Citations for
1GNAI2
Role of a heterotrimeric G-protein, Gi2, in the corticogenesis: possible involvement in periventricular nodular heterotopia and intellectual disability.
Hamada N, Negishi Y, Mizuno M, Miya F, Hattori A, Okamoto N, Kato M, Tsunoda T, Yamasaki M, Kanemura Y, Kosaki K, Tabata H, Saitoh S, Nagata KI.
J Neurochem 140(1):82-95. doi: 10.1111/jnc.13878. Epub 2016 Nov 29. 2017
2GNAI2
Lack of Gαi2 leads to dilative cardiomyopathy and increased mortality in β1-adrenoceptor overexpressing mice.
Keller K, Maass M, Dizayee S, Leiss V, Annala S, Köth J, Seemann WK, Müller-Ehmsen J, Mohr K, Nürnberg B, Engelhardt S, Herzig S, Birnbaumer L, Matthes J.
Cardiovasc Res 108(3):348-56. doi: 10.1093/cvr/cvv235. Epub 2015 Oct 13. 2015
3GNAI2
An essential role for RGS protein/Gαi2 interactions in B lymphocyte-directed cell migration and trafficking.
Hwang IY, Park C, Harrison K, Boularan C, Galés C, Kehrl JH.
J Immunol 194(5):2128-39. doi: 10.4049/jimmunol.1401952. Epub 2015 Jan 23. 2015
4GNAI2, GNAI3
Gαi2- and Gαi3-deficient mice display opposite severity of myocardial ischemia reperfusion injury.
Köhler D, Devanathan V, Bernardo de Oliveira Franz C, Eldh T, Novakovic A, Roth JM, Granja T, Birnbaumer L, Rosenberger P, Beer-Hammer S, Nürnberg B.
PLoS One 9(5):e98325. doi: 10.1371/journal.pone.0098325. eCollection 2014. Erratum in: PLoS One. 2015;10(3):e0119092. 2014
5GNAI2
Gαi2 signaling is required for skeletal muscle growth, regeneration, and satellite cell proliferation and differentiation.
Minetti GC, Feige JN, Bombard F, Heier A, Morvan F, Nürnberg B, Leiss V, Birnbaumer L, Glass DJ, Fornaro M.
Mol Cell Biol 34(4):619-30. doi: 10.1128/MCB.00957-13. Epub 2013 Dec 2. 2014
6CEBPA, GNAI2
Dual role of C/EBPα as an activator and repressor of Gαi2 gene transcription.
Xu J, Kawai Y, Arinze IJ.
Genes Cells 18(12):1082-94. doi: 10.1111/gtc.12102. Epub 2013 Nov 7. 2013
7GNAI2, GNAI3
The loss of Gnai2 and Gnai3 in B cells eliminates B lymphocyte compartments and leads to a hyper-IgM like syndrome.
Hwang IY, Park C, Luong T, Harrison KA, Birnbaumer L, Kehrl JH.
PLoS One 8(8):e72596. doi: 10.1371/journal.pone.0072596. eCollection 2013. 2013
8GNAI2, GNAI3
Gαi2 is the essential Gαi protein in immune complex-induced lung disease.
Wiege K, Ali SR, Gewecke B, Novakovic A, Konrad FM, Pexa K, Beer-Hammer S, Reutershan J, Piekorz RP, Schmidt RE, Nürnberg B, Gessner JE.
J Immunol 190(1):324-33. doi: 10.4049/jimmunol.1201398. Epub 2012 Dec 5. 2013
9GNAI1, GNAI2, GNAI3
Development of the mammalian axial skeleton requires signaling through the Gα(i) subfamily of heterotrimeric G proteins.
Plummer NW, Spicher K, Malphurs J, Akiyama H, Abramowitz J, Nürnberg B, Birnbaumer L.
Proc Natl Acad Sci U S A 109(52):21366-71. doi: 10.1073/pnas.1219810110. Epub 2012 Dec 11. 2012
10GNAI2, OXT
The essential role of Giα2 in prostate cancer cell migration.
Zhong M, Clarke S, Vo BT, Khan SA.
Mol Cancer Res 10(10):1380-8. doi: 10.1158/1541-7786.MCR-12-0219. Epub 2012 Aug 30. 2012
11CLDN5, GNAI2
Guanine nucleotide-binding protein Gαi2: a new partner of claudin-5 that regulates tight junction integrity in human brain endothelial cells.
Luissint AC, Federici C, Guillonneau F, Chrétien F, Camoin L, Glacial F, Ganeshamoorthy K, Couraud PO.
J Cereb Blood Flow Metab 32(5):860-73. doi: 10.1038/jcbfm.2011.202. Epub 2012 Feb 15. 2012
12CXCL12, GNAI2, RASGRP1, ZAP70
G alpha i2 and ZAP-70 mediate RasGRP1 membrane localization and activation of SDF-1-induced T cell functions.
Kremer KN, Kumar A, Hedin KE.
J Immunol 187(6):3177-85. doi: 10.4049/jimmunol.1100206. Epub 2011 Aug 19. 2011
13GNAI2, MTA1
Acetylation-dependent oncogenic activity of metastasis-associated protein 1 co-regulator.
