| 1 | HCN1, HCN2
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| Selective Blockade of HCN1/HCN2 Channels as a Potential Pharmacological Strategy Against Pain.
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| Dini L, Del Lungo M, Resta F, Melchiorre M, Spinelli V, Di Cesare Mannelli L, Ghelardini C, Laurino A, Sartiani L, Coppini R, Mannaioni G, Cerbai E, Romanelli MN.
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| Front Pharmacol 9:1252. doi: 10.3389/fphar.2018.01252. eCollection 2018.
2018
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| 2 | HCN1, HCN2, HCN4
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| Loss of HCN2 leads to delayed gastrointestinal motility and reduced energy intake in mice.
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| Fisher DW, Luu P, Agarwal N, Kurz JE, Chetkovich DM.
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| PLoS One 13(2):e0193012. doi: 10.1371/journal.pone.0193012. eCollection 2018.
2018
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| 3 | HCN1
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| Structures of the Human HCN1 Hyperpolarization-Activated Channel.
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| Lee CH, MacKinnon R.
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| Cell 168(1-2):111-120.e11. doi: 10.1016/j.cell.2016.12.023. Epub 2017 Jan 12.
2017
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| 4 | HCN1
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| HCN1 channels reduce the rate of exocytosis from a subset of cortical synaptic terminals.
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| Huang Z, Li G, Aguado C, Lujan R, Shah MM.
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| Sci Rep 7:40257. doi: 10.1038/srep40257.
2017
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| 5 | HCN1, HCN2, HCN3, HCN4
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| Expression and cellular localization of HCN channels in rat cerebellar granule neurons.
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| Zúñiga R, González D, Valenzuela C, Brown N, Zúñiga L.
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| Biochem Biophys Res Commun 478(3):1429-35. doi: 10.1016/j.bbrc.2016.08.141. Epub 2016 Aug 25.
2016
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| 6 | HCN1
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| HCN1 Channels Enhance Rod System Responsivity in the Retina under Conditions of Light Exposure.
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| Sothilingam V, Michalakis S, Garcia Garrido M, Biel M, Tanimoto N, Seeliger MW.
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| PLoS One 11(1):e0147728. doi: 10.1371/journal.pone.0147728. eCollection 2016.
2016
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| 7 | HCN1
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| Loss of HCN1 enhances disease progression in mouse models of CNG channel-linked retinitis pigmentosa and achromatopsia.
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| Schön C, Asteriti S, Koch S, Sothilingam V, Garcia Garrido M, Tanimoto N, Herms J, Seeliger MW, Cangiano L, Biel M, Michalakis S.
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| Hum Mol Genet 25(6):1165-75. doi: 10.1093/hmg/ddv639. Epub 2016 Jan 5.
2016
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| 8 | HCN1, HCN2, HCN4
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| Differential expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits during hippocampal development in the mouse.
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| Seo H, Seol MJ, Lee K.
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| Mol Brain 8:13. doi: 10.1186/s13041-015-0103-4.
2015
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| 9 | EIEE24, HCN1
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| De novo mutations in HCN1 cause early infantile epileptic encephalopathy.
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| Nava C, Dalle C, Rastetter A, Striano P, de Kovel CG, Nabbout R, Cancès C, Ville D, Brilstra EH, Gobbi G, Raffo E, Bouteiller D, Marie Y, Trouillard O, Robbiano A, Keren B, Agher D, Roze E, Lesage S, Nicolas A, Brice A, Baulac M, Vogt C, El Hajj N, Schneider E, Suls A, Weckhuysen S, Gormley P, Lehesjoki AE, De Jonghe P, Helbig I, Baulac S, Zara F, Koeleman BP; EuroEPINOMICS RES Consortium, Haaf T, LeGuern E, Depienne C.
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| Nat Genet 46(6):640-5. doi: 10.1038/ng.2952. Epub 2014 Apr 20.
2014
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| 10 | HCN1, HCN2
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| Hyperpolarization-activated cyclic nucleotide-gated 1 independent grid cell-phase precession in mice.
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| Eggink H, Mertens P, Storm E, Giocomo LM.
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| Hippocampus 24(3):249-56. doi: 10.1002/hipo.22231. Epub 2013 Dec 8.
2014
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| 11 | HCN1, PEX5L
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| TRIP8b is required for maximal expression of HCN1 in the mouse retina.
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| Pan Y, Bhattarai S, Modestou M, Drack AV, Chetkovich DM, Baker SA.
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| PLoS One 9(1):e85850. doi: 10.1371/journal.pone.0085850. eCollection 2014.
2014
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| 12 | HCN1
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| Sick sinus syndrome in HCN1-deficient mice.
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| Fenske S, Krause SC, Hassan SI, Becirovic E, Auer F, Bernard R, Kupatt C, Lange P, Ziegler T, Wotjak CT, Zhang H, Hammelmann V, Paparizos C, Biel M, Wahl-Schott CA.
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| Circulation 128(24):2585-94. doi: 10.1161/CIRCULATIONAHA.113.003712. Epub 2013 Nov 11.
2013
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| 13 | HCN1
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| Prefrontal cortex HCN1 channels enable intrinsic persistent neural firing and executive memory function.
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| Thuault SJ, Malleret G, Constantinople CM, Nicholls R, Chen I, Zhu J, Panteleyev A, Vronskaya S, Nolan MF, Bruno R, Siegelbaum SA, Kandel ER.
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| J Neurosci 33(34):13583-99. doi: 10.1523/JNEUROSCI.2427-12.2013.
2013
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| 14 | HCN1, HCN2, PCDH15
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| HCN1 and HCN2 proteins are expressed in cochlear hair cells: HCN1 can form a ternary complex with protocadherin 15 CD3 and F-actin-binding filamin A or can interact with HCN2.
