| 1 | GPX1, GPX2, GPX3, GPX4
|
| Regulatory Phenomena in the Glutathione Peroxidase Superfamily.
|
| Brigelius-Flohé R, Flohé L.
|
| Antioxid Redox Signal Sep 1;33(7):498-516. doi: 10.1089/ars.2019.7905. Epub 2019 Dec 31 2020
|
| 2 | GPX4
|
| Involvement of GPx4-Regulated Lipid Peroxidation in Idiopathic Pulmonary Fibrosis Pathogenesis.
|
| Tsubouchi K, Araya J, Yoshida M, Sakamoto T, Koumura T, Minagawa S, Hara H, Hosaka Y, Ichikawa A, Saito N, Kadota T, Kurita Y, Kobayashi K, Ito S, Fujita Y, Utsumi H, Hashimoto M, Wakui H, Numata T, Kaneko Y, Mori S, Asano H, Matsudaira H, Ohtsuka T, Nakayama K, Nakanishi Y, Imai H, Kuwano K.
|
| J Immunol Immunol. 2019 Sep 18. pii: ji1801232. doi: 10.4049/jimmunol.1801232. [Epub ahead of print]
2019
|
| 3 | GPX4
|
| Chaperone-mediated autophagy is involved in the execution of ferroptosis.
|
| Wu Z, Geng Y, Lu X, Shi Y, Wu G, Zhang M, Shan B, Pan H, Yuan J.
|
| Proc Natl Acad Sci U S A 116(8):2996-3005. doi: 10.1073/pnas.1819728116. Epub 2019 Feb 4.
2019
|
| 4 | GPX4
|
| Glutathione peroxidase 4 functional variant rs713041 modulates the risk for cardiovascular autonomic neuropathy in individuals with type 1 diabetes.
|
| Admoni SN, Santos-Bezerra DP, Perez RV, Patente TA, Monteiro MB, Cavaleiro AM, Parisi MC, Moura Neto A, Pavin EJ, Queiroz MS, Nery M, Correa-Giannella ML.
|
| Diab Vasc Dis Res 16(3):297-299. doi: 10.1177/1479164118820641. Epub 2019 Jan 1.
2019
|
| 5 | GPX4
|
| Glutathione peroxidase 4 overexpression inhibits ROS-induced cell death in diffuse large B-cell lymphoma.
|
| Kinowaki Y, Kurata M, Ishibashi S, Ikeda M, Tatsuzawa A, Yamamoto M, Miura O, Kitagawa M, Yamamoto K.
|
| Lab Invest 98(5):609-619. doi: 10.1038/s41374-017-0008-1. Epub 2018 Feb 20.
2018
|
| 6 | GPX4
|
| Involvement of sperm acetylated histones and the nuclear isoform of Glutathione peroxidase 4 in fertilization.
|
| Pipolo S, Puglisi R, Mularoni V, Esposito V, Fuso A, Lucarelli M, Fiorenza MT, Mangia F, Boitani C.
|
| J Cell Physiol 233(4):3093-3104. doi: 10.1002/jcp.26146. Epub 2017 Sep 20.
2018
|
| 7 | GPX4
|
| Glutathione peroxidase 4-catalyzed reduction of lipid hydroperoxides in membranes: The polar head of membrane phospholipids binds the enzyme and addresses the fatty acid hydroperoxide group toward the redox center.
|
| Cozza G, Rossetto M, Bosello-Travain V, Maiorino M, Roveri A, Toppo S, Zaccarin M, Zennaro L, Ursini F.
|
| Free Radic Biol Med 112:1-11. doi: 10.1016/j.freeradbiomed.2017.07.010. Epub 2017 Jul 12.
2017
|
| 8 | GPX4
|
| Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration.
|
| Hambright WS, Fonseca RS, Chen L, Na R, Ran Q.
|
| Redox Biol 12:8-17. doi: 10.1016/j.redox.2017.01.021. Epub 2017 Feb 1.
2017
|
| 9 | GPX4
|
| Role of Glutathione Peroxidase 4 in Corneal Endothelial Cells.
|
| Uchida T, Sakai O, Imai H, Ueta T.
|
| Curr Eye Res 42(3):380-385. doi: 10.1080/02713683.2016.1196707. Epub 2016 Jul 15.
2017
|
| 10 | GPX4
|
| Evaluation of Glutathione Peroxidase 4 role in Preeclampsia.
|
| Peng X, Lin Y, Li J, Liu M, Wang J, Li X, Liu J, Jia X, Jing Z, Huang Z, Chu K, Liu S.
|
| Sci Rep 6:33300. doi: 10.1038/srep33300.
