| 1 | GNAI2
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| Role of a heterotrimeric G-protein, Gi2, in the corticogenesis: possible involvement in periventricular nodular heterotopia and intellectual disability.
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| Hamada N, Negishi Y, Mizuno M, Miya F, Hattori A, Okamoto N, Kato M, Tsunoda T, Yamasaki M, Kanemura Y, Kosaki K, Tabata H, Saitoh S, Nagata KI.
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| J Neurochem 140(1):82-95. doi: 10.1111/jnc.13878. Epub 2016 Nov 29.
2017
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| 2 | GNAI2
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| Lack of Gαi2 leads to dilative cardiomyopathy and increased mortality in β1-adrenoceptor overexpressing mice.
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| Keller K, Maass M, Dizayee S, Leiss V, Annala S, Köth J, Seemann WK, Müller-Ehmsen J, Mohr K, Nürnberg B, Engelhardt S, Herzig S, Birnbaumer L, Matthes J.
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| Cardiovasc Res 108(3):348-56. doi: 10.1093/cvr/cvv235. Epub 2015 Oct 13.
2015
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| 3 | GNAI2
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| An essential role for RGS protein/Gαi2 interactions in B lymphocyte-directed cell migration and trafficking.
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| Hwang IY, Park C, Harrison K, Boularan C, Galés C, Kehrl JH.
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| J Immunol 194(5):2128-39. doi: 10.4049/jimmunol.1401952. Epub 2015 Jan 23.
2015
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| 4 | GNAI2, GNAI3
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| Gαi2- and Gαi3-deficient mice display opposite severity of myocardial ischemia reperfusion injury.
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| Köhler D, Devanathan V, Bernardo de Oliveira Franz C, Eldh T, Novakovic A, Roth JM, Granja T, Birnbaumer L, Rosenberger P, Beer-Hammer S, Nürnberg B.
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| PLoS One 9(5):e98325. doi: 10.1371/journal.pone.0098325. eCollection 2014. Erratum in: PLoS One. 2015;10(3):e0119092.
2014
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| 5 | GNAI2
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| Gαi2 signaling is required for skeletal muscle growth, regeneration, and satellite cell proliferation and differentiation.
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| Minetti GC, Feige JN, Bombard F, Heier A, Morvan F, Nürnberg B, Leiss V, Birnbaumer L, Glass DJ, Fornaro M.
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| Mol Cell Biol 34(4):619-30. doi: 10.1128/MCB.00957-13. Epub 2013 Dec 2.
2014
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| 6 | CEBPA, GNAI2
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| Dual role of C/EBPα as an activator and repressor of Gαi2 gene transcription.
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| Xu J, Kawai Y, Arinze IJ.
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| Genes Cells 18(12):1082-94. doi: 10.1111/gtc.12102. Epub 2013 Nov 7.
2013
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| 7 | GNAI2, GNAI3
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| The loss of Gnai2 and Gnai3 in B cells eliminates B lymphocyte compartments and leads to a hyper-IgM like syndrome.
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| Hwang IY, Park C, Luong T, Harrison KA, Birnbaumer L, Kehrl JH.
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| PLoS One 8(8):e72596. doi: 10.1371/journal.pone.0072596. eCollection 2013.
2013
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| 8 | GNAI2, GNAI3
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| Gαi2 is the essential Gαi protein in immune complex-induced lung disease.
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| Wiege K, Ali SR, Gewecke B, Novakovic A, Konrad FM, Pexa K, Beer-Hammer S, Reutershan J, Piekorz RP, Schmidt RE, Nürnberg B, Gessner JE.
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| J Immunol 190(1):324-33. doi: 10.4049/jimmunol.1201398. Epub 2012 Dec 5.
2013
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| 9 | GNAI1, GNAI2, GNAI3
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| Development of the mammalian axial skeleton requires signaling through the Gα(i) subfamily of heterotrimeric G proteins.
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| Plummer NW, Spicher K, Malphurs J, Akiyama H, Abramowitz J, Nürnberg B, Birnbaumer L.
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| Proc Natl Acad Sci U S A 109(52):21366-71. doi: 10.1073/pnas.1219810110. Epub 2012 Dec 11.
2012
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| 10 | GNAI2, OXT
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| The essential role of Giα2 in prostate cancer cell migration.
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| Zhong M, Clarke S, Vo BT, Khan SA.
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| Mol Cancer Res 10(10):1380-8. doi: 10.1158/1541-7786.MCR-12-0219. Epub 2012 Aug 30.
2012
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| 11 | CLDN5, GNAI2
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| Guanine nucleotide-binding protein Gαi2: a new partner of claudin-5 that regulates tight junction integrity in human brain endothelial cells.
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| Luissint AC, Federici C, Guillonneau F, Chrétien F, Camoin L, Glacial F, Ganeshamoorthy K, Couraud PO.
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| J Cereb Blood Flow Metab 32(5):860-73. doi: 10.1038/jcbfm.2011.202. Epub 2012 Feb 15.
2012
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| 12 | CXCL12, GNAI2, RASGRP1, ZAP70
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| G alpha i2 and ZAP-70 mediate RasGRP1 membrane localization and activation of SDF-1-induced T cell functions.
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| Kremer KN, Kumar A, Hedin KE.
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| J Immunol 187(6):3177-85. doi: 10.4049/jimmunol.1100206. Epub 2011 Aug 19.
