| 1 | GRM1, GRM5, NCDN, NDDIDE
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| Monoallelic and bi-allelic variants in NCDN cause neurodevelopmental delay, intellectual disability, and epilepsy
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| Fatima A, Hoeber J, Schuster J, Koshimizu E, Maya-Gonzalez C, Keren B, Mignot C, Akram T, Ali Z, Miyatake S, Tanigawa J, Koike T, Kato M, Murakami Y, Abdullah U, Ali MA, Fadoul R, Laan L, Castillejo-López C, Liik M, Jin Z, Birnir B, Matsumoto N, Baig SM, Klar J, Dahl N
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| Am J Hum Genet. Apr 1;108(4):739-748. doi: 10.1016/j.ajhg.2021.02.015. Epub 2021 Mar 11. 2021
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| 2 | GRM1, SCA44
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| Dominant Mutations in GRM1 Cause Spinocerebellar Ataxia Type 44.
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| Watson LM, Bamber E, Schnekenberg RP, Williams J, Bettencourt C, Lickiss J, Jayawant S, Fawcett K, Clokie S, Wallis Y, Clouston P, Sims D, Houlden H, Becker EBE, Németh AH.
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| Am J Hum Genet 101(3):451-458. doi: 10.1016/j.ajhg.2017.08.005.
2017
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| 3 | GRM1, SCA44
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| Dominant Mutations in GRM1 Cause Spinocerebellar Ataxia Type 44.
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| Watson LM, Bamber E, Schnekenberg RP, Williams J, Bettencourt C, Jayawant S, Lickiss J, Fawcett K, Clokie S, Wallis Y, Clouston P, Sims D, Houlden H, Becker EBE, Németh AH.
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| Am J Hum Genet 101(4):638. doi: 10.1016/j.ajhg.2017.09.006. No abstract available.
2017
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| 4 | GRM1
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| A Critical Role for Ubiquitination in the Endocytosis of Glutamate Receptors.
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| Gulia R, Sharma R, Bhattacharyya S.
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| J Biol Chem 292(4):1426-1437. doi: 10.1074/jbc.M116.752105. Epub 2016 Dec 23.
2017
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| 5 | GRM1, SCA44
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| Dominant Mutations in GRM1 Cause Spinocerebellar Ataxia Type 44.
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| Watson LM, Bamber E, Schnekenberg RP, Williams J, Bettencourt C, Lickiss J, Jayawant S, Fawcett K, Clokie S, Wallis Y, Clouston P, Sims D, Houlden H, Becker EBE, Németh AH.
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| Am J Hum Genet 101(5):866. doi: 10.1016/j.ajhg.2017.10.008. No abstract available.
2017
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| 6 | GRM1, GRM5
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| mGluR1 and mGluR5 Synergistically Control Cholinergic Synaptic Transmission in the Thalamic Reticular Nucleus.
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| Sun YG, Rupprecht V, Zhou L, Dasgupta R, Seibt F, Beierlein M.
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| J Neurosci 36(30):7886-96. doi: 10.1523/JNEUROSCI.0409-16.2016.
2016
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| 7 | GRM1, TRMU
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| The Role of a Novel TRMT1 Gene Mutation and Rare GRM1 Gene Defect in Intellectual Disability in Two Azeri Families.
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| Davarniya B, Hu H, Kahrizi K, Musante L, Fattahi Z, Hosseini M, Maqsoud F, Farajollahi R, Wienker TF, Ropers HH, Najmabadi H.
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| PLoS One 10(8):e0129631. doi: 10.1371/journal.pone.0129631. eCollection 2015.
2015
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| 8 | GRM1, NRG1
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| Neuregulin 1 signalling modulates mGluR1 function in mesencephalic dopaminergic neurons.
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| Ledonne A, Nobili A, Latagliata EC, Cavallucci V, Guatteo E, Puglisi-Allegra S, D'Amelio M, Mercuri NB.
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| Mol Psychiatry 20(8):959-73. doi: 10.1038/mp.2014.109. Epub 2014 Sep 30.
2015
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| 9 | GRM1
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| Metabotropic glutamate receptor 1 splice variants mGluR1a and mGluR1b combine in mGluR1a/b dimers in vivo.
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| Techlovská Š, Chambers JN, Dvořáková M, Petralia RS, Wang YX, Hájková A, Nová A, Franková D, Prezeau L, Blahos J.
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| Neuropharmacology 86:329-336. doi: 10.1016/j.neuropharm.2014.08.011. Epub 2014 Aug 23.
2014
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| 10 | GRM1, GRM5
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| Cooperative signaling between homodimers of metabotropic glutamate receptors 1 and 5.
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| Sevastyanova TN, Kammermeier PJ.
