| 1 | CDCA7, DNMT3B, HELLS, ICF1, ICF2, ICF3, ICF4, ZBTB24
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| CDCA7 and HELLS mutations undermine nonhomologous end joining in centromeric instability syndrome.
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| Unoki M, Funabiki H, Velasco G, Francastel C, Sasaki H.
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| J Clin Invest 129(1):78-92. doi: 10.1172/JCI99751. Epub 2018 Nov 19.
2019
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| 2 | CDCA7, DNMT3B, HELLS, ICF1, ICF2, ICF3, ICF4, ZBTB24
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| Three Types of Immunodeficiency, Centromeric Instability, and Facial Anomalies (ICF) Syndrome Identified by Whole-Exome Sequencing in Saudi Hypogammaglobulinemia Patients: Clinical, Molecular, and Cytogenetic Features.
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| Alghamdi HA, Tashkandi SA, Alidrissi EM, Aledielah RD, AlSaidi KA, Alharbi ES, Habazi MK, Alzahrani MS.
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| J Clin Immunol 38(8):847-853. doi: 10.1007/s10875-018-0569-9. Epub 2018 Dec 3. No abstract available.
2018
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| 3 | HELLS
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| HELLS regulates chromatin remodeling and epigenetic silencing of multiple tumor suppressor genes in human hepatocellular carcinoma.
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| Law CT, Wei L, Tsang FH, Chan CY, Xu IM, Lai RK, Ho DW, Lee JM, Wong CC, Ng IO, Wong CM.
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| Hepatology epatology. 2018 Dec 5. doi: 10.1002/hep.30414. [Epub ahead of print]
2018
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| 4 | CDCA7, HELLS, ICF2, ICF3, ICF4, ZBTB24
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| Comparative methylome analysis of ICF patients identifies heterochromatin loci that require ZBTB24, CDCA7 and HELLS for their methylated state.
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| Velasco G, Grillo G, Touleimat N, Ferry L, Ivkovic I, Ribierre F, Deleuze JF, Chantalat S, Picard C, Francastel C.
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| Hum Mol Genet 27(14):2409-2424. doi: 10.1093/hmg/ddy130.
2018
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| 5 | CDCA7, HELLS
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| HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome.
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| Jenness C, Giunta S, Müller MM, Kimura H, Muir TW, Funabiki H.
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| Proc Natl Acad Sci U S A 115(5):E876-E885. doi: 10.1073/pnas.1717509115. Epub 2018 Jan 16.
2018
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| 6 | HELLS, POU5F1
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| Tethering of Lsh at the Oct4 locus promotes gene repression associated with epigenetic changes.
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| Ren J, Hathaway NA, Crabtree GR, Muegge K.
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| Epigenetics 13(2):173-181. doi: 10.1080/15592294.2017.1338234. Epub 2018 Feb 6.
2018
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| 7 | HELLS
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| Lsh/HELLS regulates self-renewal/proliferation of neural stem/progenitor cells.
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| Han Y, Ren J, Lee E, Xu X, Yu W, Muegge K.
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| Sci Rep 7(1):1136. doi: 10.1038/s41598-017-00804-6.
2017
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| 8 | DNMT3B, HELLS
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| The SNF2 family ATPase LSH promotes cell-autonomous de novo DNA methylation in somatic cells.
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| Termanis A, Torrea N, Culley J, Kerr A, Ramsahoye B, Stancheva I.
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| Nucleic Acids Res 44(16):7592-604. doi: 10.1093/nar/gkw424. Epub 2016 May 13.
2016
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| 9 | CDCA7, HELLS, ICF3, ICF4
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| Mutations in CDCA7 and HELLS cause immunodeficiency-centromeric instability-facial anomalies syndrome.
