| 1 | ETV5, GHRL
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| ETV5 regulates GOAT/ghrelin system in an mTORC1-dependent manner.
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| Mao Z, Yang Q, Yin W, Su W, Lin H, Feng M, Pan K, Yin Y, Zhang W.
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| Mol Cell Endocrinol ol Cell Endocrinol. 2019 Feb 5. pii: S0303-7207(19)30047-4. doi: 10.1016/j.mce.2019.02.003. [Epub ahead of print]
2019
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| 2 | GHRL
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| Stress increased ghrelin secretion from pancreatic isolated islets in male rats.
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| Rostamkhani F, Zardooz H, Goshadrou F, Baveisi M, Hedayati M.
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| Gen Physiol Biophys 35(1):109-17. doi: 10.4149/gpb_2015037.
2016
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| 3 | GHRL
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| Ghrelin and Leptin Have a Complex Relationship with Risk of Barrett's Esophagus.
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| Thomas SJ, Almers L, Schneider J, Graham JE, Havel PJ, Corley DA.
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| Dig Dis Sci 61(1):70-9. doi: 10.1007/s10620-015-3867-6.
2016
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| 4 | ALB, GHRL
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| Ghrelin binding to serum albumin and its biological impact.
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| Lufrano D, Trejo SA, Llovera RE, Salgueiro M, Fernandez G, Martínez Damonte V, González Flecha FL, Raingo J, Ermácora MR, Perelló M.
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| Mol Cell Endocrinol 436:130-40. doi: 10.1016/j.mce.2016.07.016. Epub 2016 Jul 16.
2016
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| 5 | GHRL
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| Extrinsic ghrelin in the paraventricular nucleus increases small intestinal motility in rats by activating central growth hormone secretagogue and enteric cholinergic receptors.
|
| Wang Y, Chen F, Shi H, Jiang J, Li H, Qin B, Li Y.
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| Peptides 74:43-9. doi: 10.1016/j.peptides.2015.09.009.
2015
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| 6 | GHRL, NKX2-2
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| Regulation of the Human Ghrelin Promoter Activity by Transcription Factors, NF-κB and Nkx2.2.
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| Shiimura Y, Ohgusu H, Sato T, Kojima M.
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| Int J Endocrinol 2015:580908. doi: 10.1155/2015/580908. Epub 2015 Jan 28.
2015
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| 7 | GHRL
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| Ghrelin and atherosclerosis.
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| Ukkola O.
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| Curr Opin Lipidol 26(4):288-91. doi: 10.1097/MOL.0000000000000183. Review.
2015
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| 8 | GHRL
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| Ghrelin Inhibition Restores Glucose Homeostasis in Hepatocyte Nuclear Factor-1α (MODY3)-Deficient Mice.
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| Brial F, Lussier CR, Belleville K, Sarret P, Boudreau F.
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| Diabetes 64(9):3314-20. doi: 10.2337/db15-0124.
2015
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| 9 | GHRL
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| Ghrelin suppresses proliferation of fetal neural progenitor cells, and induces their differentiation into neurons.
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| Watanabe J, Matsumoto M, Kageyama H, Murai N, Sasaki S, Hirako S, Wada N, Arata S, Shioda S.
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| Peptides 69:40-6. doi: 10.1016/j.peptides.2015.03.014.
2015
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| 10 | GHRL
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| Neonatal ghrelin programs development of hypothalamic feeding circuits.
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| Steculorum SM, Collden G, Coupe B, Croizier S, Lockie S, Andrews ZB, Jarosch F, Klussmann S, Bouret SG.
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| J Clin Invest 125(2):846-58. doi: 10.1172/JCI73688.
2015
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| 11 | GHRL
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| Hyperghrelinemia in Prader-Willi syndrome begins in early infancy long before the onset of hyperphagia.
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| Kweh FA, Miller JL, Sulsona CR, Wasserfall C, Atkinson M, Shuster JJ, Goldstone AP, Driscoll DJ.
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| Am J Med Genet A 167A(1):69-79. doi: 10.1002/ajmg.a.36810.
2015
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| 12 | GHRL
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| The regulation of circulating ghrelin - with recent updates from cell-based assays.
