| 1 | CRKL, GRB2, PIK3AP1
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| Phosphorylation of the multifunctional signal transducer B-cell adaptor protein (BCAP) promotes recruitment of multiple SH2/SH3 proteins including GRB2.
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| Lauenstein JU, Udgata A, Bartram A, De Sutter D, Fisher DI, Halabi S, Eyckerman S, Gay NJ.
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| J Biol Chem 294(52):19852-19861. doi: 10.1074/jbc.RA119.009931. Epub 2019 Sep 16.
2019
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| 2 | GRAP, GRB2
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| Grb2 and GRAP connect the B cell antigen receptor to Erk MAP kinase activation in human B cells
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| Vanshylla K, Bartsch C, Hitzing C, Krümpelmann L, Wienands J, Engels N.
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| Sci Rep. Mar 9;8(1):4244. doi: 10.1038/s41598-018-22544-x. 2018
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| 3 | GRB2, WASL
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| Myogenic differentiation depends on the interplay of Grb2 and N-WASP.
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| Mitra P, Thanabalu T.
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| Biochim Biophys Acta 1864(3):487-497. doi: 10.1016/j.bbamcr.2016.12.011. Epub 2016 Dec 10.
2017
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| 4 | GRB2, PTK2, PTPRA
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| Grb2 promotes integrin-induced focal adhesion kinase (FAK) autophosphorylation and directs the phosphorylation of protein tyrosine phosphatase α by the Src-FAK kinase complex.
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| Cheng SY, Sun G, Schlaepfer DD, Pallen CJ.
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| Mol Cell Biol 34(3):348-61. doi: 10.1128/MCB.00825-13.
2014
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| 5 | GRAP2, GRB2, LAT, PLCG1
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| The role of LAT-PLCγ1 interaction in γδ T cell development and homeostasis.
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| Sullivan SA, Zhu M, Bao S, Lewis CA, Ou-Yang CW, Zhang W.
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| J Immunol 192(6):2865-74. doi: 10.4049/jimmunol.1302493. Epub 2014 Feb 12.
2014
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| 6 | FGFR2, GRB2, PTPN11
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| Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity.
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| Ahmed Z, Lin CC, Suen KM, Melo FA, Levitt JA, Suhling K, Ladbury JE.
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| J Cell Biol 200(4):493-504. doi: 10.1083/jcb.201204106.
2013
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| 7 | GRB2, SOS1
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| Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate.
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| Findlay GM, Smith MJ, Lanner F, Hsiung MS, Gish GD, Petsalaki E, Cockburn K, Kaneko T, Huang H, Bagshaw RD, Ketela T, Tucholska M, Taylor L, Bowtell DD, Moffat J, Ikura M, Li SS, Sidhu SS, Rossant J, Pawson T.
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| Cell 152(5):1008-20. doi: 10.1016/j.cell.2013.01.056.
2013
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| 8 | ATXN2, GRB2
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| Ataxin-2 modulates the levels of Grb2 and SRC but not ras signaling.
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| Drost J, Nonis D, Eich F, Leske O, Damrath E, Brunt ER, Lastres-Becker I, Heumann R, Nowock J, Auburger G.
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| J Mol Neurosci 51(1):68-81. doi: 10.1007/s12031-012-9949-4. Epub 2013 Jan 19.
2013
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| 9 | DOK3, GRB2, LYN
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| The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters.
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| Lösing M, Goldbeck I, Manno B, Oellerich T, Schnyder T, Bohnenberger H, Stork B, Urlaub H, Batista FD, Wienands J, Engelke M.
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| J Biol Chem 288(4):2303-13. doi: 10.1074/jbc.M112.406546. Epub 2012 Dec 5.
2013
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| 10 | GRB2, LAT, SOS1
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| The ability of Sos1 to oligomerize the adaptor protein LAT is separable from its guanine nucleotide exchange activity in vivo.
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| Kortum RL, Balagopalan L, Alexander CP, Garcia J, Pinski JM, Merrill RK, Nguyen PH, Li W, Agarwal I, Akpan IO, Sommers CL, Samelson LE.