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| Thijssen PE, Ito Y, Grillo G, Wang J, Velasco G, Nitta H, Unoki M, Yoshihara M, Suyama M, Sun Y, Lemmers RJ, de Greef JC, Gennery A, Picco P, Kloeckener-Gruissem B, Güngör T, Reisli I, Picard C, Kebaili K, Roquelaure B, Iwai T, Kondo I, Kubota T, van Ostaijen-Ten Dam MM, van Tol MJ, Weemaes C, Francastel C, van der Maarel SM, Sasaki H.
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| Nat Commun 6:7870. doi: 10.1038/ncomms8870. 2015
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| 10 | HELLS
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| Genome-wide DNA methylation patterns in LSH mutant reveals de-repression of repeat elements and redundant epigenetic silencing pathways.
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| Yu W, McIntosh C, Lister R, Zhu I, Han Y, Ren J, Landsman D, Lee E, Briones V, Terashima M, Leighty R, Ecker JR, Muegge K.
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| Genome Res 24(10):1613-23. doi: 10.1101/gr.172015.114. Epub 2014 Aug 28.
2014
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| 11 | E2F3, HELLS
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| The SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation.
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| von Eyss B, Maaskola J, Memczak S, Möllmann K, Schuetz A, Loddenkemper C, Tanh MD, Otto A, Muegge K, Heinemann U, Rajewsky N, Ziebold U.
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| EMBO J 31(4):972-85. doi: 10.1038/emboj.2011.451. Epub 2011 Dec 13.
2012
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| 12 | EHMT2, HELLS
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| LSH and G9a/GLP complex are required for developmentally programmed DNA methylation.
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| Myant K, Termanis A, Sundaram AY, Boe T, Li C, Merusi C, Burrage J, de Las Heras JI, Stancheva I.
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| Genome Res 21(1):83-94. Epub 2010 Dec 13. 2011
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| 13 | E2F1, HELLS
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| Transcriptional activation of the senescence regulator Lsh by E2F1.
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| Niu J, Chen T, Han L, Wang P, Li N, Tong T.
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| Mech Ageing Dev 132(4):180-6. Epub 2011 Mar 29.
2011
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| 14 | HELLS
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| Lsh mediated RNA polymerase II stalling at HoxC6 and HoxC8 involves DNA methylation.
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| Tao Y, Xi S, Briones V, Muegge K.
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| PLoS One 5(2):e9163.
2010
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| 15 | HELLS
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| Senescence delay and repression of p16INK4a by Lsh via recruitment of histone deacetylases in human diploid fibroblasts.
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| Zhou R, Han L, Li G, Tong T.
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| Nucleic Acids Res 37(15):5183-96. Epub 2009 Jun 26.
2009
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| 16 | HELLS
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| LSH cooperates with DNA methyltransferases to repress transcription.
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| Myant K, Stancheva I.
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| Mol Cell Biol 28(1):215-26. Epub 2007 Oct 29.
2008
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| 17 | HELLS
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| Lsh controls Hox gene silencing during development.
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| Xi S, Zhu H, Xu H, Schmidtmann A, Geiman TM, Muegge K.
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| Proc Natl Acad Sci U S A 104(36):14366-71. Epub 2007 Aug 28. Erratum in: Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16389.
2007
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| 18 | HELLS
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| Lsh is required for meiotic chromosome synapsis and retrotransposon silencing in female germ cells.
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| De La Fuente R, Baumann C, Fan T, Schmidtmann A, Dobrinski I, Muegge K.
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| Nat Cell Biol 8(12):1448-54. Epub 2006 Nov 19.
2006
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| 19 | HELLS
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| Lsh, a modulator of CpG methylation, is crucial for normal histone methylation.
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| Yan Q, Huang J, Fan T, Zhu H, Muegge K.
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| EMBO J 22(19):5154-62. 2003
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| 20 | HELLS
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| Characterization of gene expression, genomic structure, and chromosomal localization of Hells (Lsh).
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| Geiman TM, Durum SK, Muegge K.
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| Genomics 54 : 477-483. 1998
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