| 1 | EIF1AX, GNA11, GNAQ
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| Frequent GNAQ, GNA11, and EIF1AX Mutations in Iris Melanoma.
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| Scholz SL, Möller I, Reis H, Süßkind D, van de Nes JAP, Leonardelli S, Schilling B, Livingstone E, Schimming T, Paschen A, Sucker A, Murali R, Steuhl KP, Schadendorf D, Westekemper H, Griewank KG.
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| Invest Ophthalmol Vis Sci 58(9):3464-3470. doi: 10.1167/iovs.17-21838.
2017
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| 2 | GNA11, GNAQ
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| Somatic Activating Mutations in GNAQ and GNA11 Are Associated with Congenital Hemangioma.
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| Ayturk UM, Couto JA, Hann S, Mulliken JB, Williams KL, Huang AY, Fishman SJ, Boyd TK, Kozakewich HP, Bischoff J, Greene AK, Warman ML.
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| Am J Hum Genet 98(4):789-95. doi: 10.1016/j.ajhg.2016.03.009.
2016
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| 3 | BAP1, EIF1AX, GNA11, GNAQ
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| Chromosome 3 status combined with BAP1 and EIF1AX mutation profiles are associated with metastasis in uveal melanoma.
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| Ewens KG, Kanetsky PA, Richards-Yutz J, Purrazzella J, Shields CL, Ganguly T, Ganguly A.
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| Invest Ophthalmol Vis Sci 55(8):5160-7. doi: 10.1167/iovs.14-14550.
2014
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| 4 | CDC42, GNAQ
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| Histaminylation of glutamine residues is a novel posttranslational modification implicated in G-protein signaling.
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| Vowinckel J, Stahlberg S, Paulmann N, Bluemlein K, Grohmann M, Ralser M, Walther DJ.
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| FEBS Lett 586(21):3819-24. doi: 10.1016/j.febslet.2012.09.027. Epub 2012 Sep 26.
2012
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| 5 | GNAQ, PLCB2, SNCG
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| γ-Synuclein interacts with phospholipase Cβ2 to modulate G protein activation.
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| Golebiewska U, Guo Y, Khalikaprasad N, Zurawsky C, Yerramilli VS, Scarlata S.
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| PLoS One 7(8):e41067. doi: 10.1371/journal.pone.0041067. Epub 2012 Aug 8.
2012
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| 6 | GNA11, GNAQ
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| The Gαq/11 proteins contribute to T lymphocyte migration by promoting turnover of integrin LFA-1 through recycling.
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| Svensson L, Stanley P, Willenbrock F, Hogg N.
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| PLoS One 7(6):e38517. doi: 10.1371/journal.pone.0038517. Epub 2012 Jun 11. 2012
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| 7 | GNAQ
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| A retinoic acid receptor RARα pool present in membrane lipid rafts forms complexes with G protein αQ to activate p38MAPK.
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| Piskunov A, Rochette-Egly C.
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| Oncogene 31(28):3333-45. doi: 10.1038/onc.2011.499. Epub 2011 Nov 7.
2012
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| 8 | GNA11, GNAQ
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| Gαq and Gα11 contribute to the maintenance of cellular electrophysiology and Ca2+ handling in ventricular cardiomyocytes.
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| Pahlavan S, Oberhofer M, Sauer B, Ruppenthal S, Tian Q, Scholz A, Kaestner L, Lipp P.
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| Cardiovasc Res 95(1):48-58. doi: 10.1093/cvr/cvs162. Epub 2012 May 4.
2012
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| 9 | GNAQ, PLCB2, WDR36
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| WDR36 acts as a scaffold protein tethering a G-protein-coupled receptor, Gαq and phospholipase Cβ in a signalling complex.
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| Cartier A, Parent A, Labrecque P, Laroche G, Parent JL.
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| J Cell Sci 124(Pt 19):3292-304. doi: 10.1242/jcs.085795.