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| Sci Signal 6(301):ra99. doi: 10.1126/scisignal.2004494.
2013
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| 11 | FGFR2, GRB2
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| Inhibition of basal FGF receptor signaling by dimeric Grb2.
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| Lin CC, Melo FA, Ghosh R, Suen KM, Stagg LJ, Kirkpatrick J, Arold ST, Ahmed Z, Ladbury JE.
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| Cell 149(7):1514-24. doi: 10.1016/j.cell.2012.04.033.
2012
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| 12 | GRB2, RASGRP1, SOS1
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| TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells.
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| Warnecke N, Poltorak M, Kowtharapu BS, Arndt B, Stone JC, Schraven B, Simeoni L.
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| EMBO Rep 13(4):386-91. doi: 10.1038/embor.2012.17.
2012
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| 13 | EGFR, GRB2, TNK2
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| The activation mechanism of ACK1 (activated Cdc42-associated tyrosine kinase 1).
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| Lin Q, Wang J, Childress C, Yang W.
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| Biochem J 445(2):255-64. doi: 10.1042/BJ20111575.
2012
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| 14 | GRB2, LRRK1
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| Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor.
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| Hanafusa H, Ishikawa K, Kedashiro S, Saigo T, Iemura S, Natsume T, Komada M, Shibuya H, Nara A, Matsumoto K.
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| Nat Commun 2:158.
2011
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| 15 | CXCR5, GRB2
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| Growth-factor receptor-bound protein-2 (Grb2) signaling in B cells controls lymphoid follicle organization and germinal center reaction.
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| Jang IK, Cronshaw DG, Xie LK, Fang G, Zhang J, Oh H, Fu YX, Gu H, Zou Y.
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| Proc Natl Acad Sci U S A 108(19):7926-31. Epub 2011 Apr 20.
2011
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| 16 | GRB2, RHOU
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| GRB2 couples RhoU to epidermal growth factor receptor signaling and cell migration.
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| Zhang JS, Koenig A, Young C, Billadeau DD.
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| Mol Biol Cell 22(12):2119-30. Epub 2011 Apr 20.
2011
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| 17 | ASAP3, GRB2
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| ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin β1 recycling in cell migration.
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| Yu X, Wang F, Liu H, Adams G, Aikhionbare F, Liu D, Cao X, Fan L, Hu G, Chen Y, Frost A, Partridge E, Ding X, Yao X.
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| J Biol Chem 286(51):43735-47. doi: 10.1074/jbc.M111.278770. Epub 2011 Oct 25.
2011
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| 18 | GRB2
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| Inhibition of Grb2 expression demonstrates an important role in BCR-ABL-mediated MAPK activation and transformation of primary human hematopoietic cells.
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| Modi H, Li L, Chu S, Rossi J, Yee JK, Bhatia R.
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| Leukemia 25(2):305-12. doi: 10.1038/leu.2010.257. Epub 2010 Nov 12.
2011
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| 19 | GRB2, PTPN23
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| Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL.
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| Tanase CA.
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| PLoS One 5(12):e14339. doi: 10.1371/journal.pone.0014339.
2010
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| 20 | GRB2
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| Basic study on SH2 domain of Grb2 as a molecular probe for detection of RTK activation.
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| Saito Y, Furukawa T, Arano Y, Fujibayashi Y, Saga T.
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| Int J Oncol 37(2):281-7.
2010
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| 21 | GRB2
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| Grb2 functions at the top of the T-cell antigen receptor-induced tyrosine kinase cascade to control thymic selection.
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| Jang IK, Zhang J, Chiang YJ, Kole HK, Cronshaw DG, Zou Y, Gu H.
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| Proc Natl Acad Sci U S A 107(23):10620-5. doi: 10.1073/pnas.0905039107. Epub 2010 May 24.
2010
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| 22 | CLEC17A, GRB2
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| Prolectin, a Glycan-binding Receptor on Dividing B Cells in Germinal Centers.
