014 Jul;23(7):1582.
2014
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| 9 | HSPA4, TCL1A
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| Heat shock protein 70 regulates Tcl1 expression in leukemia and lymphomas.
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| Gaudio E, Paduano F, Ngankeu A, Lovat F, Fabbri M, Sun HL, Gasparini P, Efanov A, Peng Y, Zanesi N, Shuaib MA, Rassenti LZ, Kipps TJ, Li C, Aqeilan RI, Lesinski GB, Trapasso F, Croce CM.
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| Blood 121(2):351-9. doi: 10.1182/blood-2012-09-457374. Epub 2012 Nov 15.
2013
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| 10 | HSPA4, OLA1
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| OLA1 protects cells in heat shock by stabilizing HSP70
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| Mao RF, Rubio V, Chen H, Bai L, Mansour OC, Shi ZZ.
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| Cell Death Dis. Feb 14;4(2):e491. doi: 10.1038/cddis.2013.23. 2013
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| 11 | HSPA4, HSPBP1, PGLYRP1
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| Extracellular HspBP1 inhibits formation of a cytotoxic Tag7-Hsp70 complex in vitro and in human serum.
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| Yashin DV, Dukhanina EA, Kabanova OD, Romanova EA, Lukyanova TI, Tonevitskii AG, Belogurov AA, Raynes DA, Sheludchenkov AA, Gnuchev NV, Guerriero V, Georgiev GP, Sashchenko LP.
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| Biochimie 94(1):203-6. doi: 10.1016/j.biochi.2011.10.007. Epub 2011 Oct 21.
2012
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| 12 | DNAJA1, HSPA4
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| DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of tau.
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| Abisambra JF, Jinwal UK, Suntharalingam A, Arulselvam K, Brady S, Cockman M, Jin Y, Zhang B, Dickey CA.
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| J Mol Biol 421(4-5):653-61. doi: 10.1016/j.jmb.2012.02.003. Epub 2012 Feb 15.
2012
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| 13 | HSF4, HSPA14, HSPA4, NBN
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| Induction of HSPA4 and HSPA14 by NBS1 overexpression contributes to NBS1-induced in vitro metastatic and transformation activity.
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| Wu CY, Lin CT, Wu MZ, Wu KJ.
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| J Biomed Sci 18:1.
2011
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| 14 | HSPA4, HSPBP1, PGLYRP1
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| The heat shock-binding protein (HspBP1) protects cells against the cytotoxic action of the Tag7-Hsp70 complex.
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| Yashin DV, Dukhanina EA, Kabanova OD, Romanova EA, Lukyanova TI, Tonevitskii AG, Raynes DA, Gnuchev NV, Guerriero V, Georgiev GP, Sashchenko LP.
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| J Biol Chem 286(12):10258-64. doi: 10.1074/jbc.M110.163436. Epub 2011 Jan 19. 2011
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| 15 | HSPA4, SLC12A3
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| The thiazide-sensitive NaCl cotransporter is targeted for chaperone-dependent endoplasmic reticulum-associated degradation.
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| Needham PG, Mikoluk K, Dhakarwal P, Khadem S, Snyder AC, Subramanya AR, Brodsky JL.
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| J Biol Chem 286(51):43611-21. doi: 10.1074/jbc.M111.288928. Epub 2011 Oct 25.
2011
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| 16 | DNAJB1, HSPA4, HSPA5
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| The chaperone proteins HSP70, HSP40/DnaJ and GRP78/BiP suppress misfolding and formation of β-sheet-containing aggregates by human amylin: a potential role for defective chaperone biology in Type 2 diabetes.
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| Chien V, Aitken JF, Zhang S, Buchanan CM, Hickey A, Brittain T, Cooper GJ, Loomes KM.
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| Biochem J. 432(1):113-21. 2010
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| 17 | HSPA4, HSPH1
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| Hsp105 reduces the protein aggregation and cytotoxicity by expanded-polyglutamine proteins through the induction of Hsp70.
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| Yamagishi N, Goto K, Nakagawa S, Saito Y, Hatayama T.
