| 1 | GPC3, GPC3, GPC6, NDAS, OMD, SGBS
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| Pathogenic Variants in GPC4 Cause Keipert Syndrome.
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| Amor DJ, Stephenson SEM, Mustapha M, Mensah MA, Ockeloen CW, Lee WS, Tankard RM, Phelan DG, Shinawi M, de Brouwer APM, Pfundt R, Dowling C, Toler TL, Sutton VR, Agolini E, Rinelli M, Capolino R, Martinelli D, Zampino G, Dumić M, Reardon W, Shaw-Smith C, Leventer RJ, Delatycki MB, Kleefstra T, Mundlos S, Mortier G, Bahlo M, Allen NJ, Lockhart PJ.
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| Am J Hum Genet 104(5):914-924. doi: 10.1016/j.ajhg.2019.02.026. Epub 2019 Apr 11.
2019
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| 2 | GPC3, MAGEA1, MAGEA3
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| MAGE-A gene expression in peripheral blood serves as a poor prognostic marker for patients with lung cancer.
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| Gu L, Sang M, Yin D, Liu F, Wu Y, Liu S, Huang W, Shan B.
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| Thorac Cancer 9(4):431-438. doi: 10.1111/1759-7714.12571. Epub 2018 Feb 12.
2018
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| 3 | AKT3, BRWD3, CLOVES, DNMT3A, DNMT3OGS, EZH2, GPC3, HIST1H1E, MCAUTS, MPPH2, MRD35, MRX93, MSMR, MSMS, MTOR, NFIX, NSD1, OGID1, PIK3CA, PPP2R5D, PTEN, SGBS, STOL1, WVSS1, WVSS2
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| Mutations in Epigenetic Regulation Genes Are a Major Cause of Overgrowth with Intellectual Disability.
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| Tatton-Brown K, Loveday C, Yost S, Clarke M, Ramsay E, Zachariou A, Elliott A, Wylie H, Ardissone A, Rittinger O, Stewart F, Temple IK, Cole T; Childhood Overgrowth Collaboration, Mahamdallie S, Seal S, Ruark E, Rahman N.
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| Am J Hum Genet 100(5):725-736. doi: 10.1016/j.ajhg.2017.03.010. 2017
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| 4 | GPC3, ZHX2
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| Reduced nucleic ZHX2 involves in oncogenic activation of glypican 3 in human hepatocellular carcinoma.
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| Luan F, Liu P, Ma H, Yue X, Liu J, Gao L, Liang X, Ma C.
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| Int J Biochem Cell Biol. Oct;55:129-35. doi: 10.1016/j.biocel.2014.08.021. Epub 2014 Sep 6 2014
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| 5 | GPC3, SGBS
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| A patient with a unique frameshift mutation in GPC3, causing Simpson-Golabi-Behmel syndrome, presenting with craniosynostosis, penoscrotal hypospadias, and a large prostatic utricle.
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| Villarreal DD, Villarreal H, Paez AM, Peppas D, Lynch J, Roeder E, Powers GC.
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| Am J Med Genet A m J Med Genet A. 2013 Oct 2. doi: 10.1002/ajmg.a.36086. [Epub ahead of print]
2013
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| 6 | GPC3
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| Reevaluation of glypican-3 as a serological marker for hepatocellular carcinoma.
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| Chen M, Li G, Yan J, Lu X, Cui J, Ni Z, Cheng W, Qian G, Zhang J, Tu H.
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| Clin Chim Acta 423:105-11. doi: 10.1016/j.cca.2013.04.026. Epub 2013 May 2.
2013
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| 7 | GPC3
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| A comparison of glypican-3 with alpha-fetoprotein as a serum marker for hepatocellular carcinoma: a meta-analysis.
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| Xu C, Yan Z, Zhou L, Wang Y.
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| J Cancer Res Clin Oncol 139(8):1417-24. doi: 10.1007/s00432-013-1458-5. Epub 2013 Jun 7.
2013
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| 8 | GPC3
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| Therapeutically targeting glypican-3 via a conformation-specific single-domain antibody in hepatocellular carcinoma.
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| Feng M, Gao W, Wang R, Chen W, Man YG, Figg WD, Wang XW, Dimitrov DS, Ho M.
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| Proc Natl Acad Sci U S A 110(12):E1083-91. doi: 10.1073/pnas.1217868110. Epub 2013 Mar 5.
