| 1 | GADD45A, GADD45B, GADD45G, MAP2K7
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| GADD45 family proteins suppress JNK signaling by targeting MKK7.
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| Ueda T, Kohama Y, Kuge A, Kido E, Sakurai H.
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| Arch Biochem Biophys 635:1-7. doi: 10.1016/j.abb.2017.10.005. Epub 2017 Oct 14.
2017
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| 2 | GADD45B, MAP3K4, MAPK14
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| Phosphorylation of Atg5 by the Gadd45β-MEKK4-p38 pathway inhibits autophagy.
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| Keil E, Höcker R, Schuster M, Essmann F, Ueffing N, Hoffman B, Liebermann DA, Pfeffer K, Schulze-Osthoff K, Schmitz I.
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| Cell Death Differ 20(2):321-32. doi: 10.1038/cdd.2012.129. Epub 2012 Oct 12.
2013
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| 3 | GADD45A, GADD45B
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| Gadd45a and Gadd45b modulate innate immune functions of granulocytes and macrophages by differential regulation of p38 and JNK signaling.
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| Salerno DM, Tront JS, Hoffman B, Liebermann DA.
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| J Cell Physiol 227(11):3613-20. doi: 10.1002/jcp.24067.
2012
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| 4 | GADD45B
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| Gadd45â is an inducible coactivator of transcription that facilitates rapid liver growth in mice.
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| Tian J, Huang H, Hoffman B, Liebermann DA, Ledda-Columbano GM, Columbano A, Locker J.
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| J Clin Invest 121(11):4491-502. doi: 10.1172/JCI38760. Epub 2011 Oct 3.
2011
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| 5 | GADD45B, NR1I2
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| Pregnane X receptor PXR activates the GADD45beta gene, eliciting the p38 MAPK signal and cell migration.
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| Kodama S, Negishi M.
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| J Biol Chem 286(5):3570-8. doi: 10.1074/jbc.M110.179812. Epub 2010 Dec 2.
2011
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| 6 | CEBPB, COL10A1, GADD45B
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| GADD45beta enhances Col10a1 transcription via the MTK1/MKK3/6/p38 axis and activation of C/EBPbeta-TAD4 in terminally differentiating chondrocytes.
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| Tsuchimochi K, Otero M, Dragomir CL, Plumb DA, Zerbini LF, Libermann TA, Marcu KB, Komiya S, Ijiri K, Goldring MB.
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| J Biol Chem 285(11):8395-407. doi: 10.1074/jbc.M109.038638. Epub 2010 Jan 4.
2010
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| 7 | GADD45B
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| Gadd45b mediates Fas-induced apoptosis by enhancing the interaction between p38 and retinoblastoma tumor suppressor.
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| Cho HJ, Park SM, Hwang EM, Baek KE, Kim IK, Nam IK, Im MJ, Park SH, Bae S, Park JY, Yoo J.
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| J Biol Chem 285(33):25500-5. doi: 10.1074/jbc.M109.091413. Epub 2010 Jun 17.
2010
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| 8 | GADD45B
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| Gadd45beta is a novel mediator of cardiomyocyte apoptosis induced by ischaemia/hypoxia.
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| Kim MY, Seo EJ, Lee DH, Kim EJ, Kim HS, Cho HY, Chung EY, Lee SH, Baik EJ, Moon CH, Jung YS.
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| Cardiovasc Res 87(1):119-26. doi: 10.1093/cvr/cvq048. Epub 2010 Feb 12.
2010
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| 9 | GADD45B
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| Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis.
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| Ma, D. K.; Jang, M.-H.; Guo, J. U.; Kitabatake, Y.; Chang, M.; Pow-anpongkul, N.; Flavell, R. A.; Lu, B.; Ming, G.; Song, H.
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| Science 323: 1074-1077 2009
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| 10 | GADD45A, GADD45B
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| Gadd45b and Gadd45g are important for anti-tumor immune responses.
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| Ju S, Zhu Y, Liu L, Dai S, Li C, Chen E, He Y, Zhang X, Lu B.
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| Eur J Immunol 39(11):3010-8. doi: 10.1002/eji.200839154.
2009
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| 11 | GADD45B
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| Growth arrest and DNA damage protein 45b (Gadd45b) protects retinal ganglion cells from injuries.
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| Liu B, Suyeoka G, Papa S, Franzoso G, Neufeld AH.
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| Neurobiol Dis 33(1):104-10. doi: 10.1016/j.nbd.2008.09.020. Epub 2008 Oct 14.
