| 1 | HCN1, HCN2
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| Selective Blockade of HCN1/HCN2 Channels as a Potential Pharmacological Strategy Against Pain.
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| Dini L, Del Lungo M, Resta F, Melchiorre M, Spinelli V, Di Cesare Mannelli L, Ghelardini C, Laurino A, Sartiani L, Coppini R, Mannaioni G, Cerbai E, Romanelli MN.
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| Front Pharmacol 9:1252. doi: 10.3389/fphar.2018.01252. eCollection 2018.
2018
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| 2 | HCN2
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| Regularizing firing patterns of rat subthalamic neurons ameliorates parkinsonian motor deficits.
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| Zhuang QX, Li GY, Li B, Zhang CZ, Zhang XY, Xi K, Li HZ, Wang JJ, Zhu JN.
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| J Clin Invest 128(12):5413-5427. doi: 10.1172/JCI99986. Epub 2018 Oct 29.
2018
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| 3 | HCN1, HCN2, HCN4
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| Loss of HCN2 leads to delayed gastrointestinal motility and reduced energy intake in mice.
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| Fisher DW, Luu P, Agarwal N, Kurz JE, Chetkovich DM.
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| PLoS One 13(2):e0193012. doi: 10.1371/journal.pone.0193012. eCollection 2018.
2018
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| 4 | HCN2
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| Gain-of-function HCN2 variants in genetic epilepsy.
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| Li M, Maljevic S, Phillips AM, Petrovski S, Hildebrand MS, Burgess R, Mount T, Zara F, Striano P, Schubert J, Thiele H, Nürnberg P, Wong M, Weisenberg JL, Thio LL, Lerche H, Scheffer IE, Berkovic SF, Petrou S, Reid CA.
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| Hum Mutat 39(2):202-209. doi: 10.1002/humu.23357. Epub 2017 Nov 13.
2018
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| 5 | HCN2
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| Maturation and processing of the amyloid precursor protein is regulated by the potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 2 (HCN2).
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| Frykman S, Inoue M, Ikeda A, Teranishi Y, Kihara T, Lundgren JL, Yamamoto NG, Bogdanovic N, Winblad B, Schedin-Weiss S, Tjernberg LO.
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| Biochem Biophys Res Commun 483(1):352-358. doi: 10.1016/j.bbrc.2016.12.140. Epub 2016 Dec 23.
2017
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| 6 | HCN1, HCN2, HCN3, HCN4
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| Expression and cellular localization of HCN channels in rat cerebellar granule neurons.
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| Zúñiga R, González D, Valenzuela C, Brown N, Zúñiga L.
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| Biochem Biophys Res Commun 478(3):1429-35. doi: 10.1016/j.bbrc.2016.08.141. Epub 2016 Aug 25.
2016
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| 7 | HCN1, HCN2, HCN4
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| Differential expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits during hippocampal development in the mouse.
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| Seo H, Seol MJ, Lee K.
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| Mol Brain 8:13. doi: 10.1186/s13041-015-0103-4.
2015
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| 8 | HCN2
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| Ectopic automaticity induced in ventricular myocytes by transgenic overexpression of HCN2.
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| Oshita K, Itoh M, Hirashima S, Kuwabara Y, Ishihara K, Kuwahara K, Nakao K, Kimura T, Nakamura K, Ushijima K, Takano M.
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| J Mol Cell Cardiol 80:81-9. doi: 10.1016/j.yjmcc.2014.12.019. Epub 2015 Jan 3.
2015
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| 9 | HCN2
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| HCN2 channels account for mechanical (but not heat) hyperalgesia during long-standing inflammation.
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| Schnorr S, Eberhardt M, Kistner K, Rajab H, Käßer J, Hess A, Reeh P, Ludwig A, Herrmann S.
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| Pain 155(6):1079-90. doi: 10.1016/j.pain.2014.02.006. Epub 2014 Feb 10.
2014
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| 10 | HCN1, HCN2
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| Hyperpolarization-activated cyclic nucleotide-gated 1 independent grid cell-phase precession in mice.
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| Eggink H, Mertens P, Storm E, Giocomo LM.
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| Hippocampus 24(3):249-56. doi: 10.1002/hipo.22231. Epub 2013 Dec 8.
2014
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| 11 | HCN2
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| Novel HCN2 mutation contributes to febrile seizures by shifting the channel's kinetics in a temperature-dependent manner.
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| Nakamura Y, Shi X, Numata T, Mori Y, Inoue R, Lossin C, Baram TZ, Hirose S.
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| PLoS One 8(12):e80376. doi: 10.1371/journal.pone.0080376. eCollection 2013.
2013
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| 12 | HCN1, HCN2, PCDH15
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| HCN1 and HCN2 proteins are expressed in cochlear hair cells: HCN1 can form a ternary complex with protocadherin 15 CD3 and F-actin-binding filamin A or can interact with HCN2.
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| Ramakrishnan NA, Drescher MJ, Khan KM, Hatfield JS, Drescher DG.