Ohshiro K, Rayala SK, Wigerup C, Pakala SB, Natha RS, Gururaj AE, Molli PR, Månsson SS, Ramezani A, Hawley RG, Landberg G, Lee NH, Kumar R.
EMBO Rep 11(9):691-7. Epub 2010 Jul 23. 2010
14GNAI2
Absence of the inhibitory G-protein Galphai2 predisposes to ventricular cardiac arrhythmia.
Zuberi Z, Nobles M, Sebastian S, Dyson A, Lim SY, Breckenridge R, Birnbaumer L, Tinker A.
Circ Arrhythm Electrophysiol 3(4):391-400. Epub 2010 May 21.PMID: 20495013 2010
15GNAI2, RGS1
Variations in Gnai2 and Rgs1 expression affect chemokine receptor signaling and the organization of secondary lymphoid organs.
Hwang IY, Park C, Harrision KA, Huang NN, Kehrl JH.
Genes Immun 11(5):384-96. doi: 10.1038/gene.2010.27. Epub 2010 May 27. 2010
16GNAI2
GNAI2 and regulators of G protein signaling as a potential Noonan syndrome mechanism.
Huang X, Fu Y, Charbeneau RA, Neubig RR.
Med Hypotheses 73(1):56-9. Epub 2009 Mar 17.PMID: 19282110 2009
17GNAI2, GNAI3
Requirement of Galphai in thymic homing and early T cell development.
Jin Y, Wu MX.
Mol Immunol 45(12):3401-10. Epub 2008 May 23.PMID: 18501427 2008
18GNAI2, TRPC4
The specific activation of TRPC4 by Gi protein subtype.
Jeon JP, Lee KP, Park EJ, Sung TS, Kim BJ, Jeon JH, So I.
Biochem Biophys Res Commun 377(2):538-43. doi: 10.1016/j.bbrc.2008.10.012. Epub 2008 Oct 12. 2008
19GNAI2
Role of a Galphai2 protein splice variant in the formation of an intracellular dopamine D2 receptor pool.
López-Aranda MF, Acevedo MJ, Gutierrez A, Koulen P, Khan ZU.
J Cell Sci 120(Pt 13):2171-8. Epub 2007 Jun 5.PMID: 17550964 2007
20GNAI2
Galphai2 is required for chemokine-induced neutrophil arrest.
Zarbock A, Deem TL, Burcin TL, Ley K.
Blood 110(10):3773-9. Epub 2007 Aug 15.PMID: 17699741 2007
21GNAI2
The -318 C>G single-nucleotide polymorphism in GNAI2 gene promoter region impairs transcriptional activity through specific binding of Sp1 transcription factor and is associated with high blood pressure in Caucasians from Italy.
Menzaghi C, Paroni G, De Bonis C, Soccio T, Marucci A, Bacci S, Trischitta V.
J Am Soc Nephrol 17(4 Suppl 2):S115-9. 2006
22GNAI2
Transcriptional activation of the human Galphai2 gene promoter through nuclear factor-kappaB and antioxidant response elements.
Arinze IJ, Kawai Y.
J Biol Chem 280(11):9786-95. Epub 2005 Jan 7. 2005
23GNAI2, UNC5B
Modulation of G(ialpha(2)) signaling by the axonal guidance molecule UNC5H2.
Komatsuzaki K, Dalvin S, Kinane TB.
Biochem Biophys Res Commun 297(4):898-905. 2002
24GNAI1, GNAI2
Agonists activate Gi1 alpha or Gi2 alpha fused to the human mu opioid receptor differently.
Massotte D, Brillet K, Kieffer B, Milligan G.
J Neurochem 81(6):1372-82. 2002
25GNAI2, GNAI2L
Regional localization of the human G protein alpha-i-2(GNAI2) gene : assignment to 3p21 and a related sequence (GNAI2L) to 12p12-p13.
Magovcevic I, et al.
Genomics 12 : 125-129. 1992
26GNAI1, GNAI2, GNAI2L, GNAI3, GNAZ, GNAS, GNAT1, GNAT2, GNB1, GNB2
Chromosomal localization of genes encoding guanine nucleotide-binding protein subunits in mouse and human.
Blatt C, Eversole-Cire P, Cohn VH, Zollman S, Fournier RE, Mohandas LT, Nesbitt M, Lugo T, Jones DT, Reed RR, et al.
Proc Natl Acad Sci U S A 85 : 7642-7646. 1988
27GNAT1, GNAT2, GNAI2, GNAI2L, GNAI3, GNAS, GNB1
Mapping of genes encoding the subunits of guanine nucleotide-binding proteins (G-proteins) in humans.
Sparkes RS, et al.
(HGM9) Cytogenet Cell Genet 46 : 696. 1987
28GNAI1, GNAI2, GNAI2L, GNAI3
The human genome encodes at least three non-allellic G proteins with alpha-i-type subunits.
Suki WN, et al.
FEBS Lett 220 : 187-192. 1987