| 1 | GNB2L1, OPRM1, PCBP1
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| RACK1 identified as the PCBP1-interacting protein with a novel functional role on the regulation of human MOR gene expression.
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| Nahar-Gohad P, Sultan H, Esteban Y, Stabile A, Ko JL.
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| J Neurochem Neurochem. 2012 Nov 22. doi: 10.1111/jnc.12100. [Epub ahead of print]
2012
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| 2 | BDNF, GNB2L1, YWHAZ
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| Direct interaction between scaffolding proteins RACK1 and 14-3-3ζ regulates brain-derived neurotrophic factor (BDNF) transcription.
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| Neasta J, Kiely PA, He DY, Adams DR, O'Connor R, Ron D.
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| J Biol Chem 287(1):322-36. doi: 10.1074/jbc.M111.272195. Epub 2011 Nov 8.
2012
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| 3 | GNB2L1, ZBP1
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| RACK1 is a ribosome scaffold protein for β-actin mRNA/ZBP1 complex.
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| Ceci M, Welshhans K, Ciotti MT, Brandi R, Parisi C, Paoletti F, Pistillo L, Bassell GJ, Cattaneo A.
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| PLoS One 7(4):e35034. doi: 10.1371/journal.pone.0035034. Epub 2012 Apr 16.
2012
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| 4 | GNB2L1, PTK7
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| RACK1 is a novel interaction partner of PTK7 that is required for neural tube closure.
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| Wehner P, Shnitsar I, Urlaub H, Borchers A.
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| Development 138(7):1321-7. Epub 2011 Feb 24.
2011
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| 5 | FLT1, GNB2L1
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| RACK1 regulates VEGF/Flt1-mediated cell migration via activation of a PI3K/Akt pathway.
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| Wang F, Yamauchi M, Muramatsu M, Osawa T, Tsuchida R, Shibuya M.
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| J Biol Chem 286(11):9097-106. Epub 2011 Jan 6.
2011
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| 6 | GNB2L1, VANGL2
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| Rack1 is required for Vangl2 membrane localization and planar cell polarity signaling while attenuating canonical Wnt activity.
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| Li S, Esterberg R, Lachance V, Ren D, Radde-Gallwitz K, Chi F, Parent JL, Fritz A, Chen P.
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| Proc Natl Acad Sci U S A 108(6):2264-9. Epub 2011 Jan 24.
2011
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| 7 | CDH1, GNB2L1
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| Rack1 promotes epithelial cell-cell adhesion by regulating E-cadherin endocytosis.
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| Swaminathan G, Cartwright CA.
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| Oncogene ncogene. 2011 Jun 20. doi: 10.1038/onc.2011.242. [Epub ahead of print]
2011
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| 8 | GNB2L1, ORAI1, TRPC3
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| TRPC3 regulates agonist-stimulated Ca2+ mobilization by mediating the interaction between type I inositol 1,4,5-trisphosphate receptor, RACK1, and Orai1.
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| Woodard GE, López JJ, Jardín I, Salido GM, Rosado JA.
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| J Biol Chem 285(11):8045-53. Epub 2009 Dec 18.PMID: 20022948 2010
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| 9 | ARNTL, GNB2L1
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| Identification of RACK1 and protein kinase Calpha as integral components of the mammalian circadian clock.
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| Robles MS, Boyault C, Knutti D, Padmanabhan K, Weitz CJ.
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| Science 327(5964):463-6.PMID: 20093473 2010
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| 10 | GNB2L1, PPP1R14A
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| A functional interaction between CPI-17 and RACK1 proteins in bronchial smooth muscle cells.
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| Chiba Y, Tanabe M, Sakai H, Kimura S, Misawa M.
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| Biochem Biophys Res Commun 401(3):487-90. Epub 2010 Sep 25.
2010
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| 11 | GNB2L1
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| Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C.
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| Bird RJ, Baillie GS, Yarwood SJ.
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| Biochem J. 432(1):207-16. 2010
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| 12 | GNB2L1
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| Direct link between RACK1 function and localization at the ribosome in vivo.
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| Coyle SM, Gilbert WV, Doudna JA.
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| Mol Cell Biol 29(6):1626-34. Epub 2008 Dec 29.
2009
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| 13 | GNB2L1
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| Functional mapping of the promoter region of the GNB2L1 human gene coding for RACK1 scaffold protein.
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| Del Vecchio I, Zuccotti A, Pisano F, Canneva F, Lenzken SC, Rousset F, Corsini E, Govoni S, Racchi M.
