| 1 | GRHL2, OVOL2, PPCD1, PPCD3, PPCD4, ZEB1
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| Ectopic GRHL2 Expression Due to Non-coding Mutations Promotes Cell State Transition and Causes Posterior Polymorphous Corneal Dystrophy 4.
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| Liskova P, Dudakova L, Evans CJ, Rojas Lopez KE, Pontikos N, Athanasiou D, Jama H, Sach J, Skalicka P, Stranecky V, Kmoch S, Thaung C, Filipec M, Cheetham ME, Davidson AE, Tuft SJ, Hardcastle AJ.
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| Am J Hum Genet 102(3):447-459. doi: 10.1016/j.ajhg.2018.02.002.
2018
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| 2 | GRHL2
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| Grhl2 is required in nonneural tissues for neural progenitor survival and forebrain development.
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| Menke C, Cionni M, Siggers T, Bulyk ML, Beier DR, Stottmann RW.
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| Genesis enesis. 2015 Jul 14. doi: 10.1002/dvg.22875. [Epub ahead of print]
2015
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| 3 | CLDN4, GRHL2, OVOL2, RAB25
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| A Grainyhead-Like 2/Ovo-Like 2 Pathway Regulates Renal Epithelial Barrier Function and Lumen Expansion.
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| Aue A, Hinze C, Walentin K, Ruffert J, Yurtdas Y, Werth M, Chen W, Rabien A, Kilic E, Schulzke JD, Schumann M, Schmidt-Ott KM.
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| J Am Soc Nephrol Am Soc Nephrol. 2015 Mar 18. pii: ASN.2014080759. [Epub ahead of print]
2015
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| 4 | GRHL2
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| A Grhl2-dependent gene network controls trophoblast branching morphogenesis.
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| Walentin K, Hinze C, Werth M, Haase N, Varma S, Morell R, Aue A, Pötschke E, Warburton D, Qiu A, Barasch J, Purfürst B, Dieterich C, Popova E, Bader M, Dechend R, Staff AC, Yurtdas ZY, Kilic E, Schmidt-Ott KM.
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| Development 142(6):1125-36. doi: 10.1242/dev.113829.
2015
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| 5 | ECTDS, GRHL2
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| Mutations in GRHL2 Result in an Autosomal-Recessive Ectodermal Dysplasia Syndrome.
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| Petrof G, Nanda A, Howden J, Takeichi T, McMillan JR, Aristodemou S, Ozoemena L, Liu L, South AP, Pourreyron C, Dafou D, Proudfoot LE, Al-Ajmi H, Akiyama M, McLean WH, Simpson MA, Parsons M, McGrath JA.
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| Am J Hum Genet 95(3):308-14. doi: 10.1016/j.ajhg.2014.08.001. Epub 2014 Aug 21.
2014
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| 6 | GRHL2
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| Grainyhead-like 2 (GRHL2) distribution reveals novel pathophysiological differences between human idiopathic pulmonary fibrosis and mouse models of pulmonary fibrosis.
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| Varma S, Mahavadi P, Sasikumar S, Cushing L, Hyland T, Rosser AE, Riccardi D, Lu J, Kalin TV, Kalinichenko VV, Guenther A, Ramirez MI, Pardo A, Selman M, Warburton D.
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| Am J Physiol Lung Cell Mol Physiol 306(5):L405-19. doi: 10.1152/ajplung.00143.2013. Epub 2013 Dec 27.
2014
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| 7 | DFNA28, GRHL2
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| Confirmation of GRHL2 as the gene for the DFNA28 locus.
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| Vona B, Nanda I, Neuner C, Müller T, Haaf T.
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| Am J Med Genet A 161A(8):2060-5. doi: 10.1002/ajmg.a.36017. Epub 2013 Jun 27.
2013
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| 8 | CLDN3, CLDN4, GRHL2, RAB25
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| Grainyhead-like 2 regulates epithelial morphogenesis by establishing functional tight junctions through the organization of a molecular network among claudin3, claudin4, and Rab25.
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| Senga K, Mostov KE, Mitaka T, Miyajima A, Tanimizu N.
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| Mol Biol Cell 23(15):2845-55. doi: 10.1091/mbc.E12-02-0097. Epub 2012 Jun 13.
2012
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| 9 | GRHL2
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| Grainyhead-like 2 (GRHL2) inhibits keratinocyte differentiation through epigenetic mechanism.
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| Chen W, Xiao Liu Z, Oh JE, Shin KH, Kim RH, Jiang M, Park NH, Kang MK.
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| Cell Death Dis 3:e450. doi: 10.1038/cddis.2012.190.
2012
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| 10 | GRHL2
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| Suppression of the epithelial-mesenchymal transition by Grainyhead-like-2.
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| Cieply B, Riley P 4th, Pifer PM, Widmeyer J, Addison JB, Ivanov AV, Denvir J, Frisch SM.
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| Cancer Res 72(9):2440-53. doi: 10.1158/0008-5472.CAN-11-4038. Epub 2012 Feb 29.
2012
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| 11 | GRHL2, NKX2-1
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| The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation.
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| Varma S, Cao Y, Tagne JB, Lakshminarayanan M, Li J, Friedman TB, Morell RJ, Warburton D, Kotton DN, Ramirez MI.