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| Mol Pharmacol 86(5):492-504. doi: 10.1124/mol.114.093468. Epub 2014 Aug 11.
2014
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| 11 | GRM1, STIM1
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| STIM1 controls neuronal Ca˛⁺ signaling, mGluR1-dependent synaptic transmission, and cerebellar motor behavior.
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| Hartmann J, Karl RM, Alexander RP, Adelsberger H, Brill MS, Rühlmann C, Ansel A, Sakimura K, Baba Y, Kurosaki T, Misgeld T, Konnerth A.
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| Neuron 82(3):635-44. doi: 10.1016/j.neuron.2014.03.027.
2014
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| 12 | GRM1
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| GRM1 is upregulated through gene fusion and promoter swapping in chondromyxoid fibroma.
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| Nord KH, Lilljebjörn H, Vezzi F, Nilsson J, Magnusson L, Tayebwa J, de Jong D, Bovée JV, Hogendoorn PC, Szuhai K.
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| Nat Genet 46(5):474-7. doi: 10.1038/ng.2927. Epub 2014 Mar 23.
2014
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| 13 | GRM1
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| The synaptic targeting of mGluR1 by its carboxyl-terminal domain is crucial for cerebellar function.
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| Ohtani Y, Miyata M, Hashimoto K, Tabata T, Kishimoto Y, Fukaya M, Kase D, Kassai H, Nakao K, Hirata T, Watanabe M, Kano M, Aiba A.
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| J Neurosci 34(7):2702-12. doi: 10.1523/JNEUROSCI.3542-13.2014.
2014
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| 14 | GRM1, GRM5
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| Agonist-dependent signaling by group I metabotropic glutamate receptors is regulated by association with lipid domains.
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| Kumari R, Castillo C, Francesconi A.
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| J Biol Chem 288(44):32004-19. doi: 10.1074/jbc.M113.475863. Epub 2013 Sep 17.
2013
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| 15 | GRM1
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| Two newly identified exons in human GRM1 express a novel splice variant of metabotropic glutamate 1 receptor.
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| DiRaddo JO, Pshenichkin S, Gelb T, Wroblewski JT.
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| Gene 519(2):367-73. doi: 10.1016/j.gene.2013.02.009. Epub 2013 Feb 24.
2013
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| 16 | GRM1
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| Metabotropic glutamate receptor 1 (Grm1) is an oncogene in epithelial cells.
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| Martino JJ, Wall BA, Mastrantoni E, Wilimczyk BJ, La Cava SN, Degenhardt K, White E, Chen S.
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| Oncogene 32(37):4366-76. doi: 10.1038/onc.2012.471. Epub 2012 Oct 22.
2013
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| 17 | GRM1, SCAR13
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| Autosomal-recessive congenital cerebellar ataxia is caused by mutations in metabotropic glutamate receptor 1.
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| Guergueltcheva V, Azmanov DN, Angelicheva D, Smith KR, Chamova T, Florez L, Bynevelt M, Nguyen T, Cherninkova S, Bojinova V, Kaprelyan A, Angelova L, Morar B, Chandler D, Kaneva R, Bahlo M, Tournev I, Kalaydjieva L.
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| Am J Hum Genet 91(3):553-64. Epub 2012 Aug 16.
2012
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| 18 | GRID2, GRM1
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| Glutamate receptor δ2 associates with metabotropic glutamate receptor 1 (mGluR1), protein kinase Cγ, and canonical transient receptor potential 3 and regulates mGluR1-mediated synaptic transmission in cerebellar Purkinje neurons.
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| Kato AS, Knierman MD, Siuda ER, Isaac JT, Nisenbaum ES, Bredt DS.
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| J Neurosci 32(44):15296-308. doi: 10.1523/JNEUROSCI.0705-12.2012.
2012
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| 19 | GRM1, HOMER1
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| Homer1a signaling in the amygdala counteracts pain-related synaptic plasticity, mGluR1 function and pain behaviors.
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| Tappe-Theodor A, Fu Y, Kuner R, Neugebauer V.
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| Mol Pain 7:38. doi: 10.1186/1744-8069-7-38.
2011
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| 20 | GRM1, GRM5
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| Differential distribution of group I metabotropic glutamate receptors in developing human cortex.
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| Boer K, Encha-Razavi F, Sinico M, Aronica E.
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| Brain Res 1324:24-33. Epub 2010 Feb 10.PMID: 20149785 2010
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| 21 | GRM1
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| Elucidation of a novel extracellular calcium-binding site on metabotropic glutamate receptor 1{alpha} (mGluR1{alpha}) that controls receptor activation.
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| Jiang Y, Huang Y, Wong HC, Zhou Y, Wang X, Yang J, Hall RA, Brown EM, Yang JJ.
