Citations for
1HDAC1, USP38
The Deubiquitinase USP38 Promotes NHEJ Repair through Regulation of HDAC1 Activity and Regulates Cancer Cell Response to Genotoxic Insults.
Yang Y, Yang C, Li T, Yu S, Gan T, Hu J, Cui J, Zheng X.
Cancer Res Feb 15;80(4):719-731. doi: 10.1158/0008-5472.CAN-19-2149. Epub 2019 Dec 24 2020
2HDAC1, RSF1, SGO1
The chromatin remodeler RSF1 controls centromeric histone modifications to coordinate chromosome segregation.
Lee HS, Lin Z, Chae S, Yoo YS, Kim BG, Lee Y, Johnson JL, Kim YS, Cantley LC, Lee CW, Yu H, Cho H.
Nat Commun 9(1):3848. doi: 10.1038/s41467-018-06377-w. 2018
3HDAC1, IKZF1, KDM5B
Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia.
Wang H, Song C, Ding Y, Pan X, Ge Z, Tan BH, Gowda C, Sachdev M, Muthusami S, Ouyang H, Lai L, Francis OL, Morris CL, Abdel-Azim H, Dorsam G, Xiang M, Payne KJ, Dovat S.
J Biol Chem 291(8):4004-18. doi: 10.1074/jbc.M115.679332. Epub 2015 Dec 10. 2016
4HDAC1, MORF4L1, PHF12, SIN3B
The chromatin associated Phf12 protein maintains nucleolar integrity and prevents premature cellular senescence.
Graveline R, Marcinkiewicz K, Choi S, Paquet M, Wurst W, Floss T, David G.
Mol Cell Biol ol Cell Biol. 2016 Dec 12. pii: MCB.00522-16. [Epub ahead of print] 2016
5HDAC1, SIN3A, TET3
TET3 Inhibits Type I IFN Production Independent of DNA Demethylation.
Xue S, Liu C, Sun X, Li W, Zhang C, Zhou X, Lu Y, Xiao J, Li C, Xu X, Sun B, Xu G, Wang H.
Cell Rep 16(4):1096-105. doi: 10.1016/j.celrep.2016.06.068. 2016
6BRDT, HDAC1, PRMT5, TRIM28
. BET Protein BRDT Complexes With HDAC1, PRMT5, and TRIM28 and Functions in Transcriptional Repression During Spermatogenesis
Wang L, Wolgemuth DJ
J Cell Biochem. Jun;117(6):1429-38. doi: 10.1002/jcb.25433. Epub 2015 Nov 26. 2016
7HDAC1, HDAC2, HDAC5, HDAC6, HDAC7
Quantification of histone deacetylase isoforms in human frontal cortex, human retina, and mouse brain.
Anderson KW, Chen J, Wang M, Mast N, Pikuleva IA, Turko IV.
PLoS One 10(5):e0126592. doi: 10.1371/journal.pone.0126592. eCollection 2015. 2015
8HDAC1, SLC6A4
Histone deacetylase HDAC1 downregulates transcription of the serotonin transporter (5-HTT) gene in tumor cells.
Phi van DK, Mühlbauer E, Phi-van L.
Biochim Biophys Acta 1849(8):909-18. doi: 10.1016/j.bbagrm.2015.05.008. Epub 2015 May 27. 2015
9HDAC1, MTA2, SETD6
SETD6 controls the expression of estrogen-responsive genes and proliferation of breast carcinoma cells.
O'Neill DJ, Williamson SC, Alkharaif D, Monteiro IC, Goudreault M, Gaughan L, Robson CN, Gingras AC, Binda O.
Epigenetics 9(7). [Epub ahead of print] 2014
10HDAC1, HDAC2, HDAC7, HLCS
Holocarboxylase synthetase acts as a biotin-independent transcriptional repressor interacting with HDAC1, HDAC2 and HDAC7.
Trujillo-Gonzalez I, Cervantes-Roldan R, Gonzalez-Noriega A, Michalak C, Reyes-Carmona S, Barrios-Garcia T, Meneses-Morales I, Leon-Del-Rio A.
Mol Genet Metab 111(3):321-30. doi: 10.1016/j.ymgme.2013.10.016. Epub 2013 Nov 2. 2014
11HDAC1, HDAC2, SIN3A
Sin3a-associated Hdac1 and Hdac2 are essential for hematopoietic stem cell homeostasis and contribute differentially to hematopoiesis.