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| Iwakura H, Kangawa K, Nakao K.
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| Endocr J 62(2):107-22. doi: 10.1507/endocrj.EJ14-0419. Review.
2015
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| 13 | GHRL, HHAT, PORCN
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| Membrane bound O-acyltransferases and their inhibitors.
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| Masumoto N, Lanyon-Hogg T, Rodgers UR, Konitsiotis AD, Magee AI, Tate EW.
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| Biochem Soc Trans 43(2):246-52. doi: 10.1042/BST20150018. Review.
2015
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| 14 | GHRL
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| Altered ghrelin levels in boys with autism: a novel finding associated with hormonal dysregulation.
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| Al-Zaid FS, Alhader AA, Al-Ayadhi LY.
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| Sci Rep 4:6478. doi: 10.1038/srep06478.
2014
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| 15 | GHRL
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| Function of ghrelin and ghrelin receptors in the network regulation of gastric motility.
|
| Yang CG, Liao ZF, Qiu WC, Yan J, Wang ZG.
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| Mol Med Rep 10(5):2453-8. doi: 10.3892/mmr.2014.2571.
2014
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| 16 | GHRL
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| Reduction in circulating ghrelin concentration after maturation does not affect food intake.
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| Ariyasu H, Yamada G, Iwakura H, Matsumura S, Inoue K, Kangawa K, Nakao K, Akamizu T.
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| Endocr J 61(10):1041-52.
2014
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| 17 | GHRL, LEP
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| Role of leptin and ghrelin in induction of differentiation of IL-17-producing and T-regulatory cells.
|
| Orlova EG, Shirshev SV.
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| Bull Exp Biol Med 156(6):819-22. doi: 10.1007/s10517-014-2459-3.
2014
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| 18 | GHRL, GHSR
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| Ghrelin triggers the synaptic incorporation of AMPA receptors in the hippocampus.
|
| Ribeiro LF, Catarino T, Santos SD, Benoist M, van Leeuwen JF, Esteban JA, Carvalho AL.
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| Proc Natl Acad Sci U S A 111(1):E149-58. doi: 10.1073/pnas.1313798111.
2014
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| 19 | GHRL
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| Ghrelin stimulates proliferation, migration and differentiation of neural progenitors from the subventricular zone in the adult mice.
|
| Li E, Kim Y, Kim S, Sato T, Kojima M, Park S.
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| Exp Neurol 252:75-84. doi: 10.1016/j.expneurol.2013.11.021.
2014
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| 20 | GHRL
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| Immunolocalisation of ghrelin and obestatin in human testis, seminal vesicles, prostate and spermatozoa.
|
| Moretti E, Vindigni C, Tripodi SA, Mazzi L, Nuti R, Figura N, Collodel G.
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| Andrologia 46(9):979-85. doi: 10.1111/and.12183.
2014
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| 21 | CPT1A, CPT1C, GHRL
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| Hypothalamic ceramide levels regulated by CPT1C mediate the orexigenic effect of ghrelin.
|
| Ramírez S, Martins L, Jacas J, Carrasco P, Pozo M, Clotet J, Serra D, Hegardt FG, Diéguez C, López M, Casals N.
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| Diabetes 62(7):2329-37. doi: 10.2337/db12-1451.
2013
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| 22 | GHRL
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| The role of obestatin in glucose and lipid metabolism.
|
| Gargantini E, Grande C, Trovato L, Ghigo E, Granata R.
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| Horm Metab Res 45(13):1002-8. doi: 10.1055/s-0033-1351325. Review.
2013
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| 23 | GHRL
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| Ghrelin stimulates synaptic formation in cultured cortical networks in a dose-dependent manner.
|
| Stoyanova II, le Feber J, Rutten WL.
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| Regul Pept 186:43-8. doi: 10.1016/j.regpep.2013.07.004.
2013
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| 24 | GHRL
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| Ghrelin requires p53 to stimulate lipid storage in fat and liver.
|
| Porteiro B, Díaz-Ruíz A, Martínez G, Senra A, Vidal A, Serrano M, Gualillo O, López M, Malagón MM, Diéguez C, Nogueiras R.