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| Gene 430(1-2):17-29. Epub 2008 Oct 21.
2009
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| 14 | CLEC1B, GNB2L1
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| RACK1 associates with CLEC-2 and promotes its ubiquitin-proteasome degradation.
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| Ruan Y, Guo L, Qiao Y, Hong Y, Zhou L, Sun L, Wang L, Zhu H, Wang L, Yun X, Xie J, Gu J.
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| Biochem Biophys Res Commun 390(2):217-22. Epub 2009 Sep 26.PMID: 19785988 2009
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| 15 | BAX, BCL2L11, GNB2L1
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| A novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathways.
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| Mamidipudi V, Cartwright CA.
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| Oncogene 28(50):4421-33. Epub 2009 Sep 21.PMID: 19767770 2009
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| 16 | GNB2L1
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| Structural basis and specificity of human otubain 1-mediated deubiquitination.
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| Edelmann MJ, Iphöfer A, Akutsu M, Altun M, di Gleria K, Kramer HB, Fiebiger E, Dhe-Paganon S, Kessler BM.
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| Biochem J. 418(2):379-90. 2009
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| 17 | ADAM12, GNB2L1
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| RACK1, a new ADAM12 interacting protein. Contribution to liver fibrogenesis.
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| Bourd-Boittin K, Le Pabic H, Bonnier D, L'Helgoualc'h A, Théret N.
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| J Biol Chem 283(38):26000-9. Epub 2008 Jul 11.
2008
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| 18 | BCL2L11, CISH, DYNLL1, GNB2L1
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| RACK1 and CIS mediate the degradation of BimEL in cancer cells.
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| Zhang W, Cheng GZ, Gong J, Hermanto U, Zong CS, Chan J, Cheng JQ, Wang LH.
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| J Biol Chem 283(24):16416-26. Epub 2008 Apr 17.PMID: 18420585 2008
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| 19 | GNB2L1
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| 1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, beta-arrestin and RACK1.
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| Smith KJ, Baillie GS, Hyde EI, Li X, Houslay TM, McCahill A, Dunlop AJ, Bolger GB, Klussmann E, Adams DR, Houslay MD.
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| Cell Signal 19(12):2612-24. Epub 2007 Sep 1. 2007
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| 20 | GNB2L1, SLC9A5
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| RACK1 associates with NHE5 in focal adhesions and positively regulates the transporter activity.
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| Onishi I, Lin PJ, Diering GH, Williams WP, Numata M.
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| Cell Signal 19(1):194-203. Epub 2006 Aug 22.PMID: 16920332 2007
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| 21 | GNB2L1
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| Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha.
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| Baek JH, Liu YV, McDonald KR, Wesley JB, Zhang H, Semenza GL.
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| J Biol Chem. 282(46):33358-66. 2007
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| 22 | GNB2L1, PER1
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| RACK1, a novel hPER1-interacting protein.
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| Hu L, Lu F, Wang Y, Liu Y, Liu D, Jiang Z, Wan C, Zhu B, Gan L, Wang Y, Wang Z.
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| J Mol Neurosci 29(1):55-63. 2006
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| 23 | GNB2L1, PRND
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| The prion-like protein Doppel (Dpl) interacts with the human receptor for activated C-kinase 1 (RACK1) protein.
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| Azzalin A, Del Vecchio I, Ferretti L, Comincini S.
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| Anticancer Res 26(6B):4539-47. 2006
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| 24 | GNB2L1
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| Localization of the scaffolding protein RACK1 in the developing and adult mouse brain.
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| Ashique AM, Kharazia V, Yaka R, Phamluong K, Peterson AS, Ron D.
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| Brain Res 1069(1):31-8. Epub 2006 Jan 18. 2006
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| 25 | SLC39A3R1, GNB2L1
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| The N-terminus of the WD5 repeat of human RACK1 binds to airway epithelial NHERF1.
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| Liedtke CM, Wang X.
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| Biochemistry 45(34):10270-7. 2006
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| 26 | GNB2L1
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| RACK1 recruits STAT3 specifically to insulin and insulin-like growth factor 1 receptors for activation, which is important for regulating anchorage-independent growth.
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| Zhang W, Zong CS, Hermanto U, Lopez-Bergami P, Ronai Z, Wang LH.
