1 | GRN, PSAP
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| The interaction between progranulin and prosaposin is mediated by granulins and the linker region between saposin B and C.
|
| Zhou X, Sullivan PM, Sun L, Hu F.
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| J Neurochem Neurochem. 2017 Jun 22. doi: 10.1111/jnc.14110. [Epub ahead of print]
2017
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2 | GRN, PSAP
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| Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations.
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| Zhou X, Sun L, Bracko O, Choi JW, Jia Y, Nana AL, Brady OA, Hernandez JCC, Nishimura N, Seeley WW, Hu F.
|
| Nat Commun 8:15277. doi: 10.1038/ncomms15277.
2017
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3 | CTSD, GRN
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| Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo.
|
| Beel S, Moisse M, Damme M, De Muynck L, Robberecht W, Van Den Bosch L, Saftig P, Van Damme P.
|
| Hum Mol Genet 26(15):2850-2863. doi: 10.1093/hmg/ddx162.
2017
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4 | CTSD, GRN
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| Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.
|
| Tanaka Y, Suzuki G, Matsuwaki T, Hosokawa M, Serrano G, Beach TG, Yamanouchi K, Hasegawa M, Nishihara M.
|
| Hum Mol Genet 26(5):969-988. doi: 10.1093/hmg/ddx011.
2017
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5 | GRN, RETN
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| Quantification and regulation of the adipokines resistin and progranulin in human cerebrospinal fluid.
|
| Berghoff M, Hochberg A, Schmid A, Schlegel J, Karrasch T, Kaps M, Schäffler A.
|
| Eur J Clin Invest 46(1):15-26. doi: 10.1111/eci.12558. Epub 2015 Dec 1.
2016
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6 | GRN, PSAP
|
| Prosaposin is a regulator of progranulin levels and oligomerization.
|
| Nicholson AM, Finch NA, Almeida M, Perkerson RB, van Blitterswijk M, Wojtas A, Cenik B, Rotondo S, Inskeep V, Almasy L, Dyer T, Peralta J, Jun G, Wood AR, Frayling TM, Fuchsberger C, Fowler S, Teslovich TM, Manning AK, Kumar S, Curran J, Lehman D, Abecasis G, Duggirala R, Pottier C, Zahir HA, Crook JE, Karydas A, Mitic L, Sun Y, Dickson DW, Bu G, Herz J, Yu G, Miller BL, Ferguson S, Petersen RC, Graff-Radford N, Blangero J, Rademakers R.
|
| Nat Commun 7:11992. doi: 10.1038/ncomms11992.
2016
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7 | GRN, PSAP
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| Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin.
|
| Zhou X, Sun L, Bastos de Oliveira F, Qi X, Brown WJ, Smolka MB, Sun Y, Hu F.
|
| J Cell Biol 210(6):991-1002. doi: 10.1083/jcb.201502029.
2015
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8 | ADAM15, GRN
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| ADAM15 participates in fertilization through a physical interaction with acrogranin.
|
| Pastén K, Bastian Y, Roa-Espitia AL, Maldonado-García D, Mendoza-Hernández G, Ortiz-García CI, Mújica A, Hernández-González EO.
|
| Reproduction 148(6):623-34. doi: 10.1530/REP-14-0179.
2014
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9 | GRN
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| Novel progranulin mutations with reduced serum-progranulin levels in frontotemporal lobar degeneration.
|
| Chiang HH, Forsell C, Lilius L, Oijerstedt L, Thordardottir S, Shanmugarajan K, Westerlund M, Nennesmo I, Thonberg H, Graff C.
|
| Eur J Hum Genet 21(11):1260-5. doi: 10.1038/ejhg.2013.37. Epub 2013 Mar 6.
2013
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10 | GRN, TMEM106B
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| The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and function.
|
| Brady OA, Zheng Y, Murphy K, Huang M, Hu F.
|
| Hum Mol Genet 22(4):685-95. doi: 10.1093/hmg/dds475. Epub 2012 Nov 6.