2016
|
| 11 | GPX4, GPX7
|
| GPX4 and GPX7 over-expression in human hepatocellular carcinoma tissues.
|
| Guerriero E, Capone F, Accardo M, Sorice A, Costantini M, Colonna G, Castello G, Costantini S.
|
| Eur J Histochem 59(4):2540. doi: 10.4081/ejh.2015.2540.
2015
|
| 12 | GPX4
|
| Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis.
|
| Chen L, Hambright WS, Na R, Ran Q.
|
| J Biol Chem 290(47):28097-106. doi: 10.1074/jbc.M115.680090. Epub 2015 Sep 23.
2015
|
| 13 | GPX4
|
| Role of glutathione peroxidase 4 in conjunctival epithelial cells.
|
| Sakai O, Uchida T, Imai H, Ueta T, Amano S.
|
| Invest Ophthalmol Vis Sci 56(1):538-43. doi: 10.1167/iovs.14-15463.
2015
|
| 14 | GPX4, SMDS
|
| Mutations in the enzyme glutathione peroxidase 4 cause Sedaghatian-type spondylometaphyseal dysplasia.
|
| Smith AC, Mears AJ, Bunker R, Ahmed A, MacKenzie M, Schwartzentruber JA, Beaulieu CL, Ferretti E; FORGE Canada Consortium, Majewski J, Bulman DE, Celik FC, Boycott KM, Graham GE.
|
| J Med Genet 51(7):470-4. doi: 10.1136/jmedgenet-2013-102218. Epub 2014 Apr 4.
2014
|
| 15 | GPX4
|
| Mapping of the N-linked glycoproteome of human spermatozoa.
|
| Wang G, Wu Y, Zhou T, Guo Y, Zheng B, Wang J, Bi Y, Liu F, Zhou Z, Guo X, Sha J.
|
| J Proteome Res 12(12):5750-9. doi: 10.1021/pr400753f. Epub 2013 Nov 15.
2013
|
| 16 | GPX4, GPX5
|
| Epididymis response partly compensates for spermatozoa oxidative defects in snGPx4 and GPx5 double mutant mice.
|
| Noblanc A, Peltier M, Damon-Soubeyrand C, Kerchkove N, Chabory E, Vernet P, Saez F, Cadet R, Janny L, Pons-Rejraji H, Conrad M, Drevet JR, Kocer A.
|
| PLoS One 7(6):e38565. doi: 10.1371/journal.pone.0038565. Epub 2012 Jun 14.
2012
|
| 17 | GPX4
|
| Glutathione peroxidase 4 is required for maturation of photoreceptor cells.
|
| Ueta T, Inoue T, Furukawa T, Tamaki Y, Nakagawa Y, Imai H, Yanagi Y.
|
| J Biol Chem 287(10):7675-82. doi: 10.1074/jbc.M111.335174. Epub 2011 Dec 29.
2012
|
| 18 | GPX4
|
| SNP and mRNA expression for glutathione peroxidase 4 in Kashin-Beck disease.
|
| Du XH, Dai XX, Xia Song R, Zou XZ, Yan Sun W, Mo XY, Lu Bai G, Xiong YM.
|
| Br J Nutr 107(2):164-9. doi: 10.1017/S0007114511002704. Epub 2011 Jun 23.
2012
|
| 19 | GPX4
|
| The nuclear form of glutathione peroxidase 4 is associated with sperm nuclear matrix and is required for proper paternal chromatin decondensation at fertilization.
|
| Puglisi R, Maccari I, Pipolo S, Conrad M, Mangia F, Boitani C.
|
| J Cell Physiol 227(4):1420-7. doi: 10.1002/jcp.22857.
2012
|
| 20 | GPX1, GPX3, GPX4, GPX5
|
| Glutathione peroxidases at work on epididymal spermatozoa: an example of the dual effect of reactive oxygen species on mammalian male fertilizing ability.
|
| Noblanc A, Kocer A, Chabory E, Vernet P, Saez F, Cadet R, Conrad M, Drevet JR.
|
| J Androl 32(6):641-50. Epub 2011 Mar 25. Review.