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| J Biol Chem 287(45):37628-46. doi: 10.1074/jbc.M112.375832. Epub 2012 Sep 4.
2012
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| 13 | HCN2
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| A leucine zipper motif essential for gating of hyperpolarization-activated channels.
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| Wemhöner K, Silbernagel N, Marzian S, Netter MF, Rinné S, Stansfeld PJ, Decher N.
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| J Biol Chem 287(48):40150-60. doi: 10.1074/jbc.M112.378513. Epub 2012 Oct 9.
2012
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| 14 | HCN1, HCN2, HCN4
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| Novel insights into the distribution of cardiac HCN channels: an expression study in the mouse heart.
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| Herrmann S, Layh B, Ludwig A.
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| J Mol Cell Cardiol 51(6):997-1006. doi: 10.1016/j.yjmcc.2011.09.005. Epub 2011 Sep 14.
2011
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| 15 | HCN2
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| HCN2 ion channels play a central role in inflammatory and neuropathic pain.
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| Emery EC, Young GT, Berrocoso EM, Chen L, McNaughton PA.
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| Science 333(6048):1462-6. doi: 10.1126/science.1206243.
2011
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| 16 | HCN1, HCN2
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| Evolutionary emergence of N-glycosylation as a variable promoter of HCN channel surface expression.
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| Hegle AP, Nazzari H, Roth A, Angoli D, Accili EA.
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| Am J Physiol Cell Physiol 298(5):C1066-76. doi: 10.1152/ajpcell.00389.2009. Epub 2010 Feb 3.
2010
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| 17 | HCN2, HCN4
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| Control of heart rate by cAMP sensitivity of HCN channels.
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| Alig J, Marger L, Mesirca P, Ehmke H, Mangoni ME, Isbrandt D.
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| Proc Natl Acad Sci U S A 106(29):12189-94. Epub 2009 Jul 1.
2009
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| 18 | HCN1, HCN2, HCN3, HCN4
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| Low-conductance HCN1 ion channels augment the frequency response of rod and cone photoreceptors.
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| Barrow AJ, Wu SM.
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| J Neurosci 29(18):5841-53.PMID: 19420251 2009
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| 19 | HCN1, HCN2, HCN3, HCN4
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| HCN channels: structure, cellular regulation and physiological function.
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| Wahl-Schott C, Biel M.
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| Cell Mol Life Sci 66(3):470-94. Review.PMID: 18953682 2009
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| 20 | HCN1, HCN2
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| Mutation analysis of the hyperpolarization-activated cyclic nucleotide-gated channels HCN1 and HCN2 in idiopathic generalized epilepsy.
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| Tang B, Sander T, Craven KB, Hempelmann A, Escayg A.
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| Neurobiol Dis 29(1):59-70. Epub 2007 Aug 24.PMID: 17931874 2008
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| 21 | HCN1, HCN2, HCN3, HCN4
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| Role of the hyperpolarization-activated current Ih in somatosensory neurons.
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| Momin A, Cadiou H, Mason A, McNaughton PA.
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| J Physiol 586(Pt 24):5911-29. Epub 2008 Oct 20.PMID: 18936078 2008
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| 22 | HCN1, HCN2, HCN3, HCN4
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| Functional expression of the human HCN3 channel.
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| Stieber J, Stöckl G, Herrmann S, Hassfurth B, Hofmann F.
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| J Biol Chem 280(41):34635-43. Epub 2005 Jul 25.PMID: 16043489 2005
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| 23 | HCN2, HCN4
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| Molecular basis for the different activation kinetics of the pacemaker channels HCN2 and HCN4.
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| Stieber J, Thomer A, Much B, Schneider A, Biel M, Hofmann F.
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| J Biol Chem 278(36):33672-80. Epub 2003 Jun 17. 2003
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| 24 | HCN2, HCN4
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| Functional comparison of HCN isoforms expressed in ventricular and HEK 293 cells.
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| Qu J, Altomare C, Bucchi A, DiFrancesco D, Robinson RB.
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| Pflugers Arch 444(5):597-601. Epub 2002 Jun 12.
2002
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| 25 | HCN1, HCN2
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| Functional heteromerization of HCN1 and HCN2 pacemaker channels.
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| Ulens C, Tytgat J.
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| J Biol Chem 276(9):6069-72. Epub 2000 Dec 27.PMID: 11133998 2001
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| 26 | HCN2
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| Two pacemaker channels from human heart with profoundly different activation kinetics.
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| Ludwig A, et al.
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| EMBO J 18(9):2323-2329. 1999
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| 27 | HCN2
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| The human gene coding for HCN2, a pacemaker channel of the heart.
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| Vaccari T, Moroni A, Rocchi M, Gorza L, Bianchi ME, Beltrame M, DiFrancesco D.
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| Biochim Biophys Acta 1446(3):419-25 1999
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| 28 | HCN1, HCN2, HCN3
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| A family of hyperpolarization-activated mammalian cation channels.
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| Ludwig A, Zong X, Jeglitsch M, Hofmann F, Biel M.
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| Nature 393(6685):587-91. 1998
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