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| Endocrinology 154(10):3671-9. doi: 10.1210/en.2013-1176.
2013
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| 25 | GHRL
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| Different ghrelin localisation in adult human and rat endocrine pancreas.
|
| Raghay K, Gallego R, Scoazec JY, Garcia-Caballero T, Morel G.
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| Cell Tissue Res 352(3):487-94. doi: 10.1007/s00441-013-1593-y.
2013
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| 26 | GHRL
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| High concentration of ghrelin in children with growth hormone deficiency and neurosecretory dysfunction.
|
| Stawerska R, Smyczyńska J, Czkwianianc E, Hilczer M, Lewiński A.
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| Neuro Endocrinol Lett 33(3):331-9.
2012
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| 27 | GHRL
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| Functional neuroimaging demonstrates that ghrelin inhibits the central nervous system response to ingested lipid.
|
| Jones RB, McKie S, Astbury N, Little TJ, Tivey S, Lassman DJ, McLaughlin J, Luckman S, Williams SR, Dockray GJ, Thompson DG.
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| Gut 61(11):1543-51.
2012
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| 28 | GHRL
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| The relationship of active ghrelin levels and intrauterine growth in preterm infants.
|
| Sahin H, Erener T, Erginoz E, Vural M, Ilikkan B, Kavuncuoglu S, Yildiz H, Perk Y.
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| Eur J Endocrinol 166(3):399-405. doi: 10.1530/EJE-11-0607.
2012
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| 29 | GHRL, GPR39
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| The obestatin/GPR39 system is up-regulated by muscle injury and functions as an autocrine regenerative system.
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| Gurriarán-Rodríguez U, Santos-Zas I, Al-Massadi O, Mosteiro CS, Beiroa D, Nogueiras R, Crujeiras AB, Seoane LM, Señarís J, García-Caballero T, Gallego R, Casanueva FF, Pazos Y, Camiña JP.
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| J Biol Chem 287(45):38379-89. doi: 10.1074/jbc.M112.374926. Epub 2012 Sep 19.
2012
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| 30 | GHRL
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| Ghrelin enhances olfactory sensitivity and exploratory sniffing in rodents and humans.
|
| Tong J, Mannea E, Aimé P, Pfluger PT, Yi CX, Castaneda TR, Davis HW, Ren X, Pixley S, Benoit S, Julliard K, Woods SC, Horvath TL, Sleeman MM, D'Alessio D, Obici S, Frank R, Tschöp MH.
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| J Neurosci 31(15):5841-6.
2011
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| 31 | GH1, GHRL
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| The role of ghrelin in GH secretion and GH disorders.
|
| Nass R, Gaylinn BD, Thorner MO.
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| Mol Cell Endocrinol 340(1):10-4. Epub 2011 Apr 1. Review.
2011
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| 32 | GHRL
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| Ghrelin, a novel peptide hormone in the regulation of energy balance and cardiovascular function.
|
| Ledderose C, Kreth S, Beiras-Fernandez A.
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| Recent Pat Endocr Metab Immune Drug Discov 5(1):1-6. Review.
2011
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| 33 | GHRL, GHSR
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| Ghrelin inhibits proliferation and increases T-type Ca2+ channel expression in PC-3 human prostate carcinoma cells.
|
| Díaz-Lezama N, Hernández-Elvira M, Sandoval A, Monroy A, Felix R, Monjaraz E.
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| Biochem Biophys Res Commun 403(1):24-9. Epub 2010 Oct 30.
2010
|
| 34 | GHRL, GHSR
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| Altered myocardial expression of ghrelin and its receptor (GHSR-1a) in patients with severe heart failure.
|
| Beiras-Fernandez A, Kreth S, Weis F, Ledderose C, Pöttinger T, Dieguez C, Beiras A, Reichart B.
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| Peptides 31(12):2222-8. Epub 2010 Sep 8.
2010
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| 35 | GHRL, NKX2-2
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| Nkx2.2 activates the ghrelin promoter in pancreatic islet cells.
|
| Hill JT, Chao CS, Anderson KR, Kaufman F, Johnson CW, Sussel L.
|
| Mol Endocrinol 24(2):381-90. doi: 10.1210/me.2009-0360. Epub 2009 Dec 4.
