| 1 | CNOT6, CYFIP1, EDIL3, FDFT1, GATA4, GJA5, HAND2, NEIL2, NIPA1, NIPA2, TUBGCP5
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| Contribution of global rare copy-number variants to the risk of sporadic congenital heart disease.
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| Soemedi R, Wilson IJ, Bentham J, Darlay R, Töpf A, Zelenika D, Cosgrove C, Setchfield K, Thornborough C, Granados-Riveron J, Blue GM, Breckpot J, Hellens S, Zwolinkski S, Glen E, Mamasoula C, Rahman TJ, Hall D, Rauch A, Devriendt K, Gewillig M, O' Sullivan J, Winlaw DS, Bu'lock F, Brook JD, Bhattacharya S, Lathrop M, Santibanez-Koref M, Cordell HJ, Goodship JA, Keavney BD.
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| Am J Hum Genet 91(3):489-501. Epub 2012 Aug 30.
2012
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| 2 | GATA3, HAND2
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| Cytokines inhibit norepinephrine transporter expression by decreasing Hand2.
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| Pellegrino MJ, Parrish DC, Zigmond RE, Habecker BA.
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| Mol Cell Neurosci 46(3):671-80. Epub 2011 Jan 15.
2011
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| 3 | HAND2
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| Downregulation of Dlx5 and Dlx6 expression by Hand2 is essential for initiation of tongue morphogenesis.
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| Barron F, Woods C, Kuhn K, Bishop J, Howard MJ, Clouthier DE.
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| Development 138(11):2249-59.
2011
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| 4 | HAND1, HAND2
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| Hand2 function in second heart field progenitors is essential for cardiogenesis.
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| Tsuchihashi T, Maeda J, Shin CH, Ivey KN, Black BL, Olson EN, Yamagishi H, Srivastava D.
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| Dev Biol 351(1):62-9. Epub 2010 Dec 23.
2011
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| 5 | ASCL1, DBH, HAND2, PHOX2B, TCF3
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| Interaction of Hand2 and E2a is important for transcription of Phox2b in sympathetic nervous system neuron differentiation.
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| Hashimoto Y, Tsutsumi M, Myojin R, Maruta K, Onoda F, Tashiro F, Ohtsu M, Murakami Y.
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| Biochem Biophys Res Commun 408(1):38-44. Epub 2011 Mar 29.
2011
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| 6 | HAND1, HAND2
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| Hand2 loss-of-function in Hand1-expressing cells reveals distinct roles in epicardial and coronary vessel development.
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| Barnes RM, Firulli BA, VanDusen NJ, Morikawa Y, Conway SJ, Cserjesi P, Vincentz JW, Firulli AB.
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| Circ Res 108(8):940-9. Epub 2011 Feb 24.
2011
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| 7 | HAND2
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| Targeted deletion of Hand2 in enteric neural precursor cells affects its functions in neurogenesis, neurotransmitter specification and gangliogenesis, causing functional aganglionosis.
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| Lei J, Howard MJ.
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| Development. 138(21):4789-800. 2011
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| 8 | HAND2
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| Hand2 regulates chondrogenesis in vitro and in vivo.
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| Abe M, Michikami I, Fukushi T, Abe A, Maeda Y, Ooshima T, Wakisaka S.
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| Bone 46(5):1359-68. Epub 2009 Nov 22.
2010
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| 9 | HAND2
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| Transcription factor HAND2 mutations in sporadic Chinese patients with congenital heart disease.
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| Shen L, Li XF, Shen AD, Wang Q, Liu CX, Guo YJ, Song ZJ, Li ZZ.
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| Chin Med J (Engl) 123(13):1623-7.
2010
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| 10 | HAND2
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| Hand2 ensures an appropriate environment for cardiac fusion by limiting Fibronectin function.
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| Garavito-Aguilar ZV, Riley HE, Yelon D.
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| Development 137(19):3215-20. Epub 2010 Aug 19.
2010
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| 11 | FN1, HAND2
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| Hand2 ensures an appropriate environment for cardiac fusion by limiting Fibronectin function.
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| Garavito-Aguilar ZV, Riley HE, Yelon D.
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| Development 137(19):3215-20. doi: 10.1242/dev.052225. Epub 2010 Aug 19.
2010
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| 12 | HAND2
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| Pbx acts with Hand2 in early myocardial differentiation.
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| Maves L, Tyler A, Moens CB, Tapscott SJ.
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| Dev Biol 333(2):409-18. Epub 2009 Jul 14.
2009
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| 13 | HAND2
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| Hand2 is required in the epithelium for palatogenesis in mice.
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| Xiong W, He F, Morikawa Y, Yu X, Zhang Z, Lan Y, Jiang R, Cserjesi P, Chen Y.
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| Dev Biol 330(1):131-41. Epub 2009 Mar 31.
2009
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| 14 | HAND2
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| The bHLH transcription factor Hand2 is essential for the maintenance of noradrenergic properties in differentiated sympathetic neurons.
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| Schmidt M, Lin S, Pape M, Ernsberger U, Stanke M, Kobayashi K, Howard MJ, Rohrer H.
