Citations for
1HDAC2, SS18
HDAC2 links ubiquitination to tumor suppression in synovial sarcoma.
Cooley C, Su L.
Mol Cell Oncol. Apr 25;8(3):1914291. doi: 10.1080/23723556.2021.1914291. 2021
2HDAC1, HDAC2, HDAC5, HDAC6, HDAC7
Quantification of histone deacetylase isoforms in human frontal cortex, human retina, and mouse brain.
Anderson KW, Chen J, Wang M, Mast N, Pikuleva IA, Turko IV.
PLoS One 10(5):e0126592. doi: 10.1371/journal.pone.0126592. eCollection 2015. 2015
3HDAC2, KDM7A
JHDM1D and HDAC1-3 mRNA expression levels in peripheral blood mononuclear cells of patients with systemic lupus erythematosus.
Nawrocki MJ, Strugała AJ, Piotrowski P, Wudarski M, Olesińska M, Jagodziński PP.
Z Rheumatol 74(10):902-10. doi: 10.1007/s00393-015-1619-9. 2015
4HDAC1, HDAC2, HDAC7, HLCS
Holocarboxylase synthetase acts as a biotin-independent transcriptional repressor interacting with HDAC1, HDAC2 and HDAC7.
Trujillo-Gonzalez I, Cervantes-Roldan R, Gonzalez-Noriega A, Michalak C, Reyes-Carmona S, Barrios-Garcia T, Meneses-Morales I, Leon-Del-Rio A.
Mol Genet Metab 111(3):321-30. doi: 10.1016/j.ymgme.2013.10.016. Epub 2013 Nov 2. 2014
5HDAC1, HDAC2, SIN3A
Sin3a-associated Hdac1 and Hdac2 are essential for hematopoietic stem cell homeostasis and contribute differentially to hematopoiesis.
Heideman MR, Lancini C, Proost N, Yanover E, Jacobs H, Dannenberg JH.
Haematologica 99(8):1292-303. doi: 10.3324/haematol.2013.092643. 2014
6ARG2, HDAC2
Transcriptional regulation of endothelial arginase 2 by histone deacetylase 2.
Pandey D, Sikka G, Bergman Y, Kim JH, Ryoo S, Romer L, Berkowitz D.
Arterioscler Thromb Vasc Biol 34(7):1556-1566. doi: 10.1161/ATVBAHA.114.303685. Epub 2014 May 15. 2014
7HDAC2, SLC6A4
Regulation of intestinal serotonin transporter expression via epigenetic mechanisms: role of HDAC2.
Gill RK, Kumar A, Malhotra P, Maher D, Singh V, Dudeja PK, Alrefai W, Saksena S.
Am J Physiol Cell Physiol 304(4):C334-41. doi: 10.1152/ajpcell.00361.2012. Epub 2012 Nov 28. 2013
8CCL2, HDAC2, HDAC3, MS4A2
Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.
Kim Y, Kim K, Park D, Lee E, Lee H, Lee YS, Choe J, Jeoung D.
J Biol Chem 287(31):25844-59. doi: 10.1074/jbc.M112.348284. Epub 2012 Jun 7. 2012
9HDAC2, NFE2L2
Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress.
Mercado N, Thimmulappa R, Thomas CM, Fenwick PS, Chana KK, Donnelly LE, Biswal S, Ito K, Barnes PJ.
Biochem Biophys Res Commun 406(2):292-8. Epub 2011 Feb 12. 2011
10HDAC1, HDAC2
HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells.
Jacob C, Christen CN, Pereira JA, Somandin C, Baggiolini A, Lötscher P, Ozçelik M, Tricaud N, Meijer D, Yamaguchi T, Matthias P, Suter U.
Nat Neurosci. 14(4):429-36. 2011
11HDAC2, HDAC6, SMN2
Differential regulation of the SMN2 gene by individual HDAC proteins.
Evans MC, Cherry JJ, Androphy EJ.
Biochem Biophys Res Commun 414(1):25-30. Epub 2011 Sep 6. 2011
12HDAC1, HDAC2
Histone deacetylase 1 (HDAC1), but not HDAC2, controls embryonic stem cell differentiation.
Dovey OM, Foster CT, Cowley SM.
Proc Natl Acad Sci U S A 107(18):8242-7. Epub 2010 Apr 19. 2010
13HDAC1, HDAC2
Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease.
