Citations for
1HPN, KLK14, KLK4, MMP3, TMPRSS2
Pericellular regulation of prostate cancer expressed kallikrein-related peptidases and matrix metalloproteinases by cell surface serine proteases.
Reid JC, Matsika A, Davies CM, He Y, Broomfield A, Bennett NC, Magdolen V, Srinivasan B, Clements JA, Hooper JD.
Am J Cancer Res 7(11):2257-2274. eCollection 2017. 2017
2HGFAC, HPN, SPINT2, ST14
SPINT2 Deregulation in Prostate Carcinoma.
Pereira MS, de Almeida GC, Pinto F, Viana-Pereira M, Reis RM.
J Histochem Cytochem Histochem Cytochem. 2015 Oct 6. pii: 0022155415612874. [Epub ahead of print] 2015
3HPN
Variants in the HEPSIN gene are associated with susceptibility to prostate cancer.
Kim HJ, Han JH, Chang IH, Kim W, Myung SC.
Prostate Cancer Prostatic Dis 15(4):353-8. doi: 10.1038/pcan.2012.17. Epub 2012 Jun 5. 2012
4HPN
Serine protease hepsin regulates hepatocyte size and hemodynamic retention of tumor cells by hepatocyte growth factor signaling in mice.
Hsu YC, Huang HP, Yu IS, Su KY, Lin SR, Lin WC, Wu HL, Shi GY, Tao MH, Kao CH, Wu YM, Martin PE, Lin SY, Yang PC, Lin SW.
Hepatology 56(5):1913-23. doi: 10.1002/hep.25773. Epub 2012 Oct 9. 2012
5HPN, STK11
Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity.
Partanen JI, Tervonen TA, Myllynen M, Lind E, Imai M, Katajisto P, Dijkgraaf GJ, Kovanen PE, Mäkelä TP, Werb Z, Klefström J.
Proc Natl Acad Sci U S A 109(7):E388-97. doi: 10.1073/pnas.1120421109. Epub 2012 Jan 20. 2012
6HPN
Clinical and biological significance of hepsin overexpression in breast cancer.
Xing P, Li JG, Jin F, Zhao TT, Liu Q, Dong HT, Wei XL.
J Investig Med 59(5):803-10. doi: 10.231/JIM.0b013e31821451a1. 2011
7HPN
Association of hepsin gene variants with prostate cancer risk and prognosis.
Holt SK, Kwon EM, Lin DW, Ostrander EA, Stanford JL.
Prostate 70(9):1012-9. doi: 10.1002/pros.21135. 2010
8HPN, PRSS8
Hepsin activates prostasin and cleaves the extracellular domain of the epidermal growth factor receptor.
Chen M, Chen LM, Lin CY, Chai KX.
Mol Cell Biochem 337(1-2):259-66. doi: 10.1007/s11010-009-0307-y. 2010
9HPN, ST14, TMPRSS11E, TMPRSS6
Probing the substrate specificities of matriptase, matriptase-2, hepsin and DESC1 with internally quenched fluorescent peptides.
Béliveau F, Désilets A, Leduc R.
FEBS J 276(8):2213-26. doi: 10.1111/j.1742-4658.2009.06950.x. Epub 2009 Mar 3. 2009
10HPN
Identification and characterization of small-molecule inhibitors of hepsin.
Chevillet JR, Park GJ, Bedalov A, Simon JA, Vasioukhin VI.
Mol Cancer Ther 7(10):3343-51. doi: 10.1158/1535-7163.MCT-08-0446. 2008
11HPN
Hepsin inhibits the cell growth of endometrial cancer.
Nakamura K, Takamoto N, Abarzua F, Hongo A, Kodama J, Nasu Y, Kumon H, Hiramatsu Y.
Int J Mol Med 22(3):389-97. 2008
12HPN
Expression of the serine protease hepsin and clinical outcome of human endometrial cancer.
Matsuo T, Nakamura K, Takamoto N, Kodama J, Hongo A, Abrzua F, Nasu Y, Kumon H, Hiramatsu Y.
Anticancer Res 28(1A):159-64. 2008
13HPN
Mice deficient for the type II transmembrane serine protease, TMPRSS1/hepsin, exhibit profound hearing loss.
Guipponi M, Tan J, Cannon PZ, Donley L, Crewther P, Clarke M, Wu Q, Shepherd RK, Scott HS.
Am J Pathol 171(2):608-16. Epub 2007 Jul 9. 2007
14HPN
Decreased expressions of hepsin in human hepatocellular carcinomas.
Chen CH, Su KY, Tao MH, Lin SW, Su YH, Tsai YC, Cheng KC, Jeng YM, Sheu JC.
Liver Int 26(7):774-80. 2006
15HPN
Hepsin activates pro-hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor-1B (HAI-1B) and HAI-2.
Kirchhofer D, Peek M, Lipari MT, Billeci K, Fan B, Moran P.
FEBS Lett 579(9):1945-50. 2005
16HPN
Identification and characterization of hepsin/-TM, a non-transmembrane hepsin isoform.
Li Y, Yu Z, Zhao X, Shen SH.
Biochim Biophys Acta 1681(2-3):157-65. Epub 2004 Dec 15. 2005
17HPN
HEPSIN inhibits cell growth/invasion in prostate cancer cells.
Srikantan V, Valladares M, Rhim JS, Moul JW, Srivastava S.
Cancer Res 62(23):6812-6. 2002
18HPN
Hepsin, a putative membrane-associated serine protease, activates human factor VII and initiates a pathway of blood coagulation on the cell surface leading to thrombin formation.
Kazama Y, et al.
J Biol Chem 270 : 66-72. 1995
19HPN
Hepsin, a cell membrane-associated protease. Characterization, tissue distribution, and gene localization.
Tsuji A, et al.
J Biol Chem 266 : 16948-16953. 1991