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| Exp Cell Res 316(15):2424-33. doi: 10.1016/j.yexcr.2010.06.003. Epub 2010 Jun 11.
2010
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| 18 | ENPP1, HSPA4
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| The role of HSP70 on ENPP1 expression and insulin-receptor activation.
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| Marucci A, Miscio G, Padovano L, Boonyasrisawat W, Florez JC, Doria A, Trischitta V, Di Paola R.
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| J Mol Med 87(2):139-44. Epub 2008 Dec 16.PMID: 19083193 2009
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| 19 | HSPA4, MGP
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| Heat shock protein 70 enhances vascular bone morphogenetic protein-4 signaling by binding matrix Gla protein.
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| Yao Y, Watson AD, Ji S, Boström KI.
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| Circ Res 105(6):575-84. doi: 10.1161/CIRCRESAHA.109.202333. Epub 2009 Aug 6.
2009
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| 20 | HTT, NFYA, HSPA4
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| Mutant Huntingtin reduces HSP70 expression through the sequestration of NF-Y transcription factor.
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| Yamanaka T, Miyazaki H, Oyama F, Kurosawa M, Washizu C, Doi H, Nukina N.
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| EMBO J 27(6):827-39. Epub 2008 Feb 21. 2008
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| 21 | HSPA4, RICTOR
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| Hsp70 associates with Rictor and is required for mTORC2 formation and activity.
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| Martin J, Masri J, Bernath A, Nishimura RN, Gera J.
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| Biochem Biophys Res Commun 372(4):578-83. Epub 2008 May 27. 2008
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| 22 | HSPA4, RICTOR
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| Hsp70 associates with Rictor and is required for mTORC2 formation and activity.
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| Martin J, Masri J, Bernath A, Nishimura RN, Gera J.
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| Biochem Biophys Res Commun 372(4):578-83. Epub 2008 May 27.
2008
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| 23 | CD36, HSPA4
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| CD36 signaling inhibits the translation of heat shock protein 70 induced by oxidized low density lipoprotein through activation of peroxisome proliferators-activated receptor gamma.
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| Lee KJ, Ha ES, Kim MK, Lee SH, Suh JS, Lee SH, Park KH, Park JH, Kim DJ, Kang D, Kim BC, Jeoung D, Kim YK, Kim HD, Hahn JH.
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| Exp Mol Med 40(6):658-68.
2008
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| 24 | HSPA4
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| Parkin mediates the degradation-independent ubiquitination of Hsp70.
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| Moore DJ, West AB, Dikeman DA, Dawson VL, Dawson TM.
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| J Neurochem. 105(5):1806-19. 2008
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| 25 | HSPA4
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| CoREST represses the heat shock response mediated by HSF1.
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| Gómez AV, Galleguillos D, Maass JC, Battaglioli E, Kukuljan M, Andrés ME.
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| Mol Cell Biol. 31(2):222-31. 2008
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| 26 | CDC6, HSP90AA1, HSPA4, TTC4
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| The human TPR protein TTC4 is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells.
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| Crevel G, Bennett D, Cotterill S.
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| PLoS One 3(3):e0001737. doi: 10.1371/journal.pone.0001737.
2008
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| 27 | HSPA1A, HSPA4, GATA1, CASP3
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| Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1.
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| Ribeil JA, Zermati Y, Vandekerckhove J, Cathelin S, Kersual J, Dussiot M, Coulon S, Moura IC, Zeuner A, Kirkegaard-Sorensen T, Varet B, Solary E, Garrido C, Hermine O.
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| Nature 445(7123):102-5. Epub 2006 Dec 10. 2007
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| 28 | HSPA14, HSPA1A, HSPA1B, HSPA2, HSPA3, HSPA4, HSPA7
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| The heat shock protein 70 family: Highly homologous proteins with overlapping and distinct functions.
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| Daugaard M, Rohde M, Jaatela M.
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| FEBS Lett 581(19):3702-10. Epub 2007 May 25. Review. 2007
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| 29 | HSPA4
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| Parkin interacts with LIM Kinase 1 and reduces its cofilin-phosphorylation activity via ubiquitination.
