1 | HPSE, SDC1, SDCBP
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| Heparanase activates the syndecan-syntenin-ALIX exosome pathway.
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| Roucourt B, Meeussen S, Bao J, Zimmermann P, David G.
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| Cell Res 25(4):412-28. doi: 10.1038/cr.2015.29. Epub 2015 Mar 3.
2015
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2 | HPSE
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| Structural characterization of human heparanase reveals insights into substrate recognition.
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| Wu L, Viola CM, Brzozowski AM, Davies GJ.
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| Nat Struct Mol Biol 22(12):1016-22. doi: 10.1038/nsmb.3136. Epub 2015 Nov 16. Erratum in: Nat Struct Mol Biol. 2016 Jan;23(1):91.
2015
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3 | HPSE
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| Function from within: Autophagy induction by HPSE/heparanase--new possibilities for intervention.
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| Ilan N, Shteingauz A, Vlodavsky I.
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| Autophagy 11(12):2387-9. doi: 10.1080/15548627.2015.1115174.
2015
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4 | HPSE
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| Nuclear heparanase-1 activity suppresses melanoma progression via its DNA-binding affinity.
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| Yang Y, Gorzelanny C, Bauer AT, Halter N, Komljenovic D, Bäuerle T, Borsig L, Roblek M, Schneider SW.
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| Oncogene 34(47):5832-42. doi: 10.1038/onc.2015.40. Epub 2015 Mar 9.
2015
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5 | HPSE
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| Heparanase is involved in proliferation and invasion of ovarian cancer cells.
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| Zheng H, Ruan J, Zhao P, Chen S, Pan L, Liu J.
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| Cancer Biomark 15(5):525-34. doi: 10.3233/CBM-150459.
2015
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6 | HPSE
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| The expression of heparanase in normal and preeclamptic placentas.
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| Ginath S, Lurie S, Golan A, Amsterdam A, Sandbank J, Sadan O, Kovo M.
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| J Matern Fetal Neonatal Med 28(13):1589-93. doi: 10.3109/14767058.2014.962506. Epub 2014 Sep 29.
2015
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7 | HPSE
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| Heparanase is a key player in renal fibrosis by regulating TGF-β expression and activity.
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| Masola V, Zaza G, Secchi MF, Gambaro G, Lupo A, Onisto M.
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| Biochim Biophys Acta 1843(9):2122-8. doi: 10.1016/j.bbamcr.2014.06.005. Epub 2014 Jun 15.
2014
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8 | HPSE
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| Heparanase induces inflammatory cell recruitment in vivo by promoting adhesion to vascular endothelium.
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| Lever R, Rose MJ, McKenzie EA, Page CP.
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| Am J Physiol Cell Physiol 306(12):C1184-90. doi: 10.1152/ajpcell.00269.2013. Epub 2014 Apr 16.
2014
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9 | HPSE
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| DNA methylation of heparanase promoter influences its expression and associated with the progression of human breast cancer.
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| Jiao F, Bai SY, Ma Y, Yan ZH, Yue Z, Yu Y, Wang X, Wang J.
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| PLoS One 9(3):e92190. doi: 10.1371/journal.pone.0092190. eCollection 2014.
2014
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10 | HPSE
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| Heparanase localization during palatogenesis in mice.
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| Hirata A, Katayama K, Tsuji T, Natsume N, Sugahara T, Koga Y, Takano K, Otsuki Y, Nakamura H.
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| Biomed Res Int 2013:760236. doi: 10.1155/2013/760236. Epub 2013 Feb 12.
2013
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11 | HPSE
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| Versatile role of heparanase in inflammation.
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| Goldberg R, Meirovitz A, Hirshoren N, Bulvik R, Binder A, Rubinstein AM, Elkin M.
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| Matrix Biol 32(5):234-40. doi: 10.1016/j.matbio.2013.02.008. Epub 2013 Mar 13. Review.
2013
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12 | HPSE
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| Heparanase regulates secretion, composition, and function of tumor cell-derived exosomes.
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| Thompson CA, Purushothaman A, Ramani VC, Vlodavsky I, Sanderson RD.
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| J Biol Chem 288(14):10093-9. doi: 10.1074/jbc.C112.444562. Epub 2013 Feb 21.
2013
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13 | HPSE
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| Clinical significance of heparanase splice variant (t5) in renal cell carcinoma: evaluation by a novel t5-specific monoclonal antibody.
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| Barash U, Arvatz G, Farfara R, Naroditsky I, Doweck I, Feld S, Ben-Izhak O, Ilan N, Nativ O, Vlodavsky I.
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| PLoS One 7(12):e51494. doi: 10.1371/journal.pone.0051494. Epub 2012 Dec 12.
2012
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14 | HPSE, VEGFA
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| Heparanase and vascular endothelial growth factor expression is increased in hypoxia-induced retinal neovascularization.