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| J Biol Chem 287(44):37282-95. doi: 10.1074/jbc.M112.408401. Epub 2012 Sep 6.
2012
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| 12 | GRHL2
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| The grainyhead-like 2 gene (GRHL2) single nucleotide polymorphism is not associated with age-related hearing impairment in Han Chinese.
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| Lin YH, Wu CC, Hsu CJ, Hwang JH, Liu TC.
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| Laryngoscope 121(6):1303-7. doi: 10.1002/lary.21771. Epub 2011 May 6.
2011
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| 13 | GRHL2
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| Grainyhead-like 2 regulates neural tube closure and adhesion molecule expression during neural fold fusion.
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| Pyrgaki C, Liu A, Niswander L.
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| Dev Biol 353(1):38-49. Epub 2011 Mar 4.
2011
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| 14 | GRHL2
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| Over-expression of Grhl2 causes spina bifida in the Axial defects mutant mouse.
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| Brouns MR, De Castro SC, Terwindt-Rouwenhorst EA, Massa V, Hekking JW, Hirst CS, Savery D, Munts C, Partridge D, Lamers W, Köhler E, van Straaten HW, Copp AJ, Greene ND.
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| Hum Mol Genet 20(8):1536-46. Epub 2011 Jan 24.
2011
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| 15 | GRHL1, GRHL2, GRHL3
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| The unique and cooperative roles of the Grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity.
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| Boglev Y, Wilanowski T, Caddy J, Parekh V, Auden A, Darido C, Hislop NR, Cangkrama M, Ting SB, Jane SM.
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| Dev Biol 349(2):512-22. Epub 2010 Nov 21.
2011
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| 16 | GRHL2
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| Grainyhead-like 2 enhances the human telomerase reverse transcriptase gene expression by inhibiting DNA methylation at the 5'-CpG island in normal human keratinocytes.
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| Chen W, Dong Q, Shin KH, Kim RH, Oh JE, Park NH, Kang MK.
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| J Biol Chem 285(52):40852-63. Epub 2010 Oct 11.
2010
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| 17 | GRHL2, GRHL3
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| Regional neural tube closure defined by the Grainy head-like transcription factors.
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| Rifat Y, Parekh V, Wilanowski T, Hislop NR, Auden A, Ting SB, Cunningham JM, Jane SM.
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| Dev Biol 345(2):237-45. Epub 2010 Jul 21.
2010
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| 18 | GRHL2
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| The transcription factor grainyhead-like 2 regulates the molecular composition of the epithelial apical junctional complex.
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| Werth M, Walentin K, Aue A, Schönheit J, Wuebken A, Pode-Shakked N, Vilianovitch L, Erdmann B, Dekel B, Bader M, Barasch J, Rosenbauer F, Luft FC, Schmidt-Ott KM.
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| Development 137(22):3835-45.
2010
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| 19 | GRHL2
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| The grainyhead like 2 gene (GRHL2), alias TFCP2L3, is associated with age-related hearing impairment.
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| Van Laer L, Van Eyken E, Fransen E, Huyghe JR, Topsakal V, Hendrickx JJ, Hannula S, MŠki-Torkko E, Jensen M, Demeester K, Baur M, Bonaconsa A, Mazzoli M, Espeso A, Verbruggen K, Huyghe J, Huygen P, Kunst S, Manninen M, Konings A, Diaz-Lacava AN, Steffens M, Wienker TF, Pyykkš I, Cremers CW, Kremer H, Dhooge I, Stephens D, Orzan E, Pfister M, Bille M, Parving A, Sorri M, Van de Heyning PH, Van Camp G.
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| Hum Mol Genet 17(2):159-69. Epub 2007 Oct 6. 2008
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| 20 | GRHL2
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| Gain of GRHL2 is associated with early recurrence of hepatocellular carcinoma.
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| Tanaka Y, Kanai F, Tada M, Tateishi R, Sanada M, Nannya Y, Ohta M, Asaoka Y, Seto M, Shiina S, Yoshida H, Kawabe T, Yokosuka O, Ogawa S, Omata M.
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| J Hepatol 49(5):746-57. Epub 2008 Jul 9.
2008
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| 21 | GRHL1, GRHL2, GRHL3
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| Spatial and temporal expression of the Grainyhead-like transcription factor family during murine development.
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| Auden A, Caddy J, Wilanowski T, Ting SB, Cunningham JM, Jane SM.
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| Gene Expr Patterns 6(8):964-70. Epub 2006 Apr 25.
2006
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| 22 | GRHL1, GRHL2, GRHL3
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| The identification and characterization of human Sister-of-Mammalian Grainyhead (SOM) expands the grainyhead-like family of developmental transcription factors.
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| Ting SB, Wilanowski T, Cerruti L, Zhao LL, Cunningham JM, Jane SM.
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| Biochem J 370(Pt 3):953-62. 2003
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| 23 | DFNA28, NACAP1, NCALD, ODF1, GRHL2
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| Mutation of a transcription factor, TFCP2L3, causes progressive autosomal dominant hearing loss, DFNA28.
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| Peters LM, Anderson DW, Griffith AJ, Grundfast KM, San Agustin TB, Madeo AC, Friedman TB, Morell RJ.
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| Hum Mol Genet 11(23):2877-85. 2002
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