Citations for
1HMOX1
HMOX1 Promotes Ferroptosis Induced by Erastin in Lens Epithelial Cell through Modulates Fe2+ Production.
Liao S, Huang M, Liao Y, Yuan C.
Curr Eye Res. Jan;48(1):25-33. doi: 10.1080/02713683.2022.2138450. Epub 2022 Oct 27. 2023
2HMOX1
HMOX1 Participates in Pre-Eclampsia by Regulating the Proliferation, Apoptosis, and Angiogenesis Modulation Potential of Mesenchymal Stem Cells via VEGF
Shi J, Su M.
Biochem Genet. Aug 12. doi: 10.1007/s10528-023-10474-x. Epub ahead of print 2023
3HMOX1
HMOX1 promotes lung adenocarcinoma metastasis by affecting macrophages and mitochondrion complexes
Chen B, Zhang L, Zhou H, Ye W, Luo C, Yang L, Fang N, Tang A.
Front Oncol. Aug 12;12:978006. doi: 10.3389/fonc.2022.978006 2022
4HMOX1
HMOX1 upregulation promotes ferroptosis in diabetic atherosclerosis
Meng Z, Liang H, Zhao J, Gao J, Liu C, Ma X, Liu J, Liang B, Jiao X, Cao J, Wang Y.
Life Sci. Nov 1;284:119935. doi: 10.1016/j.lfs.2021.119935. Epub 2021 Sep 8 2021
5HMOX1
The HMOX1 Pathway as a Promising Target for the Treatment and Prevention of SARS-CoV-2 of 2019 (COVID-19)
Batra N, De Souza C, Batra J, Raetz AG, Yu AM.
Int J Mol Sci. Sep 3;21(17):6412. doi: 10.3390/ijms21176412 2020
6HMOX1
Heme Oxygenase-1 as a Modulator of Intestinal Inflammation Development and Progression
Sebastián VP, Salazar GA, Coronado-Arrázola I, Schultz BM, Vallejos OP, Berkowitz L, Álvarez-Lobos MM, Riedel CA, Kalergis AM, Bueno SM.
Front Immunol. Sep 12;9:1956. doi: 10.3389/fimmu.2018.01956. 2018
7HMOX1
HMOX1 as a marker of iron excess-induced adipose tissue dysfunction, affecting glucose uptake and respiratory capacity in human adipocytes
Moreno-Navarrete JM, Ortega F, Rodríguez A, Latorre J, Becerril S, Sabater-Masdeu M, Ricart W, Frühbeck G, Fernández-Real JM.
Diabetologia. May;60(5):915-926. doi: 10.1007/s00125-017-4228-0. Epub 2017 Feb 27. 2017
8HMOX1
Heme Oxygenase-1 and 2 Common Genetic Variants and Risk for Restless Legs Syndrome.
García-Martín E, Jiménez-Jiménez FJ, Alonso-Navarro H, Martínez C, Zurdo M, Turpín-Fenoll L, Millán-Pascual J, Adeva-Bartolomé T, Cubo E, Navacerrada F, Rojo-Sebastián A, Rubio L, Ortega-Cubero S, Pastor P, Calleja M, Plaza-Nieto JF, Pilo-de-la-Fuente B, Arroyo-Solera M, García-Albea E, Agúndez JA.
Medicine (Baltimore) 94(34):e1448. doi: 10.1097/MD.0000000000001448. 2015
9ATF4, HMOX1
ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis.
Dey S, Sayers CM, Verginadis II, Lehman SL, Cheng Y, Cerniglia GJ, Tuttle SW, Feldman MD, Zhang PJ, Fuchs SY, Diehl JA, Koumenis C.
J Clin Invest 125(7):2592-608. doi: 10.1172/JCI78031. Epub 2015 May 26. 2015
10HMOX1
Distal regulation of heme binding of heme oxygenase-1 mediated by conformational fluctuations.
Harada E, Sugishima M, Harada J, Fukuyama K, Sugase K.
