| 1 | GZMB
|
| Increased levels of serum granzyme-B is associated with insulin resistance and increased cardiovascular risk in adolescent polycystic ovary syndrome patients.
|
| Oztas E, Ozler S, Tokmak A, Yilmaz N, Celik HT, Kazancı FH, Danisman N, Ergin M, Yakut HI.
|
| Eur J Obstet Gynecol Reprod Biol 198:89-93. doi: 10.1016/j.ejogrb.2016.01.009. Epub 2016 Jan 11.
2016
|
| 2 | GZMB
|
| Granzyme B Deficiency Protects against Angiotensin II-Induced Cardiac Fibrosis.
|
| Shen Y, Cheng F, Sharma M, Merkulova Y, Raithatha SA, Parkinson LG, Zhao H, Westendorf K, Bohunek L, Bozin T, Hsu I, Ang LS, Williams SJ, Bleackley RC, Eriksson JE, Seidman MA, McManus BM, Granville DJ.
|
| Am J Pathol 186(1):87-100. doi: 10.1016/j.ajpath.2015.09.010. Epub 2015 Nov 25.
2016
|
| 3 | FCGR2A, GZMB
|
| Granzyme B expression is enhanced in human monocytes by TLR8 agonists and contributes to antibody-dependent cellular cytotoxicity.
|
| Elavazhagan S, Fatehchand K, Santhanam V, Fang H, Ren L, Gautam S, Reader B, Mo X, Cheney C, Briercheck E, Vasilakos JP, Dietsch GN, Hershberg RM, Caligiuri M, Byrd JC, Butchar JP, Tridandapani S.
|
| J Immunol 194(6):2786-95. doi: 10.4049/jimmunol.1402316. Epub 2015 Feb 9.
2015
|
| 4 | GZMB
|
| Mouse cytotoxic T cell-derived granzyme B activates the mitochondrial cell death pathway in a Bim-dependent fashion.
|
| Catalán E, Jaime-Sánchez P, Aguiló N, Simon MM, Froelich CJ, Pardo J.
|
| J Biol Chem 290(11):6868-77. doi: 10.1074/jbc.M114.631564. Epub 2015 Jan 20.
2015
|
| 5 | GZMB
|
| Granzyme B mediates both direct and indirect cleavage of extracellular matrix in skin after chronic low-dose ultraviolet light irradiation.
|
| Parkinson LG, Toro A, Zhao H, Brown K, Tebbutt SJ, Granville DJ.
|
| Aging Cell 14(1):67-77. doi: 10.1111/acel.12298. Epub 2014 Dec 11.
2015
|
| 6 | GZMB
|
| Granzyme B-induced mitochondrial ROS are required for apoptosis.
|
| Jacquemin G, Margiotta D, Kasahara A, Bassoy EY, Walch M, Thiery J, Lieberman J, Martinvalet D.
|
| Cell Death Differ 22(5):862-74. doi: 10.1038/cdd.2014.180. Epub 2014 Oct 31.
2015
|
| 7 | GZMB
|
| Granzyme B promotes cytotoxic lymphocyte transmigration via basement membrane remodeling.
|
| Prakash MD, Munoz MA, Jain R, Tong PL, Koskinen A, Regner M, Kleifeld O, Ho B, Olson M, Turner SJ, Mrass P, Weninger W, Bird PI.
|
| Immunity 41(6):960-72. doi: 10.1016/j.immuni.2014.11.012. Epub 2014 Nov 28.
2014
|
| 8 | CUX1, GZMB
|
| Cytohesin-associated scaffolding protein (CASP) is a substrate for granzyme B and ubiquitination.
|
| Tompkins N, MacNeil AJ, Pohajdak B.
|
| Biochem Biophys Res Commun 452(3):473-8. doi: 10.1016/j.bbrc.2014.08.088. Epub 2014 Aug 23.
2014
|
| 9 | GZMB
|
| Granzyme B releases vascular endothelial growth factor from extracellular matrix and induces vascular permeability.
|
| Hendel A, Hsu I, Granville DJ.
|
| Lab Invest 94(7):716-25. doi: 10.1038/labinvest.2014.62. Epub 2014 May 5.
2014
|
| 10 | GZMB
|
| The serine protease granzyme B as an inflammatory marker, in relation to the insulin receptor cleavage in human obesity and type 2 diabetes mellitus.
|
| El Mesallamy HO, Hamdy NM, Mostafa DM, Amin AI.
|
| J Interferon Cytokine Res 34(3):179-86. doi: 10.1089/jir.2013.0059. Epub 2013 Nov 6.