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| Lim MK, Kawamura T, Ohsawa Y, Ohtsubo M, Asakawa S, Takayanagi A, Shimizu N.
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| Exp Cell Res. 313(13):2858-74 2007
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| 30 | SNCA, HSPA4
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| Heat shock protein 70 inhibits alpha-synuclein fibril formation via interactions with diverse intermediates.
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| Huang C, Cheng H, Hao S, Zhou H, Zhang X, Gao J, Sun QH, Hu H, Wang CC.
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| J Mol Biol 364(3):323-36. Epub 2006 Aug 26. 2006
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| 31 | HSPA4, MBP
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| Association of MBP peptides with Hsp70 in normal appearing human white matter.
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| Lund BT, Chakryan Y, Ashikian N, Mnatsakanyan L, Bevan CJ, Aguilera R, Gallaher T, Jakowec MW.
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| J Neurol Sci 249(2):122-34. Epub 2006 Jul 13.
2006
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| 32 | HSPA4
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| Invariant Leu preceding turn motif phosphorylation site controls the interaction of protein kinase C with Hsp70.
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| Gao T, Newton AC.
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| J Biol Chem. 281(43):32461-8. 2006
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| 33 | HSPA4, HSPBP1
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| Expression of the cochaperone HspBP1 is not coordinately regulated with Hsp70 expression.
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| Gottwald E, Herschbach M, Lahni B, Miesfeld RL, Kunz S, Raynes DA, Guerriero V.
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| Cell Biol Int 30(6):553-8. Epub 2006 Mar 22.
2006
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| 34 | DUSP1, HSPA4
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| Preheating accelerates mitogen-activated protein (MAP) kinase inactivation post-heat shock via a heat shock protein 70-mediated increase in phosphorylated MAP kinase phosphatase-1.
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| Lee KH, Lee CT, Kim YW, Han SK, Shim YS, Yoo CG.
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| J Biol Chem 280(13):13179-86. Epub 2005 Jan 26. 2005
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| 35 | BAG2, HSPA4, STUB1
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| Regulation of the cytoplasmic quality control protein degradation pathway by BAG2.
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| Dai Q, Qian SB, Li HH, McDonough H, Borchers C, Huang D, Takayama S, Younger JM, Ren HY, Cyr DM, Patterson C.
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| J Biol Chem 280(46):38673-81. Epub 2005 Sep 16. 2005
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| 36 | HSPA4
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| Regulation of the human apoptotic DNase/RNase endonuclease G: involvement of Hsp70 and ATP.
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| Kalinowska M, Garncarz W, Pietrowska M, Garrard WT, Widlak P.
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| Apoptosis. 10(4):821-30. 2005
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| 37 | HSPA4, MAPT, STUB1
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| CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation.
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| Petrucelli L, Dickson D, Kehoe K, Taylor J, Snyder H, Grover A, De Lucia M, McGowan E, Lewis J, Prihar G, Kim J, Dillmann WH, Browne SE, Hall A, Voellmy R, Tsuboi Y, Dawson TM, Wolozin B, Hardy J, Hutton M.
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| Hum Mol Genet 13(7):703-14. Epub 2004 Feb 12. 2004
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| 38 | BAG5, HSPA4, PRKN
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| BAG5 inhibits parkin and enhances dopaminergic neuron degeneration.
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| Kalia SK, Lee S, Smith PD, Liu L, Crocker SJ, Thorarinsdottir TE, Glover JR, Fon EA, Park DS, Lozano AM.
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| Neuron 44(6):931-45. 2004
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| 39 | HSPA4
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| Analysis of estrogen receptor alpha signaling complex at the plasma membrane.
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| Azuma K, Horie K, Inoue S, Ouchi Y, Sakai R.
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| FEBS Lett. 577(3):339-44. 2004
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| 40 | HSPA4
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| PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation.
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| Zhou J, Schmid T, Frank R, Brüne B.
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| J Biol Chem. 279(14):13506-13 2004
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| 41 | HSPA4
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| Menin missense mutants associated with multiple endocrine neoplasia type 1 are rapidly degraded via the ubiquitin-proteasome pathway.