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| Ramakrishnan NA, Drescher MJ, Khan KM, Hatfield JS, Drescher DG.
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| J Biol Chem 287(45):37628-46. doi: 10.1074/jbc.M112.375832. Epub 2012 Sep 4.
2012
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| 15 | HCN1, PEX5L
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| TRIP8b-independent trafficking and plasticity of adult cortical presynaptic HCN1 channels.
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| Huang Z, Lujan R, Martinez-Hernandez J, Lewis AS, Chetkovich DM, Shah MM.
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| J Neurosci 32(42):14835-48. doi: 10.1523/JNEUROSCI.1544-12.2012.
2012
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| 16 | HCN1, HCN2, HCN4
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| Novel insights into the distribution of cardiac HCN channels: an expression study in the mouse heart.
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| Herrmann S, Layh B, Ludwig A.
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| J Mol Cell Cardiol 51(6):997-1006. doi: 10.1016/j.yjmcc.2011.09.005. Epub 2011 Sep 14.
2011
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| 17 | HCN1, PEX5L
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| TRIP8b splice forms act in concert to regulate the localization and expression of HCN1 channels in CA1 pyramidal neurons.
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| Piskorowski R, Santoro B, Siegelbaum SA.
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| Neuron 70(3):495-509. doi: 10.1016/j.neuron.2011.03.023.
2011
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| 18 | HCN1, HCN2
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| Evolutionary emergence of N-glycosylation as a variable promoter of HCN channel surface expression.
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| Hegle AP, Nazzari H, Roth A, Angoli D, Accili EA.
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| Am J Physiol Cell Physiol 298(5):C1066-76. doi: 10.1152/ajpcell.00389.2009. Epub 2010 Feb 3.
2010
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| 19 | HCN1
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| Loss of dendritic HCN1 subunits enhances cortical excitability and epileptogenesis.
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| Huang Z, Walker MC, Shah MM.
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| J Neurosci 29(35):10979-88.PMID: 19726656 2009
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| 20 | HCN1
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| Activity-dependent regulation of HCN1 protein in cortical neurons.
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| Arimitsu T, Nuriya M, Ikeda K, Takahashi T, Yasui M.
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| Biochem Biophys Res Commun 387(1):87-91. Epub 2009 Jun 27.PMID: 19563776 2009
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| 21 | HCN1, HCN2, HCN3, HCN4
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| Low-conductance HCN1 ion channels augment the frequency response of rod and cone photoreceptors.
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| Barrow AJ, Wu SM.
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| J Neurosci 29(18):5841-53.PMID: 19420251 2009
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| 22 | HCN1, HCN2, HCN3, HCN4
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| HCN channels: structure, cellular regulation and physiological function.
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| Wahl-Schott C, Biel M.
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| Cell Mol Life Sci 66(3):470-94. Review.PMID: 18953682 2009
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| 23 | HCN1, HCN2
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| Mutation analysis of the hyperpolarization-activated cyclic nucleotide-gated channels HCN1 and HCN2 in idiopathic generalized epilepsy.
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| Tang B, Sander T, Craven KB, Hempelmann A, Escayg A.
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| Neurobiol Dis 29(1):59-70. Epub 2007 Aug 24.PMID: 17931874 2008
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| 24 | HCN1, HCN2, HCN3, HCN4
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| Role of the hyperpolarization-activated current Ih in somatosensory neurons.
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| Momin A, Cadiou H, Mason A, McNaughton PA.
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| J Physiol 586(Pt 24):5911-29. Epub 2008 Oct 20.PMID: 18936078 2008
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| 25 | HCN1
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| HCN1 channels constrain synaptically evoked Ca2+ spikes in distal dendrites of CA1 pyramidal neurons.
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| Tsay D, Dudman JT, Siegelbaum SA.
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| Neuron 56(6):1076-89.PMID: 18093528 2007
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| 26 | HCN1
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| Activity-dependent regulation of h channel distribution in hippocampal CA1 pyramidal neurons.
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| Shin M, Chetkovich DM.
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| J Biol Chem 282(45):33168-80. Epub 2007 Sep 11.PMID: 17848552 2007
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| 27 | HCN1, HCN2, HCN3, HCN4
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| Functional expression of the human HCN3 channel.
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| Stieber J, Stöckl G, Herrmann S, Hassfurth B, Hofmann F.
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| J Biol Chem 280(41):34635-43. Epub 2005 Jul 25.PMID: 16043489 2005
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| 28 | HCN1, HCN2
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| Functional heteromerization of HCN1 and HCN2 pacemaker channels.
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| Ulens C, Tytgat J.
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| J Biol Chem 276(9):6069-72. Epub 2000 Dec 27.PMID: 11133998 2001
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| 29 | HCN1
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| Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain.
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| Santoro B, Liu DT, Yao H, Bartsch D, Kandel ER, Siegelbaum SA, Tibbs GR.
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| Cell 93 : 717-729. 1998
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| 30 | ADRBK1, AR, ZFHX3, CACNA1A, CAPNS1, FOXE1, FOXF1, FMR1, AFF2, HCN1, NRXN1, CA10
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| CCG repeats in cDNAs from human brain.
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| Kleiderlein JJ, Nisson PE, Jessee J, Li WB, Becker KG, Derby ML, Ross CA, Margolis RL.
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| Hum Genet 103(6):666-73. 1998
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| 31 | HCN1, HCN2, HCN3
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| A family of hyperpolarization-activated mammalian cation channels.
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| Ludwig A, Zong X, Jeglitsch M, Hofmann F, Biel M.
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| Nature 393(6685):587-91. 1998
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| 32 | HCN1, HCN3
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| Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels.
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| Santoro B, et al.
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| Proc Natl Acad Sci U S A 94(26):14815-20. 1997
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