| 1 | CALM2, HNF4A, TAF1
|
| Identification of TAF1, HNF4A, and CALM2 as potential therapeutic target genes for liver fibrosis.
|
| Ji D, Chen GF, Wang JC, Cao LH, Lu F, Mu XX, Zhang XY, Lu XJ.
|
| J Cell Physiol 234(6):9045-9051. doi: 10.1002/jcp.27579. Epub 2018 Oct 14.
2019
|
| 2 | HNF1A, HNF4A
|
| Clinical heterogeneity of hyperinsulinism due to HNF1A and HNF4A mutations.
|
| Tung JY, Boodhansingh K, Stanley CA, De León DD.
|
| Pediatr Diabetes. Aug;19(5):910-916. doi: 10.1111/pedi.12655. Epub 2018 Mar 1 2018
|
| 3 | HNF4A, SLC22A9
|
| Variability in hepatic expression of organic anion transporter 7/SLC22A9, a novel pravastatin uptake transporter: impact of genetic and regulatory factors
|
| Emami Riedmaier A, Burk O, van Eijck BA, Schaeffeler E, Klein K, Fehr S, Biskup S, Müller S, Winter S, Zanger UM, Schwab M, Nies AT
|
| Pharmacogenomics J. Aug;16(4):341-51. doi: 10.1038/tpj.2015.55. Epub 2015 Aug 4. 2016
|
| 4 | CLDN7, HNF4A
|
| HNF4α regulates claudin-7 protein expression during intestinal epithelial differentiation.
|
| Farkas AE, Hilgarth RS, Capaldo CT, Gerner-Smidt C, Powell DR, Vertino PM, Koval M, Parkos CA, Nusrat A.
|
| Am J Pathol. Aug;185(8):2206-18. doi: 10.1016/j.ajpath.2015.04.023. 2015
|
| 5 | FOXA2, HNF4A
|
| Hippo signaling influences HNF4A and FOXA2 enhancer switching during hepatocyte differentiation.
|
| Alder O, Cullum R, Lee S, Kan AC, Wei W, Yi Y, Garside VC, Bilenky M, Griffith M, Morrissy AS, Robertson GA, Thiessen N, Zhao Y, Chen Q, Pan D, Jones SJ, Marra MA, Hoodless PA.
|
| Cell Rep 9(1):261-71. doi: 10.1016/j.celrep.2014.08.046. Epub 2014 Sep 25.
2014
|
| 6 | HNF4A, SLC2A9
|
| Transcriptional regulation of urate transportosome member SLC2A9 by nuclear receptor HNF4α.
|
| Prestin K, Wolf S, Feldtmann R, Hussner J, Geissler I, Rimmbach C, Kroemer HK, Zimmermann U, Meyer zu Schwabedissen HE.
|
| Am J Physiol Renal Physiol 307(9):F1041-51. doi: 10.1152/ajprenal.00640.2013. Epub 2014 Sep 10.
2014
|
| 7 | HES6, HNF4A
|
| All-trans-retinoic acid ameliorates hepatic steatosis in mice by a novel transcriptional cascade
|
| Kim SC, Kim CK, Axe D, Cook A, Lee M, Li T, Smallwood N, Chiang JY, Hardwick JP, Moore DD, Lee YK.
|
| Hepatology. May;59(5):1750-60. doi: 10.1002/hep.26699. Epub 2014 Mar 26. 2014
|
| 8 | HNF4A, NR3C1, SLC22A1
|
| Glucocorticoid receptor regulates organic cation transporter 1 (OCT1, SLC22A1) expression via HNF4α upregulation in primary human hepatocytes.
|
| Rulcova A, Krausova L, Smutny T, Vrzal R, Dvorak Z, Jover R, Pavek P.
|
| Pharmacol Rep 65(5):1322-35.
2013
|
| 9 | FABP1, HNF4A
|
| Liver-type fatty acid binding protein interacts with hepatocyte nuclear factor 4α.
|
| McIntosh AL, Petrescu AD, Hostetler HA, Kier AB, Schroeder F.
|
| FEBS Lett 587(23):3787-91. doi: 10.1016/j.febslet.2013.09.043. Epub 2013 Oct 15.