Heideman MR, Lancini C, Proost N, Yanover E, Jacobs H, Dannenberg JH.
Haematologica 99(8):1292-303. doi: 10.3324/haematol.2013.092643. 2014
12BCL6, BCOR, HDAC1, RNF2
Bcl6a function is required during optic cup formation to prevent p53-dependent apoptosis and colobomata.
Lee J, Lee BK, Gross JM.
Hum Mol Genet 22(17):3568-82. doi: 10.1093/hmg/ddt211. Epub 2013 May 12. 2013
13HDAC1, TP73
TAp73 protein stability is controlled by histone deacetylase 1 via regulation of Hsp90 chaperone function.
Zhang J, Xu E, Chen X.
J Biol Chem 288(11):7727-37. doi: 10.1074/jbc.M112.429522. Epub 2013 Jan 29. 2013
14HDAC1, HDAC4, TRPS1
The multi zinc-finger protein Trps1 acts as a regulator of histone deacetylation during mitosis.
Wuelling M, Pasdziernik M, Moll CN, Thiesen AM, Schneider S, Johannes C, Vortkamp A.
Cell Cycle 12(14):2219-32. doi: 10.4161/cc.25267. 2013
15HDAC1, HEXIM1, HIF1A
HEXIM1 down-regulates hypoxia-inducible factor-1α protein stability.
Yeh IJ, Ogba N, Bensigner H, Welford SM, Montano MM.
Biochem J 456(2):195-204. doi: 10.1042/BJ20130592. 2013
16HDAC1, LSD1
Lysine-specific demethylase 1 (LSD1) and histone deacetylase 1 (HDAC1) synergistically repress proinflammatory cytokines and classical complement pathway components.
Janzer A, Lim S, Fronhoffs F, Niazy N, Buettner R, Kirfel J.
Biochem Biophys Res Commun 421(4):665-70. doi: 10.1016/j.bbrc.2012.04.057. Epub 2012 Apr 17. 2012
17CCND1, FAM60A, HDAC1, SIN3A
Family with sequence similarity 60A (FAM60A) protein is a cell cycle-fluctuating regulator of the SIN3-HDAC1 histone deacetylase complex.
Muñoz IM, MacArtney T, Sanchez-Pulido L, Ponting CP, Rocha S, Rouse J.
J Biol Chem 287(39):32346-53. 2012
18HDAC1, HDAC2
HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells.
Jacob C, Christen CN, Pereira JA, Somandin C, Baggiolini A, Lötscher P, Ozçelik M, Tricaud N, Meijer D, Yamaguchi T, Matthias P, Suter U.
Nat Neurosci. 14(4):429-36. 2011
19HDAC1
Overexpression of HDAC1 induces cellular senescence by Sp1/PP2A/pRb pathway.
Chuang JY, Hung JJ.
Biochem Biophys Res Commun 407(3):587-92. Epub 2011 Mar 21. 2011
20HDAC1, SMARCAD1, TRIM28
Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.
Rowbotham SP, Barki L, Neves-Costa A, Santos F, Dean W, Hawkes N, Choudhary P, Will WR, Webster J, Oxley D, Green CM, Varga-Weisz P, Mermoud JE.
Mol Cell 42(3):285-96. 2011
21HDAC1, MORF4L1, PHF12, SIN3B
A novel mammalian complex containing Sin3B mitigates histone acetylation and RNA polymerase II progression within transcribed loci.
Jelinic P, Pellegrino J, David G.
Mol Cell Biol 31(1):54-62. doi: 10.1128/MCB.00840-10. 2011
22CDKN1A, HDAC1
The cyclin-dependent kinase inhibitor p21 is a crucial target for histone deacetylase 1 as a regulator of cellular proliferation.
Zupkovitz G, Grausenburger R, Brunmeir R, Senese S, Tischler J, Jurkin J, Rembold M, Meunier D, Egger G, Lagger S, Chiocca S, Propst F, Weitzer G, Seiser C.
Mol Cell Biol 30(5):1171-81. Epub 2009 Dec 22.PMID: 20028735 2010
23HDAC1, HDAC2
Histone deacetylase 1 (HDAC1), but not HDAC2, controls embryonic stem cell differentiation.
Dovey OM, Foster CT, Cowley SM.
Proc Natl Acad Sci U S A 107(18):8242-7. Epub 2010 Apr 19. 2010
24HDAC1, HDAC2
Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease.
