| 1 | HDAC4, HDAC5, NAE1, SIRT1
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| Neddylation Regulates Class IIa and III Histone Deacetylases to Mediate Myoblast Differentiation
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| Zhou H, Su H, Chen W.
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| Int J Mol Sci. Sep 1;22(17):9509. doi: 10.3390/ijms22179509. 2021
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| 2 | CRTC2, CRTC3, HDAC4, SIK2, SLC2A4
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| SIK2 regulates CRTCs, HDAC4 and glucose uptake in adipocytes.
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| Henriksson E, Säll J, Gormand A, Wasserstrom S, Morrice NA, Fritzen AM, Foretz M, Campbell DG, Sakamoto K, Ekelund M, Degerman E, Stenkula KG, Göransson O.
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| J Cell Sci 128(3):472-86.
2015
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| 3 | HDAC4
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| Conditional deletion of histone deacetylase-4 in the central nervous system has no major effect on brain architecture or neuronal viability.
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| Price V, Wang L, D'Mello SR.
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| J Neurosci Res 91(3):407-15. doi: 10.1002/jnr.23170. Epub 2012 Dec 14.
2013
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| 4 | HDAC1, HDAC4, TRPS1
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| The multi zinc-finger protein Trps1 acts as a regulator of histone deacetylation during mitosis.
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| Wuelling M, Pasdziernik M, Moll CN, Thiesen AM, Schneider S, Johannes C, Vortkamp A.
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| Cell Cycle 12(14):2219-32. doi: 10.4161/cc.25267.
2013
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| 5 | DEL2Q37, HDAC4
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| Phenotypic variant of Brachydactyly-mental retardation syndrome in a family with an inherited interstitial 2q37.3 microdeletion including HDAC4
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| Villavicencio-Lorini P, Klopocki E, Trimborn M, Koll R, Mundlos S, Horn D.
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| Eur J Hum Genet. Jul;21(7):743-8. doi: 10.1038/ejhg.2012.240. Epub 2012 Nov 28 2013
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| 6 | DEL2Q37, HDAC4
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| The 2q37-deletion syndrome: an update of the clinical spectrum including overweight, brachydactyly and behavioural features in 14 new patients.
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| Leroy C, Landais E, Briault S, David A, Tassy O, Gruchy N, Delobel B, Grégoire MJ, Leheup B, Taine L, Lacombe D, Delrue MA, Toutain A, Paubel A, Mugneret F, Thauvin-Robinet C, Arpin S, Le Caignec C, Jonveaux P, Beri M, Leporrier N, Motte J, Fiquet C, Brichet O, Mozelle-Nivoix M, Sabouraud P, Golovkine N, Bednarek N, Gaillard D, Doco-Fenzy M.
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| Eur J Hum Genet ur J Hum Genet. 2012 Oct 17. doi: 10.1038/ejhg.2012.230. [Epub ahead of print]
2012
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| 7 | BDMR, DEL2Q37, HDAC4
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| Dose dependent expression of HDAC4 causes variable expressivity in a novel inherited case of brachydactyly mental retardation syndrome.
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| Morris B, Etoubleau C, Bourthoumieu S, Reynaud-Perrine S, Laroche C, Lebbar A, Yardin C, Elsea SH.
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| Am J Med Genet A 158A(8):2015-20. doi: 10.1002/ajmg.a.35463. Epub 2012 Jun 29. 2012
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| 8 | BDMR, DEL2Q37, HDAC4
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| Phenotypic variant of Brachydactyly-mental retardation syndrome in a family with an inherited interstitial 2q37.3 microdeletion including HDAC4.
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| Villavicencio-Lorini P, Klopocki E, Trimborn M, Koll R, Mundlos S, Horn D.
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| Eur J Hum Genet ur J Hum Genet. 2012 Nov 28. doi: 10.1038/ejhg.2012.240. [Epub ahead of print] 2012
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| 9 | BDMR, DEL2Q27, HDAC4
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| The 2q37-deletion syndrome: an update of the clinical spectrum including overweight, brachydactyly and behavioural features in 14 new patients.
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| Leroy C, Landais E, Briault S, David A, Tassy O, Gruchy N, Delobel B, Grégoire MJ, Leheup B, Taine L, Lacombe D, Delrue MA, Toutain A, Paubel A, Mugneret F, Thauvin-Robinet C, Arpin S, Le Caignec C, Jonveaux P, Beri M, Leporrier N, Motte J, Fiquet C, Brichet O, Mozelle-Nivoix M, Sabouraud P, Golovkine N, Bednarek N, Gaillard D, Doco-Fenzy M.
