Citations for
1HPSE, SDC1, SDCBP
Heparanase activates the syndecan-syntenin-ALIX exosome pathway.
Roucourt B, Meeussen S, Bao J, Zimmermann P, David G.
Cell Res 25(4):412-28. doi: 10.1038/cr.2015.29. Epub 2015 Mar 3. 2015
2HPSE
Structural characterization of human heparanase reveals insights into substrate recognition.
Wu L, Viola CM, Brzozowski AM, Davies GJ.
Nat Struct Mol Biol 22(12):1016-22. doi: 10.1038/nsmb.3136. Epub 2015 Nov 16. Erratum in: Nat Struct Mol Biol. 2016 Jan;23(1):91. 2015
3HPSE
Function from within: Autophagy induction by HPSE/heparanase--new possibilities for intervention.
Ilan N, Shteingauz A, Vlodavsky I.
Autophagy 11(12):2387-9. doi: 10.1080/15548627.2015.1115174. 2015
4HPSE
Nuclear heparanase-1 activity suppresses melanoma progression via its DNA-binding affinity.
Yang Y, Gorzelanny C, Bauer AT, Halter N, Komljenovic D, Bäuerle T, Borsig L, Roblek M, Schneider SW.
Oncogene 34(47):5832-42. doi: 10.1038/onc.2015.40. Epub 2015 Mar 9. 2015
5HPSE
Heparanase is involved in proliferation and invasion of ovarian cancer cells.
Zheng H, Ruan J, Zhao P, Chen S, Pan L, Liu J.
Cancer Biomark 15(5):525-34. doi: 10.3233/CBM-150459. 2015
6HPSE
The expression of heparanase in normal and preeclamptic placentas.
Ginath S, Lurie S, Golan A, Amsterdam A, Sandbank J, Sadan O, Kovo M.
J Matern Fetal Neonatal Med 28(13):1589-93. doi: 10.3109/14767058.2014.962506. Epub 2014 Sep 29. 2015
7HPSE
Heparanase is a key player in renal fibrosis by regulating TGF-β expression and activity.
Masola V, Zaza G, Secchi MF, Gambaro G, Lupo A, Onisto M.
Biochim Biophys Acta 1843(9):2122-8. doi: 10.1016/j.bbamcr.2014.06.005. Epub 2014 Jun 15. 2014
8HPSE
Heparanase induces inflammatory cell recruitment in vivo by promoting adhesion to vascular endothelium.
Lever R, Rose MJ, McKenzie EA, Page CP.
Am J Physiol Cell Physiol 306(12):C1184-90. doi: 10.1152/ajpcell.00269.2013. Epub 2014 Apr 16. 2014
9HPSE
DNA methylation of heparanase promoter influences its expression and associated with the progression of human breast cancer.
Jiao F, Bai SY, Ma Y, Yan ZH, Yue Z, Yu Y, Wang X, Wang J.
PLoS One 9(3):e92190. doi: 10.1371/journal.pone.0092190. eCollection 2014. 2014
10HPSE
Heparanase localization during palatogenesis in mice.
Hirata A, Katayama K, Tsuji T, Natsume N, Sugahara T, Koga Y, Takano K, Otsuki Y, Nakamura H.
Biomed Res Int 2013:760236. doi: 10.1155/2013/760236. Epub 2013 Feb 12. 2013
11HPSE
Versatile role of heparanase in inflammation.
Goldberg R, Meirovitz A, Hirshoren N, Bulvik R, Binder A, Rubinstein AM, Elkin M.
Matrix Biol 32(5):234-40. doi: 10.1016/j.matbio.2013.02.008. Epub 2013 Mar 13. Review. 2013
12HPSE
Heparanase regulates secretion, composition, and function of tumor cell-derived exosomes.
Thompson CA, Purushothaman A, Ramani VC, Vlodavsky I, Sanderson RD.
J Biol Chem 288(14):10093-9. doi: 10.1074/jbc.C112.444562. Epub 2013 Feb 21. 2013
13HPSE
Clinical significance of heparanase splice variant (t5) in renal cell carcinoma: evaluation by a novel t5-specific monoclonal antibody.
Barash U, Arvatz G, Farfara R, Naroditsky I, Doweck I, Feld S, Ben-Izhak O, Ilan N, Nativ O, Vlodavsky I.
PLoS One 7(12):e51494. doi: 10.1371/journal.pone.0051494. Epub 2012 Dec 12. 2012
14HPSE, VEGFA
Heparanase and vascular endothelial growth factor expression is increased in hypoxia-induced retinal neovascularization.