Bradner JE, Mak R, Tanguturi SK, Mazitschek R, Haggarty SJ, Ross K, Chang CY, Bosco J, West N, Morse E, Lin K, Shen JP, Kwiatkowski NP, Gheldof N, Dekker J, DeAngelo DJ, Carr SA, Schreiber SL, Golub TR, Ebert BL.
Proc Natl Acad Sci U S A 107(28):12617-22. Epub 2010 Jun 28.PMID: 20616024 2010
25HDAC1, HDAC2
Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis.
Wilting RH, Yanover E, Heideman MR, Jacobs H, Horner J, van der Torre J, DePinho RA, Dannenberg JH.
EMBO J. 29(15):2586-97. 2010
26HDAC1
An HDAC1-binding domain within FATS bridges p21 turnover to radiation-induced tumorigenesis.
Li Z, Zhang Q, Mao JH, Weise A, Mrasek K, Fan X, Zhang X, Liehr T, Lu KH, Balmain A, Cai WW.
Oncogene. 29(18):2659-71. 2010
27HDAC1, MEF2A, MEF2D
Dual roles for MEF2A and MEF2D during human macrophage terminal differentiation and c-Jun expression.
Aude-Garcia C, Collin-Faure V, Bausinger H, Hanau D, Rabilloud T, Lemercier C.
Biochem J 430(2):237-44. 2010
28HDAC1, HDAC2
Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining.
Miller KM, Tjeertes JV, Coates J, Legube G, Polo SE, Britton S, Jackson SP.
Nat Struct Mol Biol 17(9):1144-51. Epub 2010 Aug 29. 2010
29EP300, HDAC1, NR4A1
Regulation of Nur77 protein turnover through acetylation and deacetylation induced by p300 and HDAC1.
Kang SA, Na H, Kang HJ, Kim SH, Lee MH, Lee MO.
Biochem Pharmacol 80(6):867-73. Epub 2010 May 11. 2010
30HDAC1, HDAC2
HDAC1, a novel marker for benign teratomas.
Simboeck E, Di Croce L.
EMBO J 29(23):3893-5. Epub 2010 Dec 1. No abstract available. 2010
31HDAC1, HDAC2
Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.
Hait NC, Allegood J, Maceyka M, Strub GM, Harikumar KB, Singh SK, Luo C, Marmorstein R, Kordula T, Milstien S, Spiegel S.
Science 325(5945):1254-7. Erratum in: Science. 2009 Oct 16;326(5951):366. PMID: 19729656 2009
32HDAC1, HDAC2
Expression and function of histone deacetylases in rheumatoid arthritis synovial fibroblasts.
Horiuchi M, Morinobu A, Chin T, Sakai Y, Kurosaka M, Kumagai S.
J Rheumatol 36(8):1580-9. Epub 2009 Jun 16. 2009
33APPL1, HDAC1
Functional characterization of the interactions between endosomal adaptor protein APPL1 and the NuRD co-repressor complex.
Banach-Orlowska M, Pilecka I, Torun A, Pyrzynska B, Miaczynska M.
Biochem J 423(3):389-400. 2009
34DNMT1, HDAC1, KAT5, UHRF1
UHRF1 recruits the histone acetyltransferase Tip60 and controls its expression and activity.
Achour M, Fuhrmann G, Alhosin M, Rondé P, Chataigneau T, Mousli M, Schini-Kerth VB, Bronner C.
Biochem Biophys Res Commun 390(3):523-8. Epub 2009 Oct 2.PMID: 19800870 2009
35HDAC1, HDAC2
Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development.
Montgomery RL, Hsieh J, Barbosa AC, Richardson JA, Olson EN.
Proc Natl Acad Sci U S A. 106(19):7876-81. 2009
36HDAC1
miR-449a targets HDAC-1 and induces growth arrest in prostate cancer.
Noonan EJ, Place RF, Pookot D, Basak S, Whitson JM, Hirata H, Giardina C, Dahiya R.
Oncogene. 28(14):1714-24. 2009
37HDAC1
Chfr is linked to tumour metastasis through the downregulation of HDAC1.
Oh YM, Kwon YE, Kim JM, Bae SJ, Lee BK, Yoo SJ, Chung CH, Deshaies RJ, Seol JH.