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| Mol Cell Biol. 26(2):413-24. 2006
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| 27 | GNB2L1
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| Ki-1/57 interacts with RACK1 and is a substrate for the phosphorylation by phorbol 12-myristate 13-acetate-activated protein kinase C.
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| Nery FC, Passos DO, Garcia VS, Kobarg J.
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| J Biol Chem. 279(12):11444-55. 2004
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| 28 | GNB2L1
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| Syntaxin 1A and receptor for activated C kinase interact with the N-terminal region of human dopamine transporter.
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| Lee KH, Kim MY, Kim DH, Lee YS.
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| Neurochem Res. 29(7):1405-9. 2004
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| 29 | GNB2L1, LRP12, ZFYVE9
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| ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways.
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| Battle MA, Maher VM, McCormick JJ.
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| Biochemistry 42(24):7270-82. 2003
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| 30 | GNB2L1
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| The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex.
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| Usacheva A, Tian X, Sandoval R, Salvi D, Levy D, Colamonici OR.
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| J Immunol 171(6):2989-94. 2003
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| 31 | GNB2L1, RB1
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| Function of p73, not of p53, is inhibited by the physical interaction with RACK1 and its inhibitory effect is counteracted by pRB.
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| Ozaki T, Watanabe K, Nakagawa T, Miyazaki K, Takahashi M, Nakagawara A.
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| Oncogene. 22(21):3231-42. 2003
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| 32 | GNB2L1
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| Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly.
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| Ceci M, Gaviraghi C, Gorrini C, Sala LA, Offenhäuser N, Marchisio PC, Biffo S.
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| Nature. 426(6966):579-84. 2003
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| 33 | GNB2L1
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| The scaffolding protein RACK1 interacts with androgen receptor and promotes cross-talk through a protein kinase C signaling pathway.
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| Rigas AC, Ozanne DM, Neal DE, Robson CN.
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| J Biol Chem. 278(46):46087-93. 2003
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| 34 | GNB2L1
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| Farnesyl pyrophosphate promotes and is essential for the binding of RACK1 with beta-tubulin.
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| Huang CF, Fan JH, Chuang NN.
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| J Exp Zool A Comp Exp Biol. 298(2):119-27. 2003
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| 35 | AGTRAP, GNB2L1
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| Identification and characterization of AGTRAP, a human homolog of murine Angiotensin II Receptor-Associated Protein (Agtrap).
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| Wang W, Huang Y, Zhou Z, Tang R, Zhao W, Zeng L, Xu M, Cheng C, Gu S,Ying K, Xie Y, Mao Y.
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| Int J Biochem Cell Biol 34(1):93-102. 2002
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| 36 | GNB2L1
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| RACK1: a novel substrate for the Src protein-tyrosine kinase.
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| Chang BY, Harte RA, Cartwright CA.
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| Oncogene 21(50):7619-29. Erratum in: Oncogene. 2003 Mar 20;22(11):1748. 2002
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| 37 | GNB2L1
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| RACK1, an insulin-like growth factor I (IGF-I) receptor-interacting protein, modulates IGF-I-dependent integrin signaling and promotes cell spreading and contact with extracellular matrix.
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| Hermanto U, Zong CS, Li W, Wang LH.
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| Mol Cell Biol. 22(7):2345-65. 2002
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| 38 | GNB2L1
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| Interaction with factor associated with neutral sphingomyelinase activation, a WD motif-containing protein, identifies receptor for activated C-kinase 1 as a novel component of the signaling pathways of the p55 TNF receptor.
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| Tcherkasowa AE, Adam-Klages S, Kruse ML, Wiegmann K, Mathieu S, Kolanus W, Krönke M, Adam D.
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| J Immunol. 169(9):5161-70. 2002
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| 39 | GNB2L1
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| NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1.
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| Yaka R, Thornton C, Vagts AJ, Phamluong K, Bonci A, Ron D.
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| Proc Natl Acad Sci U S A. 99(8):5710-5 2002
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| 40 | GNB2L1
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| The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins.
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| Dell EJ, Connor J, Chen S, Stebbins EG, Skiba NP, Mochly-Rosen D, Hamm HE.
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| J Biol Chem. 277(51):49888-95. 2002
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| 41 | GNB2L1
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| RACK-1, a receptor for activated C kinase, interacts with the transcription factor NFAT and represses its transactivation.
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| Han J, Kim M, Oum JH, Myung H, Lee SW, Jeong S, Sharma S, Park J.
