1 | HIPK2
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| Tumor suppressor HIPK2 regulates malignant growth via phosphorylation of Notch1.
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| Ann EJ, Kim MY, Yoon JH, Ahn JS, Jo EH, Lee HJ, Lee HW, Kang HG, Choi DW, Chun KH, Lee JS, Choi CY, Ferrando AA, Lee K, Park HS.
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| Cancer Res ancer Res. 2016 Jun 22. pii: canres.3310.2015. [Epub ahead of print]
2016
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2 | HIPK2
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| Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis.
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| Lee S, Shang Y, Redmond SA, Urisman A, Tang AA, Li KH, Burlingame AL, Pak RA, Jovičić A, Gitler AD, Wang J, Gray NS, Seeley WW, Siddique T, Bigio EH, Lee VM, Trojanowski JQ, Chan JR, Huang EJ.
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| Neuron 91(1):41-55. doi: 10.1016/j.neuron.2016.05.021. Epub 2016 Jun 16.
2016
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3 | HIPK2
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| Heat shock modulates the subcellular localization, stability, and activity of HIPK2.
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| Upadhyay M, Bhadauriya P, Ganesh S.
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| Biochem Biophys Res Commun 472(4):580-4. doi: 10.1016/j.bbrc.2016.03.035. Epub 2016 Mar 10.
2016
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4 | CNOT2, CNOT3, HIPK1, HIPK2
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| HIPK family kinases bind and regulate the function of the CCR4-NOT complex.
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| Rodriguez-Gil A, Ritter O, Hornung J, Stekman H, Krüger M, Braun T, Kremmer E, Kracht M, Schmitz ML.
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| Mol Biol Cell 27(12):1969-80. doi: 10.1091/mbc.E15-09-0629. Epub 2016 Apr 27.
2016
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5 | CREBBP, HIPK2
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| Complex regulation of CREB-binding protein by homeodomain-interacting protein kinase 2.
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| Kovács KA, Steinmann M, Halfon O, Magistretti PJ, Cardinaux JR.
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| Cell Signal 27(11):2252-60. doi: 10.1016/j.cellsig.2015.08.001. Epub 2015 Aug 4.
2015
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6 | ABL1, HIPK2, PML
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| The Tyrosine Kinase c-Abl Promotes Homeodomain-interacting Protein Kinase 2 (HIPK2) Accumulation and Activation in Response to DNA Damage.
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| Reuven N, Adler J, Porat Z, Polonio-Vallon T, Hofmann TG, Shaul Y.
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| J Biol Chem 290(27):16478-88. doi: 10.1074/jbc.M114.628982. Epub 2015 May 5.
2015
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7 | HIPK2
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| HIPK2 deficiency causes chromosomal instability by cytokinesis failure and increases tumorigenicity.
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| Valente D, Bossi G, Moncada A, Tornincasa M, Indelicato S, Piscuoglio S, Karamitopoulou ED, Bartolazzi A, Pierantoni GM, Fusco A, Soddu S, Rinaldo C.
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| Oncotarget 6(12):10320-34.
2015
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8 | HIPK1, HIPK2, HIPK3
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| Effect of tyrosine autophosphorylation on catalytic activity and subcellular localisation of homeodomain-interacting protein kinases (HIPK).
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| van der Laden J, Soppa U, Becker W.
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| Cell Commun Signal 13:3. doi: 10.1186/s12964-014-0082-6.
2015
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9 | AATF, HIPK2
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| HIPK2 sustains apoptotic response by phosphorylating Che-1/AATF and promoting its degradation.
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| De Nicola F, Catena V, Rinaldo C, Bruno T, Iezzi S, Sorino C, Desantis A, Camerini S, Crescenzi M, Floridi A, Passananti C, Soddu S, Fanciulli M.
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| Cell Death Dis 5:e1414. doi: 10.1038/cddis.2014.381.
2014
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10 | HIPK2
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| Identification of Hipk2 as an essential regulator of white fat development.
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| Sjölund J, Pelorosso FG, Quigley DA, DelRosario R, Balmain A.
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| Proc Natl Acad Sci U S A 111(20):7373-8. doi: 10.1073/pnas.1322275111. Epub 2014 Apr 30.
2014
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11 | HIPK2, PIN1, SIAH2
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| Autophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death.
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| Bitomsky N, Conrad E, Moritz C, Polonio-Vallon T, Sombroek D, Schultheiss K, Glas C, Greiner V, Herbel C, Mantovani F, del Sal G, Peri F, Hofmann TG.
