Citations for
1FRDA, FXN, HAX1
Frataxin deficiency in Friedreich's ataxia is associated with reduced levels of HAX-1, a regulator of cardiomyocyte death and survival
Tiano F, Amati F, Cherubini F, Morini E, Vancheri C, Maletta S, Fortuni S, Serio D, Quatrana A, Luffarelli R, Benini M, Alfedi G, Panarello L, Rufini A, Toschi N, Frontali M, Romano S, Marcotulli C, Casali C, Gioiosa S, Mariotti C, Mongelli A, Fichera M, Condō I, Novelli G, Testi R, Malisan F.
Hum Mol Genet. Feb 1;29(3):471-482. doi: 10.1093/hmg/ddz306. 2020
2HAX1
HAX-1 promotes the migration and invasion of hepatocellular carcinoma cells through the induction of epithelial-mesenchymal transition via the NF-κB pathway PMID:
Hu YL, Feng Y, Ma P, Wang F, Huang H, Guo YB, Li P, Mao QS, Xue WJ.
Exp Cell Res. Aug 1;381(1):66-76. doi: 10.1016/j.yexcr.2019.04.030. Epub 2019 Apr 30. 2019
3HAX1, PLN
The antiapoptotic protein HAX-1 mediates half of phospholamban's inhibitory activity on calcium cycling and contractility in the heart
Bidwell PA, Haghighi K, Kranias EG.
J Biol Chem. Jan 5;293(1):359-367. doi: 10.1074/jbc.RA117.000128. Epub 2017 Nov 17. 2018
4HAX1
Hematopoietic Substrate-1-Associated Protein X-1 Regulates the Proliferation and Apoptosis of Endothelial Progenitor Cells Through Akt Pathway Modulation
Guo XB, Deng X, Wei Y.
Stem Cells. Mar;36(3):406-419. doi: 10.1002/stem.2741. Epub 2017 Nov 26. 2018
5HAX1, SCNP3
Kostmann's Disease and HCLS1-Associated Protein X-1 (HAX1).
Klein C.
J Clin Immunol. Feb;37(2):117-122. doi: 10.1007/s10875-016-0358-2. Epub 2016 Dec 10 2017
6HAX1, KDM4B
KDM4B plays an important role in mitochondrial apoptosis by upregulating HAX1 expression in colorectal cancer.
Li H, Yang X, Wang G, Li X, Tao D, Hu J, Luo X.
Oncotarget Sep 6;7(36):57866-57877. doi: 10.18632/oncotarget.11077. 2016
7HAX1, UCP3
UCP3 is associated with Hax-1 in mitochondria in the presence of calcium ion
Hirasaka K, Mills EM, Haruna M, Bando A, Ikeda C, Abe T, Kohno S, Nowinski SM, Lago CU, Akagi K, Tochio H, Ohno A, Teshima-Kondo S, Okumura Y, Nikawa T.
Biochem Biophys Res Commun. Mar 25;472(1):108-13. doi: 10.1016/j.bbrc.2016.02.075. Epub 2016 Feb 23. 2016
8HAX1
HAX-1: a novel p-body protein
Zayat V, Balcerak A, Korczynski J, Trebinska A, Wysocki J, Sarnowska E, Chmielarczyk M, Macech E, Konopiński R, Dziembowska M, Grzybowska EA.
DNA Cell Biol. Jan;34(1):43-54. doi: 10.1089/dna.2014.2657 2015
9HAX1
HAX-1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation.
Wang Y, Huo X, Cao Z, Xu H, Zhu J, Qian L, Fu H, Xu B.
Int J Clin Exp Pathol. Jul 1;8(7):8099-106 2015
10HAX1, MAPRE2
Regulation of Focal Adhesion Dynamics and Cell Motility by the EB2 and Hax1 Protein Complex
Liu H, Yue J, Huang H, Gou X, Chen SY, Zhao Y, Wu X.
J Biol Chem. Dec 25;290(52):30771-82. doi: 10.1074/jbc.M115.671743. Epub 2015 Nov 2. Erratum in: J Biol Chem. 2019 Feb 22;294(8):2948 2015
11HAX1, SCNP3
Neurological findings and genetic alterations in patients with Kostmann syndrome and HAX1 mutations
Roques G, Munzer M, Barthez MA, Beaufils S, Beaupain B, Flood T, Keren B, Bellanné-Chantelot C, Donadieu J.
Pediatr Blood Cancer. Jun;61(6):1041-8. doi: 10.1002/pbc.24964. Epub 2014 Jan 30 2014
12HAX1
HAX1 regulates E3 ubiquitin ligase activity of cIAPs by promoting their dimerization.
Choi JS, Park BC, Chi SW, Bae KH, Kim S, Cho S, Son WC, Myung PK, Kim JH, Park SG
Oncotarget Oct 30;5(20):10084-99. doi: 10.18632/oncotarget.2459. 2014
13HAX1, RNF217
Identification and characterization of OSTL (RNF217) encoding a RING-IBR-RING protein adjacent to a translocation breakpoint involving ETV6 in childhood ALL.
Fontanari Krause LM, Japp AS, Krause A, Mooster J, Chopra M, Müschen M, Bohlander SK.
Sci Rep. Oct 9;4:6565. doi: 10.1038/srep06565. 2014
14HAX1, SCNP3
Severe congenital neutropenia in two siblings related to HAX1 mutation without neurodevelopmental disorders
Patiroglu T, Gungor HE, Triot A, Unal E
Genet Couns. ;24(3):253-8. 2013
15HAX1, TPCN1, TPCN2
Hax-1 identified as a two-pore channel (TPC)-binding protein
Lam AK, Galione A, Lai FA, Zissimopoulos S.
