Citations for
DJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosis.
Ma J, Wu R, Zhang Q, Wu JB, Lou J, Zheng Z, Ding JQ, Yuan Z.
Biochem J 462(3):489-97. doi: 10.1042/BJ20140235. 2014
RACK1 promotes neurite outgrowth by scaffolding AGAP2 to FAK.
Dwane S, Durack E, O'Connor R, Kiely PA.
Cell Signal 26(1):9-18. doi: 10.1016/j.cellsig.2013.08.036. Epub 2013 Sep 19. 2014
Fem1b promotes ubiquitylation and suppresses transcriptional activity of Gli1.
Gilder AS, Chen YB, Jackson RJ 3rd, Jiang J, Maher JF.
Biochem Biophys Res Commun 440(3):431-6. doi: 10.1016/j.bbrc.2013.09.090. Epub 2013 Sep 25. 2013
RACK1 identified as the PCBP1-interacting protein with a novel functional role on the regulation of human MOR gene expression.
Nahar-Gohad P, Sultan H, Esteban Y, Stabile A, Ko JL.
J Neurochem Neurochem. 2012 Nov 22. doi: 10.1111/jnc.12100. [Epub ahead of print] 2012
Direct interaction between scaffolding proteins RACK1 and 14-3-3ζ regulates brain-derived neurotrophic factor (BDNF) transcription.
Neasta J, Kiely PA, He DY, Adams DR, O'Connor R, Ron D.
J Biol Chem 287(1):322-36. doi: 10.1074/jbc.M111.272195. Epub 2011 Nov 8. 2012
RACK1 is a ribosome scaffold protein for β-actin mRNA/ZBP1 complex.
Ceci M, Welshhans K, Ciotti MT, Brandi R, Parisi C, Paoletti F, Pistillo L, Bassell GJ, Cattaneo A.
PLoS One 7(4):e35034. doi: 10.1371/journal.pone.0035034. Epub 2012 Apr 16. 2012
Kindlin-3 mediates integrin αLβ2 outside-in signaling, and it interacts with scaffold protein receptor for activated-C kinase 1 (RACK1).
Feng C, Li YF, Yau YH, Lee HS, Tang XY, Xue ZH, Zhou YC, Lim WM, Cornvik TC, Ruedl C, Shochat SG, Tan SM.
J Biol Chem 287(14):10714-26. doi: 10.1074/jbc.M111.299594. Epub 2012 Feb 10. 2012
Rack1 promotes epithelial cell-cell adhesion by regulating E-cadherin endocytosis.
Swaminathan G, Cartwright CA.
Oncogene 31(3):376-89. doi: 10.1038/onc.2011.242. Epub 2011 Jun 20. 2012
RACK1 promotes non-small-cell lung cancer tumorigenicity through activating sonic hedgehog signaling pathway.
Shi S, Deng YZ, Zhao JS, Ji XD, Shi J, Feng YX, Li G, Li JJ, Zhu D, Koeffler HP, Zhao Y, Xie D.
J Biol Chem 287(11):7845-58. doi: 10.1074/jbc.M111.315416. Epub 2012 Jan 19. 2012
10GNB2L1, PTK7
RACK1 is a novel interaction partner of PTK7 that is required for neural tube closure.
Wehner P, Shnitsar I, Urlaub H, Borchers A.
Development 138(7):1321-7. Epub 2011 Feb 24. 2011
11FLT1, GNB2L1
RACK1 regulates VEGF/Flt1-mediated cell migration via activation of a PI3K/Akt pathway.
Wang F, Yamauchi M, Muramatsu M, Osawa T, Tsuchida R, Shibuya M.
J Biol Chem 286(11):9097-106. Epub 2011 Jan 6. 2011
Rack1 is required for Vangl2 membrane localization and planar cell polarity signaling while attenuating canonical Wnt activity.
Li S, Esterberg R, Lachance V, Ren D, Radde-Gallwitz K, Chi F, Parent JL, Fritz A, Chen P.
Proc Natl Acad Sci U S A 108(6):2264-9. Epub 2011 Jan 24. 2011
13GNB1, GNB2L1, GNG2, WDR26
The WD40 repeat protein WDR26 binds Gβγ and promotes Gβγ-dependent signal transduction and leukocyte migration.
