| 1 | DMRTA2, HES1
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| The doublesex-related Dmrta2 safeguards neural progenitor maintenance involving transcriptional regulation of Hes1.
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| Young FI, Keruzore M, Nan X, Gennet N, Bellefroid EJ, Li M.
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| Proc Natl Acad Sci U S A 114(28):E5599-E5607. doi: 10.1073/pnas.1705186114. Epub 2017 Jun 27.
2017
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| 2 | FLT3, HES1
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| Hes1 suppresses acute myeloid leukemia development through FLT3 repression.
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| Kato T, Sakata-Yanagimoto M, Nishikii H, Ueno M, Miyake Y, Yokoyama Y, Asabe Y, Kamada Y, Muto H, Obara N, Suzukawa K, Hasegawa Y, Kitabayashi I, Uchida K, Hirao A, Yagita H, Kageyama R, Chiba S.
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| Leukemia 29(3):576-85. doi: 10.1038/leu.2014.281. Epub 2014 Sep 19.
2015
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| 3 | ADAM10, DLL4, HES1, HEY1
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| The disintegrin and metalloproteinase ADAM10 mediates a canonical Notch-dependent regulation of IL-6 through Dll4 in human endothelial cells.
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| Pabois A, Devallière J, Quillard T, Coulon F, Gérard N, Laboisse C, Toquet C, Charreau B.
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| Biochem Pharmacol 91(4):510-21. doi: 10.1016/j.bcp.2014.08.007. Epub 2014 Aug 15.
2014
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| 4 | HES1, HEY1
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| Antagonistic regulation of p57kip2 by Hes/Hey downstream of Notch signaling and muscle regulatory factors regulates skeletal muscle growth arrest.
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| Zalc A, Hayashi S, Auradé F, Bröhl D, Chang T, Mademtzoglou D, Mourikis P, Yao Z, Cao Y, Birchmeier C, Relaix F.
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| Development 141(14):2780-90. doi: 10.1242/dev.110155.
2014
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| 5 | CDKN1C, HES1
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| CDKN1C/P57 is regulated by the Notch target gene Hes1 and induces senescence in human hepatocellular carcinoma.
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| Giovannini C, Gramantieri L, Minguzzi M, Fornari F, Chieco P, Grazi GL, Bolondi L.
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| Am J Pathol 181(2):413-22. doi: 10.1016/j.ajpath.2012.04.019. Epub 2012 Jun 15.
2012
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| 6 | EZH2, GATA1, HES1
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| GATA-1 utilizes Ikaros and polycomb repressive complex 2 to suppress Hes1 and to promote erythropoiesis.
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| Ross J, Mavoungou L, Bresnick EH, Milot E.
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| Mol Cell Biol 32(18):3624-38. doi: 10.1128/MCB.00163-12. Epub 2012 Jul 9.
2012
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| 7 | HES1
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| JNK1 inhibits GluR1 expression and GluR1-mediated calcium influx through phosphorylation and stabilization of Hes-1.
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| Lin CH, Lee EH.
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| J Neurosci 32(5):1826-46. doi: 10.1523/JNEUROSCI.3380-11.2012.
2012
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| 8 | DLL1, HES1, PTF1A
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| Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism.
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| Ahnfelt-Rønne J, Jørgensen MC, Klinck R, Jensen JN, Füchtbauer EM, Deering T, MacDonald RJ, Wright CV, Madsen OD, Serup P.
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| Development 139(1):33-45. doi: 10.1242/dev.071761. Epub 2011 Nov 17.
2012
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| 9 | HES1, PDGFRA
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| Durable remission after treatment with very low doses of imatinib for FIP1L1-PDGFRα-positive chronic eosinophilic leukaemia.
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| Helbig G, Moskwa A, Hus M, Piszcz J, Swiderska A, Urbanowicz A, Całbecka M, Seferyńska I, Raźny M, Rodzaj M, Żuk E, Kyrcz-Krzemień S.
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| Cancer Chemother Pharmacol 67(4):967-9. Epub 2011 Feb 17. No abstract available.
2011
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| 10 | HES1
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| HES1 (hairy and enhancer of split 1) is a determinant of bone mass.
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| Zanotti S, Smerdel-Ramoya A, Canalis E.
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| J Biol Chem 286(4):2648-57. Epub 2010 Nov 17.
2011
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| 11 | HES1, PARP1
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| Notch/HES1-mediated PARP1 activation: a cell type-specific mechanism for tumor suppression.
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| Kannan S, Fang W, Song G, Mullighan CG, Hammitt R, McMurray J, Zweidler-McKay PA.
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| Blood 117(10):2891-900. Epub 2011 Jan 11.
2011
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| 12 | HES1
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| Hes1 regulates the number and anterior-posterior patterning of mesencephalic dopaminergic neurons at the mid/hindbrain boundary (isthmus).
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| Kameda Y, Saitoh T, Fujimura T.
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| Dev Biol 358(1):91-101. doi: 10.1016/j.ydbio.2011.07.016. Epub 2011 Jul 23.