Biochemistry 54(2):340-8. doi: 10.1021/bi5009694. Epub 2014 Dec 26. 2015
11HMOX1
Progesterone and HMOX-1 promote fetal growth by CD8+ T cell modulation
Solano ME, Kowal MK, O'Rourke GE, Horst AK, Modest K, Plösch T, Barikbin R, Remus CC, Berger RG, Jago C, Ho H, Sass G, Parker VJ, Lydon JP, DeMayo FJ, Hecher K, Karimi K, Arck PC.
J Clin Invest. Apr;125(4):1726-38. doi: 10.1172/JCI68140. Epub 2015 Mar 16 2015
12BRD4, HMOX1
The bromodomain protein BRD4 regulates the KEAP1/NRF2-dependent oxidative stress response.
Hussong M, Börno ST, Kerick M, Wunderlich A, Franz A, Sültmann H, Timmermann B, Lehrach H, Hirsch-Kauffmann M, Schweiger MR.
Cell Death Dis 5:e1195. doi: 10.1038/cddis.2014.157. 2014
13HMOX1
Heme oxygenase-1 and anti-inflammatory M2 macrophages.
Naito Y, Takagi T, Higashimura Y.
Arch Biochem Biophys 564:83-8. doi: 10.1016/j.abb.2014.09.005. Epub 2014 Sep 18. Review. 2014
14HMOX1
Heme oxygenase-1 has antitumoral effects in colorectal cancer: involvement of p53.
Andrés NC, Fermento ME, Gandini NA, Romero AL, Ferro A, Donna LG, Curino AC, Facchinetti MM.
Exp Mol Pathol 97(3):321-31. doi: 10.1016/j.yexmp.2014.09.012. Epub 2014 Sep 16. 2014
15HMOX1, NFE2L2
Nuclear heme oxygenase-1 (HO-1) modulates subcellular distribution and activation of Nrf2, impacting metabolic and anti-oxidant defenses.
Biswas C, Shah N, Muthu M, La P, Fernando AP, Sengupta S, Yang G, Dennery PA.
J Biol Chem 289(39):26882-94. doi: 10.1074/jbc.M114.567685. Epub 2014 Aug 8. 2014
16HMOX1
Critical neuroprotective roles of heme oxygenase-1 induction against axonal injury-induced retinal ganglion cell death.
Himori N, Maruyama K, Yamamoto K, Yasuda M, Ryu M, Omodaka K, Shiga Y, Tanaka Y, Nakazawa T.
J Neurosci Res 92(9):1134-42. doi: 10.1002/jnr.23398. Epub 2014 May 5. 2014
17HMOX1, PECAM1
PECAM-1-dependent heme oxygenase-1 regulation via an Nrf2-mediated pathway in endothelial cells.
Saragih H, Zilian E, Jaimes Y, Paine A, Figueiredo C, Eiz-Vesper B, Blasczyk R, Larmann J, Theilmeier G, Burg-Roderfeld M, Andrei-Selmer LC, Becker JU, Santoso S, Immenschuh S.
Thromb Haemost 111(6):1077-88. doi: 10.1160/TH13-11-0923. Epub 2014 Feb 6. 2014
18HMOX1, NFE2L2
Oncogenic potential of Nrf2 and its principal target protein heme oxygenase-1.
Na HK, Surh YJ.
Free Radic Biol Med 67:353-65. doi: 10.1016/j.freeradbiomed.2013.10.819. Epub 2013 Nov 5. Review. 2014
19HMOX1
Alternative 5' untranslated regions are involved in expression regulation of human heme oxygenase-1.
Kramer M, Sponholz C, Slaba M, Wissuwa B, Claus RA, Menzel U, Huse K, Platzer M, Bauer M.
PLoS One 8(10):e77224. doi: 10.1371/journal.pone.0077224. eCollection 2013. 2013
20HMOX1
Mitochondria-targeted heme oxygenase-1 decreases oxidative stress in renal epithelial cells.
Bolisetty S, Traylor A, Zarjou A, Johnson MS, Benavides GA, Ricart K, Boddu R, Moore RD, Landar A, Barnes S, Darley-Usmar V, Agarwal A.