Nat Cell Biol. 11(3):295-302. 2009
38HDAC1
Functional connection between deimination and deacetylation of histones.
Denis H, Deplus R, Putmans P, Yamada M, Métivier R, Fuks F.
Mol Cell Biol. 29(18):4982-93. 2009
39HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9
The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men.
Yang XJ, Seto E.
Nat Rev Mol Cell Biol 9(3):206-18. Review. 2008
40HDAC1
Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy.
Weichert W, Ršske A, Gekeler V, Beckers T, Stephan C, Jung K, Fritzsche FR, Niesporek S, Denkert C, Dietel M, Kristiansen G.
Br J Cancer 98(3):604-10. Epub 2008 Jan 22. 2008
41HDAC1, HDAC3, NIPBL
The Cohesin loading factor NIPBL recruits histone deacetylases to mediate local chromatin modifications.
Jahnke P, Xu W, Wülling M, Albrecht M, Gabriel H, Gillessen-Kaesbach G, Kaiser FJ.
Nucleic Acids Res 36(20):6450-8. Epub 2008 Oct 14. 2008
42HDAC1, HDAC2
Epstein-Barr virus nuclear antigen 3C recruits histone deacetylase activity and associates with the corepressors mSin3A and NCoR in human B-cell lines.
Knight JS, Lan K, Subramanian C, Robertson ES.
J Virol. 77(7):4261-72. 2008
43HDAC1
Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity.
Kim D, Frank CL, Dobbin MM, Tsunemoto RK, Tu W, Peng PL, Guan JS, Lee BH, Moy LY, Giusti P, Broodie N, Mazitschek R, Delalle I, Haggarty SJ, Neve RL, Lu Y, Tsai LH.
Neuron. 60(5):803-17. 2008
44HDAC1
ZNF198 stabilizes the LSD1-CoREST-HDAC1 complex on chromatin through its MYM-type zinc fingers.
Gocke CB, Yu H.
PLoS One. 3(9):e3255. 2008
45CYP1A1, HDAC1
HDAC1 bound to the Cyp1a1 promoter blocks histone acetylation associated with Ah receptor-mediated trans-activation.
Schnekenburger M, Peng L, Puga A.
Biochim Biophys Acta 1769(9-10):569-78. Epub 2007 Jul 20.PMID: 17707923 2007
46DDX5, HDAC1
SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1.
Jacobs AM, Nicol SM, Hislop RG, Jaffray EG, Hay RT, Fuller-Pace FV.
Oncogene 26(40):5866-76. Epub 2007 Mar 19.PMID: 17369852 2007
47HDAC1, HDAC2
Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility.
Montgomery RL, Davis CA, Potthoff MJ, Haberland M, Fielitz J, Qi X, Hill JA, Richardson JA, Olson EN.
Genes Dev. 21(14):1790-802. 2007
48HDAC1
Enhanced deacetylation of p53 by the anti-apoptotic protein HSCO in association with histone deacetylase 1.
Higashitsuji H, Higashitsuji H, Masuda T, Liu Y, Itoh K, Fujita J.
J Biol Chem. 282(18):13716-25. 2007
49HDAC1
HDAC1 acetylation is linked to progressive modulation of steroid receptor-induced gene transcription.
Qiu Y, Zhao Y, Becker M, John S, Parekh BS, Huang S, Hendarwanto A, Martinez ED, Chen Y, Lu H, Adkins NL, Stavreva DA, Wiench M, Georgel PT, Schiltz RL, Hager GL.
Mol Cell 22(5):669-79. 2006
50HDAC1, HDAC2
Regulatory factor for X-box family proteins differentially interact with histone deacetylases to repress collagen alpha2(I) gene (COL1A2) expression.
Xu Y, Sengupta PK, Seto E, Smith BD.
J Biol Chem. 281(14):9260-70. 2006
51SMN2, HDAC1, HDAC2
The role of histone acetylation in SMN gene expression.
Kernochan LE, Russo ML, Woodling NS, Huynh TN, Avila AM, Fischbeck KH, Sumner CJ.
Hum Mol Genet 14(9):1171-82. Epub 2005 Mar 16. 2005
52HDAC1, STAT3, PTPN6, DNMT1
STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes.
Zhang Q, Wang HY, Marzec M, Raghunath PN, Nagasawa T, Wasik MA.
