| 1 | GRM2
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| Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling.
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| El Moustaine D, Granier S, Doumazane E, Scholler P, Rahmeh R, Bron P, Mouillac B, Bančres JL, Rondard P, Pin JP.
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| Proc Natl Acad Sci U S A 109(40):16342-7. doi: 10.1073/pnas.1205838109. Epub 2012 Sep 17.
2012
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| 2 | GRM2, HTR2A
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| Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs.
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| Fribourg M, Moreno JL, Holloway T, Provasi D, Baki L, Mahajan R, Park G, Adney SK, Hatcher C, Eltit JM, Ruta JD, Albizu L, Li Z, Umali A, Shim J, Fabiato A, MacKerell AD Jr, Brezina V, Sealfon SC, Filizola M, González-Maeso J, Logothetis DE.
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| Cell 147(5):1011-23. doi: 10.1016/j.cell.2011.09.055.
2011
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| 3 | GRM2
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| Structural determinants of allosteric antagonism at metabotropic glutamate receptor 2: mechanistic studies with new potent negative allosteric modulators.
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| Lundström L, Bissantz C, Beck J, Wettstein JG, Woltering TJ, Wichmann J, Gatti S.
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| Br J Pharmacol 164(2b):521-37. doi: 10.1111/j.1476-5381.2011.01409.x.
2011
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| 4 | GRM2, GRM3
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| Hippocampal mossy fiber long-term depression in Grm2/3 double knockout mice.
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| Lyon L, Borel M, Carrión M, Kew JN, Corti C, Harrison PJ, Burnet PW, Paulsen O, Rodríguez-Moreno A.
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| Synapse 65(9):945-54. doi: 10.1002/syn.20923. Epub 2011 Mar 28.
2011
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| 5 | GRM2, HTR2A
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| Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists.
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| Moreno JL, Holloway T, Albizu L, Sealfon SC, González-Maeso J.
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| Neurosci Lett 493(3):76-9. doi: 10.1016/j.neulet.2011.01.046. Epub 2011 Jan 27.
2011
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| 6 | GRM2
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| Functional plasticity of group II metabotropic glutamate receptors in regulating spinal excitatory and inhibitory synaptic input in neuropathic pain.
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| Zhou HY, Chen SR, Chen H, Pan HL.
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| J Pharmacol Exp Ther 336(1):254-64. doi: 10.1124/jpet.110.173112. Epub 2010 Oct 5.
2011
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| 7 | GRM2
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| Metabotropic glutamate receptor mGlu2 is resistant to homologous agonist-induced desensitization but undergoes protein kinase C-mediated heterologous desensitization.
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| Lennon SM, Rivero G, Matharu A, Howson PA, Jane DE, Roberts PJ, Kelly E.
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| Eur J Pharmacol 649(1-3):29-37. doi: 10.1016/j.ejphar.2010.08.038. Epub 2010 Sep 15.
2010
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| 8 | GRM2, GRM3
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| Elevated level of metabotropic glutamate receptor 2/3 in the prefrontal cortex in major depression.
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| Feyissa AM, Woolverton WL, Miguel-Hidalgo JJ, Wang Z, Kyle PB, Hasler G, Stockmeier CA, Iyo AH, Karolewicz B.
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| Prog Neuropsychopharmacol Biol Psychiatry 34(2):279-83. doi: 10.1016/j.pnpbp.2009.11.018. Epub 2009 Nov 26.
2010
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| 9 | GRM2, HTR2A
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| Association analysis of GRM2 and HTR2A with methamphetamine-induced psychosis and schizophrenia in the Japanese population.
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| Tsunoka T, Kishi T, Kitajima T, Okochi T, Okumura T, Yamanouchi Y, Kinoshita Y, Kawashima K, Naitoh H, Inada T, Ujike H, Yamada M, Uchimura N, Sora I, Iyo M, Ozaki N, Iwata N.
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| Prog Neuropsychopharmacol Biol Psychiatry 34(4):639-44. doi: 10.1016/j.pnpbp.2010.03.002. Epub 2010 Mar 6.
2010
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| 10 | GRM2
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| The effect of mGluR2 activation on signal transduction pathways and neuronal cell survival.
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| Lee HG, Zhu X, Casadesus G, Pallŕs M, Camins A, O'Neill MJ, Nakanishi S, Perry G, Smith MA.
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| Brain Res 1249:244-50. doi: 10.1016/j.brainres.2008.10.055. Epub 2008 Nov 5.
2009
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| 11 | GRM2, HTR2A
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| Identification of a serotonin/glutamate receptor complex implicated in psychosis.
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| Gonz‡lez-Maeso J, Ang RL, Yuen T, Chan P, Weisstaub NV, L—pez-GimŽnez JF, Zhou M, Okawa Y, Callado LF, Milligan G, Gingrich JA, Filizola M, Meana JJ, Sealfon SC.
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| Nature 452(7183):93-7. Epub 2008 Feb 24. 2008
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| 12 | GRM2, GRM3
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| Metabotropic glutamate receptor 2 and 3 gene expression in the human prefrontal cortex and mesencephalon in schizophrenia.
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| Ghose S, Crook JM, Bartus CL, Sherman TG, Herman MM, Hyde TM, Kleinman JE, Akil M.
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| Int J Neurosci 118(11):1609-27. doi: 10.1080/00207450802330702. 2008
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| 13 | GRM2, GRM3
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| Altered hippocampal expression of glutamate receptors and transporters in GRM2 and GRM3 knockout mice.
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| Lyon L, Kew JN, Corti C, Harrison PJ, Burnet PW.
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| Synapse 62(11):842-50. doi: 10.1002/syn.20553.
2008
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| 14 | GRM2
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| mGluR2 acts through inhibitory Galpha subunits to regulate transmission and long-term plasticity at hippocampal mossy fiber-CA3 synapses.
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| Nicholls RE, Zhang XL, Bailey CP, Conklin BR, Kandel ER, Stanton PK.
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| Proc Natl Acad Sci U S A 103(16):6380-5. Epub 2006 Apr 10.
2006
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| 15 | GRM2
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| Glutamate receptors: RNA editing and death of motor neurons.
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| Kawahara Y, Ito K, Sun H, Aizawa H, Kanazawa I, Kwak S.
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| Nature 427(6977):801. 2004
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| 16 | GRM2
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| Glial proliferation and metabotropic glutamate receptor expression in amyotrophic lateral sclerosis.
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| Anneser JM, Chahli C, Ince PG, Borasio GD, Shaw PJ.
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| J Neuropathol Exp Neurol 63(8):831-40. 2004
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| 17 | GRM2
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| Localization of metabotropic glutamate receptor type 2 in the human brain.
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| Phillips T, Rees S, Augood S, Waldvogel H, Faull R, Svendsen C, Emson P.
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| Neuroscience 95(4):1139-56. 2000
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| 18 | GRM2
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| Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 2.
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| Flor PJ, et al.
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| Eur J Neurosci 7(4):622-9 1995
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