Am J Physiol Renal Physiol 305(3):F255-64. doi: 10.1152/ajprenal.00160.2013. Epub 2013 May 29. 2013
21HMOX1
HO-1 as modulator of the innate immune response in pregnancy.
Kahlo K, Fill Malfertheiner S, Ignatov T, Jensen F, Costa SD, Schumacher A, Zenclussen AC.
Am J Reprod Immunol 70(1):24-30. doi: 10.1111/aji.12115. Epub 2013 Mar 22. 2013
22HMOX1
Heme oxygenase-1 attenuates epithelial-to-mesenchymal transition of human peritoneal mesothelial cells.
Bang K, Jeong J, Shin JH, Kang JH, Kim CN, Yeom HJ, Yoon MO, Yang J, Ahn C, Hwang JI, Park MY, Kim JH, Lee KW.
Clin Exp Nephrol 17(2):284-93. doi: 10.1007/s10157-012-0699-y. Epub 2012 Nov 14. 2013
23HMOX1, RNF139
TRC8 suppresses tumorigenesis through targeting heme oxygenase-1 for ubiquitination and degradation.
Lin PH, Lan WM, Chau LY.
Oncogene 32(18):2325-34. doi: 10.1038/onc.2012.244. Epub 2012 Jun 11. 2013
24HMOX1
Silencing heme oxygenase-1 gene expression in retinal pigment epithelial cells inhibits proliferation, migration and tube formation of cocultured endothelial cells
Zhang W, Zhang X, Lu H, Matsukura M, Zhao J, Shinohara M.
Biochem Biophys Res Commun. May 10;434(3):492-7. doi: 10.1016/j.bbrc.2013.03.101. Epub 2013 Apr 10. 2013
25HDAC6, HMOX1
Histone deacetylase 6 (HDAC6) plays a crucial role in p38MAPK-dependent induction of heme oxygenase-1 (HO-1) in response to proteasome inhibition.
Kästle M, Woschee E, Grune T.
Free Radic Biol Med 53(11):2092-101. doi: 10.1016/j.freeradbiomed.2012.09.023. Epub 2012 Sep 23. 2012
26HMOX1
Heme oxygenase-1 protects retinal endothelial cells against high glucose- and oxidative/nitrosative stress-induced toxicity.
Castilho Á, Aveleira CA, Leal EC, Simőes NF, Fernandes CR, Meirinhos RI, Baptista FI, Ambrósio AF.
PLoS One 7(8):e42428. doi: 10.1371/journal.pone.0042428. Epub 2012 Aug 3. 2012
27HMOX1, STC2
Stanniocalcin 2, forms a complex with heme oxygenase 1, binds hemin and is a heat shock protein.
Jiang J, Westberg JA, Andersson LC.
Biochem Biophys Res Commun 421(2):274-9. doi: 10.1016/j.bbrc.2012.03.151. Epub 2012 Apr 6. 2012
28ATF1, HMOX1
Activating transcription factor 1 directs Mhem atheroprotective macrophages through coordinated iron handling and foam cell protection.
Boyle JJ, Johns M, Kampfer T, Nguyen AT, Game L, Schaer DJ, Mason JC, Haskard DO.
Circ Res 110(1):20-33. doi: 10.1161/CIRCRESAHA.111.247577. Epub 2011 Nov 3. 2012
29BACH1, HMOX1
The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.
Warnatz HJ, Schmidt D, Manke T, Piccini I, Sultan M, Borodina T, Balzereit D, Wruck W, Soldatov A, Vingron M, Lehrach H, Yaspo ML.
J Biol Chem 286(26):23521-32. Epub 2011 May 9. 2011
30BMP6, HMOX1
BMP-6 inhibits MMP-9 expression by regulating heme oxygenase-1 in MCF-7 breast cancer cells.
Wang C, Hu F, Guo S, Mi D, Shen W, Zhang J, Qiao Y, Zhu T, Yang S.