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| J Biol Chem 285(43):33463-74. Epub 2010 Aug 12.PMID: 20705606 2010
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| 22 | GRM1
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| The metabotropic glutamate receptor 1, GRM1: evaluation as a candidate gene for inherited forms of cerebellar ataxia.
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| Rossi PI, Vaccari CM, Terracciano A, Doria-Lamba L, Facchinetti S, Priolo M, Ayuso C, De Jorge L, Gimelli S, Santorelli FM, Ravazzolo R, Puliti A.
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| J Neurol 257(4):598-602. Epub 2009 Nov 19.PMID: 19924463 2010
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| 23 | AKT2, GRM1
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| AKT2 is a downstream target of metabotropic glutamate receptor 1 (Grm1).
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| Shin SS, Wall BA, Goydos JS, Chen S.
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| Pigment Cell Melanoma Res 23(1):103-11. Epub 2009 Oct 20.PMID: 19843246 2010
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| 24 | GRM1
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| Regulation of group I metabotropic glutamate receptor trafficking and signaling by the caveolar/lipid raft pathway.
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| Francesconi A, Kumari R, Zukin RS.
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| J Neurosci 29(11):3590-602.PMID: 19295163 2009
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| 25 | GOPC, GRASP, GRM1
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| A novel association of mGluR1a with the PDZ scaffold protein CAL modulates receptor activity.
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| Zhang J, Cheng S, Xiong Y, Ma Y, Luo D, Jeromin A, Zhang H, He J.
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| FEBS Lett 582(30):4117-24. Epub 2008 Nov 21.
2008
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| 26 | FMR1, GRM1
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| Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors.
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| Wang H, Wu LJ, Zhang F, Zhuo M.
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| J Neurosci 28(17):4385-97.PMID: 18434517 2008
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| 27 | GRM1
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| Group I metabotropic glutamate receptors control metaplasticity of spinal cord learning through a protein kinase C-dependent mechanism.
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| Ferguson AR, Bolding KA, Huie JR, Hook MA, Santillano DR, Miranda RC, Grau JW.
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| J Neurosci 28(46):11939-49.PMID: 19005059 2008
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| 28 | GRM1, GRM5
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| Endogenous homer proteins regulate metabotropic glutamate receptor signaling in neurons.
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| Kammermeier PJ.
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| J Neurosci 28(34):8560-7.PMID: 18716215 2008
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| 29 | GRM1
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| Transcriptional activators and repressors for the neuron-specific expression of a metabotropic glutamate receptor.
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| Crepaldi L, Lackner C, Corti C, Ferraguti F.
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| J Biol Chem 282(24):17877-89. Epub 2007 Apr 12. 2007
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| 30 | GRM1
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| Genetic analysis of the GRM1 gene in human melanoma susceptibility.
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| Ortiz P, Vanaclocha F, L—pez-Bran E, Esquivias JI, L—pez-Estebaranz JL, Mart’n-Gonz‡lez M, Arrue I, Garc’a-Romero D, Ochoa C, Gonz‡lez-Perez A, Ruiz A, Real LM.
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| Eur J Hum Genet 15(11):1176-82. Epub 2007 Jul 4. 2007
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| 31 | TRPC1, GRM1
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| Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1.
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| Kim SJ, Kim YS, Yuan JP, Petralia RS, Worley PF, Linden DJ.
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| Nature 426(6964):285-91. Epub 2003 Nov 12. 2003
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| 32 | GRM1
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| Assignment of the gene GRM1 coding for metabotropic glutamate receptor 1 to human chromosome band 6q24 by in situ hybridization.
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| Ganesh S, Amano K, Yamakawa K.
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| Cytogenet Cell Genet 88(3-4):314-5. No abstract available. 2000
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| 33 | GRM1, GRM5, HOMER1, HOMER2, HOMER3
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| Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors.
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| Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF.
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| Neuron 21(4):717-26 1998
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| 34 | GRM1, GRM5, HOMER1, HOMER2, HOMER3
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| Homer: a protein that selectively binds metabotropic glutamate receptors.
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| Brakeman PR, Lanahan AA, O'Brien R, Roche K, Barnes CA, Huganir RL, Worley PF.
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| Nature 386(6622):284-8 1997
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| 35 | GRM1
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| Human metabotropic glutamate receptor 1: mRNA distribution, chromosome localization and functional expression of two splice variants.
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| Stephan D, Bon C, Holzwarth JA, Galvan M, Pruss RM.
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| Neuropharmacology 35(12):1649-60 1996
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| 36 | GRM1
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| Cloning and expression of a human metabotropic glutamate receptor 1 alpha: enhanced coupling on co-transfection with a glutamate transporter.
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| Desai MA, Burnett JP, Mayne NG, Schoepp DD.
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| Mol Pharmacol 48(4):648-57 1995
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