Bradner JE, Mak R, Tanguturi SK, Mazitschek R, Haggarty SJ, Ross K, Chang CY, Bosco J, West N, Morse E, Lin K, Shen JP, Kwiatkowski NP, Gheldof N, Dekker J, DeAngelo DJ, Carr SA, Schreiber SL, Golub TR, Ebert BL.
Proc Natl Acad Sci U S A 107(28):12617-22. Epub 2010 Jun 28.PMID: 20616024 2010
14HDAC1, HDAC2
Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis.
Wilting RH, Yanover E, Heideman MR, Jacobs H, Horner J, van der Torre J, DePinho RA, Dannenberg JH.
EMBO J. 29(15):2586-97. 2010
15HDAC2
Coordination of PAD4 and HDAC2 in the regulation of p53-target gene expression.
Li P, Wang D, Yao H, Doret P, Hao G, Shen Q, Qiu H, Zhang X, Wang Y, Chen G, Wang Y.
Oncogene. 29(21):3153-62. 2010
16EIF4E, HDAC2, SUMO1, SUMO2, SUMO3, SUMO4
HDAC2 promotes eIF4E sumoylation and activates mRNA translation gene specifically.
Xu X, Vatsyayan J, Gao C, Bakkenist CJ, Hu J.
J Biol Chem 285(24):18139-43. Epub 2010 Apr 26.PMID: 20421305 2010
17HDAC1, HDAC2
Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining.
Miller KM, Tjeertes JV, Coates J, Legube G, Polo SE, Britton S, Jackson SP.
Nat Struct Mol Biol 17(9):1144-51. Epub 2010 Aug 29. 2010
18HDAC2, NFE2L2
Nrf2 deficiency influences susceptibility to steroid resistance via HDAC2 reduction.
Adenuga D, Caito S, Yao H, Sundar IK, Hwang JW, Chung S, Rahman I.
Biochem Biophys Res Commun 403(3-4):452-6. Epub 2010 Nov 19. 2010
19HDAC1, HDAC2
HDAC1, a novel marker for benign teratomas.
Simboeck E, Di Croce L.
EMBO J 29(23):3893-5. Epub 2010 Dec 1. No abstract available. 2010
20HDAC2, PADI4
Coordination of PAD4 and HDAC2 in the regulation of p53-target gene expression.
Li P, Wang D, Yao H, Doret P, Hao G, Shen Q, Qiu H, Zhang X, Wang Y, Chen G, Wang Y.
Oncogene 29(21):3153-62. Epub 2010 Mar 1. 2010
21AIFM1, HDAC2, HTRA1, LGALS9, MX1, NR4A2, PRDX2, TFNA13, UNC5D
Left ventricular global transcriptional profiling in human end-stage dilated cardiomyopathy.
Colak D, Kaya N, Al-Zahrani J, Al Bakheet A, Muiya P, Andres E, Quackenbush J, Dzimiri N.
Genomics 94(1):20-31. Epub 2009 Mar 28. 2009
22HDAC1, HDAC2
Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.
Hait NC, Allegood J, Maceyka M, Strub GM, Harikumar KB, Singh SK, Luo C, Marmorstein R, Kordula T, Milstien S, Spiegel S.
Science 325(5945):1254-7. Erratum in: Science. 2009 Oct 16;326(5951):366. PMID: 19729656 2009
23HDAC2
HDAC2 negatively regulates memory formation and synaptic plasticity.
Guan JS, Haggarty SJ, Giacometti E, Dannenberg JH, Joseph N, Gao J, Nieland TJ, Zhou Y, Wang X, Mazitschek R, Bradner JE, DePinho RA, Jaenisch R, Tsai LH.
Nature 459(7243):55-60. 2009
24HDAC1, HDAC2
Expression and function of histone deacetylases in rheumatoid arthritis synovial fibroblasts.
Horiuchi M, Morinobu A, Chin T, Sakai Y, Kurosaka M, Kumagai S.
J Rheumatol 36(8):1580-9. Epub 2009 Jun 16. 2009
25HDAC2
Nitration of distinct tyrosine residues causes inactivation of histone deacetylase 2.
Osoata GO, Yamamura S, Ito M, Vuppusetty C, Adcock IM, Barnes PJ, Ito K.
Biochem Biophys Res Commun 384(3):366-71. Epub 2009 May 3. 2009
26HDAC2
Loss of CFTR results in reduction of histone deacetylase 2 in airway epithelial cells.
Bartling TR, Drumm ML.