2013
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| 9 | CD81, GPC3, HHEX
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| Regulation of liver growth by glypican 3, CD81, hedgehog, and Hhex.
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| Bhave VS, Mars W, Donthamsetty S, Zhang X, Tan L, Luo J, Bowen WC, Michalopoulos GK.
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| Am J Pathol 183(1):153-9. doi: 10.1016/j.ajpath.2013.03.013. Epub 2013 May 8.
2013
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| 10 | GPC3, MYC
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| Oncogenic activation of glypican-3 by c-Myc in human hepatocellular carcinoma.
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| Li L, Jin R, Zhang X, Lv F, Liu L, Liu D, Liu K, Li N, Chen D.
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| Hepatology 56(4):1380-90. doi: 10.1002/hep.25891.
2012
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| 11 | GPC3
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| Glypican-3 as a potential differential diagnosis marker for hepatocellular carcinoma: a tissue microarray-based study.
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| Zhang L, Liu H, Sun L, Li N, Ding H, Zheng J.
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| Acta Histochem 114(6):547-52. doi: 10.1016/j.acthis.2011.10.003. Epub 2011 Nov 26.
2012
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| 12 | GPC3
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| Glypican-3, a novel prognostic marker of hepatocellular cancer, is related with postoperative metastasis and recurrence in hepatocellular cancer patients.
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| Ning S, Bin C, Na H, Peng S, Yi D, Xiang-hua Y, Fang-yin Z, Da-yong Z, Rong-cheng L.
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| Mol Biol Rep 39(1):351-7. doi: 10.1007/s11033-011-0745-y. Epub 2011 Jun 8.
2012
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| 13 | GPC3
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| Silencing glypican-3 expression induces apoptosis in human hepatocellular carcinoma cells.
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| Liu S, Li Y, Chen W, Zheng P, Liu T, He W, Zhang J, Zeng X.
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| Biochem Biophys Res Commun 419(4):656-61. doi: 10.1016/j.bbrc.2012.02.069. Epub 2012 Feb 21.
2012
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| 14 | GPC3, SGBS
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| Familial Simpson-Golabi-Behmel syndrome: studies of X-chromosome inactivation and clinical phenotypes in two female individuals with GPC3 mutations.
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| Yano S, Baskin B, Bagheri A, Watanabe Y, Moseley K, Nishimura A, Matsumoto N, Ray PN.
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| Clin Genet 80(5):466-71. doi: 10.1111/j.1399-0004.2010.01554.x. Epub 2010 Oct 18.
2011
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| 15 | GPC3
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| Glypican-3 is expressed in rhabdomyosarcomas but not adult spindle cell and pleomorphic sarcomas.
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| Thway K, Selfe J, Missiaglia E, Fisher C, Shipley J.
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| J Clin Pathol 64(7):587-91. doi: 10.1136/jclinpath-2011-200071. Epub 2011 Apr 14.
2011
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| 16 | GPC3
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| Gpc-3 is a notable diagnostic, prognostic and a latent targeted therapy marker in hepatocellular carcinoma.
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| Zou ZQ, Ding YP, Long B, Yuh JG, Xu AL, Lang ZW, Zou SY, Liu YD, Ding K, Li YY.
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| Hepatogastroenterology 57(102-103):1285-90. Review.
2010
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| 17 | GPC3, SLC2A1
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| Glypican 3 binds to GLUT1 and decreases glucose transport activity in hepatocellular carcinoma cells.
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| Cho HS, Ahn JM, Han HJ, Cho JY.
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| J Cell Biochem 111(5):1252-9. doi: 10.1002/jcb.22848.
2010
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| 18 | GPC3, SGBS
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| A patient with the Simpson-Golabi-Behmel syndrome displays a loss-of-function point mutation in GPC3 that inhibits the attachment of this proteoglycan to the cell surface.
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| Shi W, Filmus J.
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| Am J Med Genet A 149A(3):552-4. No abstract available.
2009
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| 19 | GPC3
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| Loss of glypican-3 function causes growth factor-dependent defects in cardiac and coronary vascular development.
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| Ng A, Wong M, Viviano B, Erlich JM, Alba G, Pflederer C, Jay PY, Saunders S.
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| Dev Biol 335(1):208-15. doi: 10.1016/j.ydbio.2009.08.029. Epub 2009 Sep 4.
