Citations for
Gem GTPase acts upstream Gmip/RhoA to regulate cortical actin remodeling and spindle positioning during early mitosis.
Andrieu G, Quaranta M, Leprince C, Cuvillier O, Hatzoglou A.
Carcinogenesis 35(11):2503-11. doi: 10.1093/carcin/bgu185. Epub 2014 Aug 30. 2014
Upregulation of Gem relates to retinal ganglion cells apoptosis after optic nerve crush in adult rats.
Xu F, Huang H, Wu Y, Lu L, Jiang L, Chen L, Zeng S, Li L, Li M.
J Mol Histol 45(5):565-71. doi: 10.1007/s10735-014-9579-y. Epub 2014 Jun 20. 2014
RGK protein-mediated impairment of slow depolarization- dependent Ca2+ entry into developing myotubes.
Romberg CF, Beqollari D, Meza U, Bannister RA.
Channels (Austin) 8(3):243-8. 2014
Increased expression of Gem after rat sciatic nerve injury.
Wang Y, Cheng X, Zhou Z, Wu H, Long L, Gu X, Xu G.
J Mol Histol 44(1):27-36. doi: 10.1007/s10735-012-9459-2. Epub 2012 Oct 18. 2013
The GTPase Gem and its partner Kif9 are required for chromosome alignment, spindle length control, and mitotic progression.
Andrieu G, Quaranta M, Leprince C, Hatzoglou A.
FASEB J 26(12):5025-34. doi: 10.1096/fj.12-209460. Epub 2012 Sep 10. 2012
Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handling.
Gunton JE, Sisavanh M, Stokes RA, Satin J, Satin LS, Zhang M, Liu SM, Cai W, Cheng K, Cooney GJ, Laybutt DR, So T, Molero JC, Grey ST, Andres DA, Rolph MS, Mackay CR.
PLoS One 7(6):e39462. doi: 10.1371/journal.pone.0039462. Epub 2012 Jun 28. 2012
Molecular determinants of Gem protein inhibition of P/Q-type Ca2+ channels.
Fan M, Zhang WK, Buraei Z, Yang J.
J Biol Chem 287(27):22749-58. doi: 10.1074/jbc.M111.291872. Epub 2012 May 15. 2012
RGK family G-domain:GTP analog complex structures and nucleotide-binding properties.
Sasson Y, Navon-Perry L, Huppert D, Hirsch JA.
J Mol Biol 413(2):372-89. doi: 10.1016/j.jmb.2011.08.017. Epub 2011 Aug 29. 2011
Biochemical and structural characterization of the gem GTPase.
Splingard A, Menetrey J, Perderiset M, Cicolari J, Regazzoni K, Hamoudi F, Cabanie L, El Marjou A, Wells A, Houdusse A, de Gunzburg J.
J Biol Chem 282(3):1905-15. Epub 2006 Nov 15. 2007
Gem associates with Ezrin and acts via the Rho-GAP protein Gmip to down-regulate the Rho pathway.
Hatzoglou A, Ader I, Splingard A, Flanders J, Saade E, Leroy I, Traver S, Aresta S, de Gunzburg J.
Mol Biol Cell 18(4):1242-52. Epub 2007 Jan 31. 2007
Nuclear transport of Kir/Gem requires specific signals and importin alpha5 and is regulated by calmodulin and predicted serine phosphorylations.
Mahalakshmi RN, Nagashima K, Ng MY, Inagaki N, Hunziker W, Béguin P.
Traffic 8(9):1150-63. Epub 2007 Jul 1. 2007
Structure-function studies of the G-domain from human gem, a novel small G-protein.
Opatowsky Y, Sasson Y, Shaked I, Ward Y, Chomsky-Hecht O, Litvak Y, Selinger Z, Kelly K, Hirsch JA.
FEBS Lett 580(25):5959-64. Epub 2006 Oct 6. 2006
Phosphorylation of critical serine residues in Gem separates cytoskeletal reorganization from down-regulation of calcium channel activity.
Ward Y, Spinelli B, Quon MJ, Chen H, Ikeda SR, Kelly K.
Mol Cell Biol 24(2):651-61. 2004
The Ras-like GTPase Gem is involved in cell shape remodelling and interacts with the novel kinesin-like protein KIF9.
Piddini E, Schmid JA, de Martin R, Dotti CG.
EMBO J 20(15):4076-87. 2001
Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem.
Beguin P, Nagashima K, Gonoi T, Shibasaki T, Takahashi K, Kashima Y, Ozaki N, Geering K, Iwanaga T, Seino S.
Nature 411(6838):701-6. 2001
Regional assignment of 64 human gene transcripts on chromosome 8.
Ugolini F, Chaffanet M, Houlgatte R, Patterson D, Wells D, Auffray C, Birnbaum D, Pebusque MJ.
Cytogenet Cell Genet 77(3-4):197-200. 1997
Localization of the human mitogen-induced GTP-binding protein Gem to chromosome 8q22.3.
Kapetanopoulos A, et al.
Genomics 33 : 537-538. 1996
Chromosomal organization and transcriptional regulation of human GEM and localization of the human and mouse GEM loci encoding and inducible ras-like protein.
Santoro T, et al.
Genomics 30 : 558-564. 1995
Gem : an induced, immediate early protein belonging to the Ras family.
Maguire J, et al.
Science 265 : 241-244. 1994