Am J Physiol Lung Cell Mol Physiol 297(1):L35-43. Epub 2009 May 1. 2009
27HDAC2
Histone deacetylase 1, 2, 6 and acetylated histone H4 in B- and T-cell lymphomas.
Marquard L, Poulsen CB, Gjerdrum LM, de Nully Brown P, Christensen IJ, Jensen PB, Sehested M, Johansen P, Ralfkiaer E.
Histopathology 54(6):688-98. 2009
28HDAC2
HDAC2 regulates chromatin plasticity and enhances DNA vulnerability.
Marchion DC, Bicaku E, Turner JG, Schmitt ML, Morelli DR, Munster PN.
Mol Cancer Ther 8(4):794-801. 2009
29HDAC2, RFX5
HDAC2 deacetylates class II transactivator and suppresses its activity in macrophages and smooth muscle cells.
Kong X, Fang M, Li P, Fang F, Xu Y.
J Mol Cell Cardiol 46(3):292-9. Epub 2008 Nov 7. 2009
30HDAC2, KLF4
All-trans retinoic acid increases KLF4 acetylation by inducing HDAC2 phosphorylation and its dissociation from KLF4 in vascular smooth muscle cells.
Meng F, Han M, Zheng B, Wang C, Zhang R, Zhang XH, Wen JK.
Biochem Biophys Res Commun 387(1):13-8. Epub 2009 May 30.PMID: 19486889 2009
31CDX5, HDAC2, KDM1A, L3MBTL1, L3MBTL2, SETDB1
SUMO engages multiple corepressors to regulate chromatin structure and transcription.
Ouyang J, Gill G.
Epigenetics 4(7):440-4. Epub 2009 Oct 14.PMID: 19829068 2009
32HDAC1, HDAC2
Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development.
Montgomery RL, Hsieh J, Barbosa AC, Richardson JA, Olson EN.
Proc Natl Acad Sci U S A. 106(19):7876-81. 2009
33HDAC2
FOXP3 up-regulates p21 expression by site-specific inhibition of histone deacetylase 2/histone deacetylase 4 association to the locus.
Liu R, Wang L, Chen G, Katoh H, Chen C, Liu Y, Zheng P.
Cancer Res. 69(6):2252-9. 2009
34HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9
The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men.
Yang XJ, Seto E.
Nat Rev Mol Cell Biol 9(3):206-18. Review. 2008
35HDAC2
HDAC2 blockade by nitric oxide and histone deacetylase inhibitors reveals a common target in Duchenne muscular dystrophy treatment.
Colussi C, Mozzetta C, Gurtner A, Illi B, Rosati J, Straino S, Ragone G, Pescatori M, Zaccagnini G, Antonini A, Minetti G, Martelli F, Piaggio G, Gallinari P, Steinkuhler C, Clementi E, Dell'Aversana C, Altucci L, Mai A, Capogrossi MC, Puri PL, Gaetano C.
Proc Natl Acad Sci U S A 105(49):19183-7. Epub 2008 Dec 1. Erratum in: Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1679. Steinkulher, Christian [correcte 2008
36HDAC2
S-Nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons.
Nott A, Watson PM, Robinson JD, Crepaldi L, Riccio A.
Nature 455(7211):411-5. Epub 2008 Aug 27. 2008
37HDAC2
Class I histone deacetylases 1, 2 and 3 are highly expressed in renal cell cancer.
Fritzsche FR, Weichert W, Röske A, Gekeler V, Beckers T, Stephan C, Jung K, Scholman K, Denkert C, Dietel M, Kristiansen G.
BMC Cancer 8:381. 2008
38HDAC2
An inactivating mutation in HDAC2 leads to dysregulation of apoptosis mediated by APAF1.
Hanigan CL, Van Engeland M, De Bruine AP, Wouters KA, Weijenberg MP, Eshleman JR, Herman JG.
Gastroenterology 135(5):1654-1664.e2. Epub 2008 Aug 7. 2008
39HDAC1, HDAC2
Epstein-Barr virus nuclear antigen 3C recruits histone deacetylase activity and associates with the corepressors mSin3A and NCoR in human B-cell lines.
Knight JS, Lan K, Subramanian C, Robertson ES.
J Virol. 77(7):4261-72. 2008
40HDAC1, HDAC2
Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility.
Montgomery RL, Davis CA, Potthoff MJ, Haberland M, Fielitz J, Qi X, Hill JA, Richardson JA, Olson EN.