Proc Natl Acad Sci U S A 102(19):6948-53. Epub 2005 May 3. 2005
53EID2B, EID3, HDAC1, HDAC2
A novel EID family member, EID-3, inhibits differentiation and forms a homodimer or heterodimer with EID-2.
Sasajima Y, Tanaka H, Miyake S, Yuasa Y.
Biochem Biophys Res Commun 333(3):969-75. 2005
54HDAC1, HDAC2
Cell cycle regulation of chromatin at an origin of DNA replication.
Zhou J, Chau CM, Deng Z, Shiekhattar R, Spindler MP, Schepers A, Lieberman PM.
EMBO J. 24(7):1406-17. 2005
55DNMT3B, HDAC1, HDAC2, SMARCA5, SUV39H1
DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system.
Geiman TM, Sankpal UT, Robertson AK, Zhao Y, Zhao Y, Robertson KD.
Biochem Biophys Res Commun 318(2):544-55. 2004
56HDAC1, MAGEA1
MAGE-A1 interacts with adaptor SKIP and the deacetylase HDAC1 to repress transcription.
Laduron S, Deplus R, Zhou S, Kholmanskikh O, Godelaine D, De Smet C, Hayward SD, Fuks F, Boon T, De Plaen E.
Nucleic Acids Res 32(14):4340-50. Print 2004. 2004
57HDAC1, HDAC2, PHF21A
Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression.
Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T.
Biochem Biophys Res Commun 322(2):601-8. 2004
58GSK3A, HDAC1
GSK3-mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity.
Viatour P, Dejardin E, Warnier M, Lair F, Claudio E, Bureau F, Marine JC, Merville MP, Maurer U, Green D, Piette J, Siebenlist U, Bours V, Chariot A.
Mol Cell. 16(1):35-45. 2004
59HDAC1
The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner.
Wilson BJ, Bates GJ, Nicol SM, Gregory DJ, Perkins ND, Fuller-Pace FV.
BMC Mol Biol. 5:11. 2004
60HDAC1
Site-specific acetylation of the fetal globin activator NF-E4 prevents its ubiquitination and regulates its interaction with the histone deacetylase, HDAC1.
Zhao Q, Cumming H, Cerruti L, Cunningham JM, Jane SM.
J Biol Chem. 279(40):41477-86. 2004
61ATRX, DNMT1, DNMT3B, HDAC1, HDAC2, KAT2B, KAT8, MBD1, MBD2, MECP2, SIN3A
Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns.
Craig JM, Earle E, Canham P, Wong LH, Anderson M, Choo KH.
Hum Mol Genet 12(23):3109-21. Epub 2003 Sep 30. 2003
62HDAC1, MORF4L2, MYBL2
MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner.
Tominaga K, Leung JK, Rookard P, Echigo J, Smith JR, Pereira-Smith OM.
J Biol Chem 278(49):49618-24. Epub 2003 Sep 23. 2003
63AATF, CDKN1A, HDAC1
Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter.
Di Padova M, Bruno T, De Nicola F, Iezzi S, D'Angelo C, Gallo R, Nicosia D, Corbi N, Biroccio A, Floridi A, Passananti C, Fanciulli M.
J Biol Chem 278(38):36496-504. Epub 2003 Jul 7. 2003
64HDAC1, HDAC2, MTA2
The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity.
Yao YL, Yang WM.
J Biol Chem 278(43):42560-8. Epub 2003 Aug 13. 2003
65EFCAB6, HDAC1
DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex.
Niki T, Takahashi-Niki K, Taira T, Iguchi-Ariga SM, Ariga H.
Mol Cancer Res 1(4):247-61. 2003
66HDAC1
Cytoplasmic IkappaBalpha increases NF-kappaB-independent transcription through binding to histone deacetylase (HDAC) 1 and HDAC3.
Viatour P, Legrand-Poels S, van Lint C, Warnier M, Merville MP, Gielen J, Piette J, Bours V, Chariot A.
J Biol Chem. 278(47):46541-8. 2003
67HDAC1, HDAC2
Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene.
Bhakat KK, Izumi T, Yang SH, Hazra TK, Mitra S.
EMBO J. 22(23):6299-309. 2003
68HDAC1, HDAC2
CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins.
Tai HH, Geisterfer M, Bell JC, Moniwa M, Davie JR, Boucher L, McBurney MW.
Biochem Biophys Res Commun. 308(1):170-6. 2003
69HDAC1, HDAC2
A novel EID-1 family member, EID-2, associates with histone deacetylases and inhibits muscle differentiation.