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| Graham SA, Jégouzo SA, Yan S, Powlesland AS, Brady JP, Taylor ME, Drickamer K.
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| J Biol Chem 284(27):18537-44. Epub 2009 May 6. 2009
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| 23 | GRB2, PLD2, PTPRC
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| PLD2 has both enzymatic and cell proliferation-inducing capabilities, that are differentially regulated by phosphorylation and dephosphorylation.
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| Henkels KM, Short S, Peng HJ, Di Fulvio M, Gomez-Cambronero J.
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| Biochem Biophys Res Commun 389(2):224-8. Epub 2009 Aug 26.PMID: 19715678 2009
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| 24 | KIRREL, GRB2, CSK
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| Neph1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2.
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| Harita Y, Kurihara H, Kosako H, Tezuka T, Sekine T, Igarashi T, Hattori S.
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| J Biol Chem 283(14):9177-86. Epub 2008 Feb 7. 2008
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| 25 | FASLG, GRB2
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| The adaptor protein Grb2 regulates cell surface Fas ligand in Schwann cells.
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| Thornhill PB, Cohn JB, Stanford WL, Desbarats J.
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| Biochem Biophys Res Commun 376(2):341-6. Epub 2008 Sep 16.
2008
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| 26 | GRB2, PRKAB1
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| The function study on the interaction between Grb2 and AMPK.
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| Pan Z, Wang J, Yin X, Xie P, Yang J, Jiang J, Zhang L, He F.
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| Mol Cell Biochem 307(1-2):121-7. Epub 2007 Sep 12.PMID: 17849173 2008
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| 27 | DISC1, GRB2
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| DISC1 regulates neurotrophin-induced axon elongation via interaction with Grb2.
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| Shinoda T, Taya S, Tsuboi D, Hikita T, Matsuzawa R, Kuroda S, Iwamatsu A, Kaibuchi K.
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| J Neurosci 27(1):4-14. 2007
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| 28 | LAT, SOS1, GRB2
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| Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1.
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| Houtman JC, Yamaguchi H, Barda-Saad M, Braiman A, Bowden B, Appella E, Schuck P, Samelson LE.
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| Nat Struct Mol Biol 13(9):798-805. Epub 2006 Aug 13. 2006
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| 29 | GRB2, SOS1
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| Grb2 is a negative modulator of the intrinsic Ras-GEF activity of hSos1.
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| Zarich N, Oliva JL, Martinez N, Jorge R, Ballester A, Gutierrez-Eisman S, Garcia-Vargas S, Rojas JM.
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| Mol Biol Cell 17(8):3591-7. Epub 2006 Jun 7. 2006
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| 30 | DOK1, DOK2, DOK3, GRB2
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| Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases.
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| Honma M, Higuchi O, Shirakata M, Yasuda T, Shibuya H, Iemura S, Natsume T, Yamanashi Y.
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| Genes Cells 11(2):143-51.
2006
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| 31 | MED28, NF2, GRB2
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| Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2.
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| Wiederhold T, Lee MF, James M, Neujahr R, Smith N, Murthy A, Hartwig J, Gusella JF, Ramesh V.
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| Oncogene 23(54):8815-25. 2004
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| 32 | TOP2A, GRB2, AOC3, AP2B1, KRT14, JUP, ITGA3
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| Targets of gene amplification and overexpression at 17q in gastric cancer.
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| Varis A, Wolf M, Monni O, Vakkari ML, Kokkola A, Moskaluk C, Frierson H Jr, Powell SM, Knuutila S, Kallioniemi A, El-Rifai W.
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| Cancer Res 62(9):2625-9. 2002
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| 33 | CSH1, GRB2, GRB7, SRS17, SRS7
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| Investigation of the GRB2, GRB7, and CSH1 genes as candidates for the Silver-Russell syndrome (SRS) on chromosome 17q.
|
| Hitchins MP, Abu-Amero S, Apostolidou S, Monk D, Stanier P, Preece MA, Moore GE.
