1 | HES6
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| Single-cell RNA sequencing reveals intratumoral heterogeneity in primary uveal melanomas and identifies HES6 as a driver of the metastatic disease
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| Pandiani C, Strub T, Nottet N, Cheli Y, Gambi G, Bille K, Husser C, Dalmasso M, Béranger G, Lassalle S, Magnone V, Pédeutour F, Irondelle M, Maschi C, Nahon-Estève S, Martel A, Caujolle JP, Hofman P, LeBrigand K, Davidson I, Baillif S, Barbry P, Ballotti R, Bertolotto C.
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| Cell Death Differ. Jun;28(6):1990-2000. doi: 10.1038/s41418-020-00730-7. Epub 2021 Jan 18. 2021
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2 | HES6, PPARG
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| Hairy and enhancer of split 6 prevents hepatic lipid accumulation through inhibition of Pparg2 expression. 2017 PMID:
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| Park JE, Lee M, Kim SC, Zhang Y, Hardwick JP, Lee YK.
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| Hepatol Commun. Nov 8;1(10):1085-1098. doi: 10.1002/hep4.1120. 2017
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3 | HES6
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| Hairy and Enhancer of Split 6 (Hes6) Deficiency in Mouse Impairs Neuroblast Differentiation in Dentate Gyrus Without Affecting Cell Proliferation and Integration into Mature Neurons
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| Nam SM, Kim YN, Kim JW, Kyeong DS, Lee SH, Son Y, Shin JH, Kim J, Yi SS, Yoon YS, Seong JK.
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| Cell Mol Neurobiol. 2016
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4 | HES6
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| HES6 promotes prostate cancer aggressiveness independently of Notch signalling.
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| Carvalho FL, Marchionni L, Gupta A, Kummangal BA, Schaeffer EM, Ross AE, Berman DM.
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| J Cell Mol Med. Jul;19(7):1624-36. doi: 10.1111/jcmm.12537. Epub 2015 Apr 12. 2015
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5 | HES6, HNF4A
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| All-trans-retinoic acid ameliorates hepatic steatosis in mice by a novel transcriptional cascade
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| Kim SC, Kim CK, Axe D, Cook A, Lee M, Li T, Smallwood N, Chiang JY, Hardwick JP, Moore DD, Lee YK.
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| Hepatology. May;59(5):1750-60. doi: 10.1002/hep.26699. Epub 2014 Mar 26. 2014
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6 | HES6, NFKB1, RELA
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| Interaction and antagonistic roles of NF-κB and Hes6 in the regulation of cortical neurogenesis.
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| Methot L, Hermann R, Tang Y, Lo R, Al-Jehani H, Jhas S, Svoboda D, Slack RS, Barker PA, Stifani S.
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| Mol Cell Biol. Jul;33(14):2797-808. doi: 10.1128/MCB.01610-12. Epub 2013 May 20. 2013
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7 | HES6
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| HES6 gene is selectively overexpressed in glioma and represents an important transcriptional regulator of glioma proliferation.
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| Haapa-Paananen S, Kiviluoto S, Waltari M, Puputti M, Mpindi JP, Kohonen P, Tynninen O, Haapasalo H, Joensuu H, Perälä M, Kallioniemi O.
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| Oncogene 31(10):1299-310. doi: 10.1038/onc.2011.316. Epub 2011 Jul 25.
2012
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8 | HES6
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| Hes6 is required for actin cytoskeletal organization in differentiating C2C12 myoblasts.
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| Malone CM, Domaschenz R, Amagase Y, Dunham I, Murai K, Jones PH.
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| Exp Cell Res 317(11):1590-602. doi: 10.1016/j.yexcr.2011.03.023. Epub 2011 Apr 9.
2011
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9 | HES6
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| HES6-1 and HES6-2 function through different mechanisms during neuronal differentiation.
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| Vilas-Boas F, Henrique D.
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| PLoS One 5(12):e15459.
2010
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10 | HES6
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| Hes-6, an inhibitor of Hes-1, is regulated by 17beta-estradiol and promotes breast cancer cell proliferation.
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| Hartman J, Lam EW, Gustafsson JA, Ström A.
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| Breast Cancer Res 11(6):R79. Epub 2009 Nov 5.
2009
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11 | HES6
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| Hes6 controls cell proliferation via interaction with cAMP-response element-binding protein-binding protein in the promyelocytic leukemia nuclear body.
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| Eun B, Lee Y, Hong S, Kim J, Lee HW, Kim K, Sun W, Kim H.
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| J Biol Chem 283(9):5939-49. Epub 2007 Dec 26.
2008
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12 | ATOH1, HES6
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| Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells.
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| Scheffer D, Sage C, Corey DP, Pingault V.
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| FEBS Lett 581(24):4651-6. Epub 2007 Sep 4. 2007
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13 | HES6
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| HES6 reverses nuclear reprogramming of insulin-producing cells following cell fusion.
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| Ball AJ, Abrahamsson AE, Tyrberg B, Itkin-Ansari P, Levine F.
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| Biochem Biophys Res Commun 355(2):331-7. Epub 2007 Feb 5. 2007
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14 | HES6
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| Hes6 inhibits astrocyte differentiation and promotes neurogenesis through different mechanisms.
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| Jhas S, Ciura S, Belanger-Jasmin S, Dong Z, Llamosas E, Theriault FM, Joachim K, Tang Y, Liu L, Liu J, Stifani S.
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| J Neurosci 26(43):11061-71.
2006
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15 | HES1, HES6
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| Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms.
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| Gratton MO, Torban E, Jasmin SB, Theriault FM, German MS, Stifani S.
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| Mol Cell Biol 23(19):6922-35.
2003
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16 | HES6
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| The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation.
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| Bae S, Bessho Y, Hojo M, Kageyama R.
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| Development 127(13):2933-43. 2000
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