Miyake S, Yanagisawa Y, Yuasa Y.
J Biol Chem. 278(19):17060-5. 2003
70HDAC1
Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain.
Ding Z, Gillespie LL, Paterno GD.
Mol Cell Biol. 23(1):250-8. 2003
71HDAC1
Repression of Smad transcriptional activity by PIASy, an inhibitor of activated STAT.
Long J, Matsuura I, He D, Wang G, Shuai K, Liu F.
Proc Natl Acad Sci U S A. 100(17):9791-6. 2003
72HDAC1
An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B.
Yang L, Mei Q, Zielinska-Kwiatkowska A, Matsui Y, Blackburn ML, Benedetti D, Krumm AA, Taborsky GJ Jr, Chansky HA.
Biochem J. 369(Pt 3):651-7. 2003
73HDAC1
Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1.
Nusinzon I, Horvath CM.
Proc Natl Acad Sci U S A. 100(25):14742-7. 2003
74HDAC1, PEX14
NAPP2, a Peroxisomal Membrane Protein, Is Also a Transcriptional Corepressor.
Gavva NR, Wen SC, Daftari P, Moniwa M, Yang WM, Yang-Feng LP, Seto E, Davie JR, Shen CK.
Genomics 79(3):423-31. 2002
75CREBBP, HDAC1, NFKB1, NFKB2
The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1.
Zhong H, May MJ, Jimi E, Ghosh S.
Mol Cell 9(3):625-36. 2002
76HDAC1, PCNA
Proliferating cell nuclear antigen associates with histone deacetylase activity, integrating DNA replication and chromatin modification.
Milutinovic S, Zhuang Q, Szyf M.
J Biol Chem 277(23):20974-8. 2002
77HDAC1, RFC1
The large subunit of replication factor C interacts with the histone deacetylase, HDAC1.
Anderson LA, Perkins ND.
J Biol Chem 277(33):29550-4. 2002
78HDAC1, ING1
Human ING1 proteins differentially regulate histone acetylation.
Vieyra D, Loewith R, Scott M, Bonnefin P, Boisvert FM, Cheema P, Pastyryeva S, Meijer M, Johnston RN, Bazett-Jones DP, McMahon S, Cole MD, Young D, Riabowol K.
J Biol Chem 277(33):29832-9. Epub 2002 May 15. 2002
79HDAC1, IFRD1, NCOR1, SIN3B
TIS7 interacts with the mammalian SIN3 histone deacetylase complex in epithelial cells.
Vietor I, Vadivelu SK, Wick N, Hoffman R, Cotten M, Seiser C, Fialka I, Wunderlich W, Haase A, Korinkova G, Brosch G, Huber LA.
EMBO J 21(17):4621-31. 2002
80HDAC1
The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2.
Saito M, Ishikawa F.
J Biol Chem. 277(38):35434-9. 2002
81HDAC1
Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor.
Gaughan L, Logan IR, Cook S, Neal DE, Robson CN.
J Biol Chem. 277(29):25904-13. 2002
82HDAC1
The chromatin remodeling complex NoRC targets HDAC1 to the ribosomal gene promoter and represses RNA polymerase I transcription.
Zhou Y, Santoro R, Grummt I.
EMBO J. 21(17):4632-40. 2002
83HDAC1
The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies.
Hoogeveen AT, Rossetti S, Stoyanova V, Schonkeren J, Fenaroli A, Schiaffonati L, van Unen L, Sacchi N.
Oncogene. 21(43):6703-12. 2002
84HDAC1
Dnmt3L is a transcriptional repressor that recruits histone deacetylase.
Deplus R, Brenner C, Burgers WA, Putmans P, Kouzarides T, de Launoit Y, Fuks F.
Nucleic Acids Res. 30(17):3831-8. 2002
85HDAC1
SUMO-1 modification of histone deacetylase 1 (HDAC1) modulates its biological activities.
David G, Neptune MA, DePinho RA.
J Biol Chem. 277(26):23658-63. 2002
86HDAC1, HDAC2
Murine Sall1 represses transcription by recruiting a histone deacetylase complex.
Kiefer SM, McDill BW, Yang J, Rauchman M.
J Biol Chem. 277(17):14869-76. 2002
87HDAC1, HDAC2
Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases.
Vaute O, Nicolas E, Vandel L, Trouche D.