2009
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| 20 | CFNS, DLL3, EFNB1, FOAR, FRNS, GPC3, LRP2, PAMD, SCDO1, SGBS, STRA6, UNK
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| Genetic aspects of human congenital diaphragmatic hernia.
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| Pober BR.
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| Clin Genet 74(1):1-15. Epub 2008 May 28. 2008
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| 21 | GPC3
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| Glypican-3 as a useful diagnostic marker that distinguishes hepatocellular carcinoma from benign hepatocellular mass lesions.
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| Wang HL, Anatelli F, Zhai QJ, Adley B, Chuang ST, Yang XJ.
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| Arch Pathol Lab Med 132(11):1723-8.
2008
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| 22 | GPC3, SGBS
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| Expression pattern of glypican-3 (GPC3) during human embryonic and fetal development.
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| Iglesias BV, Centeno G, Pascuccelli H, Ward F, Peters MG, Filmus J, Puricelli L, de Kier Joffé EB.
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| Histol Histopathol 23(11):1333-40.
2008
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| 23 | GPC3, SGBS
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| Glypican-3-mediated oncogenesis involves the Insulin-like growth factor-signaling pathway.
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| Cheng W, Tseng CJ, Lin TT, Cheng I, Pan HW, Hsu HC, Lee YM.
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| Carcinogenesis 29(7):1319-26. Epub 2008 Apr 15.
2008
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| 24 | GPC3
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| Anti-glypican 3 antibody as a potential antitumor agent for human liver cancer.
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| Ishiguro T, Sugimoto M, Kinoshita Y, Miyazaki Y, Nakano K, Tsunoda H, Sugo I, Ohizumi I, Aburatani H, Hamakubo T, Kodama T, Tsuchiya M, Yamada-Okabe H.
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| Cancer Res 68(23):9832-8.
2008
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| 25 | GPC3, SGBS
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| GPC3 mutations in seven patients with Simpson-Golabi-Behmel syndrome.
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| Sakazume S, Okamoto N, Yamamoto T, Kurosawa K, Numabe H, Ohashi Y, Kako Y, Nagai T, Ohashi H.
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| Am J Med Genet A 143(15):1703-7. 2007
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| 26 | GPC3
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| In vivo footprinting analysis of the Glypican 3 (GPC3) promoter region in neuroblastoma cells.
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| Boily G, Ouellet S, Langlois S, Larivière M, Drouin R, Sinnett D.
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| Biochim Biophys Acta 1769(3):182-93. Epub 2007 Feb 9.
2007
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| 27 | DPP4, GPC3, SGBS
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| The Simpson-Golabi-Behmel syndrome causative glypican-3, binds to and inhibits the dipeptidyl peptidase activity of CD26.
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| Davoodi J, Kelly J, Gendron NH, MacKenzie AE.
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| Proteomics 7(13):2300-10.
2007
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| 28 | GPC3, SGBS
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| The loss of glypican-3 induces alterations in Wnt signaling.
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| Song HH, Shi W, Xiang YY, Filmus J.
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| J Biol Chem 280(3):2116-25. Epub 2004 Nov 10. 2005
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| 29 | GPC3
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| Upregulation of Glypican-3 expression in hepatocellular carcinoma but downregulation in cholangiocarcinoma indicates its differential diagnosis value in primary liver cancers.
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| Man XB, Tang L, Zhang BH, Li SJ, Qiu XH, Wu MC, Wang HY.
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| Liver Int 25(5):962-6. 2005
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| 30 | GPC3
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| Glypican-3, overexpressed specifically in human hepatocellular carcinoma, is a novel tumor marker.
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| Nakatsura T, Yoshitake Y, Senju S, Monji M, Komori H, Motomura Y, Hosaka S, Beppu T, Ishiko T, Kamohara H, Ashihara H, Katagiri T, Furukawa Y, Fujiyama S, Ogawa M, Nakamura Y, Nishimura Y.
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| Biochem Biophys Res Commun 306(1):16-25. 2003
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| 31 | GPC3
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| Glypican-3 expression is silenced in human breast cancer.
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| Xiang YY, Ladeda V, Filmus J.
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| Oncogene 20(50):7408-12. 2001
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| 32 | GPC3
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| Expression of GPC3, an X-linked recessive overgrowth gene, is silenced in malignant mesothelioma.
