1 | HCRT, PMCH
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| Cerebrospinal fluid melanin-concentrating hormone (MCH) and hypocretin-1 (HCRT-1, orexin-A) in Alzheimer's disease.
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| Schmidt FM, Kratzsch J, Gertz HJ, Tittmann M, Jahn I, Pietsch UC, Kaisers UX, Thiery J, Hegerl U, Schönknecht P.
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| PLoS One 8(5):e63136. doi: 10.1371/journal.pone.0063136. Print 2013. Erratum in: PLoS One. 2013;8(6). doi:10.1371/annotation/7a79c40c-c1c 2013
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2 | HCRT
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| Ectopic overexpression of orexin alters sleep/wakefulness states and muscle tone regulation during REM sleep in mice.
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| Willie JT, Takahira H, Shibahara M, Hara J, Nomiyama M, Yanagisawa M, Sakurai T.
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| J Mol Neurosci 43(2):155-61. Epub 2010 Aug 14.
2011
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3 | HCRT
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| Orexin/hypocretin modulates response of ventral tegmental dopamine neurons to prefrontal activation: diurnal influences.
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| Moorman DE, Aston-Jones G.
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| J Neurosci 30(46):15585-99.
2010
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4 | HCRT
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| Hypocretin deficiency in narcolepsy with cataplexy is associated with a normal body core temperature modulation.
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| Grimaldi D, Agati P, Pierangeli G, Franceschini C, Guaraldi P, Barletta G, Vandi S, Cevoli S, Plazzi G, Montagna P, Cortelli P.
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| Chronobiol Int 27(8):1596-608.
2010
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5 | HCRT
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| Effects of sleep on the cardiovascular and thermoregulatory systems: a possible role for hypocretins.
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| Schwimmer H, Stauss HM, Abboud F, Nishino S, Mignot E, Zeitzer JM.
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| J Appl Physiol 109(4):1053-63. Epub 2010 Aug 12.
2010
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6 | HCRT
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| Reduced hypocretin (orexin) levels in dementia with Lewy bodies.
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| Lessig S, Ubhi K, Galasko D, Adame A, Pham E, Remidios K, Chang M, Hansen LA, Masliah E.
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| Neuroreport 21(11):756-60.
2010
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7 | HCRT, NR6A1
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| Transcriptional regulation of the hypocretin/orexin gene by NR6A1.
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| Tanaka S, Kodama T, Nonaka T, Toyoda H, Arai M, Fukazawa M, Honda Y, Honda M, Mignot E.
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| Biochem Biophys Res Commun 403(2):178-83. Epub 2010 Nov 5.
2010
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8 | HCRT
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| Loss of hypocretin (orexin) neurons with traumatic brain injury.
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| Baumann CR, Bassetti CL, Valko PO, Haybaeck J, Keller M, Clark E, Stocker R, Tolnay M, Scammell TE.
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| Ann Neurol 66(4):555-9.
2009
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9 | HCRT
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| Sleep homeostasis modulates hypocretin-mediated sleep-to-wake transitions.
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| Carter ME, Adamantidis A, Ohtsu H, Deisseroth K, de Lecea L.
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| J Neurosci 29(35):10939-49.
2009
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10 | HCRT, IGFBP3
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| IGFBP3 colocalizes with and regulates hypocretin (orexin).
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| Honda M, Eriksson KS, Zhang S, Tanaka S, Lin L, Salehi A, Hesla PE, Maehlen J, Gaus SE, Yanagisawa M, Sakurai T, Taheri S, Tsuchiya K, Honda Y, Mignot E.
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| PLoS One 4(1):e4254. Epub 2009 Jan 22.
2009
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11 | HCRT
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| Circadian and dark-pulse activation of orexin/hypocretin neurons.
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| Marston OJ, Williams RH, Canal MM, Samuels RE, Upton N, Piggins HD.
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| Mol Brain 1:19.
2008
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12 | HCRT
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| Hypocretin /orexin preferentially activates caudomedial ventral tegmental area dopamine neurons.
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| Vittoz NM, Schmeichel B, Berridge CW.
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| Eur J Neurosci 28(8):1629-40.
2008
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13 | HCRT
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| The neurohormone orexin stimulates hypoxia-inducible factor-1 activity.
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| Sikder D, Kodadek T.
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| Genes Dev 21(22):2995-3005.
2007
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14 | HCRT, HTT, HD
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| Orexin loss in Huntington's disease.
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| Petersen A, Gil J, Maat-Schieman ML, Bjorkqvist M, Tanila H, Araujo IM, Smith R, Popovic N, Wierup N, Norlen P, Li JY, Roos RA, Sundler F, Mulder H, Brundin P.
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| Hum Mol Genet 14(1):39-47. Epub 2004 Nov 03. 2005
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15 | NRCLP1, HCRT
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| Monozygotic twins concordant for narcolepsy-cataplexy without any detectable abnormality in the hypocretin (orexin) pathway.
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| Khatami R, Maret S, Werth E, Retey J, Schmid D, Maly F, Tafti M, Bassetti CL.
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| Lancet 363(9416):1199-200. 2004
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16 | HCRT
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| Orexin-A expression in human peripheral tissues.
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| Nakabayashi M, Suzuki T, Takahashi K, Totsune K, Muramatsu Y, Kaneko C, Date F, Takeyama J, Darnel AD, Moriya T, Sasano H.
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| Mol Cell Endocrinol 205(1-2):43-50. 2003
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17 | HCRT, SLC17A7, SLC17A6
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| Hypothalamic orexin (hypocretin) neurons express vesicular glutamate transporters VGLUT1 or VGLUT2.
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| Rosin DL, Weston MC, Sevigny CP, Stornetta RL, Guyenet PG.
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| J Comp Neurol 465(4):593-603. 2003
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18 | NRCLP1, HCRT
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| Normal plasma levels of orexin A (hypocretin-1) in narcoleptic patients.
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| Dalal MA, Schuld A, Haack M, Uhr M, Geisler P, Eisensehr I, Noachtar S, Pollmacher T.
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| Neurology 56(12):1749-51. Erratum in: Neurology 2002 Jan 22;58(2):334. 2001
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19 | NRCLP1, HCRT
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| A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains.
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| Peyron C, Faraco J, Rogers W, Ripley B, Overeem S, Charnay Y, Nevsimalova S, Aldrich M, Reynolds D, Albin R, Li R, Hungs M, Pedrazzoli M, Padigaru M, Kucherlapati M, Fan J, Maki R, Lammers GJ, Bouras C, Kucherlapati R, Nishino S, Mignot E.
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| Nat Med 6(9):991-7. 2000
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20 | HCRT, HCRTR2
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| Narcolepsy: a key role for hypocretins.
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| Siegel JM.
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| Cell 98(4):409-12. No abstract available 1999
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21 | HCRT, HCRTR1, HCRTR2
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| Orexins and orexin receptors : a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.
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| Sakurai T, et al.
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| Cell 92 : 573-585. 1998
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22 | HCRT
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| The hypocretins : hypothalamus-specific peptides with neuroexcitatory activity.
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| De Lecea L, et al.
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| Proc Natl Acad Sci U S A 95 : 322-327. 1998
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