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| Proc Natl Acad Sci U S A 110(45):E4203-12. doi: 10.1073/pnas.1310001110. Epub 2013 Oct 21.
2013
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12 | HIPK2, SIRT1
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| SIRT1 negatively regulates the protein stability of HIPK2.
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| Hwang J, Lee SY, Choi JR, Shin KS, Choi CY, Kang SJ.
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| Biochem Biophys Res Commun 441(4):799-804. doi: 10.1016/j.bbrc.2013.10.133. Epub 2013 Nov 5.
2013
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13 | HIPK2
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| Homeodomain-interacting protein kinase2 in human idiopathic pulmonary fibrosis.
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| Ricci A, Cherubini E, Ulivieri A, Lavra L, Sciacchitano S, Scozzi D, Mancini R, Ciliberto G, Bartolazzi A, Bruno P, Graziano P, Mariotta S.
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| J Cell Physiol 228(1):235-41. doi: 10.1002/jcp.24129.
2013
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14 | HIPK1, HIPK2
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| Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-β-TAK1-dependent mechanism.
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| Shang Y, Doan CN, Arnold TD, Lee S, Tang AA, Reichardt LF, Huang EJ.
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| PLoS Biol 11(4):e1001527. doi: 10.1371/journal.pbio.1001527. Epub 2013 Apr 2.
2013
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15 | HIPK2
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| A redox-regulated SUMO/acetylation switch of HIPK2 controls the survival threshold to oxidative stress.
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| de la Vega L, Grishina I, Moreno R, Krüger M, Braun T, Schmitz ML.
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| Mol Cell 46(4):472-83. doi: 10.1016/j.molcel.2012.03.003. Epub 2012 Apr 12.
2012
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16 | HIPK2, ZYX
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| Zyxin is a critical regulator of the apoptotic HIPK2-p53 signaling axis.
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| Crone J, Glas C, Schultheiss K, Moehlenbrink J, Krieghoff-Henning E, Hofmann TG.
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| Cancer Res 71(6):2350-9. Epub 2011 Jan 19.
2011
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17 | HIPK2
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| Role of the SUMO-interacting motif in HIPK2 targeting to the PML nuclear bodies and regulation of p53.
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| Sung KS, Lee YA, Kim ET, Lee SR, Ahn JH, Choi CY.
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| Exp Cell Res 317(7):1060-70. Epub 2010 Dec 28.
2011
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18 | CDKN1B, HIPK2
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| Homeodomain-interacting protein kinase-2 stabilizes p27(kip1) by its phosphorylation at serine 10 and contributes to cell motility.
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| Pierantoni GM, Esposito F, Tornincasa M, Rinaldo C, Viglietto G, Soddu S, Fusco A.
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| J Biol Chem 286(33):29005-13. Epub 2011 Jun 29.
2011
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19 | HIPK2
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| HIPK2 phosphorylates ΔNp63α and promotes its degradation in response to DNA damage.
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| Lazzari C, Prodosmo A, Siepi F, Rinaldo C, Galli F, Gentileschi M, Bartolazzi A, Costanzo A, Sacchi A, Guerrini L, Soddu S.
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| Oncogene 30(48):4802-13. doi: 10.1038/onc.2011.182. Epub 2011 May 23.
2011
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20 | HIPK2
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| Homeodomain-interacting protein kinase 2 (HIPK2) targets beta-catenin for phosphorylation and proteasomal degradation.
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| Kim EA, Kim JE, Sung KS, Choi DW, Lee BJ, Choi CY.
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| Biochem Biophys Res Commun 394(4):966-71. Epub 2010 Mar 20.
2010
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21 | HIPK1, HIPK2, HIPK3, HIPK4
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| Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis.
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| Inoue T, Kagawa T, Inoue-Mochita M, Isono K, Ohtsu N, Nobuhisa I, Fukushima M, Tanihara H, Taga T.
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| FEBS Lett 584(14):3233-8. Epub 2010 Jun 19.
2010
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22 | HIPK1, HIPK2, HIPK3, HIPK4
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| Characterization of Human Homeodomain-interacting Protein Kinase 4 (HIPK4) as a Unique Member of the HIPK Family.
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| He Q, Shi J, Sun H, An J, Huang Y, Sheikh MS.
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| Mol Cell Pharmacol 2(2):61-68.PMID: 20508833 2010
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23 | DCAF7, DYRK1A, DYRK1B, HIPK2, MAP3K1
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| The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions.
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| Ritterhoff S, Farah CM, Grabitzki J, Lochnit G, Skurat AV, Schmitz ML.
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| EMBO J 29(22):3750-61. Epub 2010 Oct 12. 2010
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24 | HIPK2, SIAH2
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| An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response.