Nucleic Acids Res. 30(2):475-81. 2002
88HDAC1
Human class I histone deacetylase complexes show enhanced catalytic activity in the presence of ATP and co-immunoprecipitate with the ATP-dependent chaperone protein Hsp70.
Johnson CA, White DA, Lavender JS, O'Neill LP, Turner BM.
J Biol Chem. 277(11):9590-7. 2002
89HDAC1, MYOD1
A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: inhibition of the myogenic program.
Mal A, Sturniolo M, Schiltz RL, Ghosh MK, Harter ML.
EMBO J 20(7):1739-53. 2001
90DNMT3A, HDAC1, ZBTB18
Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription.
Fuks F, Burgers WA, Godin N, Kasai M, Kouzarides T.
EMBO J 20(10):2536-2544. 2001
91HDAC1, TGIF1, TGIF2
TGIF2 interacts with histone deacetylase 1 and represses transcription.
Melhuish TA, Gallo CM, Wotton D.
J Biol Chem 276(34):32109-14. 2001
92HDAC1, HDAC2, PML
The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases.
Wu WS, Vallian S, Seto E, Yang WM, Edmondson D, Roth S, Chang KS.
Mol Cell Biol. 21(7):2259-68 2001
93HDAC1, HDAC2
The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor.
Potter GB, Beaudoin GM 3rd, DeRenzo CL, Zarach JM, Chen SH, Thompson CC.
Genes Dev. 15(20):2687-701. 2001
94HDAC1
Homo-oligomerisation and nuclear localisation of mouse histone deacetylase 1.
Taplick J, Kurtev V, Kroboth K, Posch M, Lechner T, Seiser C.
J Mol Biol. 308(1):27-38. 2001
95HDAC1
Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis.
Johnson CA, Padget K, Austin CA, Turner BM.
J Biol Chem. 276(7):4539-42. 2001
96HDAC1, HDAC2
The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1.
Yang WM, Yao YL, Seto E.
EMBO J. 20(17):4814-25. 2001
97HDAC1
The leukaemia-associated transcription factors EVI-1 and MDS1/EVI1 repress transcription and interact with histone deacetylase.
Vinatzer U, Taplick J, Seiser C, Fonatsch C, Wieser R.
Br J Haematol. 114(3):566-73. 2001
98HDAC1
Class I histone deacetylases sequentially interact with MyoD and pRb during skeletal myogenesis.
Puri PL, Iezzi S, Stiegler P, Chen TT, Schiltz RL, Muscat GE, Giordano A, Kedes L, Wang JY, Sartorelli V.
Mol Cell. 8(4):885-97. 2001
99HDAC1, HDAC2
The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression.
Ashburner BP, Westerheide SD, Baldwin AS Jr.
Mol Cell Biol. 21(20):7065-77. 2001
100HDAC1, HDAC2
Sharp, an inducible cofactor that integrates nuclear receptor repression and activation.
Shi Y, Downes M, Xie W, Kao HY, Ordentlich P, Tsai CC, Hon M, Evans RM.
Genes Dev. 15(9):1140-51. 2001
101HDAC1, HDAC2
CoREST is an integral component of the CoREST- human histone deacetylase complex.
You A, Tong JK, Grozinger CM, Schreiber SL.
Proc Natl Acad Sci U S A. 98(4):1454-8. 2001
102HDAC1
ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain.
Amann JM, Nip J, Strom DK, Lutterbach B, Harada H, Lenny N, Downing JR, Meyers S, Hiebert SW.
Mol Cell Biol. 21(19):6470-83. 2001
103HDAC1, HDAC2
Regulation of transcription factor YY1 by acetylation and deacetylation.
Yao YL, Yang WM, Seto E.
Mol Cell Biol. 21(17):5979-91. 2001
104HDAC1
DNA methyltransferase dnmt1 associates with histone deacetylase activity.
Fuks F, Burgers WA, Brehm A, Hughes-Davies L, Kouzarides T.
Nat Genet 24(1):88-91 2000
105HDAC1, HDAC2
Histone deacetylase interacts directly with DNA topoisomerase II.
Tsai SC, Valkov N, Yang WM, Gump J, Sullivan D, Seto E.
Nat Genet 26(3):349-53. 2000
106BCOR, HDAC1, HDAC2
BCoR, a novel corepressor involved in BCL-6 repression.
