Citations for
1CCNT1, HEXIM1
Hexim1, an RNA-controlled protein hub.
Michels AA, Bensaude O.
Transcription ranscription. 2018 Feb 23. doi: 10.1080/21541264.2018.1429836. [Epub ahead of print] 2018
2HEXIM1, NEAT1
HEXIM1 Has Different Functions within Different RNA-Protein Complexes.
Bensaude O.
Mol Cell 67(3):357-359. doi: 10.1016/j.molcel.2017.07.021. 2017
3HEXIM1, NEAT1
HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex that Regulates DNA-Mediated Innate Immune Response.
Morchikh M, Cribier A, Raffel R, Amraoui S, Cau J, Severac D, Dubois E, Schwartz O, Bennasser Y, Benkirane M.
Mol Cell 67(3):387-399.e5. doi: 10.1016/j.molcel.2017.06.020. Epub 2017 Jul 14. 2017
4CCNT1, CDK9, HEXIM1
An evolutionary conserved Hexim1 peptide binds to the Cdk9 catalytic site to inhibit P-TEFb.
Kobbi L, Demey-Thomas E, Braye F, Proux F, Kolesnikova O, Vinh J, Poterszman A, Bensaude O.
Proc Natl Acad Sci U S A roc Natl Acad Sci U S A. 2016 Oct 25. pii: 201612331. [Epub ahead of print] 2016
5HEXIM1
Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma.
Tan JL, Fogley RD, Flynn RA, Ablain J, Yang S, Saint-André V, Fan ZP, Do BT, Laga AC, Fujinaga K, Santoriello C, Greer CB, Kim YJ, Clohessy JG, Bothmer A, Pandell N, Avagyan S, Brogie JE, van Rooijen E, Hagedorn EJ, Shyh-Chang N, White RM, Price DH, Pandolfi PP, Peterlin BM, Zhou Y, Kim TH, Asara JM, Chang HY, Young RA, Zon LI.
Mol Cell 62(1):34-46. doi: 10.1016/j.molcel.2016.03.013. 2016
6HEXIM1
Hexim1, a Novel Regulator of Leptin Function, Modulates Obesity and Glucose Disposal.
Dhar-Mascareno M, Ramirez SN, Rozenberg I, Rouille Y, Kral JG, Mascareno EJ.
Mol Endocrinol 30(3):314-24. doi: 10.1210/me.2015-1211. Epub 2016 Feb 9. 2016
7CCNT1, HEXIM1, LARP7, MEPCE, TAT
Solution structure of the 5'-terminal hairpin of the 7SK small nuclear RNA.
Bourbigot S, Dock-Bregeon AC, Eberling P, Coutant J, Kieffer B, Lebars I.
RNA 22(12):1844-1858. Epub 2016 Oct 20. 2016
8HEXIM1, LARP7, MEPCE
Intermolecular recognition of the non-coding RNA 7SK and HEXIM protein in perspective.
Martinez-Zapien D, Saliou JM, Han X, Atmanene C, Proux F, Cianférani S, Dock-Bregeon AC.
Biochimie 117:63-71. doi: 10.1016/j.biochi.2015.03.020. Epub 2015 Apr 8. 2015
9HEXIM1
HEXIM1 plays a critical role in the inhibition of the androgen receptor by anti-androgens.
Yeh IJ, Song K, Wittmann BM, Bai X, Danielpour D, Montano MM.
Biochem J 462(2):315-27. doi: 10.1042/BJ20140174. 2014
10CCNT1, HEXIM1, LARP7, MEPCE
Release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein (snRNP) activates hexamethylene bisacetamide-inducible protein (HEXIM1) transcription.
Liu P, Xiang Y, Fujinaga K, Bartholomeeusen K, Nilson KA, Price DH, Peterlin BM.
J Biol Chem 289(14):9918-25. doi: 10.1074/jbc.M113.539015. Epub 2014 Feb 10. 2014
11HDAC1, HEXIM1, HIF1A
HEXIM1 down-regulates hypoxia-inducible factor-1α protein stability.
Yeh IJ, Ogba N, Bensigner H, Welford SM, Montano MM.
Biochem J 456(2):195-204. doi: 10.1042/BJ20130592. 2013
12HEXIM1
HEXIM1 induces differentiation of human pluripotent stem cells.
Ding V, Lew QJ, Chu KL, Natarajan S, Rajasegaran V, Gurumurthy M, Choo AB, Chao SH.
PLoS One 8(8):e72823. doi: 10.1371/journal.pone.0072823. eCollection 2013. 2013
13HEXIM1
Inhibition of metastasis by HEXIM1 through effects on cell invasion and angiogenesis.