2010
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| 36 | GHRL, KLF4
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| KLF4 positively regulates human ghrelin expression.
|
| Lee HJ, Kang YM, Moon CS, Joe MK, Lim JH, Suh YH, Song J, Jung MH.
|
| Biochem J 420(3):403-11.
2009
|
| 37 | GHRL, GHSR
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| Expression of ghrelin and its receptor in human tissues.
|
| Ueberberg B, Unger N, Saeger W, Mann K, Petersenn S.
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| Horm Metab Res 41(11):814-21. Epub 2009 Aug 10.
2009
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| 38 | GHRL
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| Hyperghrelinemia precedes obesity in Prader-Willi syndrome.
|
| Feigerlova E, Diene G, Conte-Auriol F, Molinas C, Gennero I, Salles JP, Arnaud C, Tauber M.
|
| J Clin Endocrinol Metab 93(7):2800-5. Epub 2008 May 6. 2008
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| 39 | GHRL
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| Obestatin: its physicochemical characteristics and physiological functions.
|
| Tang SQ, Jiang QY, Zhang YL, Zhu XT, Shu G, Gao P, Feng DY, Wang XQ, Dong XY.
|
| Peptides 29(4):639-45. Epub 2008 Jan 31. Review.
2008
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| 40 | GHRL, PAX4
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| Ghrelin is a novel target of Pax4 in endocrine progenitors of the pancreas and duodenum.
|
| Wang Q, Elghazi L, Martin S, Martins I, Srinivasan RS, Geng X, Sleeman M, Collombat P, Houghton J, Sosa-Pineda B.
|
| Dev Dyn 237(1):51-61.PMID: 18058910 2008
|
| 41 | GHRL
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| Obestatin promotes survival of pancreatic beta-cells and human islets and induces expression of genes involved in the regulation of beta-cell mass and function.
|
| Granata R, Settanni F, Gallo D, Trovato L, Biancone L, Cantaluppi V, Nano R, Annunziata M, Campiglia P, Arnoletti E, Ghè C, Volante M, Papotti M, Muccioli G, Ghigo E.
|
| Diabetes 57(4):967-79. Epub 2007 Dec 27.PMID: 18162507 2008
|
| 42 | GHRL, GPR39
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| Obestatin induction of early-response gene expression in gastrointestinal and adipose tissues and the mediatory role of G protein-coupled receptor, GPR39.
|
| Zhang JV, Jahr H, Luo CW, Klein C, Van Kolen K, Ver Donck L, De A, Baart E, Li J, Moechars D, Hsueh AJ.
|
| Mol Endocrinol 22(6):1464-75. Epub 2008 Mar 12.PMID: 18337590 2008
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| 43 | GHRL
|
| Circulating obestatin levels in normal subjects and in patients with impaired glucose regulation and type 2 diabetes mellitus.
|
| Qi X, Li L, Yang G, Liu J, Li K, Tang Y, Liou H, Boden G.
|
| Clin Endocrinol (Oxf) 66(4):593-7.
2007
|
| 44 | GHRL, GPR39
|
| The obestatin receptor (GPR39) is expressed in human adipose tissue and is down-regulated in obesity-associated type 2 diabetes mellitus.
|
| Catalán V, Gómez-Ambrosi J, Rotellar F, Silva C, Gil MJ, Rodríguez A, Cienfuegos JA, Salvador J, Frühbeck G.
|
| Clin Endocrinol (Oxf) 66(4):598-601.
2007
|
| 45 | GHRL
|
| Ghrelin reduces hepatic mitochondrial fatty acid beta oxidation.
|
| Rigault C, Le Borgne F, Georges B, Demarquoy J.
|
| J Endocrinol Invest 30(4):RC4-8.
2007
|
| 46 | GHRL
|
| Ghrelin as a novel locally produced relaxing peptide of the iris sphincter and dilator muscles.
|
| Rocha-Sousa A, Saraiva J, Henriques-Coelho T, Falcão-Reis F, Correia-Pinto J, Leite-Moreira AF.
|
| Exp Eye Res 83(5):1179-87. Epub 2006 Aug 10.