2011
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| 13 | HES1, HES5
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| HES1 and HES5 Are Dispensable for Cartilage and Endochondral Bone Formation.
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| Karlsson C, Brantsing C, Kageyama R, Lindahl A.
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| Cells Tissues Organs ells Tissues Organs. 2010 Feb 4. [Epub ahead of print]PMID: 20134146 2010
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| 14 | HES1, HES2, ID4, RUNX2
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| Id4, a new candidate gene for senile osteoporosis, acts as a molecular switch promoting osteoblast differentiation.
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| Tokuzawa Y, Yagi K, Yamashita Y, Nakachi Y, Nikaido I, Bono H, Ninomiya Y, Kanesaki-Yatsuka Y, Akita M, Motegi H, Wakana S, Noda T, Sablitzky F, Arai S, Kurokawa R, Fukuda T, Katagiri T, Schönbach C, Suda T, Mizuno Y, Okazaki Y.
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| PLoS Genet 6(7):e1001019.PMID: 20628571 2010
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| 15 | HES1, NFIA
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| NFIA controls telencephalic progenitor cell differentiation through repression of the Notch effector Hes1.
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| Piper M, Barry G, Hawkins J, Mason S, Lindwall C, Little E, Sarkar A, Smith AG, Moldrich RX, Boyle GM, Tole S, Gronostajski RM, Bailey TL, Richards LJ.
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| J Neurosci 30(27):9127-39.
2010
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| 16 | FRS2, HES1
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| FRS2α regulates Erk levels to control a self-renewal target Hes1 and proliferation of FGF-responsive neural stem/progenitor cells.
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| Sato T, Shimazaki T, Naka H, Fukami S, Satoh Y, Okano H, Lax I, Schlessinger J, Gotoh N.
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| Stem Cells 28(9):1661-73. doi: 10.1002/stem.488.
2010
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| 17 | FAAP100, HES, HES1
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| The fanconi anemia core complex acts as a transcriptional co-regulator in hairy enhancer of split 1 signaling.
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| Tremblay CS, Huard CC, Huang FF, Habi O, Bourdages V, Lévesque G, Carreau M.
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| J Biol Chem 284(20):13384-95. Epub 2009 Mar 25. 2009
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| 18 | HES1
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| The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells.
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| Kobayashi T, Mizuno H, Imayoshi I, Furusawa C, Shirahige K, Kageyama R.
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| Genes Dev 23(16):1870-5.
2009
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| 19 | HES1, PROP1
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| Premature differentiation and aberrant movement of pituitary cells lacking both Hes1 and Prop1.
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| Himes AD, Raetzman LT.
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| Dev Biol 325(1):151-61. doi: 10.1016/j.ydbio.2008.10.010. Epub 2008 Nov 1.
2009
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| 20 | HES1
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| Control of the reversibility of cellular quiescence by the transcriptional repressor HES1.
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| Sang L, Coller HA, Roberts JM.
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| Science 321(5892):1095-100.
2008
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| 21 | HES1
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| HES1 is a novel interactor of the Fanconi anemia core complex.
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| Tremblay CS, Huang FF, Habi O, Huard CC, Godin C, Lévesque G, Carreau M.
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| Blood 112(5):2062-70. Epub 2008 Jun 11.
2008
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| 22 | HES1, HES2, HES3, HES5
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| Roles of Hes genes in neural development.
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| Kageyama R, Ohtsuka T, Kobayashi T.
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| Dev Growth Differ 50 Suppl 1:S97-103. Epub 2008 Apr 22. Review.PMID: 18430159 2008
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| 23 | HES1, HEY2
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| Hey2 functions in parallel with Hes1 and Hes5 for mammalian auditory sensory organ development.
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| Li S, Mark S, Radde-Gallwitz K, Schlisner R, Chin MT, Chen P.
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| BMC Dev Biol 8:20. 2008
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| 24 | HES1, UBQLN1, ASCL1
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| Ubiquilin-1 is a novel HASH-1-complexing protein that regulates levels of neuronal bHLH transcription factors in human neuroblastoma cells.
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| Persson P, Stockhausen MT, Pahlman S, Axelson H.
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| Int J Oncol 25(5):1213-21. 2004
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| 25 | HES1, PDGFRA
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| Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome.
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| Griffin JH, Leung J, Bruner RJ, Caligiuri MA, Briesewitz R.
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| Proc Natl Acad Sci U S A 100(13):7830-5. Epub 2003 Jun 13.
2003
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| 26 | HES1, HES6
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| Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms.
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| Gratton MO, Torban E, Jasmin SB, Theriault FM, German MS, Stifani S.
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| Mol Cell Biol 23(19):6922-35.
2003
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| 27 | HES1, OPA1
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| Dominant optic atrophy : exclusion and fine genetic mapping of the candidate gene, HRY.
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| Votruba M, et al.
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| Mamm Genome 9 : 784-787. 1998
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| 28 | HES1
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| Genomic cloning and chromosomal localization of HRY, the human homolog to the Drosophila segmentation gene, hairy.
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| Feder JN, et al.
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| Genomics 20 : 56-61. 1994
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