Genes Dev. 21(14):1790-802. 2007
41HDAC2
A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition.
Ropero S, Fraga MF, Ballestar E, Hamelin R, Yamamoto H, Boix-Chornet M, Caballero R, Alaminos M, Setien F, Paz MF, Herranz M, Palacios J, Arango D, Orntoft TF, Aaltonen LA, Schwartz S, Esteller M.
Nat Genet 38(5):566-9. Epub 2006 Apr 16. 2006
42CUDP, HDAC2
Role of Brg1 and HDAC2 in GR trans-repression of the pituitary POMC gene and misexpression in Cushing disease.
Bilodeau S, Vallette-Kasic S, Gauthier Y, Figarella-Branger D, Brue T, Berthelet F, Lacroix A, Batista D, Stratakis C, Hanson J, Meij B, Drouin J.
Genes Dev 20(20):2871-86.PMID: 17043312 2006
43HDAC1, HDAC2
Regulatory factor for X-box family proteins differentially interact with histone deacetylases to repress collagen alpha2(I) gene (COL1A2) expression.
Xu Y, Sengupta PK, Seto E, Smith BD.
J Biol Chem. 281(14):9260-70. 2006
44SMN2, HDAC1, HDAC2
The role of histone acetylation in SMN gene expression.
Kernochan LE, Russo ML, Woodling NS, Huynh TN, Avila AM, Fischbeck KH, Sumner CJ.
Hum Mol Genet 14(9):1171-82. Epub 2005 Mar 16. 2005
45EID2B, EID3, HDAC1, HDAC2
A novel EID family member, EID-3, inhibits differentiation and forms a homodimer or heterodimer with EID-2.
Sasajima Y, Tanaka H, Miyake S, Yuasa Y.
Biochem Biophys Res Commun 333(3):969-75. 2005
46HDAC1, HDAC2
Cell cycle regulation of chromatin at an origin of DNA replication.
Zhou J, Chau CM, Deng Z, Shiekhattar R, Spindler MP, Schepers A, Lieberman PM.
EMBO J. 24(7):1406-17. 2005
47DNMT3B, HDAC1, HDAC2, SMARCA5, SUV39H1
DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system.
Geiman TM, Sankpal UT, Robertson AK, Zhao Y, Zhao Y, Robertson KD.
Biochem Biophys Res Commun 318(2):544-55. 2004
48HDAC1, HDAC2, PHF21A
Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression.
Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T.
Biochem Biophys Res Commun 322(2):601-8. 2004
49ATRX, DNMT1, DNMT3B, HDAC1, HDAC2, KAT2B, KAT8, MBD1, MBD2, MECP2, SIN3A
Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns.
Craig JM, Earle E, Canham P, Wong LH, Anderson M, Choo KH.
Hum Mol Genet 12(23):3109-21. Epub 2003 Sep 30. 2003
50HDAC1, HDAC2, MTA2
The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity.
Yao YL, Yang WM.
J Biol Chem 278(43):42560-8. Epub 2003 Aug 13. 2003
51HDAC1, HDAC2
Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene.
Bhakat KK, Izumi T, Yang SH, Hazra TK, Mitra S.
EMBO J. 22(23):6299-309. 2003
52HDAC1, HDAC2
CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins.
Tai HH, Geisterfer M, Bell JC, Moniwa M, Davie JR, Boucher L, McBurney MW.
Biochem Biophys Res Commun. 308(1):170-6. 2003
53HDAC1, HDAC2
A novel EID-1 family member, EID-2, associates with histone deacetylases and inhibits muscle differentiation.
Miyake S, Yanagisawa Y, Yuasa Y.
J Biol Chem. 278(19):17060-5. 2003
54HDAC2
Repression of E2F1-mediated transcription by the ErbB3 binding protein Ebp1 involves histone deacetylases.
Zhang Y, Woodford N, Xia X, Hamburger AW.
Nucleic Acids Res. 31(8):2168-77. 2003
55HDAC10, HDAC2
Isolation and characterization of a novel class II histone deacetylase, HDAC10.
Fischer DD, Cai R, Bhatia U, Asselbergs FA, Song C, Terry R, Trogani N, Widmer R, Atadja P, Cohen D.
J Biol Chem 277(8):6656-66. Epub 2001 Dec 05. 2002
56HDAC1, HDAC2
Murine Sall1 represses transcription by recruiting a histone deacetylase complex.
Kiefer SM, McDill BW, Yang J, Rauchman M.