2013
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11 | C9orf72, FTDP17, FTDU17, GRN, MAPT
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| Neuroimaging signatures of frontotemporal dementia genetics: C9ORF72, tau, progranulin and sporadics.
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| Whitwell JL, Weigand SD, Boeve BF, Senjem ML, Gunter JL, DeJesus-Hernandez M, Rutherford NJ, Baker M, Knopman DS, Wszolek ZK, Parisi JE, Dickson DW, Petersen RC, Rademakers R, Jack CR Jr, Josephs KA.
|
| Brain 135(Pt 3):794-806. doi: 10.1093/brain/aws001. 2012
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12 | GRN, JUNB, MYOD1
|
| GEP constitutes a negative feedback loop with MyoD and acts as a novel mediator in controlling skeletal muscle differentiation.
|
| Wang D, Bai X, Tian Q, Lai Y, Lin EA, Shi Y, Mu X, Feng JQ, Carlson CS, Liu CJ.
|
| Cell Mol Life Sci 69(11):1855-73. doi: 10.1007/s00018-011-0901-5. Epub 2011 Dec 17.
2012
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13 | CLN11, GRN
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| Strikingly different clinicopathological phenotypes determined by progranulin-mutation dosage.
|
| Smith KR, Damiano J, Franceschetti S, Carpenter S, Canafoglia L, Morbin M, Rossi G, Pareyson D, Mole SE, Staropoli JF, Sims KB, Lewis J, Lin WL, Dickson DW, Dahl HH, Bahlo M, Berkovic SF.
|
| Am J Hum Genet 90(6):1102-7. doi: 10.1016/j.ajhg.2012.04.021. Epub 2012 May 17.
2012
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14 | GRN
|
| Misregulation of human sortilin splicing leads to the generation of a nonfunctional progranulin receptor.
|
| Prudencio M, Jansen-West KR, Lee WC, Gendron TF, Zhang YJ, Xu YF, Gass J, Stuani C, Stetler C, Rademakers R, Dickson DW, Buratti E, Petrucelli L.
|
| Proc Natl Acad Sci U S A 109(52):21510-5. doi: 10.1073/pnas.1211577110. Epub 2012 Dec 10.
2012
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15 | GRN
|
| Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury.
|
| Martens LH, Zhang J, Barmada SJ, Zhou P, Kamiya S, Sun B, Min SW, Gan L, Finkbeiner S, Huang EJ, Farese RV Jr.
|
| J Clin Invest 122(11):3955-9. doi: 10.1172/JCI63113. Epub 2012 Oct 8.
2012
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16 | GRN, MMP12, SLPI
|
| Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12).
|
| Suh HS, Choi N, Tarassishin L, Lee SC.
|
| PLoS One 7(4):e35115. doi: 10.1371/journal.pone.0035115. Epub 2012 Apr 11.
2012
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17 | FTDU17, GRN
|
| Progranulin: an emerging target for FTLD therapies.
|
| Gass J, Prudencio M, Stetler C, Petrucelli L.
|
| Brain Res 1462:118-28. doi: 10.1016/j.brainres.2012.01.047. Epub 2012 Jan 28. Review.
2012
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18 | GRN
|
| PGRN is a key adipokine mediating high fat diet-induced insulin resistance and obesity through IL-6 in adipose tissue.
|
| Matsubara T, Mita A, Minami K, Hosooka T, Kitazawa S, Takahashi K, Tamori Y, Yokoi N, Watanabe M, Matsuo E, Nishimura O, Seino S.
|
| Cell Metab 15(1):38-50. doi: 10.1016/j.cmet.2011.12.002.
2012
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19 | GRN, SORT1
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| Progranulin regulates neuronal outgrowth independent of sortilin.
|
| Gass J, Lee WC, Cook C, Finch N, Stetler C, Jansen-West K, Lewis J, Link CD, Rademakers R, Nykjær A, Petrucelli L.
|
| Mol Neurodegener. Jul 10;7:33. doi: 10.1186/1750-1326-7-33 2012
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20 | FTDU17, GRN
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| A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells.
|
| Kao AW, Eisenhut RJ, Martens LH, Nakamura A, Huang A, Bagley JA, Zhou P, de Luis A, Neukomm LJ, Cabello J, Farese RV Jr, Kenyon C.
|
| Proc Natl Acad Sci U S A 108(11):4441-6. Epub 2011 Feb 28.