2014
|
| 11 | GZMB
|
| CD8+ T cell granzyme B activates keratinocyte endogenous IL-18.
|
| Akeda T, Yamanaka K, Tsuda K, Omoto Y, Gabazza EC, Mizutani H.
|
| Arch Dermatol Res 306(2):125-30. doi: 10.1007/s00403-013-1382-1. Epub 2013 Jul 3.
2014
|
| 12 | GZMB
|
| Rapid reuptake of granzyme B leads to emperitosis: an apoptotic cell-in-cell death of immune killer cells inside tumor cells.
|
| Wang S, He MF, Chen YH, Wang MY, Yu XM, Bai J, Zhu HY, Wang YY, Zhao H, Mei Q, Nie J, Ma J, Wang JF, Wen Q, Ma L, Wang Y, Wang XN.
|
| Cell Death Dis 4:e856. doi: 10.1038/cddis.2013.352.
2013
|
| 13 | GZMB
|
| Granzyme B-mediated damage of CD8+ T cells impairs graft-versus-tumor effect.
|
| Bian G, Ding X, Leigh ND, Tang Y, Capitano ML, Qiu J, McCarthy PL, Liu H, Cao X.
|
| J Immunol 190(3):1341-50. doi: 10.4049/jimmunol.1201554. Epub 2012 Dec 21.
2013
|
| 14 | GZMB
|
| Granzyme B cleavage of fibronectin disrupts endothelial cell adhesion, migration and capillary tube formation.
|
| Hendel A, Granville DJ.
|
| Matrix Biol 32(1):14-22. doi: 10.1016/j.matbio.2012.11.013. Epub 2012 Dec 7.
2013
|
| 15 | FGFR1, GZMB
|
| FGFR1 cleavage and nuclear translocation regulates breast cancer cell behavior.
|
| Chioni AM, Grose R.
|
| J Cell Biol 197(6):801-17. doi: 10.1083/jcb.201108077. Epub 2012 Jun 4.
2012
|
| 16 | GZMB
|
| Granzyme B regulates antiviral CD8+ T cell responses.
|
| Salti SM, Hammelev EM, Grewal JL, Reddy ST, Zemple SJ, Grossman WJ, Grayson MH, Verbsky JW.
|
| J Immunol 187(12):6301-9. doi: 10.4049/jimmunol.1100891. Epub 2011 Nov 14.
2011
|
| 17 | GZMA, GZMB
|
| A critical role for granzymes in antigen cross-presentation through regulating phagocytosis of killed tumor cells.
|
| Hoves S, Sutton VR, Haynes NM, Hawkins ED, Fernández Ruiz D, Baschuk N, Sedelies KA, Schnurr M, Stagg J, Andrews DM, Villadangos JA, Trapani JA.
|
| J Immunol 187(3):1166-75. doi: 10.4049/jimmunol.1001670. Epub 2011 Jun 27.
2011
|
| 18 | GZMB
|
| Cleavage of Notch1 by granzyme B disables its transcriptional activity.
|
| van Tetering G, Bovenschen N, Meeldijk J, van Diest PJ, Vooijs M.
|
| Biochem J 437(2):313-22. doi: 10.1042/BJ20110226.
2011
|
| 19 | GZMB
|
| Granzyme B is recovered by natural killer cells via clathrin-dependent endocytosis.
|
| Li P, Zheng G, Yang Y, Zhang C, Xiong P, Xu Y, Fang M, Tan Z, Zheng F, Gong F.
|
| Cell Mol Life Sci 67(18):3197-208. doi: 10.1007/s00018-010-0377-8. Epub 2010 May 7.
2010
|
| 20 | GZMB
|
| Differential expression of granzyme B and C in murine cytotoxic lymphocytes.
|
| Cai SF, Fehniger TA, Cao X, Mayer JC, Brune JD, French AR, Ley TJ.
|
| J Immunol 182(10):6287-97. doi: 10.4049/jimmunol.0804333.
2009
|
| 21 | GZMB
|
| Elevation of plasma granzyme B levels after acute myocardial infarction.
|
| Kondo H, Hojo Y, Tsuru R, Nishimura Y, Shimizu H, Takahashi N, Hirose M, Ikemoto T, Ohya K, Katsuki T, Yashiro T, Shimada K.
|
| Circ J 73(3):503-7. Epub 2009 Jan 15.