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| Eur J Hum Genet ur J Hum Genet. 2012 Oct 17. doi: 10.1038/ejhg.2012.230. [Epub ahead of print] 2012
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| 10 | HDAC4, NOX4
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| Increased Oxidative Stress in the Nucleus Caused by Nox4 Mediates Oxidation of HDAC4 and Cardiac Hypertrophy.
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| Matsushima S, Kuroda J, Ago T, Zhai P, Park JY, Xie LH, Tian B, Sadoshima J.
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| Circ Res irc Res. 2012 Dec 27. [Epub ahead of print]
2012
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| 11 | HDAC4
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| Stress-induced epigenetic transcriptional memory of acetylcholinesterase by HDAC4.
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| Sailaja BS, Cohen-Carmon D, Zimmerman G, Soreq H, Meshorer E.
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| Proc Natl Acad Sci U S A 109(52):E3687-95. doi: 10.1073/pnas.1209990110. Epub 2012 Dec 10.
2012
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| 12 | HDAC4
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| HDAC4 governs a transcriptional program essential for synaptic plasticity and memory.
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| Sando R 3rd, Gounko N, Pieraut S, Liao L, Yates J 3rd, Maximov A.
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| Cell 151(4):821-34. doi: 10.1016/j.cell.2012.09.037.
2012
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| 13 | HDAC4
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| An essential role for histone deacetylase 4 in synaptic plasticity and memory formation.
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| Kim MS, Akhtar MW, Adachi M, Mahgoub M, Bassel-Duby R, Kavalali ET, Olson EN, Monteggia LM.
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| J Neurosci 32(32):10879-86. doi: 10.1523/JNEUROSCI.2089-12.2012.
2012
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| 14 | HDAC4
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| Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia.
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| Li J, Chen J, Ricupero CL, Hart RP, Schwartz MS, Kusnecov A, Herrup K.
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| Nat Med 18(5):783-90. doi: 10.1038/nm.2709.
2012
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| 15 | BCL6, HDAC4, MIR155
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| miR-155 targets histone deacetylase 4 (HDAC4) and impairs transcriptional activity of B-cell lymphoma 6 (BCL6) in the Eμ-miR-155 transgenic mouse model.
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| Sandhu SK, Volinia S, Costinean S, Galasso M, Neinast R, Santhanam R, Parthun MR, Perrotti D, Marcucci G, Garzon R, Croce CM.
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| Proc Natl Acad Sci U S A 109(49):20047-52. doi: 10.1073/pnas.1213764109. Epub 2012 Nov 19.
2012
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| 16 | HDAC4
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| Ubiquitin-dependent degradation of HDAC4, a new regulator of random cell motility.
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| Cernotta N, Clocchiatti A, Florean C, Brancolini C.
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| Mol Biol Cell 22(2):278-89. Epub 2010 Nov 30.
2011
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| 17 | HDAC4, HIF1A
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| HDAC4 protein regulates HIF1α protein lysine acetylation and cancer cell response to hypoxia.
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| Geng H, Harvey CT, Pittsenbarger J, Liu Q, Beer TM, Xue C, Qian DZ.
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| J Biol Chem 286(44):38095-102. doi: 10.1074/jbc.M111.257055. Epub 2011 Sep 14.
2011
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| 18 | HDAC4, NUP155
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| Modulation of chromatin position and gene expression by HDAC4 interaction with nucleoporins.
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| Kehat I, Accornero F, Aronow BJ, Molkentin JD.
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| J Cell Biol 193(1):21-9. doi: 10.1083/jcb.201101046.
2011
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| 19 | HDAC4, MEF2A
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| Selective repression of MEF2 activity by PKA-dependent proteolysis of HDAC4.
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| Backs J, Worst BC, Lehmann LH, Patrick DM, Jebessa Z, Kreusser MM, Sun Q, Chen L, Heft C, Katus HA, Olson EN.
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| J Cell Biol 195(3):403-15. doi: 10.1083/jcb.201105063.
2011
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| 20 | BDMR, DEL2Q37, HDAC4, SMS
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| Haploinsufficiency of HDAC4 Causes Brachydactyly Mental Retardation Syndrome, with Brachydactyly Type E, Developmental Delays, and Behavioral Problems.