2011
|
| 21 | GPX4, SELENOP, SELENOS
|
| Genetic variants in selenoprotein genes increase risk of colorectal cancer.
|
| Méplan C, Hughes DJ, Pardini B, Naccarati A, Soucek P, Vodickova L, Hlavatá I, Vrána D, Vodicka P, Hesketh JE.
|
| Carcinogenesis 31(6):1074-9. doi: 10.1093/carcin/bgq076. Epub 2010 Apr 8. 2010
|
| 22 | GPX1, GPX3, GPX4
|
| Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy.
|
| Mistry HD, Kurlak LO, Williams PJ, Ramsay MM, Symonds ME, Broughton Pipkin F.
|
| Placenta 31(5):401-8. doi: 10.1016/j.placenta.2010.02.011. Epub 2010 Mar 19.
2010
|
| 23 | GPX4
|
| Short form glutathione peroxidase 4 is the essential isoform required for survival and somatic mitochondrial functions.
|
| Liang H, Yoo SE, Na R, Walter CA, Richardson A, Ran Q.
|
| J Biol Chem 284(45):30836-44. Epub 2009 Sep 10.PMID: 19744930 2009
|
| 24 | GPX4
|
| Specific systemic antioxidant response to preeclampsia in late pregnancy: the study of intracellular glutathione peroxidases in maternal and fetal blood.
|
| Boutet M, Roland L, Thomas N, Bilodeau JF.
|
| Am J Obstet Gynecol 200(5):530.e1-7. Epub 2009 Mar 14.PMID: 19285650 2009
|
| 25 | GPX4, GRSF1
|
| Translational regulation of glutathione peroxidase 4 expression through guanine-rich sequence-binding factor 1 is essential for embryonic brain development.
|
| Ufer C, Wang CC, Fähling M, Schiebel H, Thiele BJ, Billett EE, Kuhn H, Borchert A.
|
| Genes Dev 22(13):1838-50. doi: 10.1101/gad.466308.
2008
|
| 26 | GPX4
|
| Structural basis for catalytic activity and enzyme polymerization of phospholipid hydroperoxide glutathione peroxidase-4 (GPx4).
|
| Scheerer P, Borchert A, Krauss N, Wessner H, Gerth C, Hšhne W, Kuhn H.
|
| Biochemistry 46(31):9041-9. Epub 2007 Jul 13. 2007
|
| 27 | GPX4, HXALI, ALOXE3, ALOX12B
|
| Biological role of hepoxilins: upregulation of phospholipid hydroperoxide glutathione peroxidase as a cellular response to oxidative stress?
|
| Zafiriou MP, Deva R, Ciccoli R, Siafaka-Kapadai A, Nigam S.
|
| Prostaglandins Leukot Essent Fatty Acids 77(3-4):209-15. Epub 2007 Nov 7. 2007
|
| 28 | GPX4
|
| Molecular biology of glutathione peroxidase 4: from genomic structure to developmental expression and neural function.
|
| Savaskan NE, Ufer C, Kühn H, Borchert A.
|
| Biol Chem 388(10):1007-17. Review.PMID: 17937614 2007
|
| 29 | GPX4
|
| cAMP-response element modulator-tau activates a distinct promoter element for the expression of the phospholipid hydroperoxide/sperm nucleus glutathione peroxidase gene.
|
| Tramer F, Vetere A, Martinelli M, Paroni F, Marsich E, Boitani C, Sandri G, Panfili E.
|
| Biochem J 383(Pt 1):179-85. 2004
|
| 30 | GPX4
|
| Regulation of expression of the phospholipid hydroperoxide/sperm nucleus glutathione peroxidase gene. Tissue-specific expression pattern and identification of functional cis- and trans-regulatory elements.
|
| Borchert A, Savaskan NE, Kuhn H.
|
| J Biol Chem 278(4):2571-80. Epub 2002 Nov 8. 2003
|
| 31 | GPX4
|
| Molecular cloning and functional expression of nucleolar phospholipid hydroperoxide glutathione peroxidase in mammalian cells.
|
| Nakamura T, Imai H, Tsunashima N, Nakagawa Y.
|
| Biochem Biophys Res Commun 311(1):139-48. 2003
|
| 32 | GPX4
|
| Male fertility is linked to the selenoprotein phospholipid hydroperoxide glutathione peroxidase.
|
| Foresta C, Flohe L, Garolla A, Roveri A, Ursini F, Maiorino M.
|
| Biol Reprod 67(3):967-71. 2002
|
| 33 | GPX2, GPX3, GPX4
|
| The human glutathione peroxidase genes GPX2, GPX3, and GPX4 map to chromosomes 14, 5, and 19, respectively.
|
| Chu FF.
|
| Cytogenet Cell Genet 66 : 96-98. 1994
|