2011
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21 | GRN
|
| Progranulin, a glycoprotein deficient in frontotemporal dementia, is a novel substrate of several protein disulfide isomerase family proteins.
|
| Almeida S, Zhou L, Gao FB.
|
| PLoS One 6(10):e26454. doi: 10.1371/journal.pone.0026454. Epub 2011 Oct 18.
2011
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22 | GRN
|
| Low plasma progranulin levels in children with autism.
|
| Al-Ayadhi LY, Mostafa GA.
|
| J Neuroinflammation 8:111. doi: 10.1186/1742-2094-8-111.
2011
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23 | FTDU17, GRN
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| Altered microRNA expression in frontotemporal lobar degeneration with TDP-43 pathology caused by progranulin mutations.
|
| Kocerha J, Kouri N, Baker M, Finch N, DeJesus-Hernandez M, Gonzalez J, Chidamparam K, Josephs KA, Boeve BF, Graff-Radford NR, Crook J, Dickson DW, Rademakers R.
|
| BMC Genomics 12:527. doi: 10.1186/1471-2164-12-527.
2011
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24 | GRN
|
| Granulin-epithelin precursor is an oncofetal protein defining hepatic cancer stem cells.
|
| Cheung PF, Cheng CK, Wong NC, Ho JC, Yip CW, Lui VC, Cheung AN, Fan ST, Cheung ST.
|
| PLoS One 6(12):e28246. doi: 10.1371/journal.pone.0028246. Epub 2011 Dec 16.
2011
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25 | GRN
|
| Increased progranulin in the skin of amyotrophic lateral sclerosis: an immunohistochemical study.
|
| Yasui K, Oketa Y, Higashida K, Fukazawa H, Ono S.
|
| J Neurol Sci 309(1-2):110-4. doi: 10.1016/j.jns.2011.07.003. Epub 2011 Jul 28.
2011
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26 | GRN
|
| Progranulin: a promising therapeutic target for rheumatoid arthritis.
|
| Liu CJ.
|
| FEBS Lett 585(23):3675-80. doi: 10.1016/j.febslet.2011.04.065. Epub 2011 May 4. Review.
2011
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27 | GRN, GSK3B
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| Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β.
|
| Gao X, Joselin AP, Wang L, Kar A, Ray P, Bateman A, Goate AM, Wu JY.
|
| Protein Cell 1(6):552-62. doi: 10.1007/s13238-010-0067-1. Epub 2010 Jul 7.
2010
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28 | GRN
|
| GEP, a local growth factor, is critical for odontogenesis and amelogenesis.
|
| Cao Z, Jiang B, Xie Y, Liu CJ, Feng JQ.
|
| Int J Biol Sci 6(7):719-29.
2010
|
29 | ADAMTS7, GRN, PTHLH
|
| ADAMTS-7, a direct target of PTHrP, adversely regulates endochondral bone growth by associating with and inactivating GEP growth factor.
|
| Bai XH, Wang DW, Kong L, Zhang Y, Luan Y, Kobayashi T, Kronenberg HM, Yu XP, Liu CJ.
|
| Mol Cell Biol 29(15):4201-19. Epub 2009 Jun 1.
2009
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30 | GRN
|
| Progranulin is expressed within motor neurons and promotes neuronal cell survival.
|
| Ryan CL, Baranowski DC, Chitramuthu BP, Malik S, Li Z, Cao M, Minotti S, Durham HD, Kay DG, Shaw CA, Bennett HP, Bateman A.
|
| BMC Neurosci 10:130. doi: 10.1186/1471-2202-10-130.