2013
|
| 10 | ANKS4B, HNF4A
|
| Anks4b, a novel target of HNF4α protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells.
|
| Sato Y, Hatta M, Karim MF, Sawa T, Wei FY, Sato S, Magnuson MA, Gonzalez FJ, Tomizawa K, Akaike T, Yoshizawa T, Yamagata K.
|
| J Biol Chem 287(27):23236-45. doi: 10.1074/jbc.M112.368779. Epub 2012 May 15.
2012
|
| 11 | HNF4A, MED25
|
| Med25 is required for RNA polymerase II recruitment to specific promoters, thus regulating xenobiotic and lipid metabolism in human liver.
|
| Rana R, Surapureddi S, Kam W, Ferguson S, Goldstein JA.
|
| Mol Cell Biol 31(3):466-81. Epub 2010 Dec 6.
2011
|
| 12 | HNF4A
|
| Multiple post-translational modifications in hepatocyte nuclear factor 4α.
|
| Yokoyama A, Katsura S, Ito R, Hashiba W, Sekine H, Fujiki R, Kato S.
|
| Biochem Biophys Res Commun 410(4):749-53. Epub 2011 Jun 17.
2011
|
| 13 | HNF4A
|
| The stable repression of mesenchymal program is required for hepatocyte identity: a novel role for hepatocyte nuclear factor 4α.
|
| Santangelo L, Marchetti A, Cicchini C, Conigliaro A, Conti B, Mancone C, Bonzo JA, Gonzalez FJ, Alonzi T, Amicone L, Tripodi M.
|
| Hepatology 53(6):2063-74. doi: 10.1002/hep.24280.
2011
|
| 14 | HNF4A
|
| Expression profile analysis of the inflammatory response regulated by hepatocyte nuclear factor 4α.
|
| Wang Z, Bishop EP, Burke PA.
|
| BMC Genomics 12:128.
2011
|
| 15 | HNF4A
|
| Hepatic hepatocyte nuclear factor 4α is essential for maintaining triglyceride and cholesterol homeostasis.
|
| Yin L, Ma H, Ge X, Edwards PA, Zhang Y.
|
| Arterioscler Thromb Vasc Biol 31(2):328-36. Epub 2010 Nov 11.
2011
|
| 16 | HNF4A
|
| A role for coding functional variants in HNF4A in type 2 diabetes susceptibility.
|
| Jafar-Mohammadi B, Groves CJ, Gjesing AP, Herrera BM, Winckler W, Stringham HM, Morris AP, Lauritzen T, Doney AS, Morris AD, Weedon MN, Swift AJ, Kuusisto J, Laakso M, Altshuler D, Hattersley AT, Collins FS, Boehnke M, Hansen T, Pedersen O, Palmer CN, Frayling TM; DIAGRAM Consortium, Gloyn AL, McCarthy MI.
|
| Diabetologia 54(1):111-9. Epub 2010 Sep 29.
2011
|
| 17 | HNF4A
|
| HNF4A is essential for specification of hepatic progenitors from human pluripotent stem cells.
|
| DeLaForest A, Nagaoka M, Si-Tayeb K, Noto FK, Konopka G, Battle MA, Duncan SA.
|
| Development 138(19):4143-53. Epub 2011 Aug 18.
2011
|
| 18 | HADH, HNF4A
|
| Congenital hyperinsulinism due to mutations in HNF4A and HADH.
|
| Kapoor RR, Heslegrave A, Hussain K.
|
| Rev Endocr Metab Disord 11(3):185-91. Review.
2010
|
| 19 | HNF4A
|
| Modification in oxidative stress, inflammation, and lipoprotein assembly in response to hepatocyte nuclear factor 4alpha knockdown in intestinal epithelial cells.
|
| Marcil V, Seidman E, Sinnett D, Boudreau F, Gendron FP, Beaulieu JF, Ménard D, Precourt LP, Amre D, Levy E.
|
| J Biol Chem 285(52):40448-60. Epub 2010 Sep 24.