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| Dev Biol 329(2):191-200. Epub 2009 Feb 27.
2009
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| 15 | HAND2
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| Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2.
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| Funato N, Chapman SL, McKee MD, Funato H, Morris JA, Shelton JM, Richardson JA, Yanagisawa H.
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| Development 136(4):615-25. Epub 2009 Jan 14.
2009
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| 16 | HAND1, HAND2
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| HAND transcription factors are required for neonatal sympathetic neuron survival.
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| Doxakis E, Howard L, Rohrer H, Davies AM.
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| EMBO Rep 9(10):1041-7. Epub 2008 Aug 22.
2008
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| 17 | HAND2
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| Cardiac neural crest expression of Hand2 regulates outflow and second heart field development.
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| Morikawa Y, Cserjesi P.
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| Circ Res 103(12):1422-9. Epub 2008 Nov 13.
2008
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| 18 | HAND2
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| The bHLH transcription factor hand2 is essential for noradrenergic differentiation of sympathetic neurons.
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| Lucas ME, MŸller F, RŸdiger R, Henion PD, Rohrer H.
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| Development 133(20):4015-24. 2006
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| 19 | HAND2
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| Hand, an evolutionarily conserved bHLH transcription factor required for Drosophila cardiogenesis and hematopoiesis.
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| Han Z, Yi P, Li X, Olson EN.
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| Development 133(6):1175-82. Epub 2006 Feb 8. 2006
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| 20 | TWIST1, HAND2, ACS3
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| Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities.
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| Firulli BA, Krawchuk D, Centonze VE, Vargesson N, Virshup DM, Conway SJ, Cserjesi P, Laufer E, Firulli AB.
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| Nat Genet 37(4):373-81. Epub 2005 Feb 27. 2005
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| 21 | COPS5, HAND2
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| JAB1 enhances HAND2 transcriptional activity by regulating HAND2 DNA binding.
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| Dai YS, Hao J, Bonin C, Morikawa Y, Cserjesi P.
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| J Neurosci Res 76(5):613-22. 2004
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| 22 | HAND2
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| The interaction between dHAND and Arix at the dopamine beta-hydroxylase promoter region is independent of direct dHAND binding to DNA.
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| Rychlik JL, Gerbasi V, Lewis EJ.
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| J Biol Chem. 278(49):49652-60. 2003
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| 23 | HAND2
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| PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation.
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| Firulli BA, Howard MJ, McDaid JR, McIlreavey L, Dionne KM, Centonze VE, Cserjesi P, Virshup DM, Firulli AB.
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| Mol Cell. 12(5):1225-37. 2003
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| 24 | HAND2
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| Evidence for a gene influencing heart rate on chromosome 4 among hypertensives.
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| Wilk JB, Myers RH, Zhang Y, Lewis CE, Atwood L, Hopkins PN, Ellison RC.
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| Hum Genet 111(2):207-13. 2002
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| 25 | DEL4Q, HAND2
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| Cardiac phenotypes in chromosome 4q- syndrome with and without a deletion of the dHAND gene.
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| Huang T, Lin AE, Cox GF, Golden WL, Feldman GL, Ute M, Schrander-Stumpel C, Kamisago M, Vermeulen SJ.
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| Genet Med 4(6):464-7. 2002
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| 26 | HAND2, TCF3
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| The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer.
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| Dai YS, Cserjesi P.
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| J Biol Chem. 277(15):12604-12. 2002
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| 27 | HAND2
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| The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanism.
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| Dai YS, Cserjesi P, Markham BE, Molkentin JD.
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| J Biol Chem. 277(27):24390-8 2002
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| 28 | HAND1, HAND2
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| Human eHAND, but not dHAND, is down-regulated in cardiomyopathies.
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| Natarajan A, Yamagishi H, Ahmad F, Li D, Roberts R, Matsuoka R, Hill S, Srivastava D.
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| J Mol Cell Cardiol 33(9):1607-14. 2001
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| 29 | DLX6,HAND2
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| Role of Dlx6 in regulation of an endothelin-1-dependent, dHAND branchial arch enhancer.
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| Charite J, McFadden DG, Merlo G, Levi G, Clouthier DE, Yanagisawa M, Richardson JA, Olson EN.
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| Genes Dev 15(22):3039-49. 2001
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| 30 | HAND2
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| The basic helix-loop-helix transcription factor, dHAND, is required for vascular development.
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| Yamagishi H, Olson EN, Srivastava D.
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| J Clin Invest. 105(3):261-70. 2000
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| 31 | HAND1, HAND2
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| HAND proteins: molecular mediators of cardiac development and congenital heart disease.
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| Srivastava D.
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| Trends Cardiovasc Med 9(1-2):11-8. Review. 1999
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| 32 | HAND2
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| Molecular cloning of the human HAND2 gene.
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| Russell MW, et al.
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| Biochim Biophys Acta 1443(3):393-9. 1998
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| 33 | HAND2
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| Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND.
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| Srivastava D, et al.
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| Nat Genet 16(2):154-60. 1997
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