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| J Med Genet 39(3):E13. No abstract available. 2002
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| 34 | GRB2
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| The Gene Structure of the Human Growth Factor Bound Protein GRB2.
|
| Bochmann H, et al.
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| Genomics 56(2):203-207. 1999
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| 35 | ATF4B, ATF4C, D17S1534, D17S802, D17S929, D17S939, EBJPAB, GRB2, HNA, ITGB4, LGALS3BP, NPTX1, SRSF2, ST6GALNAC2
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| A sequence-ready BAC/PAC contig and partial transcript map of approximately 1.5 Mb in human chromosome 17q25 comprising multiple disease genes.
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| Kuhlenbaumer G, Schirmacher A, Meuleman J, Tissir F, Del-Favero J, Stogbauer F, Young P, Ringelstein B, Van Broeckhoven C, Timmerman V.
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| Genomics 62(2):242-50. 1999
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| 36 | GRB2
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| Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation.
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| Cheng AM, Saxton TM, Sakai R, Kulkarni S, Mbamalu G, Vogel W, Tortorice CG, Cardiff RD, Cross JC, Muller WJ, Pawson T.
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| Cell 95 : 793-803. 1998
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| 37 | FYN, GRB2, SF1, QKI
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| The quaking gene product necessary in embryogenesis and myelination combines features of RNA binding and signal transduction proteins.
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| Ebersole TA, Chen Q, Justice MJ, Artzt K.
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| Nat Genet 12(3):260-5. 1996
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| 38 | GRB2, NCK1, SHC1
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| Chromosome locations of genes encoding human signal transduction adapter proteins, Nck (NCK), Shc (SHC1), and Grb2 (GRB2).
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| Huebner K, et al.
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| Genomics 22 : 281-287. 1994
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| 39 | GRB2
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| Mapping GRB2, a signal transduction gene in the human and the mouse.
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| Yulug IG, et al.
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| Genomics 22 : 313-318. 1994
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| 40 | EWSR1, FMR1, FXR1, FXR2, FYN, GRB2, HDLBP, HNRNPA1, HNRNPA2B1, NCL, PTBP1, RBMXP1, RBMY1A1, RBMY1A2, RBM3, SF1
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| Conserved structures and diversity of functions of RNA-binding proteins.
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| Burd CG, et al.
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| Science 265 : 615-621. 1994
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| 41 | EGFR, GRB2, SHC1, SOS1
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| The signaling pathway coupling epidermal growth factor receptors to activation of p21ras.
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| Sasaoka T, et al.
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| J Biol Chem 269(51):32621-5. 1994
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| 42 | GRB2
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| Cloning of a Grb2 isoform with apoptotic properties.
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| Fath I, Schweighoffer F, Rey I, Multon MC, Boiziau J, Duchesne M, Tocque B.
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| Science 264(5161):971-4. 1994
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| 43 | GRB2
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| The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1.
|
| Rozakis-Adcock M, et al.
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| Nature 363 : 83-85. 1993
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| 44 | GRB2
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| Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling.
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| Li N, et al.
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| Nature 363 : 85-88. 1993
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| 45 | GRB2
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| The function of GRB2 in linking the insulin receptor to Ras signaling pathways.
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| Skolnik EY, et al.
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| Science 260(5116):1953-5. 1993
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| 46 | GRB2
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| Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor.
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| Buday L, et al.
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| Cell 73(3):611-20. 1993
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| 47 | GRB2
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| Ash/Grb-2, a SH2/SH3-containing protein, couples to signaling for mitogenesis and cytoskeletal reorganization by EGF and PDGF.
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| Matuoka K, Shibasaki F, Shibata M, Takenawa T.
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| EMBO J 12(9):3467-73. 1993
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| 48 | GRB2
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| The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling.
|
| Lowenstein EJ, et al.
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| Cell 70(3):431-42. 1992
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| 49 | GRB2
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| Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries.
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| Matuoka K, Shibata M, Yamakawa A, Takenawa T.
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| Proc Natl Acad Sci U S A 89(19):9015-9. 1992
|