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| Williams SR, Aldred MA, Der Kaloustian VM, Halal F, Gowans G, McLeod DR, Zondag S, Toriello HV, Magenis RE, Elsea SH.
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| Am J Hum Genet 87(2):219-228.PMID: 20691407 2010
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| 21 | HDAC4, MMP13
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| HDAC4 represses matrix metalloproteinase-13 transcription in osteoblastic cells, and parathyroid hormone controls this repression.
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| Shimizu E, Selvamurugan N, Westendorf JJ, Olson EN, Partridge NC.
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| J Biol Chem 285(13):9616-26. doi: 10.1074/jbc.M109.094862. Epub 2010 Jan 22.
2010
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| 22 | HDAC4
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| HDAC4 regulates neuronal survival in normal and diseased retinas.
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| Chen B, Cepko CL.
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| Science 323(5911):256-9.
2009
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| 23 | CDKN1A, HDAC4
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| HDAC4 represses p21(WAF1/Cip1) expression in human cancer cells through a Sp1-dependent, p53-independent mechanism.
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| Mottet D, Pirotte S, Lamour V, Hagedorn M, Javerzat S, Bikfalvi A, Bellahcčne A, Verdin E, Castronovo V.
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| Oncogene 28(2):243-56. Epub 2008 Oct 13.
2009
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| 24 | HDAC4, MEF2A, MEF2B, MEF2C
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| The deacetylase HDAC4 controls myocyte enhancing factor-2-dependent structural gene expression in response to neural activity.
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| Cohen TJ, Barrientos T, Hartman ZC, Garvey SM, Cox GA, Yao TP.
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| FASEB J 23(1):99-106. Epub 2008 Sep 9.
2009
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| 25 | HDAC4, RUNX2, VEGFA
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| HDAC4 represses vascular endothelial growth factor expression in chondrosarcoma by modulating RUNX2 activity.
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| Sun X, Wei L, Chen Q, Terek RM.
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| J Biol Chem 284(33):21881-90. Epub 2009 Jun 9.PMID: 19509297 2009
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| 26 | HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9
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| The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men.
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| Yang XJ, Seto E.
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| Nat Rev Mol Cell Biol 9(3):206-18. Review.
2008
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| 27 | HDAC4
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| HDAC4 inhibits cell-cycle progression and protects neurons from cell death.
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| Majdzadeh N, Wang L, Morrison BE, Bassel-Duby R, Olson EN, D'Mello SR.
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| Dev Neurobiol 68(8):1076-92.
2008
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| 28 | ATXN1, HDAC4, MEF2A, MEF2B, MEF2C, MEF2D
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| The neurodegenerative disease protein ataxin-1 antagonizes the neuronal survival function of myocyte enhancer factor-2.
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| Bolger TA, Zhao X, Cohen TJ, Tsai CC, Yao TP.
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| J Biol Chem 282(40):29186-92. Epub 2007 Jul 23. 2007
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| 29 | ANKRA2, HDAC4, HDAC5, AHRR
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| Molecular mechanism of transcriptional repression of AhR repressor involving ANKRA2, HDAC4, and HDAC5.
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| Oshima M, Mimura J, Yamamoto M, Fujii-Kuriyama Y.
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| Biochem Biophys Res Commun 364(2):276-82. Epub 2007 Oct 11. 2007
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| 30 | BACH2, HDAC4, NCOR2
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| Co-repressor SMRT and class II histone deacetylases promote Bach2 nuclear retention and formation of nuclear foci that are responsible for local transcriptional repression.
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| Hoshino H, Nishino TG, Tashiro S, Miyazaki M, Ohmiya Y, Igarashi K, Horinouchi S, Yoshida M.
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| J Biochem 141(5):719-27. Epub 2007 Mar 23.
2007
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| 31 | ANKRA2, HDAC4, HDAC5
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| Class II histone deacetylases confer signal responsiveness to the ankyrin-repeat proteins ANKRA2 and RFXANK.
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| McKinsey TA, Kuwahara K, Bezprozvannaya S, Olson EN.
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| Mol Biol Cell 17(1):438-47. Epub 2005 Oct 19. 2006
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| 32 | AHCYL2, HDAC4, RPS6KA6, TCP1
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| New p53 related genes in human tumors: significant downregulation in colon and lung carcinomas.