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| Yaguchi H, Ohkura N, Takahashi M, Nagamura Y, Kitabayashi I, Tsukada T.
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| Mol Cell Biol. 24(15):6569-80. 2004
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| 42 | DNAJB1, DNAJB1P, HSPA4, HSPBP1
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| Cooperative interaction of Hsp40 and TPR1 with Hsp70 reverses Hsp70-HspBp1 complex formation.
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| Oh WK, Song J.
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| Mol Cells 16(1):84-91. 2003
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| 43 | BAG3, HSPA4
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| CAIR-1/BAG-3 abrogates heat shock protein-70 chaperone complex-mediated protein degradation: accumulation of poly-ubiquitinated Hsp90 client proteins.
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| Doong H, Rizzo K, Fang S, Kulpa V, Weissman AM, Kohn EC.
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| J Biol Chem 278(31):28490-500. Epub 2003 May 14. 2003
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| 44 | HSP90A1, HSP90AA2, HSPA4, TOMM70A
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| Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70.
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| Young JC, Hoogenraad NJ, Hartl FU.
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| Cell 112(1):41-50. 2003
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| 45 | HSPA4
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| Identification of novel protein-protein interactions using a versatile mammalian tandem affinity purification expression system.
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| Knuesel M, Wan Y, Xiao Z, Holinger E, Lowe N, Wang W, Liu X.
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| Mol Cell Proteomics. 2(11):1225-33 2003
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| 46 | HSPA4
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| Interaction of the molecular chaperone Hsp70 with human NAD(P)H:quinone oxidoreductase 1.
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| Anwar A, Siegel D, Kepa JK, Ross D.
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| J Biol Chem. 277(16):14060-7. 2002
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| 47 | HSPA4
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| CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity.
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| Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama KI, Takahashi R.
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| Mol Cell. 10(1):55-67. 2002
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| 48 | FANCC, HSPA4
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| FANCC interacts with Hsp70 to protect hematopoietic cells from IFN-gamma/TNF-alpha-mediated cytotoxicity.
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| Pang Q, Keeble W, Christianson TA, Faulkner GR, Bagby GC.
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| EMBO J 20(16):4478-89. 2001
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| 49 | HSPA4
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| A DnaJ protein, apobec-1-binding protein-2, modulates apolipoprotein B mRNA editing.
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| Lau PP, Villanueva H, Kobayashi K, Nakamuta M, Chang BH, Chan L.
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| J Biol Chem. 276(49):46445-52. 2001
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| 50 | HSBP1, HSPA4
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| Negative regulation of the heat shock transcriptional response by HSBP1.
|
| Satyal SH, Chen D, Fox SG, Kramer JM, Morimoto RI.
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| Genes Dev 12(13):1962-74. 1998
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| 51 | DNAJB1, HSPA4
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| Molecular chaperones as HSF1-specific transcriptional repressors.
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| Shi Y, Mosser DD, Morimoto RI.
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| Genes Dev. 12(5):654-66. 1998
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| 52 | HSPA4
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| Cloning of apg-2 encoding a novel member of heat shock protein 110 family.
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| Kaneko Y, Kimura T, Kishishita M, Noda Y, Fujita J.
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| Gene 189(1):19-24 1997
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| 53 | HSPA4
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| BAG-1 modulates the chaperone activity of Hsp70/Hsc70.
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| Takayama S, Bimston DN, Matsuzawa S, Freeman BC, Aime-Sempe C, Xie Z, Morimoto RI, Reed JC.
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| EMBO J. 16(16):4887-96. 1997
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| 54 | HSPA4
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| The 70-kDa heat shock proteins associate with glandular intermediate filaments in an ATP-dependent manner.
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| Liao J, Lowthert LA, Ghori N, Omary MB.
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| J Biol Chem. 270(2):915-22. 1995
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| 55 | HSPA4
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| Molecular cloning of a novel human hsp70 from a B cell line and its assignment to chromosome 5.
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| Fathallah DM, et al.
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| J Immunol 151 : 810-813. 1993
|