Ketchart W, Smith KM, Krupka T, Wittmann BM, Hu Y, Rayman PA, Doughman YQ, Albert JM, Bai X, Finke JH, Xu Y, Exner AA, Montano MM.
Oncogene 32(33):3829-39. doi: 10.1038/onc.2012.405. Epub 2012 Sep 10. 2013
14HEXIM1, TP53
Identification of HEXIM1 as a positive regulator of p53.
Lew QJ, Chia YL, Chu KL, Lam YT, Gurumurthy M, Xu S, Lam KP, Cheong N, Chao SH.
J Biol Chem 287(43):36443-54. doi: 10.1074/jbc.M112.374157. Epub 2012 Sep 4. 2012
15CCNT1, HEXIM1
Functional characterization of a human cyclin T1 mutant reveals a different binding surface for Tat and HEXIM1.
Kuzmina A, Hadad U, Fujinaga K, Taube R.
Virology 426(2):152-61. doi: 10.1016/j.virol.2012.01.033. Epub 2012 Feb 18. 2012
16CCNT1, HEXIM1
HEXIM1 controls satellite cell expansion after injury to regulate skeletal muscle regeneration.
Hong P, Chen K, Huang B, Liu M, Cui M, Rozenberg I, Chaqour B, Pan X, Barton ER, Jiang XC, Siddiqui MA.
J Clin Invest 122(11):3873-87. 2012
17CCNT1, HEXIM1
Structure and dynamics of a stabilized coiled-coil domain in the P-TEFb regulator Hexim1.
Bigalke JM, Dames SA, Blankenfeldt W, Grzesiek S, Geyer M.
J Mol Biol 414(5):639-53. doi: 10.1016/j.jmb.2011.10.022. Epub 2011 Oct 18. 2011
18HEXIM1
HEXIM1 modulates vascular endothelial growth factor expression and function in breast epithelial cells and mammary gland.
Ogba N, Doughman YQ, Chaplin LJ, Hu Y, Gargesha M, Watanabe M, Montano MM.
Oncogene 29(25):3639-49. Epub 2010 May 10.PMID: 20453883 2010
19HEXIM1, RN7SK
HEXIM1 targets a repeated GAUC motif in the riboregulator of transcription 7SK and promotes base pair rearrangements.
Lebars I, Martinez-Zapien D, Durand A, Coutant J, Kieffer B, Dock-Bregeon AC.
Nucleic Acids Res ucleic Acids Res. 2010 Jul 31. [Epub ahead of print]PMID: 20675720 2010
20HEXIM1
A flexible bipartite coiled coil structure is required for the interaction of Hexim1 with the P-TEFB subunit cyclin T1.
Schönichen A, Bigalke JM, Urbanke C, Grzesiek S, Dames SA, Geyer M.
Biochemistry 49(14):3083-91.PMID: 20210365 2010
21CCNT1, HEXIM1, RN7SK
The mechanism of release of P-TEFb and HEXIM1 from the 7SK snRNP by viral and cellular activators includes a conformational change in 7SK.
Krueger BJ, Varzavand K, Cooper JJ, Price DH.
PLoS One 5(8):e12335. doi: 10.1371/journal.pone.0012335. 2010
22CCNT1, CDK9, HEXIM1, RNS7SK
T-loop phosphorylated Cdk9 localizes to nuclear speckle domains which may serve as sites of active P-TEFb function and exchange between the Brd4 and 7SK/HEXIM1 regulatory complexes.
Dow EC, Liu H, Rice AP.
J Cell Physiol 224(1):84-93. doi: 10.1002/jcp.22096. 2010
23HEXIM1, MDM2
Ubiquitination of HEXIM1 by HDM2.
Lau J, Lew QJ, Diribarne G, Michels AA, Dey A, Bensaude O, Lane DP, Chao SH.
Cell Cycle 8(14):2247-54.PMID: 19617712 2009
24CCNT1, HEXIM1, RN7SK
7SK RNA, a non-coding RNA regulating P-TEFb, a general transcription factor.
Diribarne G, Bensaude O.
RNA Biol 6(2):122-8. Epub 2009 Apr 6. Review.PMID: 19246988 2009
25LARP7, CCNT1, HEXIM1
LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated.
Krueger BJ, Jeronimo C, Roy BB, Bouchard A, Barrandon C, Byers SA, Searcey CE, Cooper JJ, Bensaude O, Cohen EA, Coulombe B, Price DH.