2009
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| 12 | GADD45B, MAP2K7
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| GADD45B inhibits MKK7-induced cardiac hypertrophy and the polymorphisms of GADD45B is associated with inter-ventricular septum hypertrophy.
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| Wang J, Wang H, Chen J, Wang X, Sun K, Wang Y, Wang J, Yang X, Song X, Xin Y, Liu Z, Hui R.
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| Biochem Biophys Res Commun 372(4):623-8. Epub 2008 Jun 2.
2008
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| 13 | GADD45B
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| Gadd45beta promotes hepatocyte survival during liver regeneration in mice by modulating JNK signaling.
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| Papa S, Zazzeroni F, Fu YX, Bubici C, Alvarez K, Dean K, Christiansen PA, Anders RA, Franzoso G.
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| J Clin Invest 118(5):1911-23. doi: 10.1172/JCI33913.
2008
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| 14 | MAP2K7, GADD45B
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| Insights into the structural basis of the GADD45beta-mediated inactivation of the JNK kinase, MKK7/JNKK2.
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| Papa S, Monti SM, Vitale RM, Bubici C, Jayawardena S, Alvarez K, De Smaele E, Dathan N, Pedone C, Ruvo M, Franzoso G.
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| J Biol Chem 282(26):19029-41. Epub 2007 May 7. 2007
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| 15 | GADD45B,MMP13
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| A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation.
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| Ijiri K, Zerbini LF, Peng H, Correa RG, Lu B, Walsh N, Zhao Y, Taniguchi N, Huang XL, Otu H, Wang H, Wang JF, Komiya S, Ducy P, Rahman MU, Flavell RA, Gravallese EM, Oettgen P, Libermann TA, Goldring MB.
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| J Biol Chem 280(46):38544-55. Epub 2005 Sep 2. 2005
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| 16 | GADD45B
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| Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2.
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| Papa S, Zazzeroni F, Bubici C, Jayawardena S, Alvarez K, Matsuda S, Nguyen DU, Pham CG, Nelsbach AH, Melis T, De Smaele E, Tang WJ, D'Adamio L, Franzoso G.
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| Nat Cell Biol. 6(2):146-53 2004
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| 17 | GADD45B, GADD45GIP1
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| CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle.
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| Chung HK, Yi YW, Jung NC, Kim D, Suh JM, Kim H, Park KC, Song JH, Kim DW,Hwang ES, Yoon SH, Bae YS, Kim JM, Bae I, Shong M.
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| J Biol Chem 278(30):28079-88. Epub 2003 Apr 25. 2003
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| 18 | BRCA1, GADD45A, GADD45B, GADD45G, NFYA, POU2F1
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| BRCA1 regulates GADD45 through its interactions with the OCT-1 and CAAT motifs.
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| Fan W, Jin S, Tong T, Zhao H, Fan F, Antinore MJ, Rajasekaran B, Wu M, Zhan Q.
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| J Biol Chem 277(10):8061-7. 2002
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| 19 | GADD45B
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| GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress
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| Vairapandi M, Balliet AG, Hoffman B, Liebermann DA.
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| J Cell Physiol. 192(3):327-38 2002
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| 20 | GADD45B
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| Oligomerization of human Gadd45a protein.
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| Kovalsky O, Lung FD, Roller PP, Fornace AJ Jr.
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| J Biol Chem. 276(42):39330-9 2001
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| 21 | GADD45A, GADD45B
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| Identification of a functional domain in a GADD45-mediated G2/M checkpoint.
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| Yang Q, Manicone A, Coursen JD, Linke SP, Nagashima M, Forgues M, Wang XW.
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| J Biol Chem 275(47):36892-8. 2000
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| 22 | GADD45B
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| Gadd45 family proteins are coactivators of nuclear hormone receptors.
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| Yi YW, Kim D, Jung N, Hong SS, Lee HS, Bae I.
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| Biochem Biophys Res Commun. ;272(1):193-8 2000
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| 23 | GADD45A, GADD45B, MAP3K4
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| A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK.
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| Takekawa M, et al.
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| Cell 95(4):521-30 1998
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| 24 | CDKN1A, GADD45B, PCNA
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| The differentiation primary response gene MyD118, related to GADD45, encodes for a nuclear protein which interacts with PCNA and p21WAF1/CIP1.
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| Vairapandi M, Balliet AG, Fornace AJ Jr, Hoffman B, Liebermann DA.
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| Oncogene 12(12):2579-94. 1996
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| 25 | GADD45B
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| Sequence and expression of a cDNA encoding MyD118: a novel myeloid differentiation primary response gene induced by multiple cytokines.
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| Abdollahi A, et al.
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| Oncogene 6(1):165-7 1991
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