| 1 | HIC1, LCN2
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| HIC1 silencing in triple-negative breast cancer drives progression through misregulation of LCN2.
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| Cheng G, Sun X, Wang J, Xiao G, Wang X, Fan X, Zu L, Hao M, Qu Q, Mao Y, Xue Y, Wang J.
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| Cancer Res 74(3):862-72. doi: 10.1158/0008-5472.CAN-13-2420. Epub 2013 Dec 2.
2014
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| 2 | HIC1, LRP8, VLDLR
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| The Reelin receptors ApoER2 and VLDLR are direct target genes of HIC1 (Hypermethylated In Cancer 1).
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| Dubuissez M, Faiderbe P, Pinte S, Dehennaut V, Rood BR, Leprince D.
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| Biochem Biophys Res Commun 440(3):424-30. doi: 10.1016/j.bbrc.2013.09.091. Epub 2013 Sep 25.
2013
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| 3 | HIC1, STAT3
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| HIC1 interacts with and modulates the activity of STAT3.
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| Lin YM, Wang CM, Jeng JC, Leprince D, Shih HM.
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| Cell Cycle 12(14):2266-76. doi: 10.4161/cc.25365.
2013
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| 4 | HIC1
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| DNA double-strand breaks lead to activation of hypermethylated in cancer 1 (HIC1) by SUMOylation to regulate DNA repair.
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| Dehennaut V, Loison I, Dubuissez M, Nassour J, Abbadie C, Leprince D.
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| J Biol Chem 288(15):10254-64. doi: 10.1074/jbc.M112.421610. Epub 2013 Feb 15.
2013
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| 5 | HIC1
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| HIC1 modulates prostate cancer progression by epigenetic modification.
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| Zheng J, Wang J, Sun X, Hao M, Ding T, Xiong D, Wang X, Zhu Y, Xiao G, Cheng G, Zhao M, Zhang J, Wang J.
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| Clin Cancer Res 19(6):1400-10. doi: 10.1158/1078-0432.CCR-12-2888. Epub 2013 Jan 22.
2013
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| 6 | CDKN1A, HIC1
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| Identification of p21 (CIP1/WAF1) as a direct target gene of HIC1 (Hypermethylated In Cancer 1).
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| Dehennaut V, Loison I, Boulay G, Van Rechem C, Leprince D.
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| Biochem Biophys Res Commun 430(1):49-53. doi: 10.1016/j.bbrc.2012.11.045. Epub 2012 Nov 22.
2013
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| 7 | EPHA2, HIC1
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| The receptor tyrosine kinase EphA2 is a direct target gene of hypermethylated in cancer 1 (HIC1).
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| Foveau B, Boulay G, Pinte S, Van Rechem C, Rood BR, Leprince D.
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| J Biol Chem 287(8):5366-78. doi: 10.1074/jbc.M111.329466. Epub 2011 Dec 19.
2012
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| 8 | EPHA1, HIC1
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| A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1.
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| Zhang W, Zeng X, Briggs KJ, Beaty R, Simons B, Chiu Yen RW, Tyler MA, Tsai HC, Ye Y, Gesell GS, Herman JG, Baylin SB, Watkins DN.
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| Oncogene 29(17):2467-76. doi: 10.1038/onc.2010.12. Epub 2010 Feb 15.
2010
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| 9 | ACKR3, HIC1
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| Scavenger Chemokine (CXC Motif) Receptor 7 (CXCR7) Is a Direct Target Gene of HIC1 (Hypermethylated in Cancer 1).
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| Van Rechem C, Rood BR, Touka M, Pinte S, Jenal M, Guérardel C, Ramsey K, Monté D, Bégue A, Tschan MP, Stephan DA, Leprince D.
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| J Biol Chem 284(31):20927-35. Epub 2009 Jun 12. 2009
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| 10 | ARID1A, E2F1, HIC1, SMARCA4
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| HIC1 interacts with a specific subunit of SWI/SNF complexes, ARID1A/BAF250A.
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| Van Rechem C, Boulay G, Leprince D.
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| Biochem Biophys Res Commun 385(4):586-90. Epub 2009 May 30. 2009
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| 11 | E2F1, HIC1
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| Requirement for chromatin-remodeling complex in novel tumor suppressor HIC1-mediated transcriptional repression and growth control.
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| Zhang B, Chambers KJ, Leprince D, Faller DV, Wang S.
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| Oncogene 28(5):651-61. Epub 2008 Nov 17.
2009
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| 12 | HIC1
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| Detailed mapping of chromosome 17p deletions reveals HIC1 as a novel tumor suppressor gene candidate telomeric to TP53 in diffuse large B-cell lymphoma.