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| Hu J, Song X, He YQ, Freeman C, Parish CR, Yuan L, Yu H, Tang S.
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| Invest Ophthalmol Vis Sci 53(11):6810-7. doi: 10.1167/iovs.11-9144.
2012
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15 | HPSE
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| Heparanase is highly expressed and regulates proliferation in GH-secreting pituitary tumor cells.
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| Rubinfeld H, Cohen-Kaplan V, Nass D, Ilan N, Meisel S, Cohen ZR, Hadani M, Vlodavsky I, Shimon I.
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| Endocrinology 152(12):4562-70. doi: 10.1210/en.2011-0273. Epub 2011 Oct 18.
2011
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16 | HPSE
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| Heparanase levels are elevated in the urine and plasma of type 2 diabetes patients and associate with blood glucose levels.
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| Shafat I, Ilan N, Zoabi S, Vlodavsky I, Nakhoul F.
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| PLoS One 6(2):e17312. doi: 10.1371/journal.pone.0017312.
2011
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17 | HPSE
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| Heparanase plays a dual role in driving hepatocyte growth factor (HGF) signaling by enhancing HGF expression and activity.
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| Ramani VC, Yang Y, Ren Y, Nan L, Sanderson RD.
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| J Biol Chem 286(8):6490-9. doi: 10.1074/jbc.M110.183277. Epub 2010 Dec 3.
2011
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18 | HPSE
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| Post-transcriptional regulation of heparanase gene expression by a 3' AU-rich element.
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| Arvatz G, Barash U, Nativ O, Ilan N, Vlodavsky I.
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| FASEB J 24(12):4969-76. doi: 10.1096/fj.10-156372. Epub 2010 Aug 26.
2010
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19 | CHST11, CSGALNACT1, CSGALNACT2, HPSE, HS2ST1, HS3ST2
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| Expression of genes encoding for proteins involved in heparan sulphate and chondroitin sulphate chain synthesis and modification in normal and malignant plasma cells.
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| Bret C, Hose D, Reme T, Sprynski AC, Mahtouk K, Schved JF, Quittet P, Rossi JF, Goldschmidt H, Klein B.
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| Br J Haematol 145(3):350-68. Epub 2009 Mar 2. 2009
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20 | HPSE
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| Cloning, expression, and characterization of an alternatively spliced variant of human heparanase.
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| Nasser NJ, Avivi A, Shushy M, Vlodavsky I, Nevo E.
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| Biochem Biophys Res Commun 354(1):33-8. Epub 2007 Jan 2.
2007
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21 | HPSE
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| HPSE-1 expression and functionality in differentiating neural cells.
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| Moretti M, Sinnappah-Kang ND, Toller M, Curcio F, Marchetti D.
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| J Neurosci Res 83(4):694-701. 2006
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22 | HPSE
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| Identification and characterization of heparin/heparan sulfate binding domains of the endoglycosidase heparanase.
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| Levy-Adam F, Abboud-Jarrous G, Guerrini M, Beccati D, Vlodavsky I, Ilan N.
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| J Biol Chem 280(21):20457-66. Epub 2005 Mar 10. 2005
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23 | HPSE
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| Heparanase-1 gene expression in normal, hyperplastic and neoplastic prostatic tissue.
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| Stadlmann S, Moser PL, Pollheimer J, Steiner P, Krugmann J, Dirnhofer S, Mikuz G, Margreiter R, Amberger A.
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| Eur J Cancer 39(15):2229-33. 2003
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24 | HPSE
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| Molecular properties and involvement of heparanase in cancer progression and normal development.
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| Vlodavsky I, Goldshmidt O, Zcharia E, Metzger S, Chajek-Shaul T, Atzmon R, Guatta-Rangini Z, Friedmann Y.
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| Biochimie 83(8):831-9. Review. 2001
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25 | HPSE
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| Genomic organization and chromosome localization of the newly identified human heparanase gene.
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| Dong J, Kukula AK, Toyoshima M, Nakajima M.
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| Gene 253(2):171-8. 2000
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26 | HPSE
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| Human heparanase. Purification, characterization, cloning, and expression.
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| Toyoshima M, et al.
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| J Biol Chem 274(34):24153-60 1999
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27 | HPSE
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| Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis.
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| Hulett MD, et al.
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| Nat Med 5(7):803-9 1999
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28 | HPSE
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| Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis.
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| Vlodavsky I, et al.
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| Nat Med 5(7):793-802 1999
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29 | HPSE
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| Cloning and functional expression of a human heparanase gene.
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| Kussie PH, Hulmes JD, Ludwig DL, Patel S, Navarro EC, Seddon AP, Giorgio NA, Bohlen P.
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| Biochem Biophys Res Commun 261(1):183-7. 1999
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30 | HPSE
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| An AvaII polymorphism in the haptoglobin alpha gene (HPA).
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| Bashir A, et al.
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| Nucleic Acids Res 17 : 4906. 1989
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