2006
|
| 47 | GHRL
|
| Ghrelin and bone metabolism in adolescent girls with anorexia nervosa and healthy adolescents.
|
| Misra M, Miller KK, Stewart V, Hunter E, Kuo K, Herzog DB, Klibanski A.
|
| J Clin Endocrinol Metab 90(9):5082-7. Epub 2005 Jul 5. 2005
|
| 48 | GHRL
|
| Plasma concentrations of adrenomedullin and ghrelin in hemodialysis patients with sustained and episodic hypotension.
|
| Iwanaga K, Takamura N, Abe Y, Zhaojia Y, Shinzato K, Hosoda H, Kangawa K, Ohtsuru A, Kohno S, Yamashita S, Aoyagi K.
|
| Endocr J 52(1):23-8. 2005
|
| 49 | GHRL
|
| Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake.
|
| Zhang JV, Ren PG, Avsian-Kretchmer O, Luo CW, Rauch R, Klein C, Hsueh AJ.
|
| Science 310(5750):996-9. 2005
|
| 50 | GHRL
|
| Genomic structure and characterization of the 5'-flanking region of the human ghrelin gene.
|
| Kanamoto N, Akamizu T, Tagami T, Hataya Y, Moriyama K, Takaya K, Hosoda H, Kojima M, Kangawa K, Nakao K.
|
| Endocrinology 145(9):4144-53. Epub 2004 May 13. 2004
|
| 51 | GHRL
|
| Cloning and characterization of the 5(')-flanking region of the human ghrelin gene.
|
| Kishimoto M, Okimura Y, Nakata H, Kudo T, Iguchi G, Takahashi Y, Kaji H, Chihara K.
|
| Biochem Biophys Res Commun 305(1):186-92. 2003
|
| 52 | GHRL
|
| Characterization of partially truncated human midkine expressed in Pichia pastoris.
|
| Murasugi A, Tohma-Aiba Y.
|
| Biosci Biotechnol Biochem 66(6):1295-300. 2002
|
| 53 | GHRL
|
| Ghrelin and the hyposomatotropism of obesity.
|
| Lindeman JH, Pijl H, Van Dielen FM, Lentjes EG, Van Leuven C, Kooistra T.
|
| Obes Res 10(11):1161-6. 2002
|
| 54 | GHRL
|
| Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion.
|
| Date Y, Nakazato M, Hashiguchi S, Dezaki K, Mondal MS, Hosoda H, Kojima M, Kangawa K, Arima T, Matsuo H, Yada T, Matsukura S.
|
| Diabetes 51(1):124-9. 2002
|
| 55 | GHRL
|
| Ghrelin gene: identification of missense variants and a frameshift mutation in extremely obese children and adolescents and healthy normal weight students.
|
| Hinney A, Hoch A, Geller F, Schafer H, Siegfried W, Goldschmidt H, Remschmidt H, Hebebrand J.
|
| J Clin Endocrinol Metab 87(6):2716. 2002
|
| 56 | GHRL
|
| Ghrelin, a novel placental-derived hormone.
|
| Gualillo O, Caminos J, Blanco M, Garcia-Caballero T, Kojima M, Kangawa K, Dieguez C, Casanueva F.
|
| Endocrinology 142(2):788-94. 2001
|
| 57 | GHRL
|
| Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans.
|
| Date Y, Kojima M, Hosoda H, Sawaguchi A, Mondal MS, Suganuma T, Matsukura S, Kangawa K, Nakazato M.
|
| Endocrinology 141(11):4255-61. 2000
|
| 58 | GHRL
|
| Kidney produces a novel acylated peptide, ghrelin.
|
| Mori K, Yoshimoto A, Takaya K, Hosoda K, Ariyasu H, Yahata K, Mukoyama M, Sugawara A, Hosoda H, Kojima M, Kangawa K, Nakao K.
|
| FEBS Lett 486(3):213-6. 2000
|
| 59 | GHRL
|
| Genomic organization of the human GHRELIN gene.
|
| Wajnrajch MP, Ten IS, Gertner JM, Leibel RL.
|
| J Endocrine Genet 1 : 231-233. 2000
|