Citations for
1GLI1, GLI2, NEK2, SUFU
Nek2A/SuFu feedback loop regulates Gli-mediated Hedgehog signaling pathway.
Zhou F, Huang D, Li Y, Hu G, Rao H, Lu Q, Luo S, Wang Y.
Int J Oncol 50(2):373-380. doi: 10.3892/ijo.2016.3819. Epub 2016 Dec 23. 2017
2CREBBP, GLI2, GLI3, PRKACA
Mutations of the Sonic Hedgehog Pathway Underlie Hypothalamic Hamartoma with Gelastic Epilepsy.
Hildebrand MS, Griffin NG, Damiano JA, Cops EJ, Burgess R, Ozturk E, Jones NC, Leventer RJ, Freeman JL, Harvey AS, Sadleir LG, Scheffer IE, Major H, Darbro BW, Allen AS, Goldstein DB, Kerrigan JF, Berkovic SF, Heinzen EL.
Am J Hum Genet 99(2):423-9. doi: 10.1016/j.ajhg.2016.05.031. Epub 2016 Jul 21. 2016
3GLI2, GLI3, SPOP
Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling.
Cai H, Liu A.
Proc Natl Acad Sci U S A 113(51):14751-14756. doi: 10.1073/pnas.1612520114. Epub 2016 Dec 5. 2016
4GLI1, GLI2, GLI3, KIF3A, KIF3B, KIFAP3
The heterotrimeric kinesin-2 complex interacts with and regulates GLI protein function.
Carpenter BS, Barry RL, Verhey KJ, Allen BL.
J Cell Sci 128(5):1034-50. doi: 10.1242/jcs.162552. Epub 2015 Jan 14. 2015
5GLI1, GLI2, TAF9, TP53
p53 modulates the activity of the GLI1 oncogene through interactions with the shared coactivator TAF9.
Yoon JW, Lamm M, Iannaccone S, Higashiyama N, Leong KF, Iannaccone P, Walterhouse D.
DNA Repair (Amst). Oct;34:9-17. doi: 10.1016/j.dnarep.2015.06.006. Epub 2015 Aug 1 2015
6ACDMPV, DEL16Q241, FOXF1, GLI2
Small noncoding differentially methylated copy-number variants, including lncRNA genes, cause a lethal lung developmental disorder.
Szafranski P, Dharmadhikari AV, Brosens E, Gurha P, Kolodziejska KE, Zhishuo O, Dittwald P, Majewski T, Mohan KN, Chen B, Person RE, Tibboel D, de Klein A, Pinner J, Chopra M, Malcolm G, Peters G, Arbuckle S, Guiang SF 3rd, Hustead VA, Jessurun J, Hirsch R, Witte DP, Maystadt I, Sebire N, Fisher R, Langston C, Sen P, Stankiewicz P.
Genome Res 23(1):23-33. doi: 10.1101/gr.141887.112. Epub 2012 Oct 3. 2013
7GLI1, GLI2, MAP3K10
MAP3K10 promotes the proliferation and decreases the sensitivity of pancreatic cancer cells to gemcitabine by upregulating Gli-1 and Gli-2.
An Y, Cai B, Chen J, Lv N, Yao J, Xue X, Tu M, Tang D, Wei J, Jiang K, Wu J, Li Q, Gao W, Miao Y.
Cancer Lett 329(2):228-35. doi: 10.1016/j.canlet.2012.11.005. Epub 2012 Nov 23. 2013
8GLI2, GLI3
Specific requirement of Gli transcription factors in Hedgehog-mediated intestinal development.
Huang H, Cotton JL, Wang Y, Rajurkar M, Zhu LJ, Lewis BC, Mao J.
J Biol Chem 288(24):17589-96. doi: 10.1074/jbc.M113.467498. Epub 2013 May 3. 2013
9GLI1, GLI2, PKD1L1, PKD2L1
Primary cilia are specialized calcium signalling organelles.
Delling M, DeCaen PG, Doerner JF, Febvay S, Clapham DE.
Nature 504(7479):311-4. doi: 10.1038/nature12833. 2013
10GLI1, GLI2, GLI3
Gli1 protein participates in Hedgehog-mediated specification of osteoblast lineage during endochondral ossification.
Hojo H, Ohba S, Yano F, Saito T, Ikeda T, Nakajima K, Komiyama Y, Nakagata N, Suzuki K, Takato T, Kawaguchi H, Chung UI.
J Biol Chem 287(21):17860-9. doi: 10.1074/jbc.M112.347716. Epub 2012 Apr 9. 2012
11GLI2, GLI3
Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3.
Bowers M, Eng L, Lao Z, Turnbull RK, Bao X, Riedel E, Mackem S, Joyner AL.
Dev Biol 370(1):110-24. doi: 10.1016/j.ydbio.2012.07.017. Epub 2012 Jul 25. 2012
12GLI2, GLI3, TMEM107
Forward genetics uncovers Transmembrane protein 107 as a novel factor required for ciliogenesis and Sonic hedgehog signaling.