2010
|
| 20 | ASAH2, HNF4A
|
| Identification of a functional hepatocyte nuclear factor 4 binding site in the neutral ceramidase promoter.
|
| Maltesen HR, Troelsen JT, Olsen J.
|
| J Cell Biochem 111(5):1330-6. doi: 10.1002/jcb.22862.
2010
|
| 21 | HNF4A
|
| Hepatocyte nuclear factor-4α interacts with other hepatocyte nuclear factors in regulating transthyretin gene expression.
|
| Wang Z, Burke PA.
|
| FEBS J 277(19):4066-75. doi: 10.1111/j.1742-4658.2010.07802.x. Epub 2010 Aug 23.
2010
|
| 22 | AGT, HNF4A
|
| A nuclear receptor, hepatocyte nuclear factor 4, differently contributes to the human and mouse angiotensinogen promoter activities.
|
| Oishi T, Date S, Shimamoto Y, Saito T, Hirota K, Sugaya T, Kon Y, Fukamizu A, Tanimoto K.
|
| J Recept Signal Transduct Res 30(6):484-92. Epub 2010 Aug 4.
2010
|
| 23 | HNF4A
|
| Novel monogenic diabetes mutations in the P2 promoter of the HNF4A gene are associated with impaired function in vitro.
|
| Wirsing A, Johnstone KA, Harries LW, Ellard S, Ryffel GU, Stanik J, Gasperikova D, Klimes I, Murphy R.
|
| Diabet Med 27(6):631-5.
2010
|
| 24 | ABCC6, HNF4A
|
| The ERK1/2-hepatocyte nuclear factor 4alpha axis regulates human ABCC6 gene expression in hepatocytes.
|
| de Boussac H, Ratajewski M, Sachrajda I, Köblös G, Tordai A, Pulaski L, Buday L, Váradi A, Arányi T.
|
| J Biol Chem 285(30):22800-8. Epub 2010 May 12.
2010
|
| 25 | HNF4A
|
| Hepatocyte nuclear factor-4alpha induces transdifferentiation of hematopoietic cells into hepatocytes.
|
| Khurana S, Jaiswal AK, Mukhopadhyay A.
|
| J Biol Chem 285(7):4725-31. Epub 2009 Dec 16.
2010
|
| 26 | HNF4A
|
| Hepatocyte nuclear factor 4alpha coordinates a transcription factor network regulating hepatic fatty acid metabolism.
|
| Martinez-Jimenez CP, Kyrmizi I, Cardot P, Gonzalez FJ, Talianidis I.
|
| Mol Cell Biol 30(3):565-77. Epub 2009 Nov 23.
2010
|
| 27 | CYP2B6, ERG1, HNF4A
|
| Early growth response 1 loops the CYP2B6 promoter for synergistic activation by the distal and proximal nuclear receptors CAR and HNF4alpha.
|
| Inoue K, Negishi M.
|
| FEBS Lett 583(12):2126-30. Epub 2009 May 23.
2009
|
| 28 | HNF4A, RBP2
|
| Hepatocyte nuclear factor-4alpha regulates human cellular retinol-binding protein type II gene expression in intestinal cells.
|
| Yamaguchi N, Miyamoto S, Ogura Y, Goda T, Suruga K.
|
| Am J Physiol Gastrointest Liver Physiol 296(3):G524-33. Epub 2009 Jan 15.
2009
|
| 29 | CREBZF, HNF4A
|
| Molecular characterization of SMILE as a novel corepressor of nuclear receptors.
|
| Xie YB, Nedumaran B, Choi HS.
|
| Nucleic Acids Res 37(12):4100-15. Epub 2009 May 8.
2009
|
| 30 | HNF4A
|
| Hepatocyte nuclear factor 4alpha, a key factor for homeostasis, cell architecture, and barrier function of the adult intestinal epithelium.
|
| Cattin AL, Le Beyec J, Barreau F, Saint-Just S, Houllier A, Gonzalez FJ, Robine S, Pinçon-Raymond M, Cardot P, Lacasa M, Ribeiro A.
|
| Mol Cell Biol 29(23):6294-308. Epub 2009 Oct 5.
2009
|
| 31 | HNF4A
|
| Mapping of HNF4alpha target genes in intestinal epithelial cells.
|
| Boyd M, Bressendorff S, Mřller J, Olsen J, Troelsen JT.
|
| BMC Gastroenterol 9:68.