2011
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| 13 | GNAI2, MTA1
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| Acetylation-dependent oncogenic activity of metastasis-associated protein 1 co-regulator.
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| Ohshiro K, Rayala SK, Wigerup C, Pakala SB, Natha RS, Gururaj AE, Molli PR, Månsson SS, Ramezani A, Hawley RG, Landberg G, Lee NH, Kumar R.
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| EMBO Rep 11(9):691-7. Epub 2010 Jul 23. 2010
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| 14 | GNAI2
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| Absence of the inhibitory G-protein Galphai2 predisposes to ventricular cardiac arrhythmia.
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| Zuberi Z, Nobles M, Sebastian S, Dyson A, Lim SY, Breckenridge R, Birnbaumer L, Tinker A.
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| Circ Arrhythm Electrophysiol 3(4):391-400. Epub 2010 May 21.PMID: 20495013 2010
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| 15 | GNAI2, RGS1
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| Variations in Gnai2 and Rgs1 expression affect chemokine receptor signaling and the organization of secondary lymphoid organs.
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| Hwang IY, Park C, Harrision KA, Huang NN, Kehrl JH.
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| Genes Immun 11(5):384-96. doi: 10.1038/gene.2010.27. Epub 2010 May 27.
2010
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| 16 | GNAI2
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| GNAI2 and regulators of G protein signaling as a potential Noonan syndrome mechanism.
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| Huang X, Fu Y, Charbeneau RA, Neubig RR.
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| Med Hypotheses 73(1):56-9. Epub 2009 Mar 17.PMID: 19282110 2009
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| 17 | GNAI2, GNAI3
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| Requirement of Galphai in thymic homing and early T cell development.
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| Jin Y, Wu MX.
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| Mol Immunol 45(12):3401-10. Epub 2008 May 23.PMID: 18501427 2008
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| 18 | GNAI2, TRPC4
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| The specific activation of TRPC4 by Gi protein subtype.
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| Jeon JP, Lee KP, Park EJ, Sung TS, Kim BJ, Jeon JH, So I.
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| Biochem Biophys Res Commun 377(2):538-43. doi: 10.1016/j.bbrc.2008.10.012. Epub 2008 Oct 12.
2008
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| 19 | GNAI2
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| Role of a Galphai2 protein splice variant in the formation of an intracellular dopamine D2 receptor pool.
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| López-Aranda MF, Acevedo MJ, Gutierrez A, Koulen P, Khan ZU.
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| J Cell Sci 120(Pt 13):2171-8. Epub 2007 Jun 5.PMID: 17550964 2007
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| 20 | GNAI2
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| Galphai2 is required for chemokine-induced neutrophil arrest.
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| Zarbock A, Deem TL, Burcin TL, Ley K.
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| Blood 110(10):3773-9. Epub 2007 Aug 15.PMID: 17699741 2007
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| 21 | GNAI2
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| The -318 C>G single-nucleotide polymorphism in GNAI2 gene promoter region impairs transcriptional activity through specific binding of Sp1 transcription factor and is associated with high blood pressure in Caucasians from Italy.
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| Menzaghi C, Paroni G, De Bonis C, Soccio T, Marucci A, Bacci S, Trischitta V.
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| J Am Soc Nephrol 17(4 Suppl 2):S115-9. 2006
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| 22 | GNAI2
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| Transcriptional activation of the human Galphai2 gene promoter through nuclear factor-kappaB and antioxidant response elements.
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| Arinze IJ, Kawai Y.
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| J Biol Chem 280(11):9786-95. Epub 2005 Jan 7. 2005
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| 23 | GNAI2, UNC5B
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| Modulation of G(ialpha(2)) signaling by the axonal guidance molecule UNC5H2.
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| Komatsuzaki K, Dalvin S, Kinane TB.
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| Biochem Biophys Res Commun 297(4):898-905. 2002
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| 24 | GNAI1, GNAI2
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| Agonists activate Gi1 alpha or Gi2 alpha fused to the human mu opioid receptor differently.
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| Massotte D, Brillet K, Kieffer B, Milligan G.
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| J Neurochem 81(6):1372-82. 2002
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| 25 | GNAI2, GNAI2L
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| Regional localization of the human G protein alpha-i-2(GNAI2) gene : assignment to 3p21 and a related sequence (GNAI2L) to 12p12-p13.
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| Magovcevic I, et al.
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| Genomics 12 : 125-129. 1992
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| 26 | GNAI1, GNAI2, GNAI2L, GNAI3, GNAZ, GNAS, GNAT1, GNAT2, GNB1, GNB2
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| Chromosomal localization of genes encoding guanine nucleotide-binding protein subunits in mouse and human.
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| Blatt C, Eversole-Cire P, Cohn VH, Zollman S, Fournier RE, Mohandas LT, Nesbitt M, Lugo T, Jones DT, Reed RR, et al.
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| Proc Natl Acad Sci U S A 85 : 7642-7646. 1988
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| 27 | GNAT1, GNAT2, GNAI2, GNAI2L, GNAI3, GNAS, GNB1
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| Mapping of genes encoding the subunits of guanine nucleotide-binding proteins (G-proteins) in humans.
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| Sparkes RS, et al.
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| (HGM9) Cytogenet Cell Genet 46 : 696. 1987
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| 28 | GNAI1, GNAI2, GNAI2L, GNAI3
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| The human genome encodes at least three non-allellic G proteins with alpha-i-type subunits.
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| Suki WN, et al.
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| FEBS Lett 220 : 187-192. 1987
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