J Cancer Res Clin Oncol 137(6):985-95. Epub 2010 Dec 7. 2011
31HMOX1
Human haem oxygenase-1 induction by nitro-linoleic acid is mediated by cAMP, AP-1 and E-box response element interactions.
Wright MM, Kim J, Hock TD, Leitinger N, Freeman BA, Agarwal A.
Biochem J 422(2):353-61. 2009
32BACH1, HMOX1
BACH1 is a specific repressor of HMOX1 that is inactivated by arsenite.
Reichard JF, Sartor MA, Puga A.
J Biol Chem 283(33):22363-70. Epub 2008 Jun 11. 2008
33HMOX1
Identification of heat shock protein 32 (Hsp32) as a novel survival factor and therapeutic target in neoplastic mast cells.
Kondo R, Gleixner KV, Mayerhofer M, Vales A, Gruze A, Samorapoompichit P, Greish K, Krauth MT, Aichberger KJ, Pickl WF, Esterbauer H, Sillaber C, Maeda H, Valent P.
Blood 110(2):661-9. Epub 2007 Apr 9. 2007
34HMOX1
Expression and characterization of full-length human heme oxygenase-1: the presence of intact membrane-binding region leads to increased binding affinity for NADPH cytochrome P450 reductase.
Huber WJ 3rd, Backes WL.
Biochemistry 46(43):12212-9. Epub 2007 Oct 4.PMID: 17915953 2007
35HMOX1, FOXP3
Critical role of heme oxygenase-1 in Foxp3-mediated immune suppression.
Choi BM, Pae HO, Jeong YR, Kim YM, Chung HT.
Biochem Biophys Res Commun 327(4):1066-71. 2005
36HMOX1, BACH1
Role of Bach-1 in regulation of heme oxygenase-1 in human liver cells: insights from studies with small interfering RNAS.
Shan Y, Lambrecht RW, Ghaziani T, Donohue SE, Bonkovsky HL.
J Biol Chem 279(50):51769-74. Epub 2004 Oct 1. 2004
37HMOX1
Interaction of nitric oxide with human heme oxygenase-1.
Wang J, Lu S, Moenne-Loccoz P, Ortiz de Montellano PR.
J Biol Chem 278(4):2341-7. Epub 2002 Nov 13. 2003
38HMOX1
Association of a promoter variant of the haeme oxygenase-1 gene with hypertension in women.
Ono K, Mannami T, Iwai N.
J Hypertens 21(8):1497-503. 2003
39HMOX1
Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema.
Yamada N, Yamaya M, Okinaga S, Nakayama K, Sekizawa K, Shibahara S, Sasaki H.
Am J Hum Genet 66(1):187-95. 2000
40HMOX1
Microsatellite polymorphism in the human heme oxygenase-1 gene promoter and its application in association studies with Alzheimer and Parkinson disease.
Kimpara T, Takeda A, Watanabe K, Itoyama Y, Ikawa S, Watanabe M, Arai H, Sasaki H, Higuchi S, Okita N, Takase S, Saito H, Takahashi K, Shibahara S.
Hum Genet 100(1):145-7. 1997
41EPHX1, HMOX1
Association between polymorphism in gene for microsomal epoxide hydrolase and susceptibility to emphysema.
Smith CA, Harrison DJ.
Lancet 350(9078):630-3. 1997
42HMOX1, HMOX2
Heme oxygenase : a novel target for the modulation of the inflammatory response.
Willis D, Moore AR, Frederick R, Willoughby DA.
Nat Med 2 : 87-90. 1996
43HMOX2, HMOX1
Chromosomal localization fo the human heme oxygenase genes : heme oxygenase-1 (HMOX1) maps to chromosome 22q12 and heme oxygenase-2 (HMOX2) maps to chromosome 16p13.3.
Kutty RK, et al.
Genomics 20 : 513-516. 1994
44HMOX1
Mapping of the human gene for inducible heme oxygenase to chromosome 22q12.
Kuwano A, et al.
Tohoku J Exp Med 172 : 389-392. 1994