2011
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| 10 | ADRBK1, GNA11, GNAQ
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| Regulation of the epithelial Na+ channel by the RH domain of G protein-coupled receptor kinase, GRK2, and Galphaq/11.
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| Lee IH, Song SH, Campbell CR, Kumar S, Cook DI, Dinudom A.
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| J Biol Chem 286(22):19259-69. doi: 10.1074/jbc.M111.239772. Epub 2011 Apr 4.
2011
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| 11 | GNAQ, PTH
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| G alpha(q) signal in osteoblasts is inhibitory to the osteoanabolic action of parathyroid hormone.
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| Ogata N, Shinoda Y, Wettschureck N, Offermanns S, Takeda S, Nakamura K, Segre GV, Chung UI, Kawaguchi H.
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| J Biol Chem 286(15):13733-40. doi: 10.1074/jbc.M110.200196. Epub 2011 Feb 23.
2011
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| 12 | GNAQ
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| Analysis of GNAQ mutations, proliferation and MAPK pathway activation in uveal melanomas.
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| Pópulo H, Vinagre J, Lopes JM, Soares P.
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| Br J Ophthalmol 95(5):715-9. doi: 10.1136/bjo.2009.174417. Epub 2010 Aug 30.
2011
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| 13 | GNA11, GNAQ
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| Mutations in GNA11 in uveal melanoma.
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| Van Raamsdonk CD, Griewank KG, Crosby MB, Garrido MC, Vemula S, Wiesner T, Obenauf AC, Wackernagel W, Green G, Bouvier N, Sozen MM, Baimukanova G, Roy R, Heguy A, Dolgalev I, Khanin R, Busam K, Speicher MR, O'Brien J, Bastian BC.
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| N Engl J Med 363(23):2191-9. doi: 10.1056/NEJMoa1000584. Epub 2010 Nov 17.
2010
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| 14 | GNAQ
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| An N-terminal polybasic motif of Gαq is required for signaling and influences membrane nanodomain distribution.
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| Crouthamel M, Abankwa D, Zhang L, DiLizio C, Manning DR, Hancock JF, Wedegaertner PB.
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| Mol Pharmacol 78(4):767-77. doi: 10.1124/mol.110.066340. Epub 2010 Jul 27.
2010
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| 15 | GNAQ, TBXA2R
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| Structural and functional analysis of the C-terminus of Galphaq in complex with the human thromboxane A2 receptor provides evidence of constitutive activity.
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| Chillar A, Wu J, Cervantes V, Ruan KH.
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| Biochemistry 49(30):6365-74. doi: 10.1021/bi100047n.
2010
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| 16 | GNAQ
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| A functional GNAQ promoter haplotype is associated with altered Gq expression and with insulin resistance and obesity in women with polycystic ovary syndrome.
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| Klenke S, Tan S, Hahn S, Mann K, Hauner H, Manthey I, Peters J, Siffert W, Frey UH.
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| Pharmacogenet Genomics 20(8):476-84. doi: 10.1097/FPC.0b013e32833b7497.
2010
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| 17 | GNA11, GNAQ, KISSiR
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| GPR54 regulates ERK1/2 activity and hypothalamic gene expression in a Gα(q/11) and β-arrestin-dependent manner.
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| Szereszewski JM, Pampillo M, Ahow MR, Offermanns S, Bhattacharya M, Babwah AV.
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| PLoS One 5(9):e12964. doi: 10.1371/journal.pone.0012964.
2010
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| 18 | GNAQ, PLCB1, TSNAX
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| Identification of a novel binding partner of phospholipase cβ1: translin-associated factor X.
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| Aisiku OR, Runnels LW, Scarlata S.
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| PLoS One 5(11):e15001. doi: 10.1371/journal.pone.0015001.
2010
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| 19 | GNAQ
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| Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi.