2009
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31 | GRN, FTDU17
|
| Progranulin locus deletion in frontotemporal dementia.
|
| Gijselinck I, van der Zee J, Engelborghs S, Goossens D, Peeters K, Mattheijssens M, Corsmit E, Del-Favero J, De Deyn PP, Van Broeckhoven C, Cruts M.
|
| Hum Mutat 29(1):53-8. 2008
|
32 | GRN, FTDU17, TARDBP
|
| Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion.
|
| Shankaran SS, Capell A, Hruscha AT, Fellerer K, Neumann M, Schmid B, Haass C.
|
| J Biol Chem 283(3):1744-53. Epub 2007 Nov 5. 2008
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33 | GRN, FTDU17
|
| Loss of progranulin function in frontotemporal lobar degeneration.
|
| Cruts M, Van Broeckhoven C.
|
| Trends Genet 24(4):186-94. Epub 2008 Mar 6. 2008
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34 | GRN, FTDU17
|
| Molecular characterization of novel progranulin (GRN) mutations in frontotemporal dementia.
|
| Mukherjee O, Wang J, Gitcho M, Chakraverty S, Taylor-Reinwald L, Shears S, Kauwe JS, Norton J, Levitch D, Bigio EH, Hatanpaa KJ, White CL, Morris JC, Cairns NJ, Goate A.
|
| Hum Mutat 29(4):512-21. 2008
|
35 | TARDBP, GRN
|
| Variations in the progranulin gene affect global gene expression in frontotemporal lobar degeneration.
|
| Chen-Plotkin AS, Geser F, Plotkin JB, Clark CM, Kwong LK, Yuan W, Grossman M, Van Deerlin VM, Trojanowski JQ, Lee VM.
|
| Hum Mol Genet 17(10):1349-62. Epub 2008 Jan 25. 2008
|
36 | FTDU17, GRN
|
| Granulin mutations associated with frontotemporal lobar degeneration and related disorders: an update.
|
| Gijselinck I, Van Broeckhoven C, Cruts M.
|
| Hum Mutat 29(12):1373-86.
2008
|
37 | FTDU17, GRN
|
| Phenotype variability in progranulin mutation carriers: a clinical, neuropsychological, imaging and genetic study.
|
| Le Ber I, Camuzat A, Hannequin D, Pasquier F, Guedj E, Rovelet-Lecrux A, Hahn-Barma V, van der Zee J, Clot F, Bakchine S, Puel M, Ghanim M, Lacomblez L, Mikol J, Deramecourt V, Lejeune P, de la Sayette V, Belliard S, Vercelletto M, Meyrignac C, Van Broeckhoven C, Lambert JC, Verpillat P, Campion D, Habert MO, Dubois B, Brice A; French research network on FTD/FTD-MND.
|
| Brain 131(Pt 3):732-46. Epub 2008 Feb 1.PMID: 18245784 2008
|
38 | GRN, RUNDC3A
|
| Progranulin locus deletion in frontotemporal dementia.
|
| Gijselinck I, van der Zee J, Engelborghs S, Goossens D, Peeters K, Mattheijssens M, Corsmit E, Del-Favero J, De Deyn PP, Van Broeckhoven C, Cruts M.
|
| Hum Mutat 29(1):53-8.
2008
|
39 | FTDU17,GRN
|
| Progranulin mutations in Dutch familial frontotemporal lobar degeneration.
|
| Bronner IF, Rizzu P, Seelaar H, van Mil SE, Anar B, Azmani A, Kaat LD, Rosso S, Heutink P, van Swieten JC.
|
| Eur J Hum Genet 15(3):369-74. Epub 2007 Jan 17. 2007
|
40 | FTDU17,GRN
|
| Mutations other than null mutations producing a pathogenic loss of progranulin in frontotemporal dementia.