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| Mol Cells. 14(3):420-4. 2002
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| 42 | GNB2L1
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| Activation of Integrin-RACK1/PKCalpha signalling in human articular chondrocyte mechanotransduction.
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| Lee HS, Millward-Sadler SJ, Wright MO, Nuki G, Al-Jamal R, Salter DM.
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| Osteoarthritis Cartilage. 10(11):890-7. 2002
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| 43 | GNB2L1, RASA1
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| RACK1, a protein kinase C scaffolding protein, interacts with the PH domain of p120GAP.
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| Koehler JA, Moran MF.
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| Biochem Biophys Res Commun 283(4):888-95. 2001
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| 44 | GNB2L1
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| The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor.
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| Usacheva A, Smith R, Minshall R, Baida G, Seng S, Croze E, Colamonici O.
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| J Biol Chem. 276(25):22948-53. 2001
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| 45 | GNB2L1
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| The PTPmu protein-tyrosine phosphatase binds and recruits the scaffolding protein RACK1 to cell-cell contacts.
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| Mourton T, Hellberg CB, Burden-Gulley SM, Hinman J, Rhee A, Brady-Kalnay SM.
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| J Biol Chem. 276(18):14896-901. 2001
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| 46 | GNB2L1
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| Rack1 binds HIV-1 Nef and can act as a Nef-protein kinase C adaptor.
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| Gallina A, Rossi F, Milanesi G.
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| Virology. 283(1):7-18. 2001
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| 47 | GNB2L1
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| RACK1 is up-regulated in angiogenesis and human carcinomas.
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| Berns H, Humar R, Hengerer B, Kiefer FN, Battegay EJ.
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| FASEB J 14(15):2549-58. 2000
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| 48 | GNB2L1
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| Structure and coding content of CST (BART) family RNAs of Epstein-Barr virus.
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| Smith PR, de Jesus O, Turner D, Hollyoake M, Karstegl CE, Griffin BE, Karran L, Wang Y, Hayward SD, Farrell PJ.
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| J Virol. 74(7):3082-92. 2000
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| 49 | GNB2L1
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| Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor.
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| Croze E, Usacheva A, Asarnow D, Minshall RD, Perez HD, Colamonici O.
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| J Immunol. 165(9):5127-32. 2000
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| 50 | GNB2L1
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| The PKC targeting protein RACK1 interacts with the Epstein-Barr virus activator protein BZLF1.
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| Baumann M, Gires O, Kolch W, Mischak H, Zeidler R, Pich D, Hammerschmidt W.
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| Eur J Biochem. 267(12):3891-901. 2000
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| 51 | GNB2L1
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| RACK1, a protein kinase C anchoring protein, coordinates the binding of activated protein kinase C and select pleckstrin homology domains in vitro.
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| Rodriguez MM, Ron D, Touhara K, Chen CH, Mochly-Rosen D.
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| Biochemistry 38(42):13787-94 1999
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| 52 | GNB2L1
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| The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform.
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| Yarwood SJ, Steele MR, Scotland G, Houslay MD, Bolger GB.
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| J Biol Chem. 274(21):14909-17. 1999
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| 53 | GNB2L1
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| Association of RACK1 and PKCbeta with the common beta-chain of the IL-5/IL-3/GM-CSF receptor.
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| Geijsen N, Spaargaren M, Raaijmakers JA, Lammers JW, Koenderman L, Coffer PJ.
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| Oncogene. 18(36):5126-30. 1999
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| 54 | GNB1, GNB2, GNB2L1, GNB3, GNB4, GNB5
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| Folding a WD repeat propeller. Role of highly conserved aspartic acid residues in the G protein beta subunit and Sec13.
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| Garcia-Higuera I, Gaitatzes C, Smith TF, Neer EJ.
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| J Biol Chem 273(15):9041-9. 1998
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| 55 | GNB2L1
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| Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit.
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| Liliental J, Chang DD.
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| J Biol Chem 273(4):2379-83. 1998
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| 56 | GNB2L1
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| Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins.
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| Ron D, Chen CH, Caldwell J, Jamieson L, Orr E, Mochly-Rosen D.
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| Proc Natl Acad Sci U S A 91(3):839-43 1994
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| 57 | GNB2L1
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| Phospholipase C-gamma 1 binding to intracellular receptors for activated protein kinase C.
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| Disatnik MH, Hernandez-Sotomayor SM, Jones G, Carpenter G, Mochly-Rosen D.
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| Proc Natl Acad Sci U S A. 91(2):559-63. 1994
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