| 1 | HRK, TFAP2A
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| Synergistic silencing by promoter methylation and reduced AP-2α transactivation of the proapoptotic HRK gene confers apoptosis resistance and enhanced tumor growth.
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| Xu M, Chen X, Chen N, Nie L, Li X, Li Q, Zeng H, Zhou Q.
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| Am J Pathol 182(1):84-95. doi: 10.1016/j.ajpath.2012.09.018. Epub 2012 Nov 13.
2013
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| 2 | BBC3, HRK, PMAIP1
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| ATF4 orchestrates a program of BH3-only protein expression in severe hypoxia.
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| Pike LR, Phadwal K, Simon AK, Harris AL.
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| Mol Biol Rep 39(12):10811-22. doi: 10.1007/s11033-012-1975-3. Epub 2012 Oct 23.
2012
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| 3 | HRK, SUZ12
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| SUZ12 promotes human epithelial ovarian cancer by suppressing apoptosis via silencing HRK.
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| Li H, Cai Q, Wu H, Vathipadiekal V, Dobbin ZC, Li T, Hua X, Landen CN, Birrer MJ, Sánchez-Beato M, Zhang R.
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| Mol Cancer Res 10(11):1462-72. doi: 10.1158/1541-7786.MCR-12-0335. Epub 2012 Sep 10.
2012
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| 4 | BCL2L1, HRK
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| Deficiency of pro-apoptotic Hrk attenuates programmed cell death in the developing murine nervous system but does not affect Bcl-x deficiency-induced neuron apoptosis.
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| Ghosh AP, Cape JD, Klocke BJ, Roth KA.
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| J Histochem Cytochem 59(11):976-83. doi: 10.1369/0022155411424311.
2011
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| 5 | HRK
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| Intrinsic order and disorder in the bcl-2 member harakiri: insights into its proapoptotic activity.
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| Barrera-Vilarmau S, Obregón P, de Alba E.
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| PLoS One 6(6):e21413. doi: 10.1371/journal.pone.0021413. Epub 2011 Jun 23.
2011
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| 6 | HRK
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| Mitochondrial dysfunction links ceramide activated HRK expression and cell death.
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| Rizvi F, Heimann T, Herrnreiter A, O'Brien WJ.
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| PLoS One 6(3):e18137. doi: 10.1371/journal.pone.0018137.
2011
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| 7 | BCL2L10, HRK
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| Characterization of a novel interaction between Bcl-2 members Diva and Harakiri.
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| Sborgi L, Barrera-Vilarmau S, Obregón P, de Alba E.
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| PLoS One 5(12):e15575. doi: 10.1371/journal.pone.0015575.
2010
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| 8 | HRK
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| Signaling by IL-1beta+IFN-gamma and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic beta-cell apoptosis.
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| Gurzov EN, Ortis F, Cunha DA, Gosset G, Li M, Cardozo AK, Eizirik DL.
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| Cell Death Differ 16(11):1539-50. doi: 10.1038/cdd.2009.99. Epub 2009 Jul 24.
2009
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| 9 | HRK
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| The role of HRK gene in human cancer.
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| Nakamura M, Shimada K, Konishi N.
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| Oncogene 27 Suppl 1:S105-13. doi: 10.1038/onc.2009.48. Review.
2008
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| 10 | HRK
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| HRK inactivation associated with promoter methylation and LOH in prostate cancer.
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| Higuchi T, Nakamura M, Shimada K, Ishida E, Hirao K, Konishi N.
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| Prostate 68(1):105-13.
2008
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| 11 | HRK
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| Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis.
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| Coultas L, Terzano S, Thomas T, Voss A, Reid K, Stanley EG, Scott CL, Bouillet P, Bartlett P, Ham J, Adams JM, Strasser A.
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| J Cell Sci 120(Pt 12):2044-52. Epub 2007 May 29.
2007
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| 12 | HRK
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| Structure of the C-terminal domain of the pro-apoptotic protein Hrk and its interaction with model membranes.
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| Bernabeu A, Guillén J, Pérez-Berná AJ, Moreno MR, Villalaín J.
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| Biochim Biophys Acta 1768(6):1659-70. Epub 2007 Mar 14.
2007
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| 13 | HRK
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| Physical and functional interaction between BH3-only protein Hrk and mitochondrial pore-forming protein p32.
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| Sunayama J, Ando Y, Itoh N, Tomiyama A, Sakurada K, Sugiyama A, Kang D, Tashiro F, Gotoh Y, Kuchino Y, Kitanaka C.
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| Cell Death Differ 11(7):771-81.
2004
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| 14 | HRK
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| Expression of apoptosis-related genes during human preimplantation embryo development: potential roles for the Harakiri gene product and Caspase-3 in blastomere fragmentation
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| Jurisicova A, Antenos M, Varmuza S, Tilly JL, Casper RF.
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| Mol Hum Reprod 9(3):133-41. 2003
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| 15 | HRK
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| Upregulation of the pro-apoptotic BH3-only peptide harakiri in spinal neurons of amyotrophic lateral sclerosis patients
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| Shinoe T, Wanaka A, Nikaido T, Kanazawa K, Shimizu J, Imaizumi K, Kanazawa I.
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| Neurosci Lett 313(3):153-7. 2001
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| 16 | HRK
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| Interleukin 3-dependent activation of DREAM is involved in transcriptional silencing of the apoptotic Hrk gene in hematopoietic progenitor cells
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| Sanz C, Mellstrom B, Link WA, Naranjo JR, Fernandez-Luna JL.
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| EMBO J 20(9):2286-92. 2001
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| 17 | HRK
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| Specific and rapid induction of the proapoptotic protein Hrk after growth factor withdrawal in hematopoietic progenitor cells
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| Sanz C, Benito A, Inohara N, Ekhterae D, Nunez G, Fernandez-Luna JL.
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| Blood 95(9):2742-7. 2000
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| 18 | HRK
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| harakiri, a novel regulator of cell death, encodes a protein that activatesapoptosis and interacts selectively with survival-promoting proteins Bcl-2 andBcl-X(L).
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| Inohara N, Ding L, Chen S, Nunez G.
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| EMBO J 16(7):1686-94. 1997
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