Sun Z, Tang X, Lin F, Chen S.
J Biol Chem 286(51):43902-12. Epub 2011 Nov 7. 2011
TRPC3 regulates agonist-stimulated Ca2+ mobilization by mediating the interaction between type I inositol 1,4,5-trisphosphate receptor, RACK1, and Orai1.
Woodard GE, López JJ, Jardín I, Salido GM, Rosado JA.
J Biol Chem 285(11):8045-53. Epub 2009 Dec 18.PMID: 20022948 2010
Identification of RACK1 and protein kinase Calpha as integral components of the mammalian circadian clock.
Robles MS, Boyault C, Knutti D, Padmanabhan K, Weitz CJ.
Science 327(5964):463-6.PMID: 20093473 2010
16GNB2L1, PPP1R14A
A functional interaction between CPI-17 and RACK1 proteins in bronchial smooth muscle cells.
Chiba Y, Tanabe M, Sakai H, Kimura S, Misawa M.
Biochem Biophys Res Commun 401(3):487-90. Epub 2010 Sep 25. 2010
Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C.
Bird RJ, Baillie GS, Yarwood SJ.
Biochem J. 432(1):207-16. 2010
Direct link between RACK1 function and localization at the ribosome in vivo.
Coyle SM, Gilbert WV, Doudna JA.
Mol Cell Biol 29(6):1626-34. Epub 2008 Dec 29. 2009
Functional mapping of the promoter region of the GNB2L1 human gene coding for RACK1 scaffold protein.
Del Vecchio I, Zuccotti A, Pisano F, Canneva F, Lenzken SC, Rousset F, Corsini E, Govoni S, Racchi M.
Gene 430(1-2):17-29. Epub 2008 Oct 21. 2009
RACK1 associates with CLEC-2 and promotes its ubiquitin-proteasome degradation.
Ruan Y, Guo L, Qiao Y, Hong Y, Zhou L, Sun L, Wang L, Zhu H, Wang L, Yun X, Xie J, Gu J.
Biochem Biophys Res Commun 390(2):217-22. Epub 2009 Sep 26.PMID: 19785988 2009
21BAX, BCL2L11, GNB2L1
A novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathways.
Mamidipudi V, Cartwright CA.
Oncogene 28(50):4421-33. Epub 2009 Sep 21.PMID: 19767770 2009
Structural basis and specificity of human otubain 1-mediated deubiquitination.
Edelmann MJ, Iphöfer A, Akutsu M, Altun M, di Gleria K, Kramer HB, Fiebiger E, Dhe-Paganon S, Kessler BM.
Biochem J. 418(2):379-90. 2009
23ADAM12, GNB2L1
RACK1, a new ADAM12 interacting protein. Contribution to liver fibrogenesis.
Bourd-Boittin K, Le Pabic H, Bonnier D, L'Helgoualc'h A, Théret N.
J Biol Chem 283(38):26000-9. Epub 2008 Jul 11. 2008
RACK1 and CIS mediate the degradation of BimEL in cancer cells.
Zhang W, Cheng GZ, Gong J, Hermanto U, Zong CS, Chan J, Cheng JQ, Wang LH.
J Biol Chem 283(24):16416-26. Epub 2008 Apr 17.PMID: 18420585 2008
1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, beta-arrestin and RACK1.
Smith KJ, Baillie GS, Hyde EI, Li X, Houslay TM, McCahill A, Dunlop AJ, Bolger GB, Klussmann E, Adams DR, Houslay MD.
Cell Signal 19(12):2612-24. Epub 2007 Sep 1. 2007
26GNB2L1, SLC9A5
RACK1 associates with NHE5 in focal adhesions and positively regulates the transporter activity.
Onishi I, Lin PJ, Diering GH, Williams WP, Numata M.
Cell Signal 19(1):194-203. Epub 2006 Aug 22.PMID: 16920332 2007
Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha.
Baek JH, Liu YV, McDonald KR, Wesley JB, Zhang H, Semenza GL.
J Biol Chem. 282(46):33358-66. 2007
28GNB2L1, PER1
RACK1, a novel hPER1-interacting protein.
Hu L, Lu F, Wang Y, Liu Y, Liu D, Jiang Z, Wan C, Zhu B, Gan L, Wang Y, Wang Z.