2009
|
| 22 | CX3CR1, GZMB, IGFBP7, IL2RB, KIR3DL2, PAM, PRF1, S1PR5, SH2D1B, SPON2, ZBTB16
|
| Gene expression changes in children with autism.
|
| Gregg JP, Lit L, Baron CA, Hertz-Picciotto I, Walker W, Davis RA, Croen LA, Ozonoff S, Hansen R, Pessah IN, Sharp FR.
|
| Genomics 91(1):22-9. Epub 2007 Nov 14. 2008
|
| 23 | GZMB
|
| The ratio of FOXP3+ regulatory T cells to granzyme B+ cytotoxic T/NK cells predicts prognosis in classical Hodgkin lymphoma and is independent of bcl-2 and MAL expression.
|
| Kelley TW, Pohlman B, Elson P, Hsi ED.
|
| Am J Clin Pathol 128(6):958-65. 2007
|
| 24 | ATM, COQ7, GZMB, GZMH
|
| Aberrant recombination involving the granzyme locus occurs in Atm-/- T-cell lymphomas.
|
| Winrow CJ, Pankratz DG, Vibat CR, Bowen TJ, Callahan MA, Warren AJ, Hilbush BS, Wynshaw-Boris A, Hasel KW, Weaver Z, Lockhart DJ, Barlow C.
|
| Hum Mol Genet 14(18):2671-84. Epub 2005 Aug 8. 2005
|
| 25 | GZMB
|
| Granzyme B encoded by the commonly occurring human RAH allele retains pro-apoptotic activity.
|
| Sun J, Bird CH, Thia KY, Matthews AY, Trapani JA, Bird PI.
|
| J Biol Chem 279(17):16907-11. Epub 2004 Jan 29. 2004
|
| 26 | GZMB
|
| Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK.
|
| Thomas DA, Scorrano L, Putcha GV, Korsmeyer SJ, Ley TJ.
|
| Proc Natl Acad Sci U S A 98(26):14985-90. 2001
|
| 27 | GZMB, SERPINB9
|
| Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction.
|
| Hirst CE, Buzza MS, Sutton VR, Trapani JA, Loveland KL, Bird PI.
|
| Mol Hum Reprod 7(12):1133-42. 2001
|
| 28 | GZMB, IGF2R
|
| Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis.
|
| Motyka B, Korbutt G, Pinkoski MJ, Heibein JA, Caputo A, Hobman M, Barry M, Shostak I, Sawchuk T, Holmes CF, Gauldie J, Bleackley RC.
|
| Cell 103(3):491-500. 2000
|
| 29 | GZMB, GZMA
|
| The human granzyme A (HFSP, CTLA3) gene maps to 5q11-q12 and defines a new locus of the serine protease superfamily.
|
| Fink TM, et al.
|
| Genomics 18 : 401-403. 1993
|
| 30 | GZMB
|
| Polymorphism of the CTLA1 gene on chromosome 14.
|
| Nguyen V, et al.
|
| Hum Mol Genet 1 : 286. 1992
|
| 31 | GZMB, GZMH, SPAS@, CTSG
|
| A cluster of hematopoietic serine protease genes is found on the same chromosomal band as the human alpha/delta T-cell receptor locus.
|
| Hanson RD, et al.
|
| Proc Natl Acad Sci U S A 87 : 960-963. 1990
|
| 32 | GZMB
|
| Isolation of a cDNA clone encoding a novel form of granzyme B from human NK cells and mapping to chromosome 14.
|
| Dahl CA, et al.
|
| Hum Genet 84 : 465-470. 1990
|
| 33 | GZMB, CTLA4
|
| Genomic organization and chromosomal assignment for a serine protease gene (CSPB) expressed by human cytotoxic lymphocytes.
|
| Klein JL, et al.
|
| Genomics 5 : 110-117. 1989
|
| 34 | GZMB
|
| Proximity of CTLA-1 serine esterase and Tcrî loci in mouse and man.
|
| Harper K, Mattei MG, Simon D, Suzan M, Guenet JL, Haddad P, Sasportes M, Golstein P.
|
| Immunogenetics 28 : 439-444. 1988
|
| 35 | GZMB
|
| The inducible cytotoxic T-lymphocyte-associated gene transcript CTLA-1 sequence and gene localization to mouse chromosome 14.
|
| Brunet JF, Dosseto M, Denizot F, Mattei MG, Clark WR, Haqqi TM, Ferrier P, Nabholz M, Schmitt-Verhulst AM, Luciani MF, et al.
|
| Nature 322 : 268-271. 1988
|