FEBS Lett. Nov 29;587(23):3782-6. doi: 10.1016/j.febslet.2013.10.031. Epub 2013 Nov 1. 2013
16HAX1
Hax1 regulates neutrophil adhesion and motility through RhoA.
Cavnar PJ, Berthier E, Beebe DJ, Huttenlocher A.
J Cell Biol 193(3):465-73. Epub 2011 Apr 25. 2011
17HAX1, SAV1
hSav1 interacts with HAX1 and attenuates its anti-apoptotic effects in MCF-7 breast cancer cells.
Luo X, Li Z, Li X, Wang G, Liu W, Dong S, Cai S, Tao D, Yan Q, Wang J, Leng Y, Gong J, Hu J.
Int J Mol Med 28(3):349-55. doi: 10.3892/ijmm.2011.692. Epub 2011 May 6. 2011
18HAX1, XIAP
Molecular interaction between HAX-1 and XIAP inhibits apoptosis.
Kang YJ, Jang M, Park YK, Kang S, Bae KH, Cho S, Lee CK, Park BC, Chi SW, Park SG.
Biochem Biophys Res Commun 393(4):794-9. Epub 2010 Feb 18.PMID: 20171186 2010
19EIF3G, HAX1, PELO, SRPX
Pelota interacts with HAX1, EIF3G and SRPX and the resulting protein complexes are associated with the actin cytoskeleton.
Burnicka-Turek O, Kata A, Buyandelger B, Ebermann L, Kramann N, Burfeind P, Hoyer-Fender S, Engel W, Adham IM.
BMC Cell Biol 11:28. 2010
20HAX1
HAX1 deficiency: impact on lymphopoiesis and B-cell development.
Peckl-Schmid D, Wolkerstorfer S, Königsberger S, Achatz-Straussberger G, Feichtner S, Schwaiger E, Zaborsky N, Huemer M, Gratz IK, Schibli R, Lamers M, Crameri R, Moser K, Luger EO, Achatz G.
Eur J Immunol 40(11):3161-72. doi: 10.1002/eji.200940221. Epub 2010 Sep 24. 2010
21HAX1
The anti-apoptotic protein HAX-1 is a regulator of cardiac function.
Zhao W, Waggoner JR, Zhang ZG, Lam CK, Han P, Qian J, Schroder PM, Mitton B, Kontrogianni-Konstantopoulos A, Robia SL, Kranias EG.
Proc Natl Acad Sci U S A roc Natl Acad Sci U S A. 2009 Nov 17. [Epub ahead of print]PMID: 19920172 2009
22HAX1, SCNP3
A novel missense mutation in the HAX1 gene in severe congenital neutropenia patients (Kostmann disease).
Faiyaz-Ul-Haque M, Al-Jefri A, Abalkhail HA, Toulimat M, Al-Muallimi MA, Pulicat MS, Gaafar A, Alaiya AA, Al-Dayel F, Peltekova I, Zaidi SH.
Clin Genet 76(6):569-72. Epub 2009 Oct 1. No abstract available. PMID: 19796188 2009
23HTRA2, HAX1
Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons.
Chao JR, Parganas E, Boyd K, Hong CY, Opferman JT, Ihle JN.
Nature 452(7183):98-102. Epub 2008 Feb 20. 2008
24HAX1, SCNP3
Neurodevelopmental abnormalities associated with severe congenital neutropenia due to the R86X mutation in the HAX1 gene.
Ishikawa N, Okada S, Miki M, Shirao K, Kihara H, Tsumura M, Nakamura K, Kawaguchi H, Ohtsubo M, Yasunaga S, Matsubara K, Sako M, Hara J, Shiohara M, Kojima S, Sato T, Takihara Y, Kobayashi M.
J Med Genet 45(12):802-7. Epub 2008 Jul 8. 2008
25SCNP3, HAX1
HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease).
Klein C, Grudzien M, Appaswamy G, Germeshausen M, Sandrock I, Schaffer AA, Rathinam C, Boztug K, Schwinzer B, Rezaei N, Bohn G, Melin M, Carlsson G, Fadeel B, Dahl N, Palmblad J, Henter JI, Zeidler C, Grimbacher B, Welte K.
Nat Genet 39(1):86-92. Epub 2006 Dec 24. 2007
26CASP9, HAX1
Overexpression of HAX-1 protects cardiac myocytes from apoptosis through caspase-9 inhibition.
Han Y, Chen YS, Liu Z, Bodyak N, Rigor D, Bisping E, Pu WT, Kang PM.
Circ Res 99(4):415-23. Epub 2006 Jul 20. 2006
27HAX1
HAX-1, identified by differential display reverse transcription polymerase chain reaction, is overexpressed in lesional psoriasis.
Mirmohammadsadegh A, Tartler U, Michel G, Baer A, Walz M, Wolf R, Ruzicka T, Hengge UR.
J Invest Dermatol 120(6):1045-51. 2003
28BLOM7, HAX1, MCKD1, SYT11, TPM3, UBAP2L
Refinement of the gene locus for autosomal dominant medullary cystic kidney disease type 1 (MCKD1) and construction of a physical and partial transcriptional map of the region.
Fuchshuber A, Kroiss S, Karle S, Berthold S, Huck K, Burton C, Rahman N, Koptides M, Deltas C, Otto E, Ruschendorf F, Feest T, Hildebrandt F.
Genomics 72(3):278-84. 2001
29HAX1
Evidence that HAX-1 is an interleukin-1 alpha N-terminal binding protein.
Yin H, Morioka H, Towle CA, Vidal M, Watanabe T, Weissbach L.
Cytokine 15(3):122-37. 2001