| 1 | FUBP1, HK1, HK2
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| Fubp1 supports the lactate-Akt-mTOR axis through the upregulation of Hk1 and Hk2.
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| Kang M, Lee SM, Kim W, Lee KH, Kim DY.
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| Biochem Biophys Res Commun. Apr 23;512(1):93-99. doi: 10.1016/j.bbrc.2019.03.005. Epub 2019 Mar 11 2019
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| 2 | CYGB, HK2, SLC2A1
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| The epigenetically downregulated factor CYGB suppresses breast cancer through inhibition of glucose metabolism
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| Feng Y, Wu M, Li S, He X, Tang J, Peng W, Zeng B, Deng C, Ren G, Xiang T.
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| J Exp Clin Cancer Res. Dec 13;37(1):313. doi: 10.1186/s13046-018-0979-9. 2018
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| 3 | ATP6V0C, HK2
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| Vma3p protects cells from programmed cell death through the regulation of Hxk2p expression. 2017
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| Konarzewska P, Sherr GL, Ahmed S, Ursomanno B, Shen CH.
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| Biochem Biophys Res Commun. Nov 4;493(1):233-239. doi: 10.1016/j.bbrc.2017.09.041. Epub 2017 Sep 9 2017
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| 4 | HK2
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| Hexokinase 2 in colorectal cancer: a potent prognostic factor associated with glycolysis, proliferation and migration.
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| Katagiri M, Karasawa H, Takagi K, Nakayama S, Yabuuchi S, Fujishima F, Naitoh T, Watanabe M, Suzuki T, Unno M, Sasano H.
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| Histol Histopathol. Apr;32(4):351-360. doi: 10.14670/HH-11-799. Epub 2016 Jul 1. 2017
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| 5 | HK2, SLC2A1, TRAF3
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| TRAF3 deficiency promotes metabolic reprogramming in B cells
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| Mambetsariev N, Lin WW, Wallis AM, Stunz LL, Bishop GA
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| Sci Rep. Oct 18;6:35349. doi: 10.1038/srep35349. 2016
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| 6 | HK2
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| Inhibition of glycolytic enzyme hexokinase II (HK2) suppresses lung tumor growth.
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| Wang H, Wang L, Zhang Y, Wang J, Deng Y, Lin D.
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| Cancer Cell Int Feb 16;16:9. doi: 10.1186/s12935-016-0280-y. eCollection 2016 2016
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| 7 | HK2
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| HK2/hexokinase-II integrates glycolysis and autophagy to confer cellular protection.
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| Tan VP, Miyamoto S.
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| Autophagy. 11(6):963-4. doi: 10.1080/15548627.2015.1042195. 2015
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| 8 | HK2
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| Hexokinase 2 regulates G1/S checkpoint through CDK2 in cancer-associated fibroblasts.
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| Hu JW, Sun P, Zhang DX, Xiong WJ, Mi J.
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| Cell Signal. Oct;26(10):2210-6. doi: 10.1016/j.cellsig.2014.04.015. Epub 2014 Apr 26 2014
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| 9 | HK2
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| Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer
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| Patra KC, Wang Q, Bhaskar PT, Miller L, Wang Z, Wheaton W, Chandel N, Laakso M, Muller WJ, Allen EL, Jha AK, Smolen GA, Clasquin MF, Robey B, Hay N.
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| Cancer Cell. Aug 12;24(2):213-228. doi: 10.1016/j.ccr.2013.06.014. Epub 2013 Aug 1. Erratum in: Cancer Cell. 2013 Sep 9;24(3):399 2013
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| 10 | HK2, UCP3
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| Hexokinase II acts through UCP3 to suppress mitochondrial reactive oxygen species production and maintain aerobic respiration.
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| Mailloux RJ, Dumouchel T, Aguer C, deKemp R, Beanlands R, Harper ME.
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| Biochem J 437(2):301-11.
2011
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| 11 | HK2
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| Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme
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| Wolf A, Agnihotri S, Micallef J, Mukherjee J, Sabha N, Cairns R, Hawkins C, Guha A.
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| J Exp Med. Feb 14;208(2):313-26. doi: 10.1084/jem.20101470. Epub 2011 Jan 17. 2011
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| 12 | HK1, HK2, VDAC1
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| Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its anti-apoptotic activity.
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| Arzoine L, Zilberberg N, Ben-Romano R, Shoshan-Barmatz V.
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| J Biol Chem 284(6):3946-55. Epub 2008 Dec 2.PMID: 19049977 2009
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| 13 | HK1, HK2
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| Enzymatic properties of the N- and C-terminal halves of human hexokinase II.
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| Ahn KJ, Kim J, Yun M, Park JH, Lee JD.
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| BMB Rep 42(6):350-5.PMID: 19558793 2009
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| 14 | GSK3B, HK2
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| Mitochondrial hexokinase II promotes neuronal survival and acts downstream of glycogen synthase kinase-3.
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| Gimenez-Cassina A, Lim F, Cerrato T, Palomo GM, Diaz-Nido J.
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| J Biol Chem 284(5):3001-11. Epub 2008 Nov 25.PMID: 19033437 2009
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| 15 | TFE3, IRS2, HK2, INSIG1
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| TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes.
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| Nakagawa Y, Shimano H, Yoshikawa T, Ide T, Tamura M, Furusawa M, Yamamoto T, Inoue N, Matsuzaka T, Takahashi A, Hasty AH, Suzuki H, Sone H, Toyoshima H, Yahagi N, Yamada N.
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| Nat Med 12(1):107-13. Epub 2005 Dec 4. 2006
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| 16 | HK2
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| Hypoxia stimulates proliferation of human hepatoma cells through the induction of hexokinase II expression.
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| Gwak GY, Yoon JH, Kim KM, Lee HS, Chung JW, Gores GJ.
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| J Hepatol 42(3):358-64.PMID: 15710218 2005
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| 17 | HK2
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| Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53.
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| Mathupala SP, Heese C, Pedersen PL.
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| J Biol Chem 272(36):22776-80. 1997
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| 18 | HK2
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| A novel (TA)n polymorphism in the hexokinase II gene : application to noninsulin-dependent diabetes mellitus in the Pima Indians.
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| Ardehali H, et al.
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| Hum Genet 97 : 482-485. 1996
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| 19 | HK2, HK2P1
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| Human hexokinase II gene : exon-intron organization, mutation screening in NIDDM, and its relationship to muscle hexokinase activity.
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| Lehto M, et al.
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| Diabetologia 38 : 1466-1474. 1995
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| 20 | HK2
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| Human hexokinase II mRNA and gene structure.
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| Printz RL, et al.
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| Diabetes 44 : 290-294. 1995
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| 21 | HK2
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| Human hexokinase II : localization of the polymorphic gene to chromosome 2.
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| Lehto M, et al.
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| Diabetologia 36 : 1299-1302. 1993
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