2009
|
| 32 | HNF4A
|
| Convergence of Wnt signaling on the HNF4alpha-driven transcription in controlling liver zonation.
|
| Colletti M, Cicchini C, Conigliaro A, Santangelo L, Alonzi T, Pasquini E, Tripodi M, Amicone L.
|
| Gastroenterology 137(2):660-72. Epub 2009 May 18. Erratum in: Gastroenterology. 2010 Feb;138(2):793.
2009
|
| 33 | CDH22, HNF4A, PREX1, PTPN1, SLC2A10
|
| Bento JL, Palmer ND, Zhong M, Roh B, Lewis JP, Wing MR, Pandya H, Freedman BI, Langefeld CD, Rich SS, Bowden DW, Mychaleckyj JC.
|
| Heterogeneity in gene loci associated with type 2 diabetes on human chromosome 20q13.
|
| Genomics 92(4):226-34. Epub 2008 Aug 9.
2008
|
| 34 | HNF4A
|
| Structural basis of natural promoter recognition by a unique nuclear receptor, HNF4alpha. Diabetes gene product.
|
| Lu P, Rha GB, Melikishvili M, Wu G, Adkins BC, Fried MG, Chi YI.
|
| J Biol Chem 283(48):33685-97. Epub 2008 Oct 1.
2008
|
| 35 | HNF4A
|
| Expression of HNF4alpha variants in pancreatic islets and Ins-1 beta cells.
|
| Huang J, Karakucuk V, Levitsky LL, Rhoads DB.
|
| Diabetes Metab Res Rev 24(7):533-43.
2008
|
| 36 | FABP2, HNF4A
|
| The human intestinal fatty acid binding protein (hFABP2) gene is regulated by HNF-4alpha.
|
| Klapper M, Böhme M, Nitz I, Döring F.
|
| Biochem Biophys Res Commun 356(1):147-52. Epub 2007 Feb 26.
2007
|
| 37 | HNF4A
|
| Association study on chromosome 20q11.21-13.13 locus and its contribution to type 2 diabetes susceptibility in Japanese.
|
| Tanahashi T, Osabe D, Nomura K, Shinohara S, Kato H, Ichiishi E, Nakamura N, Yoshikawa T, Takata Y, Miyamoto T, Shiota H, Keshavarz P, Yamaguchi Y, Kunika K, Moritani M, Inoue H, Itakura M.
|
| Hum Genet 120(4):527-42. Epub 2006 Sep 6.
2006
|
| 38 | HNF1A, MODY3, HNF4A, MODY1
|
| Mutations in the genes encoding the transcription factors hepatocyte nuclear factor 1 alpha (HNF1A) and 4 alpha (HNF4A) in maturity-onset diabetes of the young.
|
| Ellard S, Colclough K.
|
| Hum Mutat 27(9):854-69. 2006
|
| 39 | HNF4A
|
| Inhibition of hepatocyte nuclear factor 4 transcriptional activity by the nuclear factor kappaB pathway.
|
| Nikolaidou-Neokosmidou V, Zannis VI, Kardassis D.
|
| Biochem J 398(3):439-50. 2006
|
| 40 | VIP, CREM, G6PC, HNF1A, HNF4A
|
| Transcriptional regulation of the glucose-6-phosphatase gene by cAMP/vasoactive intestinal peptide in the intestine. Role of HNF4alpha, CREM, HNF1alpha, and C/EBPalpha.
|
| Gautier-Stein A, Zitoun C, Lalli E, Mithieux G, Rajas F.
|
| J Biol Chem 281(42):31268-78. Epub 2006 Aug 7. 2006
|
| 41 | HNF1A, HNF4A, PROS1
|
| Regulation of the human protein S gene promoter by liver enriched transcription factors.
|
| Hall AJ, Peake IR, Winship PR.
|
| Br J Haematol 135(4):538-46.
2006
|
| 42 | HNF4A, NFE2
|
| HNF4alpha and NF-E2 are key transcriptional regulators of the murine Abcc6 gene expression.
|
| Douet V, VanWart CM, Heller MB, Reinhard S, Le Saux O.
|
| Biochim Biophys Acta 1759(8-9):426-36. Epub 2006 Aug 11.