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| LLeonart ME, Vidal F, Gallardo D, Diaz-Fuertes M, Rojo F, Cuatrecasas M, López-Vicente L, Kondoh H, Blanco C, Carnero A, Ramón y Cajal S.
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| Oncol Rep 16(3):603-8.
2006
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| 33 | HDAC4, RUNX2
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| HDAC4: a corepressor controlling bone development.
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| Hug BA.
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| Cell 119(4):448-9. 2004
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| 34 | HDAC4, RUNX2
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| Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis.
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| Vega RB, Matsuda K, Oh J, Barbosa AC, Yang X, Meadows E, McAnally J, Pomajzl C, Shelton JM, Richardson JA, Karsenty G, Olson EN.
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| Cell 119(4):555-66. 2004
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| 35 | MEF2A, MEF2B, HDAC4
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| Functional characterization of an amino-terminal region of HDAC4 that possesses MEF2 binding and transcriptional repressive activity.
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| Chan JK, Sun L, Yang XJ, Zhu G, Wu Z.
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| J Biol Chem 278(26):23515-21. Epub 2003 Apr 21. 2003
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| 36 | HDAC4, SALL3, TCEB3C, WFS1
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| A genome-wide screen for normally methylated human CpG islands that can identify novel imprinted genes.
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| Strichman-Almashanu LZ, Lee RS, Onyango PO, Perlman E, Flam F, Frieman MB, Feinberg AP.
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| Genome Res 12(4):543-54. 2002
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| 37 | HDAC4
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| The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase.
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| Kirsh O, Seeler JS, Pichler A, Gast A, Muller S, Miska E, Mathieu M, Harel-Bellan A, Kouzarides T, Melchior F, Dejean A.
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| EMBO J 21(11):2682-91. 2002
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| 38 | HDAC3, HDAC4, HDAC5, NCOR1, NCOR2
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| Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR.
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| Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E.
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| Mol Cell 9(1):45-57. 2002
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| 39 | HDAC4, SOX6
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| Differential localization of HDAC4 orchestrates muscle differentiation.
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| Miska EA, Langley E, Wolf D, Karlsson C, Pines J, Kouzarides T.
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| Nucleic Acids Res 29(16):3439-47. 2001
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| 40 | HDAC4, HDAC5
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| Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation.
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| McKinsey TA, Zhang CL, Lu J, Olson EN.
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| Nature 408(6808):106-11. 2000
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| 41 | HDAC4, HDAC5
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| Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization.
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| Grozinger CM, Schreiber SL.
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| Proc Natl Acad Sci U S A 97(14):7835-40. 2000
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| 42 | CABIN1, HDAC4, MEF2C
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| Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4.
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| Youn HD, Grozinger CM, Liu JO.
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| J Biol Chem 275(29):22563-7. 2000
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| 43 | HDAC4, HDAC5
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| Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5.
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| McKinsey TA, Zhang CL, Olson EN.
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| Proc Natl Acad Sci U S A 97(26):14400-5. 2000
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| 44 | HDAC4, MAPK1, MAPK3
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| Histone deacetylase 4 associates with extracellular signal-regulated kinases 1 and 2, and its cellular localization is regulated by oncogenic Ras.
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| Zhou X, Richon VM, Wang AH, Yang XJ, Rifkind RA, Marks PA.
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| Proc Natl Acad Sci U S A 97(26):14329-33. 2000
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| 45 | HDAC4
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| Regulation of histone deacetylase 4 by binding of 14-3-3 proteins.
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| Wang AH, Kruhlak MJ, Wu J, Bertos NR, Vezmar M, Posner BI, Bazett-Jones DP, Yang XJ.
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| Mol Cell Biol 20(18):6904-12. 2000
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| 46 | HDAC4
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| A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p.
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| Fischle W, et al.
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| J Biol Chem 274(17):11713-20. 1999
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| 47 | HDAC4, HDAC5, HDAC6
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| Three proteins define a class of human histone deacetylases related to yeast Hda1p.
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| Grozinger CM, Hassig CA, Schreiber SL.
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| Proc Natl Acad Sci U S A 96(9):4868-73. 1999
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| 48 | HDAC4
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| HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor.
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| Wang AH, Bertos NR, Vezmar M, Pelletier N, Crosato M, Heng HH, Th'ng J, Han J, Yang XJ.
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| Mol Cell Biol 19(11):7816-27. 1999
|