|
| van der Zee J, Le Ber I, Maurer-Stroh S, Engelborghs S, Gijselinck I, Camuzat A, Brouwers N, Vandenberghe R, Sleegers K, Hannequin D, Dermaut B, Schymkowitz J, Campion D, Santens P, Martin JJ, Lacomblez L, De Pooter T, Peeters K, Mattheijssens M, Vercelletto M, Van den Broeck M, Cruts M, De Deyn PP, Rousseau F, Brice A, Van Broeckhoven C.
|
| Hum Mutat 28(4):416 [Epub ahead of print] 2007
|
41 | GRN, FTDU17
|
| Progranulin null mutations in both sporadic and familial frontotemporal dementia.
|
| Le Ber I, van der Zee J, Hannequin D, Gijselinck I, Campion D, Puel M, Laquerriere A, De Pooter T, Camuzat A, Van den Broeck M, Dubois B, Sellal F, Lacomblez L, Vercelletto M, Thomas-Anterion C, Michel BF, Golfier V, Didic M, Salachas F, Duyckaerts C, Cruts M, Verpillat P, Van Broeckhoven C, Brice A; French Research Network on FTD/FTD-MND.
|
| Hum Mutat 28(9):846-55. 2007
|
42 | FTDU17, GRN
|
| Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions with progranulin gene (PGRN) mutations.
|
| Josephs KA, Ahmed Z, Katsuse O, Parisi JF, Boeve BF, Knopman DS, Petersen RC, Davies P, Duara R, Graff-Radford NR, Uitti RJ, Rademakers R, Adamson J, Baker M, Hutton ML, Dickson DW.
|
| J Neuropathol Exp Neurol 66(2):142-51.
2007
|
43 | FTDU17, GRN
|
| Heterogeneity within a large kindred with frontotemporal dementia: a novel progranulin mutation.
|
| Bruni AC, Momeni P, Bernardi L, Tomaino C, Frangipane F, Elder J, Kawarai T, Sato C, Pradella S, Wakutani Y, Anfossi M, Gallo M, Geracitano S, Costanzo A, Smirne N, Curcio SA, Mirabelli M, Puccio G, Colao R, Maletta RG, Kertesz A, St George-Hyslop P, Hardy J, Rogaeva E.
|
| Neurology 69(2):140-7.
2007
|
44 | FTDU17, GRN
|
| The neuropathology and clinical phenotype of FTD with progranulin mutations.
|
| Mackenzie IR.
|
| Acta Neuropathol 114(1):49-54. Epub 2007 Apr 26. Review.
2007
|
45 | GRN
|
| Oncogenic property of acrogranin in human uterine leiomyosarcoma: direct evidence of genetic contribution in in vivo tumorigenesis.
|
| Matsumura N, Mandai M, Miyanishi M, Fukuhara K, Baba T, Higuchi T, Kariya M, Takakura K, Fujii S.
|
| Clin Cancer Res 12(5):1402-11. 2006
|
46 | TARDBP, GRN
|
| Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
|
| Neumann M, Sampathu DM, Kwong LK, Truax AC, Micsenyi MC, Chou TT, Bruce J, Schuck T, Grossman M, Clark CM, McCluskey LF, Miller BL, Masliah E, Mackenzie IR, Feldman H, Feiden W, Kretzschmar HA, Trojanowski JQ, Lee VM.
|
| Science 314(5796):130-3. 2006
|
47 | FTDU17,GRN
|
| Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17.
|
| Baker M, Mackenzie IR, Pickering-Brown SM, Gass J, Rademakers R, Lindholm C, Snowden J, Adamson J, Sadovnick AD, Rollinson S, Cannon A, Dwosh E, Neary D, Melquist S, Richardson A, Dickson D, Berger Z, Eriksen J, Robinson T, Zehr C, Dickey CA, Crook R, McGowan E, Mann D, Boeve B, Feldman H, Hutton M.
|
| Nature 442(7105):916-9. Epub 2006 Jul 16. 2006
|
48 | FTDU17,GRN
|
| Bad neighbors cause dementia; a second 17q21-linked gene responsible for frontotemporal dementia.
|
| Neal SJ, Leavitt BR.
|
| Clin Genet 70(5):385-7. No abstract available. 2006
|
49 | FTDU17,GRN
|
| Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21.