J Mol Neurosci 29(1):55-63. 2006
The prion-like protein Doppel (Dpl) interacts with the human receptor for activated C-kinase 1 (RACK1) protein.
Azzalin A, Del Vecchio I, Ferretti L, Comincini S.
Anticancer Res 26(6B):4539-47. 2006
Localization of the scaffolding protein RACK1 in the developing and adult mouse brain.
Ashique AM, Kharazia V, Yaka R, Phamluong K, Peterson AS, Ron D.
Brain Res 1069(1):31-8. Epub 2006 Jan 18. 2006
31SLC39A3R1, GNB2L1
The N-terminus of the WD5 repeat of human RACK1 binds to airway epithelial NHERF1.
Liedtke CM, Wang X.
Biochemistry 45(34):10270-7. 2006
RACK1 recruits STAT3 specifically to insulin and insulin-like growth factor 1 receptors for activation, which is important for regulating anchorage-independent growth.
Zhang W, Zong CS, Hermanto U, Lopez-Bergami P, Ronai Z, Wang LH.
Mol Cell Biol. 26(2):413-24. 2006
Ki-1/57 interacts with RACK1 and is a substrate for the phosphorylation by phorbol 12-myristate 13-acetate-activated protein kinase C.
Nery FC, Passos DO, Garcia VS, Kobarg J.
J Biol Chem. 279(12):11444-55. 2004
Syntaxin 1A and receptor for activated C kinase interact with the N-terminal region of human dopamine transporter.
Lee KH, Kim MY, Kim DH, Lee YS.
Neurochem Res. 29(7):1405-9. 2004
ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways.
Battle MA, Maher VM, McCormick JJ.
Biochemistry 42(24):7270-82. 2003
The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex.
Usacheva A, Tian X, Sandoval R, Salvi D, Levy D, Colamonici OR.
J Immunol 171(6):2989-94. 2003
37GNB2L1, RB1
Function of p73, not of p53, is inhibited by the physical interaction with RACK1 and its inhibitory effect is counteracted by pRB.
Ozaki T, Watanabe K, Nakagawa T, Miyazaki K, Takahashi M, Nakagawara A.
Oncogene. 22(21):3231-42. 2003
Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly.
Ceci M, Gaviraghi C, Gorrini C, Sala LA, Offenhäuser N, Marchisio PC, Biffo S.
Nature. 426(6966):579-84. 2003
The scaffolding protein RACK1 interacts with androgen receptor and promotes cross-talk through a protein kinase C signaling pathway.
Rigas AC, Ozanne DM, Neal DE, Robson CN.
J Biol Chem. 278(46):46087-93. 2003
Farnesyl pyrophosphate promotes and is essential for the binding of RACK1 with beta-tubulin.
Huang CF, Fan JH, Chuang NN.
J Exp Zool A Comp Exp Biol. 298(2):119-27. 2003
Identification and characterization of AGTRAP, a human homolog of murine Angiotensin II Receptor-Associated Protein (Agtrap).
Wang W, Huang Y, Zhou Z, Tang R, Zhao W, Zeng L, Xu M, Cheng C, Gu S,Ying K, Xie Y, Mao Y.
Int J Biochem Cell Biol 34(1):93-102. 2002
RACK1: a novel substrate for the Src protein-tyrosine kinase.
Chang BY, Harte RA, Cartwright CA.
Oncogene 21(50):7619-29. Erratum in: Oncogene. 2003 Mar 20;22(11):1748. 2002
RACK1, an insulin-like growth factor I (IGF-I) receptor-interacting protein, modulates IGF-I-dependent integrin signaling and promotes cell spreading and contact with extracellular matrix.
Hermanto U, Zong CS, Li W, Wang LH.
Mol Cell Biol. 22(7):2345-65. 2002
Interaction with factor associated with neutral sphingomyelinase activation, a WD motif-containing protein, identifies receptor for activated C-kinase 1 as a novel component of the signaling pathways of the p55 TNF receptor.
Tcherkasowa AE, Adam-Klages S, Kruse ML, Wiegmann K, Mathieu S, Kolanus W, Krönke M, Adam D.
J Immunol. 169(9):5161-70. 2002
NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1.
Yaka R, Thornton C, Vagts AJ, Phamluong K, Bonci A, Ron D.