Christopher KJ, Wang B, Kong Y, Weatherbee SD.
Dev Biol 368(2):382-92. doi: 10.1016/j.ydbio.2012.06.008. Epub 2012 Jun 12. 2012
13GLI2
Small ubiquitin-like Modifier (SUMO) modification inhibits GLI2 protein transcriptional activity in vitro and in vivo.
Han L, Pan Y, Wang B.
J Biol Chem 287(24):20483-9. doi: 10.1074/jbc.M112.359299. Epub 2012 May 1. 2012
14GLI2, KIF7, SUFU
Antagonistic and cooperative actions of Kif7 and Sufu define graded intracellular Gli activities in Hedgehog signaling.
Law KK, Makino S, Mo R, Zhang X, Puviindran V, Hui CC.
PLoS One 7(11):e50193. doi: 10.1371/journal.pone.0050193. Epub 2012 Nov 16. 2012
15GLI2, KIF7, SUFU
Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesis.
Li ZJ, Nieuwenhuis E, Nien W, Zhang X, Zhang J, Puviindran V, Wainwright BJ, Kim PC, Hui CC.
Development 139(22):4152-61. doi: 10.1242/dev.081190. Epub 2012 Oct 3. 2012
16GLI2, MITF
Expression of microphthalmia-associated transcription factor (MITF), which is critical for melanoma progression, is inhibited by both transcription factor GLI2 and transforming growth factor-β.
Pierrat MJ, Marsaud V, Mauviel A, Javelaud D.
J Biol Chem 287(22):17996-8004. doi: 10.1074/jbc.M112.358341. Epub 2012 Apr 11. 2012
17GLI2, HDAC5
Small ubiquitin-like Modifier (SUMO) modification inhibits GLI2 protein transcriptional activity in vitro and in vivo.
Han L, Pan Y, Wang B.
J Biol Chem 287(24):20483-9. doi: 10.1074/jbc.M112.359299. Epub 2012 May 1. 2012
18DEL2Q14, GLI2
A patient with a mild holoprosencephaly spectrum phenotype and heterotaxy and a 1.3 Mb deletion encompassing GLI2.
Kevelam SH, van Harssel JJ, van der Zwaag B, Smeets HJ, Paulussen AD, Lichtenbelt KD.
Am J Med Genet A m J Med Genet A. 2011 Nov 21. doi: 10.1002/ajmg.a.34350. [Epub ahead of print] 2011
19CCL5, GLI2, IL6
GLI2 transcription factor mediates cytokine cross-talk in the tumor microenvironment.
Elsawa SF, Almada LL, Ziesmer SC, Novak AJ, Witzig TE, Ansell SM, Fernandez-Zapico ME.
J Biol Chem 286(24):21524-34. Epub 2011 Mar 18. 2011
20GLI1, GLI2
Redundant and differential roles of transcription factors Gli1 and Gli2 in the development of mouse fetal Leydig cells.
Barsoum I, Yao HH.
Biol Reprod 84(5):894-9. Epub 2011 Jan 5. 2011
21GLI2, MEF2C
Gli2 and MEF2C activate each other's expression and function synergistically during cardiomyogenesis in vitro.
Voronova A, Al Madhoun A, Fischer A, Shelton M, Karamboulas C, Skerjanc IS.
Nucleic Acids Res ucleic Acids Res. 2011 Dec 22. [Epub ahead of print] 2011
22GLI1, GLI2, GLI3
SUMOylation by Pias1 regulates the activity of the Hedgehog dependent Gli transcription factors.
Cox B, Briscoe J, Ulloa F.
PLoS One 5(8):e11996. 2010
23GLI2
GLI2-mediated melanoma invasion and metastasis.
Alexaki VI, Javelaud D, Van Kempen LC, Mohammad KS, Dennler S, Luciani F, Hoek KS, Juārez P, Goydos JS, Fournier PJ, Sibon C, Bertolotto C, Verrecchia F, Saule S, Delmas V, Ballotti R, Larue L, Saiag P, Guise TA, Mauviel A.
J Natl Cancer Inst 102(15):1148-59. Epub 2010 Jul 21. 2010
24GLI2
Primary cilia regulate Gli/Hedgehog activation in pancreas.
Cervantes S, Lau J, Cano DA, Borromeo-Austin C, Hebrok M.
Proc Natl Acad Sci U S A 107(22):10109-14. Epub 2010 May 17. 2010
25BMP2, GLI2
Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2.
Zhao M, Ko SY, Liu JH, Chen D, Zhang J, Wang B, Harris SE, Oyajobi BO, Mundy GR.
Mol Cell Biol 29(5):1291-305. Epub 2008 Dec 22. 2009
26GLI2, INHBB, INSIG2, SHFLD3
Characterization of two ectrodactyly-associated translocation breakpoints separated by 2.5 Mb on chromosome 2q14.1-q14.2.
David D, Marques B, Ferreira C, Vieira P, Corona-Rivera A, Ferreira JC, van Bokhoven H.