Hu J, Song X, He YQ, Freeman C, Parish CR, Yuan L, Yu H, Tang S.
Invest Ophthalmol Vis Sci 53(11):6810-7. doi: 10.1167/iovs.11-9144. 2012
15HPSE
Heparanase is highly expressed and regulates proliferation in GH-secreting pituitary tumor cells.
Rubinfeld H, Cohen-Kaplan V, Nass D, Ilan N, Meisel S, Cohen ZR, Hadani M, Vlodavsky I, Shimon I.
Endocrinology 152(12):4562-70. doi: 10.1210/en.2011-0273. Epub 2011 Oct 18. 2011
16HPSE
Heparanase levels are elevated in the urine and plasma of type 2 diabetes patients and associate with blood glucose levels.
Shafat I, Ilan N, Zoabi S, Vlodavsky I, Nakhoul F.
PLoS One 6(2):e17312. doi: 10.1371/journal.pone.0017312. 2011
17HPSE
Heparanase plays a dual role in driving hepatocyte growth factor (HGF) signaling by enhancing HGF expression and activity.
Ramani VC, Yang Y, Ren Y, Nan L, Sanderson RD.
J Biol Chem 286(8):6490-9. doi: 10.1074/jbc.M110.183277. Epub 2010 Dec 3. 2011
18HPSE
Post-transcriptional regulation of heparanase gene expression by a 3' AU-rich element.
Arvatz G, Barash U, Nativ O, Ilan N, Vlodavsky I.
FASEB J 24(12):4969-76. doi: 10.1096/fj.10-156372. Epub 2010 Aug 26. 2010
19CHST11, CSGALNACT1, CSGALNACT2, HPSE, HS2ST1, HS3ST2
Expression of genes encoding for proteins involved in heparan sulphate and chondroitin sulphate chain synthesis and modification in normal and malignant plasma cells.
Bret C, Hose D, Reme T, Sprynski AC, Mahtouk K, Schved JF, Quittet P, Rossi JF, Goldschmidt H, Klein B.
Br J Haematol 145(3):350-68. Epub 2009 Mar 2. 2009
20HPSE
Cloning, expression, and characterization of an alternatively spliced variant of human heparanase.
Nasser NJ, Avivi A, Shushy M, Vlodavsky I, Nevo E.
Biochem Biophys Res Commun 354(1):33-8. Epub 2007 Jan 2. 2007
21HPSE
HPSE-1 expression and functionality in differentiating neural cells.
Moretti M, Sinnappah-Kang ND, Toller M, Curcio F, Marchetti D.
J Neurosci Res 83(4):694-701. 2006
22HPSE
Identification and characterization of heparin/heparan sulfate binding domains of the endoglycosidase heparanase.
Levy-Adam F, Abboud-Jarrous G, Guerrini M, Beccati D, Vlodavsky I, Ilan N.
J Biol Chem 280(21):20457-66. Epub 2005 Mar 10. 2005
23HPSE
Heparanase-1 gene expression in normal, hyperplastic and neoplastic prostatic tissue.
Stadlmann S, Moser PL, Pollheimer J, Steiner P, Krugmann J, Dirnhofer S, Mikuz G, Margreiter R, Amberger A.
Eur J Cancer 39(15):2229-33. 2003
24HPSE
Molecular properties and involvement of heparanase in cancer progression and normal development.
Vlodavsky I, Goldshmidt O, Zcharia E, Metzger S, Chajek-Shaul T, Atzmon R, Guatta-Rangini Z, Friedmann Y.
Biochimie 83(8):831-9. Review. 2001
25HPSE
Genomic organization and chromosome localization of the newly identified human heparanase gene.
Dong J, Kukula AK, Toyoshima M, Nakajima M.
Gene 253(2):171-8. 2000
26HPSE
Human heparanase. Purification, characterization, cloning, and expression.
Toyoshima M, et al.
J Biol Chem 274(34):24153-60 1999
27HPSE
Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis.
Hulett MD, et al.
Nat Med 5(7):803-9 1999
28HPSE
Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis.
Vlodavsky I, et al.
Nat Med 5(7):793-802 1999
29HPSE
Cloning and functional expression of a human heparanase gene.
Kussie PH, Hulmes JD, Ludwig DL, Patel S, Navarro EC, Seddon AP, Giorgio NA, Bohlen P.
Biochem Biophys Res Commun 261(1):183-7. 1999
30HPSE
An AvaII polymorphism in the haptoglobin alpha gene (HPA).
Bashir A, et al.
Nucleic Acids Res 17 : 4906. 1989