Proc Natl Acad Sci U S A. 99(8):5710-5 2002
The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins.
Dell EJ, Connor J, Chen S, Stebbins EG, Skiba NP, Mochly-Rosen D, Hamm HE.
J Biol Chem. 277(51):49888-95. 2002
RACK-1, a receptor for activated C kinase, interacts with the transcription factor NFAT and represses its transactivation.
Han J, Kim M, Oum JH, Myung H, Lee SW, Jeong S, Sharma S, Park J.
Mol Cells. 14(3):420-4. 2002
Activation of Integrin-RACK1/PKCalpha signalling in human articular chondrocyte mechanotransduction.
Lee HS, Millward-Sadler SJ, Wright MO, Nuki G, Al-Jamal R, Salter DM.
Osteoarthritis Cartilage. 10(11):890-7. 2002
RACK1, a protein kinase C scaffolding protein, interacts with the PH domain of p120GAP.
Koehler JA, Moran MF.
Biochem Biophys Res Commun 283(4):888-95. 2001
The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor.
Usacheva A, Smith R, Minshall R, Baida G, Seng S, Croze E, Colamonici O.
J Biol Chem. 276(25):22948-53. 2001
The PTPmu protein-tyrosine phosphatase binds and recruits the scaffolding protein RACK1 to cell-cell contacts.
Mourton T, Hellberg CB, Burden-Gulley SM, Hinman J, Rhee A, Brady-Kalnay SM.
J Biol Chem. 276(18):14896-901. 2001
Rack1 binds HIV-1 Nef and can act as a Nef-protein kinase C adaptor.
Gallina A, Rossi F, Milanesi G.
Virology. 283(1):7-18. 2001
RACK1 is up-regulated in angiogenesis and human carcinomas.
Berns H, Humar R, Hengerer B, Kiefer FN, Battegay EJ.
FASEB J 14(15):2549-58. 2000
Structure and coding content of CST (BART) family RNAs of Epstein-Barr virus.
Smith PR, de Jesus O, Turner D, Hollyoake M, Karstegl CE, Griffin BE, Karran L, Wang Y, Hayward SD, Farrell PJ.
J Virol. 74(7):3082-92. 2000
Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor.
Croze E, Usacheva A, Asarnow D, Minshall RD, Perez HD, Colamonici O.
J Immunol. 165(9):5127-32. 2000
The PKC targeting protein RACK1 interacts with the Epstein-Barr virus activator protein BZLF1.
Baumann M, Gires O, Kolch W, Mischak H, Zeidler R, Pich D, Hammerschmidt W.
Eur J Biochem. 267(12):3891-901. 2000
RACK1, a protein kinase C anchoring protein, coordinates the binding of activated protein kinase C and select pleckstrin homology domains in vitro.
Rodriguez MM, Ron D, Touhara K, Chen CH, Mochly-Rosen D.
Biochemistry 38(42):13787-94 1999
The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform.
Yarwood SJ, Steele MR, Scotland G, Houslay MD, Bolger GB.
J Biol Chem. 274(21):14909-17. 1999
Association of RACK1 and PKCbeta with the common beta-chain of the IL-5/IL-3/GM-CSF receptor.
Geijsen N, Spaargaren M, Raaijmakers JA, Lammers JW, Koenderman L, Coffer PJ.
Oncogene. 18(36):5126-30. 1999
60GNB1, GNB2, GNB2L1, GNB3, GNB4, GNB5
Folding a WD repeat propeller. Role of highly conserved aspartic acid residues in the G protein beta subunit and Sec13.
Garcia-Higuera I, Gaitatzes C, Smith TF, Neer EJ.
J Biol Chem 273(15):9041-9. 1998
Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit.
Liliental J, Chang DD.
J Biol Chem 273(4):2379-83. 1998
Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins.
Ron D, Chen CH, Caldwell J, Jamieson L, Orr E, Mochly-Rosen D.
Proc Natl Acad Sci U S A 91(3):839-43 1994
Phospholipase C-gamma 1 binding to intracellular receptors for activated protein kinase C.
Disatnik MH, Hernandez-Sotomayor SM, Jones G, Carpenter G, Mochly-Rosen D.
Proc Natl Acad Sci U S A. 91(2):559-63. 1994