Eur J Hum Genet 17(8):1024-33. Epub 2009 Feb 18. 2009
27GLI2
Cloning of the human GLI2 Promoter: transcriptional activation by transforming growth factor-beta via SMAD3/beta-catenin cooperation.
Dennler S, André J, Verrecchia F, Mauviel A.
J Biol Chem 284(46):31523-31. Epub 2009 Sep 21. 2009
28GLI2
Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus.
Kim J, Kato M, Beachy PA.
Proc Natl Acad Sci U S A 106(51):21666-71. Epub 2009 Dec 8.PMID: 19996169 2009
29GLI2, GLI3
The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization.
Joeng KS, Long F.
Development 136(24):4177-85. Epub 2009 Nov 11. 2009
30GLI1, GLI2, GLI3, SPOP, SUFU
Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved.
Chen MH, Wilson CW, Li YJ, Law KK, Lu CS, Gacayan R, Zhang X, Hui CC, Chuang PT.
Genes Dev 23(16):1910-28. 2009
31GLI2, TP53, TP63, TP73
Integrative genomic analyses on GLI2: mechanism of Hedgehog priming through basal GLI2 expression, and interaction map of stem cell signaling network with P53.
Katoh Y, Katoh M.
Int J Oncol 33(4):881-6. 2008
32FST, GLI2
GLI2-specific transcriptional activation of the bone morphogenetic protein/activin antagonist follistatin in human epidermal cells.
Eichberger T, Kaser A, Pixner C, Schmid C, Klingler S, Winklmayr M, Hauser-Kronberger C, Aberger F, Frischauf AM.
J Biol Chem 283(18):12426-37. Epub 2008 Mar 3. 2008
33GLI2
Role of GLI2 transcription factor in growth and tumorigenicity of prostate cells.
Thiyagarajan S, Bhatia N, Reagan-Shaw S, Cozma D, Thomas-Tikhonenko A, Ahmad N, Spiegelman VS.
Cancer Res 67(22):10642-6. 2007
34GLI1, GLI2
Overlapping and distinct transcriptional regulator properties of the GLI1 and GLI2 oncogenes.
Eichberger T, Sander V, Schnidar H, Regl G, Kasper M, Schmid C, Plamberger S, Kaser A, Aberger F, Frischauf AM.
Genomics 87(5):616-32. Epub 2006 Jan 24. 2006
35GLI2, BMP2
The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling.
Zhao M, Qiao M, Harris SE, Chen D, Oyajobi BO, Mundy GR.
Mol Cell Biol 26(16):6197-208. 2006
36GLI2
A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2.
Roessler E, Ermilov AN, Grange DK, Wang A, Grachtchouk M, Dlugosz AA, Muenke M.
Hum Mol Genet 14(15):2181-8. Epub 2005 Jun 30. 2005
37PTCH1, GLI1, GLI2, GLI3
Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site.
Agren M, Kogerman P, Kleman MI, Wessling M, Toftgard R.
Gene 330:101-14. 2004
38GLI2, FOXE1
FOXE1, a new transcriptional target of GLI2 is expressed in human epidermis and basal cell carcinoma.
Eichberger T, Regl G, Ikram MS, Neill GW, Philpott MP, Aberger F, Frischauf AM.
J Invest Dermatol 122(5):1180-7. 2004
39GLI1, GLI2
GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter.
Ikram MS, Neill GW, Regl G, Eichberger T, Frischauf AM, Aberger F, Quinn A, Philpott M.
J Invest Dermatol 122(6):1503-9. 2004
40GLI2, MEOX1, PAX3
Disruption of Meox or Gli activity ablates skeletal myogenesis in P19 cells.
Petropoulos H, Gianakopoulos PJ, Ridgeway AG, Skerjanc IS.
J Biol Chem 279(23):23874-81. Epub 2004 Mar 23. 2004
41HPE9, GLI2
Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features.
Roessler E, Du YZ, Mullor JL, Casas E, Allen WP, Gillessen-Kaesbach G, Roeder ER, Ming JE, Ruiz i Altaba A, Muenke M.
Proc Natl Acad Sci U S A 100(23):13424-9. Epub 2003 Oct 27. 2003
42GLI1, GLI2
Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma.
Regl G, Neill GW, Eichberger T, Kasper M, Ikram MS, Koller J, Hintner H, Quinn AG, Frischauf AM, Aberger F.
Oncogene 21(36):5529-39. 2002
43GLI2, GLI3
Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus.
Motoyama J, et al.
Nat Genet 20 : 54-57. 1998
44GLI2
Assignment of the human GLI2 gene to 2q14 by fluorescence in situ hybridization.
Matsumoto N, et al.
Genomics 36 : 220-221. 1996
45HKR1, ZSCAN22, ZBTB48, GLI2, GLI3, GLI4
The GLI-Kruppel family of human genes.
Ruppert JM, et al.
Mol Cell Biol 8 : 3104-3113. 1988