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| Stöcklein H, Smardova J, Macak J, Katzenberger T, Höller S, Wessendorf S, Hutter G, Dreyling M, Haralambieva E, Mäder U, Müller-Hermelink HK, Rosenwald A, Ott G, Kalla J.
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| Oncogene 27(18):2613-25. Epub 2007 Nov 5.
2008
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| 13 | HIC1
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| An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity.
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| Stankovic-Valentin N, Deltour S, Seeler J, Pinte S, Vergoten G, Guérardel C, Dejean A, Leprince D.
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| Mol Cell Biol 27(7):2661-75. Epub 2007 Feb 5.
2007
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| 14 | HIC1, SIRT1
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| Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex.
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| Zhang Q, Wang SY, Fleuriel C, Leprince D, Rocheleau JV, Piston DW, Goodman RH.
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| Proc Natl Acad Sci U S A 104(3):829-33. Epub 2007 Jan 9.
2007
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| 15 | HIC1, TCF4
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| HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies.
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| Valenta T, Lukas J, Doubravska L, Fafilek B, Korinek V.
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| EMBO J 25(11):2326-37. Epub 2006 May 25.
2006
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| 16 | HIC1
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| Identification of the p53 family-responsive element in the promoter region of the tumor suppressor gene hypermethylated in cancer 1.
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| Britschgi C, Rizzi M, Grob TJ, Tschan MP, Hügli B, Reddy VA, Andres AC, Torbett BE, Tobler A, Fey MF.
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| Oncogene 25(14):2030-9.
2006
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| 17 | HIC1, SIRT1
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| Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses.
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| Chen WY, Wang DH, Yen RC, Luo J, Gu W, Baylin SB.
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| Cell 123(3):437-48. 2005
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| 18 | HIC1
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| HIC1 promoter methylation and 17p13.3 allelic loss in invasive ductal carcinoma of the breast.
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| Parrella P, Scintu M, Prencipe M, Poeta ML, Gallo AP, Rabitti C, Rinaldi M, Tommasi S, Paradiso A, Schittulli F, Valori VM, Toma S, Altomare V, Fazio VM.
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| Cancer Lett 222(1):75-81. 2005
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| 19 | HIC1
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| Identification of a second G-C-rich promoter conserved in the human, murine and rat tumor suppressor genes HIC1.
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| Pinte S, Guerardel C, Deltour-Balerdi S, Godwin AK, Leprince D.
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| Oncogene 23(22):4023-31. 2004
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| 20 | HIC1, TSG17D
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| Epigenetic silencing of the HIC-1 gene in human medulloblastomas.
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| Waha A, Waha A, Koch A, Meyer-Puttlitz B, Weggen S, Sorensen N, Tonn JC, Albrecht S, Goodyer CG, Berthold F, Wiestler OD, Pietsch T.
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| J Neuropathol Exp Neurol 62(11):1192-201. 2003
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| 21 | HIC1
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| Identification in the human candidate tumor suppressor gene HIC-1 of a new major alternative TATA-less promoter positively regulated by p53.
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| Guerardel C, Deltour S, Pinte S, Monte D, Begue A, Godwin AK, Leprince D.
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| J Biol Chem 276(5):3078-89. 2001
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| 22 | HIC1
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| Mice deficient in the candidate tumor suppressor gene Hic1 exhibit developmental defects of structures affected in the Miller-Dieker syndrome.
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| Carter MG, Johns MA, Zeng X, Zhou L, Zink MC, Mankowski JL, Donovan DM, Baylin SB.
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| Hum Mol Genet 9(3):413-419 2000
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| 23 | CRK, HIC1
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| Physical and transcriptional mapping of the 17p13.3 region that is frequently deleted in human cancer.
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| Hoff C, Seranski P, Mollenhauer J, Korn B, Detzel T, Reinhardt R, Ramser J, Poustka A.
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| Genomics 70(1):26-33. 2000
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| 24 | HIC1
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| Isolation and embryonic expression of the novel mouse gene hic1, the homologue of HIC1, a candidate gene for the miller-dieker syndrome.
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| Grimm C, et al.
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| Hum Mol Genet 8(4):697-710. 1999
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| 25 | FXR2, HIC1
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| Ordering of 66 STSs along the entire short arm of human chromosome 17 and chromosome assignment of a transcribed sequence (FMR1L2) homologous to FMR1.
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| Wilgenbus KK, Coy JF, Mincheva A, Nicolai H, Solomon E, Lichter P, Poustka A.
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| Cytogenet Cell Genet 73(3):240-3. 1996
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| 26 | HIC1
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| p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3.
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| Wales MM, et al.
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| Nat Med 1 : 570-577. 1995
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