Citations for
1HRK, TFAP2A
Synergistic silencing by promoter methylation and reduced AP-2α transactivation of the proapoptotic HRK gene confers apoptosis resistance and enhanced tumor growth.
Xu M, Chen X, Chen N, Nie L, Li X, Li Q, Zeng H, Zhou Q.
Am J Pathol 182(1):84-95. doi: 10.1016/j.ajpath.2012.09.018. Epub 2012 Nov 13. 2013
2BBC3, HRK, PMAIP1
ATF4 orchestrates a program of BH3-only protein expression in severe hypoxia.
Pike LR, Phadwal K, Simon AK, Harris AL.
Mol Biol Rep 39(12):10811-22. doi: 10.1007/s11033-012-1975-3. Epub 2012 Oct 23. 2012
3HRK, SUZ12
SUZ12 promotes human epithelial ovarian cancer by suppressing apoptosis via silencing HRK.
Li H, Cai Q, Wu H, Vathipadiekal V, Dobbin ZC, Li T, Hua X, Landen CN, Birrer MJ, Sánchez-Beato M, Zhang R.
Mol Cancer Res 10(11):1462-72. doi: 10.1158/1541-7786.MCR-12-0335. Epub 2012 Sep 10. 2012
4BCL2L1, HRK
Deficiency of pro-apoptotic Hrk attenuates programmed cell death in the developing murine nervous system but does not affect Bcl-x deficiency-induced neuron apoptosis.
Ghosh AP, Cape JD, Klocke BJ, Roth KA.
J Histochem Cytochem 59(11):976-83. doi: 10.1369/0022155411424311. 2011
5HRK
Intrinsic order and disorder in the bcl-2 member harakiri: insights into its proapoptotic activity.
Barrera-Vilarmau S, Obregón P, de Alba E.
PLoS One 6(6):e21413. doi: 10.1371/journal.pone.0021413. Epub 2011 Jun 23. 2011
6HRK
Mitochondrial dysfunction links ceramide activated HRK expression and cell death.
Rizvi F, Heimann T, Herrnreiter A, O'Brien WJ.
PLoS One 6(3):e18137. doi: 10.1371/journal.pone.0018137. 2011
7BCL2L10, HRK
Characterization of a novel interaction between Bcl-2 members Diva and Harakiri.
Sborgi L, Barrera-Vilarmau S, Obregón P, de Alba E.
PLoS One 5(12):e15575. doi: 10.1371/journal.pone.0015575. 2010
8HRK
Signaling by IL-1beta+IFN-gamma and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic beta-cell apoptosis.
Gurzov EN, Ortis F, Cunha DA, Gosset G, Li M, Cardozo AK, Eizirik DL.
Cell Death Differ 16(11):1539-50. doi: 10.1038/cdd.2009.99. Epub 2009 Jul 24. 2009
9HRK
The role of HRK gene in human cancer.
Nakamura M, Shimada K, Konishi N.
Oncogene 27 Suppl 1:S105-13. doi: 10.1038/onc.2009.48. Review. 2008
10HRK
HRK inactivation associated with promoter methylation and LOH in prostate cancer.
Higuchi T, Nakamura M, Shimada K, Ishida E, Hirao K, Konishi N.
Prostate 68(1):105-13. 2008
11HRK
Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis.
Coultas L, Terzano S, Thomas T, Voss A, Reid K, Stanley EG, Scott CL, Bouillet P, Bartlett P, Ham J, Adams JM, Strasser A.
J Cell Sci 120(Pt 12):2044-52. Epub 2007 May 29. 2007
12HRK
Structure of the C-terminal domain of the pro-apoptotic protein Hrk and its interaction with model membranes.
Bernabeu A, Guillén J, Pérez-Berná AJ, Moreno MR, Villalaín J.
Biochim Biophys Acta 1768(6):1659-70. Epub 2007 Mar 14. 2007
13HRK
Physical and functional interaction between BH3-only protein Hrk and mitochondrial pore-forming protein p32.
Sunayama J, Ando Y, Itoh N, Tomiyama A, Sakurada K, Sugiyama A, Kang D, Tashiro F, Gotoh Y, Kuchino Y, Kitanaka C.
Cell Death Differ 11(7):771-81. 2004
14HRK
Expression of apoptosis-related genes during human preimplantation embryo development: potential roles for the Harakiri gene product and Caspase-3 in blastomere fragmentation
Jurisicova A, Antenos M, Varmuza S, Tilly JL, Casper RF.
Mol Hum Reprod 9(3):133-41. 2003
15HRK
Upregulation of the pro-apoptotic BH3-only peptide harakiri in spinal neurons of amyotrophic lateral sclerosis patients
Shinoe T, Wanaka A, Nikaido T, Kanazawa K, Shimizu J, Imaizumi K, Kanazawa I.
Neurosci Lett 313(3):153-7. 2001
16HRK
Interleukin 3-dependent activation of DREAM is involved in transcriptional silencing of the apoptotic Hrk gene in hematopoietic progenitor cells
Sanz C, Mellstrom B, Link WA, Naranjo JR, Fernandez-Luna JL.
EMBO J 20(9):2286-92. 2001
17HRK
Specific and rapid induction of the proapoptotic protein Hrk after growth factor withdrawal in hematopoietic progenitor cells
Sanz C, Benito A, Inohara N, Ekhterae D, Nunez G, Fernandez-Luna JL.
Blood 95(9):2742-7. 2000
18HRK
harakiri, a novel regulator of cell death, encodes a protein that activatesapoptosis and interacts selectively with survival-promoting proteins Bcl-2 andBcl-X(L).
Inohara N, Ding L, Chen S, Nunez G.
EMBO J 16(7):1686-94. 1997