J Biol Chem. 277(17):14869-76. 2002
57HDAC2
The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2.
Sun JM, Chen HY, Moniwa M, Litchfield DW, Seto E, Davie JR.
J Biol Chem. 277(39):35783-6. 2002
58HDAC1, HDAC2
Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases.
Vaute O, Nicolas E, Vandel L, Trouche D.
Nucleic Acids Res. 30(2):475-81. 2002
59HDAC2
Regulation of histone deacetylase 2 by protein kinase CK2.
Tsai SC, Seto E.
J Biol Chem. 277(35):31826-33. 2002
60HDAC2
Histone deacetylases augment cytokine induction of the iNOS gene.
Yu Z, Zhang W, Kone BC.
J Am Soc Nephrol. 13(8):2009-17. 2002
61HDAC1, HDAC2, PML
The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases.
Wu WS, Vallian S, Seto E, Yang WM, Edmondson D, Roth S, Chang KS.
Mol Cell Biol. 21(7):2259-68 2001
62HDAC1, HDAC2
The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor.
Potter GB, Beaudoin GM 3rd, DeRenzo CL, Zarach JM, Chen SH, Thompson CC.
Genes Dev. 15(20):2687-701. 2001
63HDAC1, HDAC2
The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1.
Yang WM, Yao YL, Seto E.
EMBO J. 20(17):4814-25. 2001
64HDAC1, HDAC2
The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression.
Ashburner BP, Westerheide SD, Baldwin AS Jr.
Mol Cell Biol. 21(20):7065-77. 2001
65HDAC1, HDAC2
Sharp, an inducible cofactor that integrates nuclear receptor repression and activation.
Shi Y, Downes M, Xie W, Kao HY, Ordentlich P, Tsai CC, Hon M, Evans RM.
Genes Dev. 15(9):1140-51. 2001
66HDAC1, HDAC2
CoREST is an integral component of the CoREST- human histone deacetylase complex.
You A, Tong JK, Grozinger CM, Schreiber SL.
Proc Natl Acad Sci U S A. 98(4):1454-8. 2001
67HDAC1, HDAC2
Regulation of transcription factor YY1 by acetylation and deacetylation.
Yao YL, Yang WM, Seto E.
Mol Cell Biol. 21(17):5979-91. 2001
68DMAP1, DNMT1, HDAC2
DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci.
Rountree MR, Bachman KE, Baylin SB.
Nat Genet 25(3):269-77. 2000
69HDAC1, HDAC2
Histone deacetylase interacts directly with DNA topoisomerase II.
Tsai SC, Valkov N, Yang WM, Gump J, Sullivan D, Seto E.
Nat Genet 26(3):349-53. 2000
70BCOR, HDAC1, HDAC2
BCoR, a novel corepressor involved in BCL-6 repression.
Huynh KD, Fischle W, Verdin E, Bardwell VJ.
Genes Dev 14(14):1810-23. 2000
71HDAC1, HDAC2
A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1.
Underhill C, Qutob MS, Yee SP, Torchia J.
J Biol Chem. 275(51):40463-70. 2000
72BRCA1, HDAC1, HDAC2
BRCA1 interacts with components of the histone deacetylase complex.
Yarden RI, et al.
Proc Natl Acad Sci U S A 96(9):4983-8 1999
73EED, HDAC1, HDAC2
Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation.
van der Vlag J, Otte AP.
Nat Genet 23(4):474-8 1999
74CHD4, HDAC2
Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4.
Schmidt DR, Schreiber SL.
Biochemistry. 38(44):14711-7. 1999
75HDAC1, HDAC2, PML, RARA, ZBTB16
Role of the histone deacetylase complex in acute promyelocytic leukaemia.
Lin RJ, et al.
Nature 391 : 811-814. 1998
76HDAC2
Human histone deacetylase 2, HDAC2 (human RPD3), is localized to 6q21 by radiation hybrid mapping.
Betz R, et al.
Genomics 52 : 245-246. 1998
77HDAC1, HDAC2, HDAC3, KAT2A, KAT2B
Identification and mapping of human histone acetylation modifier gene homologues.
Randhawa GS, et al.
Genomics 51 : 262-269. 1998
78HDAC2, NCOR1
A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression.
Heinzel T, et al.
Nature 387(6628):43-8. 1997
79HDAC2, HDAC3, YY1
Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3.
Yang WM, et al.
Proc Natl Acad Sci U S A 93 : 12845-12850. 1996