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| Murthy SS, Shen T, De Rienzo A, Lee WC, Ferriola PC, Jhanwar SC, Mossman BT, Filmus J, Testa JR.
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| Oncogene 19(3):410-6. 2000
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| 33 | GPC3, SGBS
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| Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss-of-function mutations in the GPC3 gene.
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| Veugelers M, Cat BD, Muyldermans SY, Reekmans G, Delande N, Frints S, Legius E, Fryns JP, Schrander-Stumpel C, Weidle B, Magdalena N, David G.
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| Hum Mol Genet 9(9):1321-8. 2000
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| 34 | GPC3, SGBS
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| A small interstitial deletion in the GPC3 gene causes Simpson-Golabi-Behmel syndrome in a Dutch-Canadian family.
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| Xuan JY, Hughes-Benzie RM, MacKenzie AE.
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| J Med Genet 36 : 57-58. 1999
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| 35 | GPC3, VAMP7
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| DNA methylation in transcriptional repression of two differentially expressed X-linked genes, GPC3 and SYBL1.
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| Huber R, et al.
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| Proc Natl Acad Sci U S A 96 : 616-621. 1999
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| 36 | GPC3, SGBS
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| Overgrowth syndromes and the regulation of signaling complexes by proteoglycans.
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| Selleck SB.
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| Am J Hum Genet 64(2):372-7. Review. No abstract available 1999
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| 37 | GPC3, SGBS
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| Multiple Sp1 sites efficiently drive transcription of the TATA-less promoter of the human glypican 3 (GPC3) gene.
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| Huber R, et al.
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| Gene 214 : 35-44. 1998
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| 38 | GPC3, GPC4
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| Glypican 3 and glypican 4 are juxtaposed in Xq26.1.
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| Huber R, Mazzarella R, Chen CN, Chen E, Ireland M, Lindsay S, Pilia G, Crisponi L.
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| Gene 225(1-2):9-16. 1998
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| 39 | GPC3, GPC4
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| GPC4, the gene for human K-glypican, flanks GPC3 on xq26: deletion of the GPC3-GPC4 gene cluster in one family with Simpson-Golabi-Behmel syndrome.
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| Veugelers M, Vermeesch J, Watanabe K, Yamaguchi Y, Marynen P, David G.
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| Genomics 53(1):1-11. 1998
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| 40 | GPC3
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| Mapping of the Simpson-Golabi-Behmel overgrowth syndrome gene (GPC3) to chromosome X in human and rat by fluorescence in situ hybridization.
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| Shen T, et al.
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| Mamm Genome 8 : 72. 1997
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| 41 | GPC3, SGBS
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| Large scale deletions in the GPC3 gene may account for a minority of cases of Simpson-Golabi-Behmel syndrome.
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| Lindsay S, Ireland M, O'Brien O, Clayton-Smith J, Hurst JA, Mann J, Cole T, Sampson J, Slaney S, Schlessinger D, Burn J, Pilia G.
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| J Med Genet 34(6):480-3. 1997
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| 42 | GPC3, SGBS
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| Analysis of exon/intron structure and 400 kb of genomic sequence surrounding the 5'-promoter and 3'-terminal ends of the human glypican 3 (GPC3) gene.
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| Huber R, Crisponi L, Mazzarella R, Chen CN, Su Y, Shizuya H, Chen EY, Cao A, Pilia G.
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| Genomics 45(1):48-58. 1997
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| 43 | GPC3, SGBS
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| Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome.
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| Pilia G, et al.
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| Nat Genet 12 : 241-247. 1996
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| 44 | GPC3
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| Glypicans : a growing trend.
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| Weksberg R, et al.
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| Nat Genet 12 : 225-227. 1996
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| 45 | ADFN, CD40LG, F9, GPC3, HPRT1, HPT1, HTX1, MCF2, THAS
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| YAC/STS map of 9 Mb of Xq26 at 100-kb resolution, localizing 6 ESTs, 6 genes, and 32 genetic markers.
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| Pilia G, et al.
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| Genomics 34 : 55-62. 1996
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| 46 | GPC3, INSIG1, SRSF5
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| Novel delayed-early and highly insulin-induced growth response genes. Identification of HRS, a potential regulator of alternative pre-mRNA splicing.
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| Diamond RH, et al.
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| J Biol Chem 268(20):15185-92 1993
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