Nucleic Acids Res 36(7):2219-29. Epub 2008 Feb 16. 2008
26HEXIM1, NR3C1
Role of the hinge region of glucocorticoid receptor for HEXIM1-mediated transcriptional repression.
Yoshikawa N, Shimizu N, Sano M, Ohnuma K, Iwata S, Hosono O, Fukuda K, Morimoto C, Tanaka H.
Biochem Biophys Res Commun 371(1):44-9. Epub 2008 Apr 11. 2008
27HEXIM1
HEXIM1 regulates 17beta-estradiol/estrogen receptor-alpha-mediated expression of cyclin D1 in mammary cells via modulation of P-TEFb.
Ogba N, Chaplin LJ, Doughman YQ, Fujinaga K, Montano MM.
Cancer Res 68(17):7015-24.PMID: 18757415 2008
28CCNT1, HEXIM1, LARP7, MEPCE
LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated.
Krueger BJ, Jeronimo C, Roy BB, Bouchard A, Barrandon C, Byers SA, Searcey CE, Cooper JJ, Bensaude O, Cohen EA, Coulombe B, Price DH.
Nucleic Acids Res 36(7):2219-29. doi: 10.1093/nar/gkn061. Epub 2008 Feb 16. 2008
29HEXIM1, CCNT1
Structure of the Cyclin T binding domain of Hexim1 and molecular basis for its recognition of P-TEFb.
Dames SA, Schšnichen A, Schulte A, Barboric M, Peterlin BM, Grzesiek S, Geyer M.
Proc Natl Acad Sci U S A 104(36):14312-7. Epub 2007 Aug 27. 2007
30HEXIM1
Regulation of polymerase II transcription by 7SK snRNA: two distinct RNA elements direct P-TEFb and HEXIM1 binding.
Egloff S, Van Herreweghe E, Kiss T.
Mol Cell Biol 26(2):630-42. 2006
31HEXIM1, HEXIM2
HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK.
Byers SA, Price JP, Cooper JJ, Li Q, Price DH.
J Biol Chem 280(16):16360-7. Epub 2005 Feb 14. 2005
32HEXIM1, HEXIM2
Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription.
Yik JH, Chen R, Pezda AC, Zhou Q.
J Biol Chem 280(16):16368-76. Epub 2005 Feb 14. 2005
33HEXIM1, HEXIM2
Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186.
Li Q, Price JP, Byers SA, Cheng D, Peng J, Price DH.
J Biol Chem 280(31):28819-26. Epub 2005 Jun 17. 2005
34HEXIM1
HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b.
Shimizu N, Ouchida R, Yoshikawa N, Hisada T, Watanabe H, Okamoto K, Kusuhara M, Handa H, Morimoto C, Tanaka H.
Proc Natl Acad Sci U S A 102(24):8555-60. Epub 2005 Jun 7. 2005
35HEXIM1
Interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct the inhibition of P-TEFb.
Barboric M, Kohoutek J, Price JP, Blazek D, Price DH, Peterlin BM.
EMBO J 24(24):4291-303. Epub 2005 Dec 15. 2005
36HEXIM1
Transcription-dependent association of multiple positive transcription elongation factor units to a HEXIM multimer.
Dulac C, Michels AA, Fraldi A, Bonnet F, Nguyen VT, Napolitano G, Lania L, Bensaude O.
J Biol Chem 280(34):30619-29. Epub 2005 Jun 30. 2005
37HEXIM1
The breast cell growth inhibitor, estrogen down regulated gene 1, modulates a novel functional interaction between estrogen receptor alpha and transcriptional elongation factor cyclin T1.
Wittmann BM, Fujinaga K, Deng H, Ogba N, Montano MM.
Oncogene 24(36):5576-88. 2005
38HEXIM1
Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA.
Yik JH, Chen R, Nishimura R, Jennings JL, Link AJ, Zhou Q.
Mol Cell 12(4):971-82. 2003
39HEXIM1
MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner.
Michels AA, Nguyen VT, Fraldi A, Labas V, Edwards M, Bonnet F, Lania L, Bensaude O.
Mol Cell Biol 23(14):4859-69. Erratum in: Mol Cell Biol. 2003 Dec;23(24):9405. 2003
40HEXIM1
Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells.
Ouchida R, Kusuhara M, Shimizu N, Hisada T, Makino Y, Morimoto C, Handa H, Ohsuzu F, Tanaka H.
Genes Cells 8(2):95-107. 2003
41HEXIM1
Cloning of hexamethylene-bis-acetamide-inducible transcript,HEXIM1, in human vascular smooth muscle cells.
Kusuhara,M., et Al.
Unpublished 2000