2006
|
| 43 | HNF4A, HNF1A, MODY1
|
| Molecular genetics and phenotypic characteristics of MODY caused by hepatocyte nuclear factor 4alpha mutations in a large European collection.
|
| Pearson ER, Pruhova S, Tack CJ, Johansen A, Castleden HA, Lumb PJ, Wierzbicki AS, Clark PM, Lebl J, Pedersen O, Ellard S, Hansen T, Hattersley AT.
|
| Diabetologia 48(5):878-85. Epub 2005 Apr 14. 2005
|
| 44 | HNF4A
|
| Comparative genomic analysis of the HNF-4alpha transcription factor gene.
|
| Bagwell AM, Bailly A, Mychaleckyj JC, Freedman BI, Bowden DW.
|
| Mol Genet Metab 81(2):112-21. 2004
|
| 45 | HNF4A, ONECUT1, HNF1A
|
| Control of pancreas and liver gene expression by HNF transcription factors.
|
| Odom DT, Zizlsperger N, Gordon DB, Bell GW, Rinaldi NJ, Murray HL, Volkert TL, Schreiber J, Rolfe PA, Gifford DK, Fraenkel E, Bell GI, Young RA.
|
| Science 303(5662):1378-81. 2004
|
| 46 | SREBF1, HNF4A, PPARGC1B
|
| SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes.
|
| Yamamoto T, Shimano H, Nakagawa Y, Ide T, Yahagi N, Matsuzaka T, Nakakuki M, Takahashi A, Suzuki H, Sone H, Toyoshima H, Sato R, Yamada N.
|
| J Biol Chem 279(13):12027-35. Epub 2004 Jan 13. 2004
|
| 47 | HNF4A
|
| Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis.
|
| Parviz F, Matullo C, Garrison WD, Savatski L, Adamson JW, Ning G, Kaestner KH, Rossi JM, Zaret KS, Duncan SA.
|
| Nat Genet 34(3):292-6. 2003
|
| 48 | HNF4A
|
| Mutations in hepatocyte nuclear factor 4alpha (HNF4alpha) gene associated with diabetes result in greater loss of HNF4alpha function in pancreatic beta-cells than in nonpancreatic beta-cells and in reduced activation of the apolipoprotein CIII promoter in hepatic cells.
|
| Oxombre B, Moerman E, Eeckhoute J, Formstecher P, Laine B.
|
| J Mol Med 80(7):423-30. Epub 2002 May 08. 2002
|
| 49 | HNF4A, HNF4G
|
| Liver receptor homologue-1 is expressed in human steroidogenic tissues and activates transcription of genes encoding steroidogenic enzymes.
|
| Sirianni R, Seely JB, Attia G, Stocco DM, Carr BR, Pezzi V, Rainey WE.
|
| J Endocrinol 174(3):R13-7. 2002
|
| 50 | HNF4A, MODY1, MODY3, HNF1A
|
| Naturally occurring mutations in the human HNF4alpha gene impair the function of the transcription factor to a varying degree.
|
| Lausen J, Thomas H, Lemm I, Bulman M, Borgschulze M, Lingott A, Hattersley AT, Ryffel GU.
|
| Nucleic Acids Res 28(2):430-7 2000
|
| 51 | MODY1, HNF4A
|
| A novel Phe75fsdelT mutation in the hepatocyte nuclear factor-4alpha gene in a Danish pedigree with maturity-onset diabetes of the young.
|
| Moller AM, et al.
|
| J Clin Endocrinol Metab 84(1):367-9. 1999
|
| 52 | MODY1, HNF4A
|
| Functional characterization of the MODY1 gene mutations HNF4(R127W), HNF4(V255M), and HNF4(E276Q).
|
| Navas MA, et al.
|
| Diabetes 48(7):1459-65. 1999
|
| 53 | HNF4A, HNF1A, SERPINA1
|
| The HNF-4/HNF-1alpha transactivation cascade regulates gene activity and chromatin structure of the human serine protease inhibitor gene cluster at 14q32.1.
|
| Rollini P, et al.