Huynh KD, Fischle W, Verdin E, Bardwell VJ.
Genes Dev 14(14):1810-23. 2000
107HDAC1
RbAp48 belongs to the histone deacetylase complex that associates with the retinoblastoma protein.
Nicolas E, Morales V, Magnaghi-Jaulin L, Harel-Bellan A, Richard-Foy H, Trouche D.
J Biol Chem. 275(13):9797-804. 2000
108HDAC1
Histone deacetylases specifically down-regulate p53-dependent gene activation.
Juan LJ, Shia WJ, Chen MH, Yang WM, Seto E, Lin YS, Wu CW.
J Biol Chem. 275(27):20436-43. 2000
109HDAC1
HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins.
Cai RL, Yan-Neale Y, Cueto MA, Xu H, Cohen D.
J Biol Chem. 275(36):27909-16. 2000
110HDAC1
Receptor-interacting protein 140 directly recruits histone deacetylases for gene silencing.
Wei LN, Hu X, Chandra D, Seto E, Farooqui M.
J Biol Chem. 275(52):40782-7. 2000
111HDAC1
Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5.
Zhou X, Richon VM, Rifkind RA, Marks PA.
Proc Natl Acad Sci U S A. 97(3):1056-61. 2000
112HDAC1, HDAC2
A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1.
Underhill C, Qutob MS, Yee SP, Torchia J.
J Biol Chem. 275(51):40463-70. 2000
113BRCA1, HDAC1, HDAC2
BRCA1 interacts with components of the histone deacetylase complex.
Yarden RI, et al.
Proc Natl Acad Sci U S A 96(9):4983-8 1999
114EED, HDAC1, HDAC2
Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation.
van der Vlag J, Otte AP.
Nat Genet 23(4):474-8 1999
115HDAC1, HDAC9, MEF2A
MEF-2 function is modified by a novel co-repressor, MITR
Sparrow DB, Miska EA, Langley E, Reynaud-Deonauth S, Kotecha S, Towers N, Spohr G, Kouzarides T, Mohun TJ.
EMBO J 18(18):5085-98. 1999
116HDAC1, RB1
Retinoblastoma protein recruits histone deacetylase to repress transcription.
Brehm A, et al.
Nature 391 : 597-601. 1998
117HDAC1, HDAC2, PML, RARA, ZBTB16
Role of the histone deacetylase complex in acute promyelocytic leukaemia.
Lin RJ, et al.
Nature 391 : 811-814. 1998
118HDAC1, HDAC2, HDAC3, KAT2A, KAT2B
Identification and mapping of human histone acetylation modifier gene homologues.
Randhawa GS, et al.
Genomics 51 : 262-269. 1998
119HDAC1, SAP30
SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex.
Zhang Y, Sun ZW, Iratni R, Erdjument-Bromage H, Tempst P, Hampsey M, Reinberg D.
Mol Cell 1(7):1021-31. 1998
120RUNX1T1, HDAC1, NCOR1
ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex.
Wang J, Hoshino T, Redner RL, Kajigaya S, Liu JM.
Proc Natl Acad Sci U S A 95(18):10860-5. 1998
121HDAC1
The carboxy-terminal region of adenovirus E1A activates transcription through targeting of a C-terminal binding protein-histone deacetylase complex.
Sundqvist A, Sollerbrant K, Svensson C.
FEBS Lett. 429(2):183-8. 1998
122HDAC1
A histone deacetylase corepressor complex regulates the Notch signal transduction pathway.
Kao HY, Ordentlich P, Koyano-Nakagawa N, Tang Z, Downes M, Kintner CR, Evans RM, Kadesch T.
Genes Dev. 12(15):2269-77. 1998
123HDAC1
The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase.
Ferreira R, Magnaghi-Jaulin L, Robin P, Harel-Bellan A, Trouche D.
Proc Natl Acad Sci U S A. 95(18):10493-8. 1998
124HDAC1
Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression.
Laherty CD, Yang WM, Sun JM, Davie JR, Seto E, Eisenman RN.
Cell. 89(3):349-56. 1997
125HDAC1
Isolation and mapping of a human gene (RPD3L1) that is homologous to RPD3, a transcription factor in Saccharomyces cerevisiae.
Furukawa Y, et al.
Cytogenet Cell Genet 73 : 130-133. 1996
126HDAC1
A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p.
Taunton J, et al.
Science 272 : 408-411. 1996