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| Calzado MA, de la Vega L, Möller A, Bowtell DD, Schmitz ML.
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| Nat Cell Biol 11(1):85-91. Epub 2008 Nov 30.
2009
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25 | HIPK2
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| Transcriptional regulation of hypoxia-inducible factor 1alpha by HIPK2 suggests a novel mechanism to restrain tumor growth.
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| Nardinocchi L, Puca R, Guidolin D, Belloni AS, Bossi G, Michiels C, Sacchi A, Onisto M, D'Orazi G.
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| Biochim Biophys Acta 1793(2):368-77. Epub 2008 Nov 6.
2009
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26 | HIPK2, PML
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| PML tumor suppressor is regulated by HIPK2-mediated phosphorylation in response to DNA damage.
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| Gresko E, Ritterhoff S, Sevilla-Perez J, Roscic A, Fröbius K, Kotevic I, Vichalkovski A, Hess D, Hemmings BA, Schmitz ML.
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| Oncogene 28(5):698-708. Epub 2008 Nov 17. 2009
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27 | HIPK2, ZBTB4
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| The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4.
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| Yamada D, Pérez-Torrado R, Filion G, Caly M, Jammart B, Devignot V, Sasai N, Ravassard P, Mallet J, Sastre-Garau X, Schmitz ML, Defossez PA.
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| Oncogene 28(27):2535-44. Epub 2009 May 18.
2009
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28 | HIPK2, MECP2
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| Methyl-CpG-binding protein 2 is phosphorylated by homeodomain-interacting protein kinase 2 and contributes to apoptosis.
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| Bracaglia G, Conca B, Bergo A, Rusconi L, Zhou Z, Greenberg ME, Landsberger N, Soddu S, Kilstrup-Nielsen C.
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| EMBO Rep 10(12):1327-33. Epub 2009 Oct 9.PMID: 19820693 2009
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29 | HIPK2, WSB1
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| Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1.
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| Choi DW, Seo YM, Kim EA, Sung KS, Ahn JW, Park SJ, Lee SR, Choi CY.
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| J Biol Chem 283(8):4682-9. Epub 2007 Dec 19. 2008
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30 | EP300, HIPK2, PML
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| PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation.
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| Shima Y, Shima T, Chiba T, Irimura T, Pandolfi PP, Kitabayashi I.
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| Mol Cell Biol 28(23):7126-38. Epub 2008 Sep 22.
2008
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31 | HIPK2
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| HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis.
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| Wei G, Ku S, Ma GK, Saito S, Tang AA, Zhang J, Mao JH, Appella E, Balmain A, Huang EJ.
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| Proc Natl Acad Sci U S A 104(32):13040-5. Epub 2007 Jul 31. 2007
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32 | HIPK2, HMGA1
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| Homeodomain-interacting protein kinase-2 (HIPK2) phosphorylates HMGA1a at Ser-35, Thr-52, and Thr-77 and modulates its DNA binding affinity.
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| Zhang Q, Wang Y.
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| J Proteome Res 6(12):4711-9. Epub 2007 Oct 26.
2007
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33 | HIPK1, HIPK2
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| Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation.
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| Aikawa Y, Nguyen LA, Isono K, Takakura N, Tagata Y, Schmitz ML, Koseki H, Kitabayashi I.
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| EMBO J 25(17):3955-65. Epub 2006 Aug 17.PMID: 16917507 2006
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34 | HIPK1, HIPK2, HIPK3
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| Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals.
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| Isono K, Nemoto K, Li Y, Takada Y, Suzuki R, Katsuki M, Nakagawara A, Koseki H.
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| Mol Cell Biol 26(7):2758-71.PMID: 16537918 2006
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35 | HIPK2,MDM2
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| HIPK2 inhibits both MDM2 gene and protein by, respectively, p53-dependent and independent regulations.
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| Di Stefano V, Mattiussi M, Sacchi A, D'Orazi G.
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| FEBS Lett 579(25):5473-80. Epub 2005 Sep 27. 2005
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36 | HIPK2, TP53, TP73
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| Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo.
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| Kim EJ, Park JS, Um SJ.
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| J Biol Chem 277(35):32020-8. Epub 2002 Mar 29. 2002
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37 | HIPK2
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| Human homeodomain-interacting protein kinase-2 (HIPK2) is a member of the DYRK family of protein kinases and maps to chromosome 7q32-q34.
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| Hofmann TG, Mincheva A, Lichter P, Droge W, Lienhard Schmitz M.
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| Biochimie 82(12):1123-7. 2000
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