|
| Proc Natl Acad Sci U S A 96(18):10308-10313. 1999
|
| 54 | MODY1, HNF4A
|
| A missense mutation in hepatocyte nuclear factor-4alpha, resulting in a reduced transactivation activity, in human late-onset non-insulin-dependent diabetes mellitus.
|
| Hani EH, Suaud L, Boutin P, Chevre JC, Durand E, Philippi A, Demenais F, Vionnet N, Furuta H, Velho G, Bell GI, Laine B, Froguel P.
|
| J Clin Invest 101(3):521-6. 1998
|
| 55 | HNF4A, MODY1
|
| MODY1 mutation Q268X in hepatocyte nuclear factor 4alpha allows for dimerization in solution but causes abnormal subcellular localization.
|
| Sladek FM, et al.
|
| Diabetes 47 : 985-990. 1998
|
| 56 | HNF4A, HNF1A
|
| Rescue of the HNF4->HNF1alpha pathway in hepatoma variant cells containing human chromosome 12.
|
| Bulla GA, et al.
|
| Genomics 54 : 398-407. 1998
|
| 57 | HNF4A
|
| Hepatocyte nuclear factor-4 controls transcription from a TATA-less human sex hormone-binding globulin gene promoter.
|
| Janne M, et al.
|
| J Biol Chem 273 : 34105-34114. 1998
|
| 58 | GATA6, HNF4A
|
| GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo.
|
| Morrisey EE, Tang Z, Sigrist K, Lu MM, Jiang F, Ip HS, Parmacek MS.
|
| Genes Dev 12(22):3579-90. 1998
|
| 59 | HNF4A
|
| Human hepatocyte nuclear factor-4 (hHNF-4) gene maps to 20q12-q13.1 between PLCG1 and D20S17.
|
| Argyrokastritis A, et al.
|
| Hum Genet 99 : 233-236. 1997
|
| 60 | FOXA1, FOXA2, FOXA3, HNF4A, HNF4G, ONECUT1
|
| Pancreatic islet expression studies and polymorphic DNA markers in the genes encoding hepatocyte nuclear factor-3alpha, -3beta, -3gamma, -4gamma, and -6.
|
| Vaisse C, Kim J, Espinosa R 3rd, Le Beau MM, Stoffel M.
|
| Diabetes 46(8):1364-7. 1997
|
| 61 | HNF4A, MODY1
|
| Studies of the genetic variability of the coding region of the hepatocyte nuclear factor-4alpha in Caucasians with maturity onset NIDDM.
|
| Moller AM, Urhammer SA, Dalgaard LT, Reneland R, Berglund L, Hansen T, Clausen JO, Lithell H, Pedersen O.
|
| Diabetologia 40(8):980-3. 1997
|
| 62 | MODY1, HNF4A
|
| Hepatic function in a family with a nonsense mutation (R154X) in the hepatocyte nuclear factor-4alpha/MODY1 gene.
|
| Lindner T, Gragnoli C, Furuta H, Cockburn BN, Petzold C, Rietzsch H, Weiss U, Schulze J, Bell GI.
|
| J Clin Invest 100(6):1400-5. 1997
|
| 63 | HNF4A
|
| The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolism.
|
| Stoffel M, Duncan SA.
|
| Proc Natl Acad Sci U S A 94(24):13209-14. 1997
|
| 64 | HNF4A
|
| Functional domains of the nuclear receptor hepatocyte nuclear factor 4.
|
| Hadzopoulou-Cladaras M, Kistanova E, Evagelopoulou C, Zeng S, Cladaras C, Ladias JA.
|
| J Biol Chem 272(1):539-50 1997
|
| 65 | HNF4A
|
| Isolation and characterization of a third isoform of human hepatocyte nuclear factor 4.
|
| Kritis AA, et al.
|
| Gene 173 : 275-280. 1996
|
| 66 | MODY1, HNF4A
|
| Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1).
|
| Yamagata K, et al.
|
| Nature 384 : 458-460. 1996
|
| 67 | HNF4G, HNF4A
|
| Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed gene.
|
| Drewes T, et al.
|
| Mol Cell Biol 16 : 925-931. 1996
|