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| Van Raamsdonk CD, Bezrookove V, Green G, Bauer J, Gaugler L, O'Brien JM, Simpson EM, Barsh GS, Bastian BC.
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| Nature 457(7229):599-602. Epub 2008 Dec 10.
2009
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| 20 | GNAQ
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| Oncogenic GNAQ mutations are not correlated with disease-free survival in uveal melanoma.
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| Bauer J, Kilic E, Vaarwater J, Bastian BC, Garbe C, de Klein A.
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| Br J Cancer 101(5):813-5. doi: 10.1038/sj.bjc.6605226. Epub 2009 Aug 4.
2009
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| 21 | GNA11, GNAQ
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| Anaphylactic shock depends on endothelial Gq/G11.
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| Korhonen H, Fisslthaler B, Moers A, Wirth A, Habermehl D, Wieland T, Schütz G, Wettschureck N, Fleming I, Offermanns S.
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| J Exp Med 206(2):411-20. doi: 10.1084/jem.20082150. Epub 2009 Jan 26.
2009
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| 22 | GNAQ
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| A functional polymorphism of the Galphaq (GNAQ) gene is associated with accelerated mortality in African-American heart failure.
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| Liggett SB, Kelly RJ, Parekh RR, Matkovich SJ, Benner BJ, Hahn HS, Syed FM, Galvez AS, Case KL, McGuire N, Odley AM, Sparks L, Kardia SL, Dorn GW 2nd.
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| Hum Mol Genet 16(22):2740-50. Epub 2007 Aug 24. 2007
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| 23 | EGR1, GNAQ
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| Early growth response transcription factor EGR-1 regulates Galphaq gene in megakaryocytic cells.
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| Jalagadugula G, Dhanasekaran DN, Kim S, Kunapuli SP, Rao AK.
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| J Thromb Haemost 4(12):2678-86. Epub 2006 Sep 22. 2006
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| 24 | GNA15, GNAQ
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| Proteasome involvement in the degradation of the G(q) family of Galpha subunits.
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| Johansson BB, Minsaas L, Aragay AM.
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| FEBS J 272(20):5365-77. 2005
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| 25 | GNA13, ARHGEF1, GNAQ
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| Functional consequences of G alpha 13 mutations that disrupt interaction with p115RhoGEF.
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| Grabocka E, Wedegaertner PB.
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| Oncogene 24(13):2155-65. 2005
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| 26 | ADRBK1, GNAQ
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| Differential interaction of GRK2 with members of the G alpha q family.
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| Day PW, Carman CV, Sterne-Marr R, Benovic JL, Wedegaertner PB.
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| Biochemistry 42(30):9176-84. 2003
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| 27 | GNAQ, GNA11, GNA14, VPS13A
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| Genomic organization of the human galpha14 and galphaq genes and mutation analysis in chorea-acanthocytosis.
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| Rubio JP, et al.
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| Genomics 57(1):84-93. 1999
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| 28 | GNAQ
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| Platelet signal transduction defect with Galpha subunit dysfunction and diminished Galphaq in a patient with abnormal platelet responses.
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| Gabbeta J, et al.
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| Proc Natl Acad Sci U S A 94(16):8750-5. 1997
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| 29 | GNAQ
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| Human platelet signaling defect characterized by impaired production of inositol-1,4,5-triphosphate and phosphatidic acid and diminished Pleckstrin phosphorylation: evidence for defective phospholipase C activation.
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| Yang X, et al.
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| Blood 88(5):1676-83. 1996
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| 30 | GNAQ, GNAQP
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| Molecular cloning of human Galphaq cDNA and chromosomal localization of the Galphaq gene (GNAQ) and a processed pseudogene.
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| Dong Q, et al.
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| Genomics 30 : 470-475. 1995
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| 31 | GNAQ, GNA11, GNA14
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| Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq.
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| Smrcka AV, et al.
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| Science 251(4995):804-7. 1991
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