|
| Cruts M, Gijselinck I, van der Zee J, Engelborghs S, Wils H, Pirici D, Rademakers R, Vandenberghe R, Dermaut B, Martin JJ, van Duijn C, Peeters K, Sciot R, Santens P, De Pooter T, Mattheijssens M, Van den Broeck M, Cuijt I, Vennekens K, De Deyn PP, Kumar-Singh S, Van Broeckhoven C.
|
| Nature 442(7105):920-4. Epub 2006 Jul 16. 2006
|
50 | FTDU17,GRN
|
| Progranulin mutations in ubiquitin-positive frontotemporal dementia linked to chromosome 17q21.
|
| Cruts M, Kumar-Singh S, Van Broeckhoven C.
|
| Curr Alzheimer Res 3(5):485-91. Review. 2006
|
51 | GRN, FTDU17
|
| HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin.
|
| Mukherjee O, Pastor P, Cairns NJ, Chakraverty S, Kauwe JS, Shears S, Behrens MI, Budde J, Hinrichs AL, Norton J, Levitch D, Taylor-Reinwald L, Gitcho M, Tu PH, Tenenholz Grinberg L, Liscic RM, Armendariz J, Morris JC, Goate AM.
|
| Ann Neurol 60(3):314-22. 2006
|
52 | FTDU17, GRN
|
| Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration.
|
| Gass J, Cannon A, Mackenzie IR, Boeve B, Baker M, Adamson J, Crook R, Melquist S, Kuntz K, Petersen R, Josephs K, Pickering-Brown SM, Graff-Radford N, Uitti R, Dickson D, Wszolek Z, Gonzalez J, Beach TG, Bigio E, Johnson N, Weintraub S, Mesulam M, White CL 3rd, Woodruff B, Caselli R, Hsiung GY, Feldman H, Knopman D, Hutton M, Rademakers R.
|
| Hum Mol Genet 15(20):2988-3001. Epub 2006 Sep 1. 2006
|
53 | DEL17Q21,FTDP17,FTDU17,GRN,MAPT
|
| Genomic architecture of human 17q21 linked to frontotemporal dementia uncovers a highly homologous family of low-copy repeats in the tau region.
|
| Cruts M, Rademakers R, Gijselinck I, van der Zee J, Dermaut B, de Pooter T, de Rijk P, Del-Favero J, van Broeckhoven C.
|
| Hum Mol Genet 14(13):1753-62. Epub 2005 May 11. 2005
|
54 | GRN
|
| Identification of a human glioma-associated growth factor gene, granulin, using differential immuno-absorption.
|
| Liau LM, Lallone RL, Seitz RS, Buznikov A, Gregg JP, Kornblum HI, Nelson SF, Bronstein JM.
|
| Cancer Res 60(5):1353-60. 2000
|
55 | GRN
|
| Cellular localization of gene expression for progranulin.
|
| Daniel R, He Z, Carmichael KP, Halper J, Bateman A.
|
| J Histochem Cytochem 48(7):999-1009. 2000
|
56 | GRN
|
| Progranulin gene expression regulates epithelial cell growth and promotes tumor growth in vivo.
|
| He Z, et al.
|
| Cancer Res 59(13):3222-9 1999
|
57 | GRN
|
| Acrogranin, an acrosomal cysteine-rich glycoprotein, is the precursor of the growth-modulating peptides, granulins, and epithelins, and is expressed in somatic as well as male germ cells.
|
| Baba T, Hoff HB 3rd, Nemoto H, Lee H, Orth J, Arai Y, Gerton GL.
|
| Mol Reprod Dev 34(3):233-43.
1993
|
58 | GRN
|
| Structure and chromosomal location of the human granulin gene.
|
| Bhandari V, et al.
|
| Biochem Biophys Res Commun 188 : 57-63. 1992
|
59 | GRN
|
| Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor.
|
| Lust JA, et al.
|
| Cytokine 4 : 96-100. 1992
|